Explanipedia

A newborn derived monoclonal IgM antibody selectively modulates microbial metabolism in the gut Open

Zihan He, Shijie Gong, Mu Fan, Qisheng Gu, Parag Kundu , et al. · 2025

Metabolism and gut microbiota are essential for newborn health, influencing immune function, energy balance, and growth. Breast milk provides IgA, crucial for shaping gut microbiota in infants. In non-breastfed newborns, we observe the pre…

Tunable Virtual IMU Frame by Weighted Averaging of Multiple Non-Collocated IMUs Open

Yi‐Zhou Gao, Tim Barfoot · 2025

We present a new method to combine several rigidly connected but physically separated IMUs through a weighted average into a single virtual IMU (VIMU). This has the benefits of (i) reducing process noise through averaging, and (ii) allowin…

Microbial carbon utilization for a sustainable future Open

Handong Wang, Tong Wu, Lei Wang, Yu Zhang, Xinglin Jiang , et al. · 2025

Microbial utilization of diverse carbon sources presents transformative potential for sustainable green biomanufacturing. This review examines ten distinct carbon sources including carbon dioxide, carbon monoxide, formic acid, sugars, arom…

Merlin condensates: A solid foundation for the Hippo signaling pathway Open

Xiaoyan Wang, Jinlong Suo, Xue Feng, Yi‐Zhou Gao, Yang Li , et al. · 2024

iMeta Conference 2024: Building an innovative scientific research ecosystem for microbiome and One Health Open

Yao Wang, Huiyu Hou, Hao Luo, Jinrui Xun, Chuang Ma , et al. · 2024

The iMeta Conference 2024 provides a platform to promote the development of an innovative scientific research ecosystem for microbiome and One Health. The four key components - Technology, Research (Biology), Academic journals, and …

Optimization of ultrasound-mediated DNA transfer for bacteria and preservation of frozen competent cells Open

Meng Zhang, Rongkang Tang, Fang-Xia Li, Wenyu Jin, Jiaxin Guo , et al. · 2024

The transformation of DNA into cells is the basis of molecular biology. Commonly employed techniques include heat shock transformation, electro-transformation, conjugation, transduction, and protoplast fusion. Recently, ultrasonic transfor…

Bacterial load in meconium Open

Wenyu Jin, Peng Jing, Jinping Dai, Rongkang Tang, Jiaxin Guo , et al. · 2024

The spike-in plasmid method was utilized to perform an analysis on meconium and second-pass feces, yielding both relative and absolute quantitative results. With the absolute quantitative data, the abundance of bacteria in 17 meconium samp…

New antibiotic against multi-drug resistant bacteria Open

Jiawei Huang, Xiangfu Zhong, Yi‐Zhou Gao · 2024

Spatial resolved transcriptomics: Computational insights into gene transcription across tissue and organ architecture in diverse applications Open

Zhen Miao, Tian Tian, Wei Chen, Qianwen Wang, Liang Ma , et al. · 2024

The advent of spatially resolved transcriptomics (SRT) has revolutionized our understanding of spatial gene expression patterns within tissue architecture, shifting the paradigm of molecular biology and genetics. This breakthrough technolo…

Crop-livestock integration: Implications for food security, resource efficiency and greenhouse gas mitigation Open

Min Wang, Dan Wan, Xin Xie, Zhaohai Bai, Rong Wang , et al. · 2024

Artificial intelligence for life sciences: A comprehensive guide and future trends Open

Ming Luo, Wenyu Yang, Long Bai, Lin Zhang, Jiawei Huang , et al. · 2024

Artificial intelligence has had a profound impact on life sciences. This review discusses the application, challenges, and future development directions of artificial intelligence in various branches of life sciences, including zoology, pl…

Editorial: Omics-originated exploration of pathogenic patterns and molecular mechanisms in human and animal fungal pathogens Open

Xu Chuan, David Kadosh, Donglei Sun, Guohong Zeng, Yi‐Zhou Gao · 2023

EDITORIAL article Front. Microbiol., 11 July 2023Sec. Systems Microbiology Volume 14 - 2023 | https://doi.org/10.3389/fmicb.2023.1243709

Emerging paradigms in exploring the interactions among diet, probiotics, and cancer immunotherapeutic response Open

Shi Huang, Chengyong He, Jiufeng Li, Yi‐Zhou Gao, Zuoyun Wang , et al. · 2023

In the new issue of Cell, Dr. Meisel's team characterized how the orally administrated probiotic bacteria Lactobacillus reuteri (Lr) translocated from the gut to tumors in mice with melanoma.1Bender M.J. McPherson A.C. Phelps C.M. et al.Di…

Stem cell retrograde: A new reason why colorectal cancer is more common than small intestinal cancer? Open

Rongkang Tang, Philippe Joseph Sansonetti, Yi‐Zhou Gao · 2023

The intestine is exposed to a dynamic internal environment that is full of physiological stimuli and has a high risk of being invaded by pathogenic factors. It has dynamic fold units referred to as crypts that are composed of epithelial ce…

A whole-cell hydrogen peroxide biosensor and its application in visual food analysis Open

Yi‐Zhou Gao, Yun Wang, Mengmeng Ji, Ning‐Yi Zhou, Wei E. Huang · 2023

Hydrogen peroxide (H₂O₂) is broadly used in the food industry for bleaching, sterilization, and deodorization. Detection of H₂O₂ in food/drinks is important for food safety. In this study, the H<…

The role of extratumoral and intratumoral microorganisms in cancer immunotherapy Open

Yurong Du, Lei Liu, Wang Ma, Weiliang Yan, Wenhao Mao , et al. · 2023

Microbiome is ubiquitous in human and distributed in not only normal organs such as gut, but also in tumor tissues of the host. Numerous studies have proven that the extratumoral microbiota (mainly gut microbiota) has a close relationship …

Optimization of Ultrasound-Mediated DNA Transfer for Bacteria and Preservation of Frozen Competent Cells Open

Meng Zhang, Rong-Kang Tang, Fang-Xia Li, Jiaxin Guo, Guangxun Meng , et al. · 2023

Absolute quantification of the microbiota spatial distribution in the murine large intestine Open

Wenyu Jin, Jiaxin Guo, Meng Zhang, Lin-Zuo Teng, Yanjie Chao , et al. · 2023

The species diversity, abundance, and location of intestinal bacteria bear major consequences on host intestinal functions, affecting the balance between health and disease. Recent studies addressed the relative abundance of bacteria in fe…

A Recently Assembled Degradation Pathway for 2,3-Dichloronitrobenzene in Diaphorobacter sp. Strain JS3051 Open

Tao Li, Yi‐Zhou Gao, Jia Xu, Shuting Zhang, Yuan Guo , et al. · 2021

Because anthropogenic nitroaromatic compounds have entered the biosphere relatively recently, exploration of the recently evolved catabolic pathways can provide clues for adaptive evolutionary mechanisms in bacteria. The concept that nitro…

Resveratrol activates PI3K/AKT to reduce myocardial cell apoptosis and mitochondrial oxidative damage caused by myocardial ischemia/reperfusion injury Open

Dongmin Yu, Jianxian Xiong, Yi‐Zhou Gao, Jinghang Li, Dawei Zhu , et al. · 2021

Resveratrol is a kind of iPolyphenols widely existing in herbal medicine. Here we aim to investigate whether resveratrol can reduce the degree of myocardial ischemia/reperfusion (IR) injury and inhibit the development of oxidative stress, …

ROBI: A Multi-View Dataset for Reflective Objects in Robotic Bin-Picking Open

Jun Yang, Yi‐Zhou Gao, Dong Li, Steven L. Waslander · 2021

In robotic bin-picking applications, the perception of texture-less, highly reflective parts is a valuable but challenging task. The high glossiness can introduce fake edges in RGB images and inaccurate depth measurements especially in hea…

Special Features of Bat Microbiota Differ From Those of Terrestrial Mammals Open

Donglei Sun, Yi‐Zhou Gao, Xing‐Yi Ge, Zheng‐Li Shi, Ning‐Yi Zhou · 2020

Bats (order Chiroptera) are one of the most diverse and widely distributed group of mammals with a close relationship to humans. Over the past few decades, a number of studies have been performed on bat viruses; in contrast, bacterial path…

Handheld instrument for wound-conformal delivery of skin precursor sheets improves healing in full-thickness burns Open

Richard Cheng, Gertraud Eylert, J Gariepy, S He, Hasan Ahmad , et al. · 2020

The current standard of care for patients with severe large-area burns consists of autologous skin grafting or acellular dermal substitutes. While emerging options to accelerate wound healing involve treatment with allogeneic or autologous…

A Bph-Like Nitroarene Dioxygenase Catalyzes the Conversion of 3-Nitrotoluene to 3-Methylcatechol by Rhodococcus sp. Strain ZWL3NT Open

Yi‐Zhou Gao, Xiaoyang Liu, Hong Liu, Yuan Guo, Ning‐Yi Zhou · 2019

Nitroarenes are synthetic molecules widely used in the chemical industry. Microbial degradation of nitroarenes has attracted extensive attention, not only because this class of xenobiotic compounds is recalcitrant in the environment but al…

CasLocusAnno: a web‐based server for annotating cas loci and their corresponding (sub)types Open

Chuan Dong, Zhi Jiang Zeng, Dong‐Kai Pu, Qing‐Feng Wen, Shuo Liu , et al. · 2019

In prokaryotes, Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and CRISPR‐associated protein (Cas) systems constitute adaptive immune systems against mobile genetic elements (MGEs). Here, we introduce the Markov cluster…

Geptop 2.0: An Updated, More Precise, and Faster Geptop Server for Identification of Prokaryotic Essential Genes Open

Qing‐Feng Wen, Shuo Liu, Chuan Dong, Haixia Guo, Yi‐Zhou Gao , et al. · 2019

Geptop has performed effectively in the identification of prokaryotic essential genes since its first release in 2013. It estimates gene essentiality for prokaryotes based on orthology and phylogeny. Genome-scale essentiality data of more …

Vgas: A Viral Genome Annotation System Open

Kai-Yue Zhang, Yi‐Zhou Gao, Meng‐Ze Du, Shuo Liu, Chuan Dong , et al. · 2019

The in-depth study of viral genomes is of great help in many aspects, especially in the treatment of human diseases caused by viral infections. With the rapid accumulation of viral sequencing data, improved, or alternative gene-finding sys…

CasLocusAnno: a web-based server for annotating Cas loci and their corresponding (sub)types Open

Chuan Dong, Zhi Jiang Zeng, Qing‐Feng Wen, Shuo Liu, Meng‐Ze Du , et al. · 2018

CRISPR-Cas systems are prevalent in bacterial and archaeal genomes, and these systems provide a powerful adaptive immune system against predation by phages and other mobile genetic elements (MGEs). They also contribute to other functions, …

Mutation Landscape of Base Substitutions, Duplications, and Deletions in the Representative Current Cholera Pandemic Strain Open

Wen Wei, Lifeng Xiong, Yuan‐Nong Ye, Meng‐Ze Du, Yi‐Zhou Gao , et al. · 2018

Pandemic cholera is a major concern for public health because of its high mortality and morbidity. Mutation accumulation (MA) experiments were performed on a representative strain of the current cholera pandemic. Although the base-pair sub…

Metabolic pathway databases and model repositories Open

Abraham Alemayehu Labena, Yi‐Zhou Gao, Chuan Dong, Hong‐Li Hua, Feng‐Biao Guo · 2017

Background The number of biological Knowledge bases/databases storing metabolic pathway information and models has been growing rapidly. These resources are diverse in the type of information/data, the analytical tools, and objectives. Her…

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