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View article: Against all odds: The road to success in the development of human immune reconstitution mice
Against all odds: The road to success in the development of human immune reconstitution mice Open
The mouse genome has a high degree of homology with the human genome, and its physiological, biochemical, and developmental regulation mechanisms are similar to those of humans; therefore, mice are widely used as experimental animals. Howe…
View article: Dclre1c-Mutation-Induced Immunocompromised Mice Are a Novel Model for Human Xenograft Research
Dclre1c-Mutation-Induced Immunocompromised Mice Are a Novel Model for Human Xenograft Research Open
Severe combined immunodeficient (SCID) mice serve as a critical model for human xenotransplantation studies, yet they often suffer from low engraftment rates and susceptibility to graft-versus-host disease (GVHD). Moreover, certain SCID st…