Yan Su
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View article: MiR-4664-3p as a potential diagnostic, prognostic, and immunotherapeutic biomarker in NSCLC: modulation of tumor progression through CD8 + T cell regulation
MiR-4664-3p as a potential diagnostic, prognostic, and immunotherapeutic biomarker in NSCLC: modulation of tumor progression through CD8 + T cell regulation Open
Introduction Non-small cell lung cancer (NSCLC) is one of the leading causes of cancer-related deaths worldwide, largely due to complex interactions within the tumor-immune microenvironment that limit treatment efficacy. MicroRNAs (miRNAs)…
View article: Urban–rural disparity in preterm neonatal mortality in China: a retrospective study
Urban–rural disparity in preterm neonatal mortality in China: a retrospective study Open
This study demonstrates persistent urban-rural disparities in cause-specific mortality and gestational age distribution among preterm neonates. Findings may help local governments develop targeted strategies to further reduce overall neona…
View article: Ewing’s sarcoma family of tumors in adolescents in Beijing 2010–2019: a multicenter retrospective cohort study
Ewing’s sarcoma family of tumors in adolescents in Beijing 2010–2019: a multicenter retrospective cohort study Open
Metastasis is a prevalent and critical prognostic factor in adolescent ESFT patients. Multimodal treatment and timely initiation of local therapy may contribute to improved survival outcomes. These findings underscore the importance of ear…
View article: Whole-tumor histogram analysis of diffusion weighted imaging, diffusion kurtosis imaging, and intravoxel incoherent motion for adult diffuse glioma genotyping
Whole-tumor histogram analysis of diffusion weighted imaging, diffusion kurtosis imaging, and intravoxel incoherent motion for adult diffuse glioma genotyping Open
The prediction of IDH mutation status in adult diffuse glioma and the 1p/19q codeletion status in IDH mutant glioma could be improved through histogram features of IVIM-derived parameters and the combined model.
View article: Clinical Efficacy and Safety Evaluation of Radiotherapy/Chemoradiotherapy with or without Immunotherapy in Elderly Patients with Inoperable Locally Advanced Non-Small Cell Lung Cancer
Clinical Efficacy and Safety Evaluation of Radiotherapy/Chemoradiotherapy with or without Immunotherapy in Elderly Patients with Inoperable Locally Advanced Non-Small Cell Lung Cancer Open
View article: Cancer cell membrane-camouflaged pH-responsive nanoparticles for enhancing siRNA effect and synergistic anti-tumor therapy
Cancer cell membrane-camouflaged pH-responsive nanoparticles for enhancing siRNA effect and synergistic anti-tumor therapy Open
View article: Single-cell spatial analysis of pediatric high-grade glioma reveals a novel population of SPP1+/GPNMB+ myeloid cells with immunosuppressive and tumor-promoting capabilities
Single-cell spatial analysis of pediatric high-grade glioma reveals a novel population of SPP1+/GPNMB+ myeloid cells with immunosuppressive and tumor-promoting capabilities Open
Background Pediatric-type diffuse high-grade gliomas (pHGGs) are a leading cause of pediatric cancer-related mortality. Although immunotherapy offers a promising treatment avenue, clinical responses in pHGG patients remain limited. A detai…
View article: RadFabric: Agentic AI System with Reasoning Capability for Radiology
RadFabric: Agentic AI System with Reasoning Capability for Radiology Open
Chest X ray (CXR) imaging remains a critical diagnostic tool for thoracic conditions, but current automated systems face limitations in pathology coverage, diagnostic accuracy, and integration of visual and textual reasoning. To address th…
View article: The potential role of biomarkers CD28 and PF4 in the pathogenesis of idiopathic pulmonary fibrosis and their impact on the prognosis: an immune microenvironment analysis
The potential role of biomarkers CD28 and PF4 in the pathogenesis of idiopathic pulmonary fibrosis and their impact on the prognosis: an immune microenvironment analysis Open
View article: Meta-analysis of clinical efficacy of percutaneous endoscopic gastrostomy <i>vs</i> percutaneous radiologic gastrostomy
Meta-analysis of clinical efficacy of percutaneous endoscopic gastrostomy <i>vs</i> percutaneous radiologic gastrostomy Open
View article: Cancer cell membrane-camouflaged pH-responsive nanoparticles for enhancing siRNA effect and synergistic anti-tumor therapy
Cancer cell membrane-camouflaged pH-responsive nanoparticles for enhancing siRNA effect and synergistic anti-tumor therapy Open
RNA-based therapies, especially small interfering RNA (siRNA), have attracted extensive attention for tumor treatment. However, most siRNA can’t exert a therapeutic effect due to a lack of targeting to tumor cells and entrapment in lysosom…
View article: Urban–Rural Disparity in Preterm Neonatal Mortality in China: A Retrospective Study
Urban–Rural Disparity in Preterm Neonatal Mortality in China: A Retrospective Study Open
Background The neonatal mortality rate (NMR) is a vital indicator for assessing maternal and child health, and preterm birth is one of the leading causes of neonatal mortality. Since 2010, China has implemented multiple maternal and child …
View article: Fact-finding and risk factor analysis of chemotherapy-induced nausea and vomiting in children with solid tumors: a prospective observational study
Fact-finding and risk factor analysis of chemotherapy-induced nausea and vomiting in children with solid tumors: a prospective observational study Open
Children with solid tumors treated with HEC at our center experienced suboptimal control of CINV. Older age, female, and a longer duration of the chemotherapy block were identified as risk factors for complete CIV control. Receipt of 5HT3R…
View article: Supplementary Figure 8 from Spatial and Single-Cell Analyses Reveal Heterogeneity of DNAM-1 Receptor–Ligand Interactions That Instructs Intratumoral γδT-cell Activity
Supplementary Figure 8 from Spatial and Single-Cell Analyses Reveal Heterogeneity of DNAM-1 Receptor–Ligand Interactions That Instructs Intratumoral γδT-cell Activity Open
Supplementary Figure 8 Enriched pathways and functional characteristics of CD8 T and NK cells. (A) The enriched KEGG pathways in CD8 T cells from high-ratio and low-ratio groups are shown in dot plots. The dot size in KEGG enrichment analy…
View article: Supplementary Figure 12 from Spatial and Single-Cell Analyses Reveal Heterogeneity of DNAM-1 Receptor–Ligand Interactions That Instructs Intratumoral γδT-cell Activity
Supplementary Figure 12 from Spatial and Single-Cell Analyses Reveal Heterogeneity of DNAM-1 Receptor–Ligand Interactions That Instructs Intratumoral γδT-cell Activity Open
Supplementary Figure 12 The effects of CD112 on γδT-cell-cytotoxicity against neuroblastoma, and on proliferation and migration of NB cells. (A-D) rhCD112 is used to treat γδT cells for 24 h. TIGIT, CD96 and CD112R are detected by FACS (le…
View article: Supplementary Figure 5 from Spatial and Single-Cell Analyses Reveal Heterogeneity of DNAM-1 Receptor–Ligand Interactions That Instructs Intratumoral γδT-cell Activity
Supplementary Figure 5 from Spatial and Single-Cell Analyses Reveal Heterogeneity of DNAM-1 Receptor–Ligand Interactions That Instructs Intratumoral γδT-cell Activity Open
Supplementary Figure 5 The expression of CD112 and CD155 in tumor and para-tumor tissue sections detected by immunohistochemistry.
View article: Supplementary Figure 13 from Spatial and Single-Cell Analyses Reveal Heterogeneity of DNAM-1 Receptor–Ligand Interactions That Instructs Intratumoral γδT-cell Activity
Supplementary Figure 13 from Spatial and Single-Cell Analyses Reveal Heterogeneity of DNAM-1 Receptor–Ligand Interactions That Instructs Intratumoral γδT-cell Activity Open
Supplementary Figure 13 The effects of CD155 on γδT-cell-cytotoxicity against neuroblastoma, and on proliferation and migration of NB cells. (A) and (B) α-TIGIT is used in the rhCD155 treatment of γδT cells. DNAM-1 is detected by FACS and …
View article: Supplementary Figure 10 from Spatial and Single-Cell Analyses Reveal Heterogeneity of DNAM-1 Receptor–Ligand Interactions That Instructs Intratumoral γδT-cell Activity
Supplementary Figure 10 from Spatial and Single-Cell Analyses Reveal Heterogeneity of DNAM-1 Receptor–Ligand Interactions That Instructs Intratumoral γδT-cell Activity Open
Supplementary Figure 10 Identification of Tet-on system, ROC curves and survival curves of different groups for NB tumor. (A) and (B) The variation of CD112 and CD155 expression in SK-N-BE2 cells treated with different concentration of dox…
View article: Supplementary Figure 9 from Spatial and Single-Cell Analyses Reveal Heterogeneity of DNAM-1 Receptor–Ligand Interactions That Instructs Intratumoral γδT-cell Activity
Supplementary Figure 9 from Spatial and Single-Cell Analyses Reveal Heterogeneity of DNAM-1 Receptor–Ligand Interactions That Instructs Intratumoral γδT-cell Activity Open
Supplementary Figure 9 The characteristics of NB tumors and immune cells in CD112/CD155 high-ratio and low-ratio groups revealed by bulk RNA sequencing analysis. (A) A total of 3537 DEGs between CD112/CD155 high-ratio and low-ratio groups …
View article: Supplementary Figure 3 from Spatial and Single-Cell Analyses Reveal Heterogeneity of DNAM-1 Receptor–Ligand Interactions That Instructs Intratumoral γδT-cell Activity
Supplementary Figure 3 from Spatial and Single-Cell Analyses Reveal Heterogeneity of DNAM-1 Receptor–Ligand Interactions That Instructs Intratumoral γδT-cell Activity Open
Supplementary Figure 3 The expression analysis of CD112 and CD155 in NB. (A) and (B) The expression of CD112 in NB cell lines and primary NB tumor tissues are identified using qPCR and Western blot. (C) and (D) The expression of CD112 in N…
View article: Supplementary Tables from Spatial and Single-Cell Analyses Reveal Heterogeneity of DNAM-1 Receptor–Ligand Interactions That Instructs Intratumoral γδT-cell Activity
Supplementary Tables from Spatial and Single-Cell Analyses Reveal Heterogeneity of DNAM-1 Receptor–Ligand Interactions That Instructs Intratumoral γδT-cell Activity Open
Supplementary Tables and Supplementary Figure legends
View article: Supplementary Figure 14 from Spatial and Single-Cell Analyses Reveal Heterogeneity of DNAM-1 Receptor–Ligand Interactions That Instructs Intratumoral γδT-cell Activity
Supplementary Figure 14 from Spatial and Single-Cell Analyses Reveal Heterogeneity of DNAM-1 Receptor–Ligand Interactions That Instructs Intratumoral γδT-cell Activity Open
Supplementary Figure 14 The effects of soluble CD155 or CD155 on NB cells on DNAM-1, PD-1, TIM-3 and TIGIT expression levels in γδT cells during the interaction with NB microenvironment. (A-C) α-CD155 is used in the co-culture of γδT cells…
View article: Supplementary Figure 2 from Spatial and Single-Cell Analyses Reveal Heterogeneity of DNAM-1 Receptor–Ligand Interactions That Instructs Intratumoral γδT-cell Activity
Supplementary Figure 2 from Spatial and Single-Cell Analyses Reveal Heterogeneity of DNAM-1 Receptor–Ligand Interactions That Instructs Intratumoral γδT-cell Activity Open
Supplementary Figure 2 Gating strategies of FACS analysis and the expression pattern of TIGIT in NB. (A) Gating strategies for the FACS analysis of circulating γδT cells. (B) Gating strategies for the FACS analysis of tumor infiltrating im…
View article: Supplementary Figure 11 from Spatial and Single-Cell Analyses Reveal Heterogeneity of DNAM-1 Receptor–Ligand Interactions That Instructs Intratumoral γδT-cell Activity
Supplementary Figure 11 from Spatial and Single-Cell Analyses Reveal Heterogeneity of DNAM-1 Receptor–Ligand Interactions That Instructs Intratumoral γδT-cell Activity Open
Supplementary Figure 11 Low-dose doxorubicin affects the expression of CD112 and CD155 in NB cells. (A) The apoptosis of SH-SY5Y and SK-N-BE2 cells treated with low-dose doxorubicin (0.1 μM) is detected by FACS (left) and AV+ proportion is…
View article: Supplementary Figure 4 from Spatial and Single-Cell Analyses Reveal Heterogeneity of DNAM-1 Receptor–Ligand Interactions That Instructs Intratumoral γδT-cell Activity
Supplementary Figure 4 from Spatial and Single-Cell Analyses Reveal Heterogeneity of DNAM-1 Receptor–Ligand Interactions That Instructs Intratumoral γδT-cell Activity Open
Supplementary Figure 4 Quality control and annotation genes for NB tumor spatial transcriptome analysis. (A) Violin plots and heatmaps showing the number of features, RNA counts and percent mitochondrial transcripts found in NB tumor sampl…
View article: Supplementary Figure 6 from Spatial and Single-Cell Analyses Reveal Heterogeneity of DNAM-1 Receptor–Ligand Interactions That Instructs Intratumoral γδT-cell Activity
Supplementary Figure 6 from Spatial and Single-Cell Analyses Reveal Heterogeneity of DNAM-1 Receptor–Ligand Interactions That Instructs Intratumoral γδT-cell Activity Open
Supplementary Figure 6 The cell-cycle scores and expression of functional genes in tumor cells and γδT cells in spatial transcriptome analysis and scRNA sequencing analysis. (A) Cell-cycle score analysis of tumor cells in spatial transcrip…
View article: Supplementary Figure 7 from Spatial and Single-Cell Analyses Reveal Heterogeneity of DNAM-1 Receptor–Ligand Interactions That Instructs Intratumoral γδT-cell Activity
Supplementary Figure 7 from Spatial and Single-Cell Analyses Reveal Heterogeneity of DNAM-1 Receptor–Ligand Interactions That Instructs Intratumoral γδT-cell Activity Open
Supplementary Figure 7 Metabolic states of high-ratio and low-ratio tumor cells. (A) Enriched metabolic reactions in high-ratio and low-ratio tumor cells revealed by COMPASS analysis. (B) Changes in metabolic KEGG pathways revealed by spat…
View article: Supplementary Figure 1 from Spatial and Single-Cell Analyses Reveal Heterogeneity of DNAM-1 Receptor–Ligand Interactions That Instructs Intratumoral γδT-cell Activity
Supplementary Figure 1 from Spatial and Single-Cell Analyses Reveal Heterogeneity of DNAM-1 Receptor–Ligand Interactions That Instructs Intratumoral γδT-cell Activity Open
Supplementary Figure 1 Identified major cell types, cell proportion analysis and CD112 and CD155 expression in NB tumor scRNA-seq analysis. (A) Violin plots showing the number of features, RNA counts and percent mitochondrial transcripts f…
View article: Subtalar arthroereisis for simultaneous treatment of flexible pes planus during surgical correction of hallux valgus
Subtalar arthroereisis for simultaneous treatment of flexible pes planus during surgical correction of hallux valgus Open
View article: Supplementary Figure 11 from Spatial and Single-Cell Analyses Reveal Heterogeneity of DNAM-1 Receptor–Ligand Interactions That Instructs Intratumoral γδT-cell Activity
Supplementary Figure 11 from Spatial and Single-Cell Analyses Reveal Heterogeneity of DNAM-1 Receptor–Ligand Interactions That Instructs Intratumoral γδT-cell Activity Open
Supplementary Figure 11 Low-dose doxorubicin affects the expression of CD112 and CD155 in NB cells. (A) The apoptosis of SH-SY5Y and SK-N-BE2 cells treated with low-dose doxorubicin (0.1 μM) is detected by FACS (left) and AV+ proportion is…