Yiyun Zhu
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View article: Molecular mechanism of <i>SmMYB53</i> activates the expression of <i>SmCYP71D375</i>, thereby modulating tanshinone accumulation in <i>Salvia miltiorrhiza</i>
Molecular mechanism of <i>SmMYB53</i> activates the expression of <i>SmCYP71D375</i>, thereby modulating tanshinone accumulation in <i>Salvia miltiorrhiza</i> Open
Tanshinones are bioactive diterpenoid chemicals of the herb Salvia miltiorrhiza with a characteristic furan D-ring. As a newly identified downstream enzyme, SmCYP71D375, catalyzes hydroxylation by 14,16-ether (hetero)cyclization to form th…
View article: Amphibians as a source of bioactive antioxidant peptides: Emerging insights and therapeutic potential
Amphibians as a source of bioactive antioxidant peptides: Emerging insights and therapeutic potential Open
Oxidative stress arises from disruption of the balance between reactive oxygen species (ROS) production and detoxification and constitutes a fundamental driver of diverse pathological diseases. Skin photoaging is a well-recognized example,…
View article: PSTK exerts protective role in cisplatin‐tubular cell injury via BAX/BCL2/Caspase3 pathway
PSTK exerts protective role in cisplatin‐tubular cell injury via BAX/BCL2/Caspase3 pathway Open
Cisplatin is a widely used anticancer drug, but its accumulation in renal tubular epithelial cells (TECs) can cause acute kidney injury. Phosphoseryl‐tRNA kinase (PSTK) is an intermediate product produced under oxidative stress conditions.…
View article: Pstk Activated Pkm2 Phosphorylation at Ser37 in Renal Epithelial Hk-2 Tubular Cells
Pstk Activated Pkm2 Phosphorylation at Ser37 in Renal Epithelial Hk-2 Tubular Cells Open
View article: Atractylodes macrocephala Root Rot Affects Microbial Communities in Various Root-Associated Niches
Atractylodes macrocephala Root Rot Affects Microbial Communities in Various Root-Associated Niches Open
Atractylodes macrocephala, a perennial herb widely used in traditional Chinese medicine, is highly prone to root rot, which significantly reduces its yield and quality. This study compared the physicochemical properties of soil from health…
View article: 478 NLRP3 inhibitor treatment reverses melanoma-induced vitiligo in mice
478 NLRP3 inhibitor treatment reverses melanoma-induced vitiligo in mice Open
View article: High-yielding nitrate transporter cultivars also mitigate methane and nitrous oxide emissions in paddy
High-yielding nitrate transporter cultivars also mitigate methane and nitrous oxide emissions in paddy Open
Development of high yield rice varieties is critical to ensuring global food security. However, the emission of greenhouse gases (GHG) such as Methane (CH 4 ) and Nitrous oxide (N 2 O) from paddy fields threatens environmental sustainabili…
View article: Wnt signaling pathway-derived score for predicting therapeutic resistance and tumor microenvironment in lung adenocarcinoma
Wnt signaling pathway-derived score for predicting therapeutic resistance and tumor microenvironment in lung adenocarcinoma Open
Background: Lung adenocarcinoma (LUAD) is the most common subtype of lung cancer. Due to tumor heterogeneity, understanding the pathological mechanism of tumor progression helps to improve the diagnosis process and clinical treatment strat…
View article: Immunization with rEmCRT provides protection against Echinococcus multilocularis infection in BALB/c mice
Immunization with rEmCRT provides protection against Echinococcus multilocularis infection in BALB/c mice Open
Background Alveolar echinococcosis (AE) is a severe parasitic zoonosis, caused by the larval stage of Echinococcus multilocularis. Identification of the antigens eliciting acquired immunity during infection is important for vaccine develop…
View article: Mining of the CULLIN E3 ubiquitin ligase genes in the whole genome of Salvia miltiorrhiza
Mining of the CULLIN E3 ubiquitin ligase genes in the whole genome of Salvia miltiorrhiza Open
CULLIN (CUL) proteins are E3 ubiquitin ligases that are involved in a wide variety of biological processes as well as in response to stress in plants. In Salvia miltiorrhiza, CUL genes have not been characterized and its role…
View article: A Single Nucleotide Polymorphism in an R2R3 MYB Transcription Factor Triggers ms6 (Ames1) Male Sterility in Soybean
A Single Nucleotide Polymorphism in an R2R3 MYB Transcription Factor Triggers ms6 (Ames1) Male Sterility in Soybean Open
Soybean [Glycine max (L.) Merr.] is an important crop providing vegetable oils and proteins. Increasing demand on soy products heightens the urgency of soybean yield improvement. Hybrid breeding with male sterility system is an effective m…
View article: Co-Overexpression of OsNAR2.1 and OsNRT2.3a Increased Agronomic Nitrogen Use Efficiency in Transgenic Rice Plants
Co-Overexpression of OsNAR2.1 and OsNRT2.3a Increased Agronomic Nitrogen Use Efficiency in Transgenic Rice Plants Open
The NO3 - transporter plays an important role in rice nitrogen acquisition and nitrogen-use efficiency. Our previous studies have shown that the high affinity systems for nitrate uptake in rice is mediated by a two-co…
View article: Knockdown of a Novel Gene OsTBP2.2 Increases Sensitivity to Drought Stress in Rice
Knockdown of a Novel Gene OsTBP2.2 Increases Sensitivity to Drought Stress in Rice Open
Drought stress is a major environmental stress, which adversely affects the biological and molecular processes of plants, thereby impairing their growth and development. In the present study, we found that the expression level of OsTBP2.2 …
View article: Overexpression of the High-Affinity Nitrate Transporter OsNRT2.3b Driven by Different Promoters in Barley Improves Yield and Nutrient Uptake Balance
Overexpression of the High-Affinity Nitrate Transporter OsNRT2.3b Driven by Different Promoters in Barley Improves Yield and Nutrient Uptake Balance Open
Improving nitrogen use efficiency (NUE) is very important for crops throughout the world. Rice mainly utilizes ammonium as an N source, but it also has four NRT2 genes involved in nitrate transport. The OsNRT2.3b transporter is important f…
View article: BASP1 Suppresses Cell Growth and Metastasis through Inhibiting Wnt/<i>β</i>‐Catenin Pathway in Gastric Cancer
BASP1 Suppresses Cell Growth and Metastasis through Inhibiting Wnt/<i>β</i>‐Catenin Pathway in Gastric Cancer Open
Objective . Our research is designed to explore the function of brain acid soluble protein 1 (BASP1) in the progression of gastric cancer (GC) and its underlying molecular mechanisms. Methods . In this study, the expression of BASP1 was de…
View article: Effect of three different mineral components on the properties of wood flour/high-density polyethylene composites: A comparison
Effect of three different mineral components on the properties of wood flour/high-density polyethylene composites: A comparison Open
To investigate the properties of wood flour/high-density polyethylene composites (WF/HDPE) filled with different kinds of mineral components (CaCO3, talc powder, and wollastonite), WF/HDPE was prepared via a molding method. The thermal pro…
View article: Catalpol Inhibits Amyloid-β Generation Through Promoting α-Cleavage of APP in Swedish Mutant APP Overexpressed N2a Cells
Catalpol Inhibits Amyloid-β Generation Through Promoting α-Cleavage of APP in Swedish Mutant APP Overexpressed N2a Cells Open
Amyloid-β (Aβ) peptides play a crucial role in the pathogenesis of Alzheimer's disease (AD), due to its neurotoxicity. Thus, blocking Aβ generation and aggregation in the brain has been realized as an efficient way for the prevention of AD…
View article: Bigelovin triggered apoptosis in colorectal cancer in vitro and in vivo via upregulating death receptor 5 and reactive oxidative species
Bigelovin triggered apoptosis in colorectal cancer in vitro and in vivo via upregulating death receptor 5 and reactive oxidative species Open
Colorectal cancer (CRC) is the third most prevalent cancer and the third highest cancer-related mortality in the United States. Bigelovin, a sesquiterpene lactone isolated from Inula helianthus aquatica , has been proven to induce apoptosi…
View article: Rubipodanin A, the First Natural N-Desmonomethyl Rubiaceae-Type Cyclopeptide from Rubia podantha, Indicating an Important Role of the N9-Methyl Group in the Conformation and Bioactivity
Rubipodanin A, the First Natural N-Desmonomethyl Rubiaceae-Type Cyclopeptide from Rubia podantha, Indicating an Important Role of the N9-Methyl Group in the Conformation and Bioactivity Open
One new cyclic hexapeptide named rubipodanin A (1), which is the first identified natural N-desmonomethyl Rubiaceae-type cyclopeptide, together with six known Rubiaceae-type cyclopeptides (2-7) were obtained using the TLC cyclopeptide prot…