Yong Du
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View article: JointMap identified SERPINA3<sup>+</sup> chondrocytes as a therapeutic target for osteoarthritis
JointMap identified SERPINA3<sup>+</sup> chondrocytes as a therapeutic target for osteoarthritis Open
Background Osteoarthritis (OA) is a prevalent degenerative joint disease that affects nearly half of the population aged over 65. Recent single-cell transcriptional studies have identified heterogeneous OA-specific chondrocyte subtypes, ye…
View article: hucMSC-derived exosomes targeting macrophage polarization attenuate systemic inflammation in T1DM via INS/SOD1 delivery
hucMSC-derived exosomes targeting macrophage polarization attenuate systemic inflammation in T1DM via INS/SOD1 delivery Open
View article: Deep learning for automated grading of radiographic sacroiliitis
Deep learning for automated grading of radiographic sacroiliitis Open
The AI model demonstrated high diagnostic accuracy and can greatly enhance the precision of radiographic sacroiliitis grading.
View article: Pretraining Deformable Image Registration Networks with Random Images
Pretraining Deformable Image Registration Networks with Random Images Open
Recent advances in deep learning-based medical image registration have shown that training deep neural networks~(DNNs) does not necessarily require medical images. Previous work showed that DNNs trained on randomly generated images with ca…
View article: Investigation of PANoptosis pathway in age-related macular degeneration triggered by Aβ1-40
Investigation of PANoptosis pathway in age-related macular degeneration triggered by Aβ1-40 Open
Our study aimed to identify PANoptosis in Aβ1-40-induced AMD, both in vivo and in vitro, and to determine if AIM2-PANoptosome mediates this process. We used transcriptomics to explore the signaling pathways and target genes linked to PANop…
View article: Correlation Ratio for Unsupervised Learning of Multi-modal Deformable Registration
Correlation Ratio for Unsupervised Learning of Multi-modal Deformable Registration Open
In recent years, unsupervised learning for deformable image registration has been a major research focus. This approach involves training a registration network using pairs of moving and fixed images, along with a loss function that combin…
View article: Validating the Utility of Supervised Clustering Algorithm for Precise [<sup>11</sup>C]DPA-713 PET Brain Image Quantification
Validating the Utility of Supervised Clustering Algorithm for Precise [<sup>11</sup>C]DPA-713 PET Brain Image Quantification Open
The reliance of quantitative PET imaging on the arterial input function makes brain PET challenging to perform in certain populations, limiting the sample size. To address this challenge, a supervised clustering algorithm (SVCA) has been i…
View article: Impact of red blood cell transfusion in massive burn: a multicenter cohort study
Impact of red blood cell transfusion in massive burn: a multicenter cohort study Open
View article: Innovative therapeutic strategies for intrauterine adhesions: Role of umbilical cord mesenchymal stem cells in rat models
Innovative therapeutic strategies for intrauterine adhesions: Role of umbilical cord mesenchymal stem cells in rat models Open
Intrauterine adhesions (IUAs) represent a considerable impediment to female reproductive health. Despite ongoing debate regarding the optimally efficacious route of administration and dosage of stem cells for IUA treatment, human umbilical…
View article: Species Number of Invasive Plants Negatively Regulates Carbon Contents, Enzyme Activities, and Bacterial Alpha Diversity in Soil
Species Number of Invasive Plants Negatively Regulates Carbon Contents, Enzyme Activities, and Bacterial Alpha Diversity in Soil Open
View article: Establishing genetically stable Escherichia coli for high effective myo-inositol production
Establishing genetically stable Escherichia coli for high effective myo-inositol production Open
View article: Unsupervised learning of spatially varying regularization for diffeomorphic image registration
Unsupervised learning of spatially varying regularization for diffeomorphic image registration Open
Spatially varying regularization accommodates the deformation variations that may be necessary for different anatomical regions during deformable image registration. Historically, optimization-based registration models have harnessed spati…
View article: Deep learning-based lesion characterization and outcome prediction of prostate cancer on [ 18 F]DCFPyL PSMA imaging
Deep learning-based lesion characterization and outcome prediction of prostate cancer on [ 18 F]DCFPyL PSMA imaging Open
Background This study aimed to develop deep learning (DL) models for lesion characterization and outcome prediction in prostate cancer (PCa) patients using Prostate-Specific Membrane Antigen (PSMA) PET/CT imaging. Methods The study include…
View article: Unsupervised Learning of Multi-modal Affine Registration for PET/CT
Unsupervised Learning of Multi-modal Affine Registration for PET/CT Open
Affine registration plays a crucial role in PET/CT imaging, where aligning PET with CT images is challenging due to their respective functional and anatomical representations. Despite the significant promise shown by recent deep learning (…
View article: A radioligand for in vitro autoradiography of CSF1R in post-mortem CNS tissues
A radioligand for in vitro autoradiography of CSF1R in post-mortem CNS tissues Open
View article: Hippocampal Availability of the α7 Nicotinic Acetylcholine Receptor in Recent-Onset Psychosis
Hippocampal Availability of the α7 Nicotinic Acetylcholine Receptor in Recent-Onset Psychosis Open
Importance Studies using human postmortem tissue and imaging with positron emission tomography (PET) support a low hippocampal availability of the α7 nicotinic acetylcholine receptor (α7-nAChR) in psychotic conditions, particularly in schi…
View article: Head and Neck Cancer: United Kingdom National Multidisciplinary Guidelines, Sixth Edition
Head and Neck Cancer: United Kingdom National Multidisciplinary Guidelines, Sixth Edition Open
View article: From Registration Uncertainty to Segmentation Uncertainty
From Registration Uncertainty to Segmentation Uncertainty Open
Understanding the uncertainty inherent in deep learning-based image registration models has been an ongoing area of research. Existing methods have been developed to quantify both transformation and appearance uncertainties related to the …
View article: Deep Semisupervised Transfer Learning for Fully Automated Whole-Body Tumor Quantification and Prognosis of Cancer on PET/CT
Deep Semisupervised Transfer Learning for Fully Automated Whole-Body Tumor Quantification and Prognosis of Cancer on PET/CT Open
Automatic detection and characterization of cancer are important clinical needs to optimize early treatment. We developed a deep, semisupervised transfer learning approach for fully automated, whole-body tumor segmentation and prognosis on…
View article: 18F-FDG and 18F-AIF-NOTA-Octreotide PET/CT Confirmed a Rare Case of Cutaneous Merkel Cell Carcinoma With a Solitary Local Nodal Metastasis
18F-FDG and 18F-AIF-NOTA-Octreotide PET/CT Confirmed a Rare Case of Cutaneous Merkel Cell Carcinoma With a Solitary Local Nodal Metastasis Open
Cutaneous Merkel cell carcinoma with local nodal metastasis is a rare entity. A 56-year-old man presented with a nontender left inguinal mass, and ultrasound-guided biopsy of this nodal mass confirmed nodal metastasis with strong neuroendo…
View article: Radium-223 in metastatic castration-resistant prostate cancer: whole-body diffusion-weighted magnetic resonance imaging scanning to assess response
Radium-223 in metastatic castration-resistant prostate cancer: whole-body diffusion-weighted magnetic resonance imaging scanning to assess response Open
Background Radium-223 is a bone-seeking, ɑ-emitting radionuclide used to treat men with bone metastases from castration-resistant prostate cancer. Sclerotic bone lesions cannot be evaluated using Response Evaluation Criteria in Solid Tumor…
View article: The value of baseline 18F-sodium fluoride and 18F-choline PET activity for identifying responders to radium-223 treatment in castration-resistant prostate cancer bone metastases
The value of baseline 18F-sodium fluoride and 18F-choline PET activity for identifying responders to radium-223 treatment in castration-resistant prostate cancer bone metastases Open
View article: Results of the SEL-I-METRY Phase II Trial on Resensitization of Advanced Iodine Refractory Differentiated Thyroid Cancer to Radioiodine Therapy
Results of the SEL-I-METRY Phase II Trial on Resensitization of Advanced Iodine Refractory Differentiated Thyroid Cancer to Radioiodine Therapy Open
View article: A survey on deep learning in medical image registration: new technologies, uncertainty, evaluation metrics, and beyond
A survey on deep learning in medical image registration: new technologies, uncertainty, evaluation metrics, and beyond Open
Deep learning technologies have dramatically reshaped the field of medical image registration over the past decade. The initial developments, such as regression-based and U-Net-based networks, established the foundation for deep learning i…
View article: Girth‐based administered activity for pediatric<sup>99m</sup>Tc‐DMSA SPECT
Girth‐based administered activity for pediatric<sup>99m</sup>Tc‐DMSA SPECT Open
Background Pediatric molecular imaging requires a balance between administering an activity that will yield sufficient diagnostic image quality while maintaining patient radiation exposure at acceptable levels. In current clinical practice…
View article: Exploring [<sup>11</sup>C]CPPC as a CSF1R-targeted PET Imaging Marker for Early Parkinson’s Disease Severity
Exploring [<sup>11</sup>C]CPPC as a CSF1R-targeted PET Imaging Marker for Early Parkinson’s Disease Severity Open
Neuroinflammation through enhanced innate immunity is thought play a role in the pathogenesis of Parkinson’s disease (PD). Methods for monitoring neuroinflammation in living patients with PD are currently limited to positron emission tomog…
View article: The Role of Pretherapy Quantitative Imaging and Dosimetry in Radioiodine Therapy for Advanced Thyroid Cancer
The Role of Pretherapy Quantitative Imaging and Dosimetry in Radioiodine Therapy for Advanced Thyroid Cancer Open
Radioactive iodine is well established as a successful treatment for differentiated thyroid cancer (DTC), although around 15% of patients have local recurrence or develop distant metastases and may become refractory to radioactive iodine (…
View article: Deep learning and radiomics framework for PSMA-RADS classification of prostate cancer on PSMA PET
Deep learning and radiomics framework for PSMA-RADS classification of prostate cancer on PSMA PET Open
Background Accurate classification of sites of interest on prostate-specific membrane antigen (PSMA) positron emission tomography (PET) images is an important diagnostic requirement for the differentiation of prostate cancer (PCa) from foc…
View article: First-in-human use of 11C-CPPC with positron emission tomography for imaging the macrophage colony-stimulating factor 1 receptor
First-in-human use of 11C-CPPC with positron emission tomography for imaging the macrophage colony-stimulating factor 1 receptor Open
Purpose Study of the contribution of microglia to onset and course of several neuropsychiatric conditions is challenged by the fact that these resident immune cells often take on different phenotypes and functions outside the living brain.…
View article: TransMorph: Transformer for unsupervised medical image registration
TransMorph: Transformer for unsupervised medical image registration Open