Yonggao Mou
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View article: Integration of Freestanding High‐ <i>k</i> Oxide Membranes for 2D Ferroelectric Field‐Effect Transistors
Integration of Freestanding High‐ <i>k</i> Oxide Membranes for 2D Ferroelectric Field‐Effect Transistors Open
Ferroelectric field‐effect transistors (FeFETs) based on oxides with exceptional dielectric and ferroelectric properties offer compelling prospects for energy‐efficient logic, nonvolatile memory, and neuromorphic computing. However, integr…
View article: SURG-02. Analysis of Prognostic Factors in Patients After En Bloc Resection of Brain Metastases
SURG-02. Analysis of Prognostic Factors in Patients After En Bloc Resection of Brain Metastases Open
OBJECTIVE To investigate the survival prognosis and influencing factors in patients with brain metastases undergoing En bloc resection. METHODS Clinical data of 342 brain metastasis patients treated with En bloc resection were retrospectiv…
View article: DNA methylation mediates the immunosuppressive tumour microenvironment in metastatic endometrial clear cell carcinoma
DNA methylation mediates the immunosuppressive tumour microenvironment in metastatic endometrial clear cell carcinoma Open
This work was supported by the National Natural Science Foundation of China, Joint Foundation Programme, Qingdao Municipal Science and Technology Bureau Municipal Science, Shenzhen Science and Technology Programme, and the Affiliated Hospi…
View article: Efficacy and Safety of T‐ <scp>DXd</scp> in <scp>HER2</scp> + and Low/Zero Metastatic <scp>BCBM</scp> : A Retrospective Multicenter Real‐World Study
Efficacy and Safety of T‐ <span>DXd</span> in <span>HER2</span> + and Low/Zero Metastatic <span>BCBM</span> : A Retrospective Multicenter Real‐World Study Open
Accumulating data demonstrate the robust overall and intracranial activity of trastuzumab deruxtecan (T‐DXd) in HER2‐positive breast cancer brain metastasis (BCBM). Limited data are available on HER2‐low/zero BCBM, as well as patients with…
View article: Prediction of future brain disorder risk using imaging data in 46,090 adults
Prediction of future brain disorder risk using imaging data in 46,090 adults Open
The advent of biobank level datasets offers unprecedented opportunities to discover novel imaging markers and develop prediction models for brain diseases. In this study, we first performed a prospective cohort study and derived a comprehe…
View article: Prone Sites of Brain Metastases in Breast Cancer: A Voxel-wise Analysis Based on Clinical Features
Prone Sites of Brain Metastases in Breast Cancer: A Voxel-wise Analysis Based on Clinical Features Open
Purpose Brain metastases (BMs) occur in 15–30% of breast cancer patients, particularly in HER2-positive and triple-negative subtypes, and signify poor prognosis. This study aimed to identify vulnerable BM locations through voxel-wise analy…
View article: The Impact of Retirement and Grandchild Caregiving on Mental Health in China: The Role of Intergenerational Support
The Impact of Retirement and Grandchild Caregiving on Mental Health in China: The Role of Intergenerational Support Open
Background This study explores the impact of retirement, grandchild caregiving, and intergenerational support on the mental health of older adults in China, focusing on how these factors interact. Methods Using data from the 2018 China Hea…
View article: Evaluating the Diagnostic and Prognostic Value of Peripheral Immune Markers in Glioma Patients: A Prospective Multi-Institutional Cohort Study of 1282 Patients
Evaluating the Diagnostic and Prognostic Value of Peripheral Immune Markers in Glioma Patients: A Prospective Multi-Institutional Cohort Study of 1282 Patients Open
The nSII can serve as a robust non-invasive diagnostic and prognostic biomarker in glioma, thus promoting clinical management in screening, stratification, and treatment optimization. This study also provides a comprehensive perspective on…
View article: Joint modeling histology and molecular markers for cancer classification
Joint modeling histology and molecular markers for cancer classification Open
Cancers are characterized by remarkable heterogeneity and diverse prognosis. Accurate cancer classification is essential for patient stratification and clinical decision-making. Although digital pathology has been advancing cancer diagnosi…
View article: Joint Modelling Histology and Molecular Markers for Cancer Classification
Joint Modelling Histology and Molecular Markers for Cancer Classification Open
Cancers are characterized by remarkable heterogeneity and diverse prognosis. Accurate cancer classification is essential for patient stratification and clinical decision-making. Although digital pathology has been advancing cancer diagnosi…
View article: Analysis of the Development Trend of Frontier Science and Technology in the Field of Quantum Communication Processing
Analysis of the Development Trend of Frontier Science and Technology in the Field of Quantum Communication Processing Open
In order to enhance the understanding of the development trend analysis of frontier science and technology. Based on the analysis of the frontier core papers, this paper uses cite space, VOS viewer and other software for visual analysis, a…
View article: CTNI-05. A PROSPECTIVE STUDY OF TUMOR-TREATING FIELDS COMBINED WITH SYSTEMIC THERAPY IN RECURRENT GLIOBLASTOMA
CTNI-05. A PROSPECTIVE STUDY OF TUMOR-TREATING FIELDS COMBINED WITH SYSTEMIC THERAPY IN RECURRENT GLIOBLASTOMA Open
BACKGROUND Tumor-treating Fields (TTFields) monotherapy was approved for recurrent glioblastoma. However, TTFields combined with systemic therapy has not been well studied in China. This study aims to explore the efficacy and safety of suc…
View article: Independent associations of educational attainment and its joint associations with LE8 score for risk of cardiovascular disease incidence and mortality among Chinese people
Independent associations of educational attainment and its joint associations with LE8 score for risk of cardiovascular disease incidence and mortality among Chinese people Open
Background/Introduction Educational attainment is a social determinant of health. Quantifying its associations with risk of cardiovascular disease (CVD) incidence and mortality has public health importance. Recently, the American Heart Ass…
View article: P14.04.A A PROSPECTIVE STUDY OF TUMOR-TREATING FIELDS COMBINED WITH SYSTEMIC THERAPY IN RECURRENT GLIOBLASTOMA
P14.04.A A PROSPECTIVE STUDY OF TUMOR-TREATING FIELDS COMBINED WITH SYSTEMIC THERAPY IN RECURRENT GLIOBLASTOMA Open
BACKGROUND Tumor-treating Fields (TTFields) monotherapy was approved for recurrent glioblastoma. However, TTFields combined with systemic therapy has not been well studied in China. This study aims to explore the efficacy and safety of suc…
View article: P06.01.A TARGETING MRNA DECAPPING ENZYME SCAVENGER (DCPS) IS A PROMISING STRATEGY AGAINST GLIOBLASTOMA VIA THE DOWN-REGULATION OF STAT5B
P06.01.A TARGETING MRNA DECAPPING ENZYME SCAVENGER (DCPS) IS A PROMISING STRATEGY AGAINST GLIOBLASTOMA VIA THE DOWN-REGULATION OF STAT5B Open
BACKGROUND Patients with glioblastoma (GBM) have poor prognosis and limited treatment options. The mRNA decapping enzyme scavenger (DCPS) is a cap-hydrolyzing enzyme. The inhibitor targeting DCPS exhibited excellent central nervous system …
View article: Automated segmentation of brain metastases with deep learning: A multi-center, randomized crossover, multi-reader evaluation study
Automated segmentation of brain metastases with deep learning: A multi-center, randomized crossover, multi-reader evaluation study Open
Background Artificial intelligence has been proposed for brain metastasis (BM) segmentation but it has not been fully clinically validated. The aim of this study was to develop and evaluate a system for BM segmentation. Methods A deep-lear…
View article: Association between psychiatric disorders and glioma risk: evidence from Mendelian randomization analysis
Association between psychiatric disorders and glioma risk: evidence from Mendelian randomization analysis Open
Background Observational studies have explored the association of psychiatric disorders and the risk of brain cancers. However, the causal effect of specific mental illness on glioma remains elusive due to the lack of solid evidence. Metho…
View article: Clinical application of a three-dimensional-printed model in the treatment of intracranial and extracranial communicating tumors: a pilot study
Clinical application of a three-dimensional-printed model in the treatment of intracranial and extracranial communicating tumors: a pilot study Open
Background Surgical management for intracranial and extracranial communicating tumors is difficult due to the complex anatomical structures. Therefore, assisting methods are urgently needed. Accordingly, this study aimed to investigate the…
View article: Integrated Analyses of Multi-omic Data Derived from Paired Primary Lung Cancer and Brain Metastasis Reveals the Metabolic Vulnerability as a Novel Therapeutic Target
Integrated Analyses of Multi-omic Data Derived from Paired Primary Lung Cancer and Brain Metastasis Reveals the Metabolic Vulnerability as a Novel Therapeutic Target Open
Lung cancer brain metastases (LC-BrMs) are frequently associated with dismal mortality rates in patients with lung cancer; however, standard of care therapies for LC-BrMs are still limited in their efficacy. A deep understanding of molecul…