Yixin Pan
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View article: Behavioural and clinical biomarkers of the human bed nucleus of stria terminalis from direct neural recordings
Behavioural and clinical biomarkers of the human bed nucleus of stria terminalis from direct neural recordings Open
Identifying novel neuromodulatory targets for deep brain stimulation (DBS) in psychiatric disorders is an urgent clinical need. Equally critical is the discovery of simple oscillatory biomarkers that bridge behaviour and clinical symptoms,…
View article: Hybrid pneumatic-hydraulic actuation for MRI-guided robotic stereotactic neurointervention
Hybrid pneumatic-hydraulic actuation for MRI-guided robotic stereotactic neurointervention Open
Stereotactic neurointervention is a common procedure for biopsy, injection, ablation, and implantation of electrodes for deep brain stimulation. Guided by preoperative imaging, conventional approaches are mostly performed manually, lacking…
View article: Similarity of Biological Information Captured by <sup>68</sup>Ga-PSMA-11 PET and ASL Perfusion MRI in Glioblastoma
Similarity of Biological Information Captured by <sup>68</sup>Ga-PSMA-11 PET and ASL Perfusion MRI in Glioblastoma Open
GBM＝ glioblastoma; PSMA＝prostate-specific membrane antigen; ASL = arterial spin-labeling; CE = contrast enhanced; DSC = Dice similarity coefficients; OV = overlap volume; MVD = microvascular density; TBR = tumor-to-background ratio.
View article: Dissociable Physiological Biomarkers of Psychiatric Symptoms in Parkinson’s disease in the Subthalamic Nucleus: Evidence from Deep Brain Stimulation Intracranial Recordings
Dissociable Physiological Biomarkers of Psychiatric Symptoms in Parkinson’s disease in the Subthalamic Nucleus: Evidence from Deep Brain Stimulation Intracranial Recordings Open
Psychiatric symptoms in Parkinson’s disease (PD) are highly prevalent and challenging to treat. This study maps oscillatory neural activity to diverse psychiatric symptoms in PD, using resting-state subthalamic nucleus (STN) local field po…
View article: Long non-coding RNA BCAR4 regulates osteosarcoma progression by targeting microRNA-1260a
Long non-coding RNA BCAR4 regulates osteosarcoma progression by targeting microRNA-1260a Open
Long non-coding RNAs (lncRNAs) play a crucial role in modulating cancer progression and metastasis. This study investigates the tumor-promoting function of long non-coding RNA BCAR4 in osteosarcoma and elucidates its regulatory mechanism. …
View article: Subthalamic stimulation causally modulates human voluntary decision-making to stay or go
Subthalamic stimulation causally modulates human voluntary decision-making to stay or go Open
The voluntary nature of decision-making is fundamental to human behavior. The subthalamic nucleus is important in reactive decision-making, but its role in voluntary decision-making remains unclear. We recorded from deep brain stimulation …
View article: Bed Nucleus of the Stria Terminalis-Nucleus Accumbens Deep Brain Stimulation for Depression: A Randomized Controlled Trial and an Intracranial Physiological Biomarker Predictor
Bed Nucleus of the Stria Terminalis-Nucleus Accumbens Deep Brain Stimulation for Depression: A Randomized Controlled Trial and an Intracranial Physiological Biomarker Predictor Open
Therapeutic options for refractory depression are urgently needed. We conducted a deep brain stimulation (DBS) randomized controlled trial of the bed nucleus of the stria terminalis (BNST), an extended amygdala structure, and nucleus accum…
View article: Modeling impulsivity and risk aversion in the subthalamic nucleus with deep brain stimulation
Modeling impulsivity and risk aversion in the subthalamic nucleus with deep brain stimulation Open
Risk evaluation is ubiquitous in decisions. Deep brain stimulation of the subthalamic nucleus is effective for Parkinson’s disease and obsessive–compulsive disorder, and can be associated with impulsivity and hypomania. Subthalamic stimula…
View article: Anterior capsulotomy combined with subthalamic nucleus deep brain stimulation for tardive dystonia
Anterior capsulotomy combined with subthalamic nucleus deep brain stimulation for tardive dystonia Open
Bilateral anterior capsulotomy combined with bilateral STN-DBS may be an effective and relatively safe treatment option for severe TD comorbid with major psychiatric disorders.
View article: Presurgical structural imaging and clinical outcome in combined bed nucleus of the stria terminalis–nucleus accumbens deep brain stimulation for treatment-resistant depression
Presurgical structural imaging and clinical outcome in combined bed nucleus of the stria terminalis–nucleus accumbens deep brain stimulation for treatment-resistant depression Open
Background Structural imaging holds great potential for precise targeting and stimulation for deep brain stimulation (DBS). The anatomical information it provides may serve as potential biomarkers for predicting the efficacy of DBS in trea…
View article: Superior cerebellar peduncle deep brain stimulation for cerebral palsy
Superior cerebellar peduncle deep brain stimulation for cerebral palsy Open
OBJECTIVE Patients with coexisting spastic cerebral palsy (CP) and dystonia have limited treatment options. In this study, the authors aimed to evaluate the efficacy of deep brain stimulation (DBS) targeting the superior cerebellar peduncl…
View article: Adding injury to insult: Unfair treatment at work and occupational injury among hospital patient‐care workers
Adding injury to insult: Unfair treatment at work and occupational injury among hospital patient‐care workers Open
Background Hospital patient‐care workers have high occupational injury rates. While physical hazards within hospital work environments are established determinants of injury, social exposures may also contribute. This study examined how re…
View article: Prediction of subthalamic stimulation efficacy on isolated dystonia via support vector regression
Prediction of subthalamic stimulation efficacy on isolated dystonia via support vector regression Open
STN-DBS demonstrated significant and rapid therapeutic effects in patients with isolated dystonia, by possibly affecting the pallidofugal fibers. Early improvement highly indicates the ultimate outcomes. SVR proves valid in outcome predict…
View article: Rescue subthalamic stimulation after unsatisfactory outcome of pallidal stimulation in Parkinson's disease: a case series and review
Rescue subthalamic stimulation after unsatisfactory outcome of pallidal stimulation in Parkinson's disease: a case series and review Open
Background Subthalamic nucleus (STN) and globus pallidus interna (GPi) are two main structures primarily targeted by deep brain stimulation (DBS) to treat advanced Parkinson's disease (PD). A subset of cases with unsatisfactory outcomes ma…
View article: Risk and aversion coding in human habenula high gamma activity
Risk and aversion coding in human habenula high gamma activity Open
Neurons in the primate lateral habenula fire in response to punishments and are inhibited by rewards. Through its modulation of midbrain monoaminergic activity, the habenula is believed to play an important role in adaptive behavioural res…
View article: A systematic review of brain morphometry related to deep brain stimulation outcome in Parkinson’s disease
A systematic review of brain morphometry related to deep brain stimulation outcome in Parkinson’s disease Open
While the efficacy of deep brain stimulation (DBS) is well-established in Parkinson’s Disease (PD), the benefit of DBS varies across patients. Using imaging features for outcome prediction offers potential in improving effectiveness, where…
View article: Effects of High Cervical Spinal Cord Stimulation on Gait Disturbance and Dysarthropneumophonia in Parkinson’s Disease and Parkinson Variant of Multiple System Atrophy: A Case Series
Effects of High Cervical Spinal Cord Stimulation on Gait Disturbance and Dysarthropneumophonia in Parkinson’s Disease and Parkinson Variant of Multiple System Atrophy: A Case Series Open
High cervical spinal cord stimulation (HCSCS) was found to have therapeutic effects on Parkinsonian gait disturbance. However, the results were inconsistent and confounded with symptoms of pain. This study aimed to reveal the gait and dysa…
View article: Cortical and Subcortical Structural Abnormalities in Patients With Idiopathic Cervical and Generalized Dystonia
Cortical and Subcortical Structural Abnormalities in Patients With Idiopathic Cervical and Generalized Dystonia Open
Objectives In this study, we sought to investigate structural imaging alterations of patients with idiopathic dystonia at the cortical and subcortical levels. The common and specific changes in two subtypes of dystonia, cervical dystonia (…