Yoan Renaud
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View article: TET exhibits enzymatic-independent and-dependent functions during Drosophila flight muscle development and aging
TET exhibits enzymatic-independent and-dependent functions during Drosophila flight muscle development and aging Open
View article: Enhanced Multiplexed Single-Cell RNA-Sequencing for Accurate Detection of Treatment Effects Without Batch Correction in the Avian Embryonic Model
Enhanced Multiplexed Single-Cell RNA-Sequencing for Accurate Detection of Treatment Effects Without Batch Correction in the Avian Embryonic Model Open
Summary Single-cell RNA sequencing has revolutionized our ability to explore cellular heterogeneity and is a powerful tool to study the impact of environmental perturbations on multiple cell states. However, environmental perturbations can…
View article: Binding of heterochromatin protein Rhino to a subset of piRNA clusters depends on a combination of two histone marks
Binding of heterochromatin protein Rhino to a subset of piRNA clusters depends on a combination of two histone marks Open
Animal germ cells deploy a specialized small RNA-based silencing system, called the PIWI-interacting RNA (piRNA) pathway, to prevent unwanted expression of transposable elements (TEs) and maintain genome integrity. In Drosophila melanogast…
View article: LXR pathway drives hormonal response intensity in polycystic ovary syndrome
LXR pathway drives hormonal response intensity in polycystic ovary syndrome Open
Gonadotropin injections used to stimulate oocyte production during assisted reproductive technology (ART) procedures are associated with the risk of an abnormal response in predisposed patients suffering polycystic ovary syndrome (PCOS). L…
View article: Gap junctions allow transfer of metabolites between germ cells and somatic cells to promote germ cell growth in the Drosophila ovary
Gap junctions allow transfer of metabolites between germ cells and somatic cells to promote germ cell growth in the Drosophila ovary Open
Gap junctions allow the exchange of small molecules between cells. How this function could be used to promote cell growth is not yet fully understood. During Drosophila ovarian follicle development, germ cells, which are surrounded by epit…
View article: Enhanced Multiplexed Single-Cell RNA-Sequencing for Accurate Detection of Treatment Effects Without Batch Correction in the Avian Embryonic Model
Enhanced Multiplexed Single-Cell RNA-Sequencing for Accurate Detection of Treatment Effects Without Batch Correction in the Avian Embryonic Model Open
View article: Exploring the Epigenetic Landscape of Spermatozoa: Impact of Oxidative Stress and Antioxidant Supplementation on DNA Methylation and Hydroxymethylation
Exploring the Epigenetic Landscape of Spermatozoa: Impact of Oxidative Stress and Antioxidant Supplementation on DNA Methylation and Hydroxymethylation Open
Reproductive success is dependent on gamete integrity, and oxidative stress alters male nuclei, meaning that no DNA repair is possible due to chromatin compaction. The composition of sperm makes it highly sensitive to reactive oxygen speci…
View article: Amalgam plays a dual role in controlling the number of leg muscle progenitors and regulating their interactions with the developing Drosophila tendon
Amalgam plays a dual role in controlling the number of leg muscle progenitors and regulating their interactions with the developing Drosophila tendon Open
Formation of functional organs requires cell–cell communication between different cell lineages and failure in this communication can result in severe developmental defects. Hundreds of possible interacting pairs of proteins are known, but…
View article: Liver X Receptors Enhance Epithelial to Mesenchymal Transition in Metastatic Prostate Cancer Cells
Liver X Receptors Enhance Epithelial to Mesenchymal Transition in Metastatic Prostate Cancer Cells Open
Prostate cancer (PCa) is one of the most common cancers in men. Metastasis is the leading cause of death in prostate cancer patients. One of the crucial processes involved in metastatic spread is the “epithelial–mesenchymal transition” (EM…
View article: <i>Drosophila</i> TET acts with PRC1 to activate gene expression independently of its catalytic activity
<i>Drosophila</i> TET acts with PRC1 to activate gene expression independently of its catalytic activity Open
Enzymes of the ten-eleven translocation (TET) family play a key role in the regulation of gene expression by oxidizing 5-methylcytosine (5mC), a prominent epigenetic mark in many species. Yet, TET proteins also have less characterized nonc…
View article: A dual histone code specifies the binding of heterochromatin protein Rhino to a subset of piRNA source loci
A dual histone code specifies the binding of heterochromatin protein Rhino to a subset of piRNA source loci Open
Animal germ cells deploy a specialized small RNA-based silencing system, called the PIWI-interacting RNA (piRNA) pathway, to prevent unwanted expression of transposable elements and maintain genome integrity. In Drosophila germ cells, the …
View article: Author Response: Adenine methylation is very scarce in the Drosophila genome and not erased by the ten-eleven translocation dioxygenase
Author Response: Adenine methylation is very scarce in the Drosophila genome and not erased by the ten-eleven translocation dioxygenase Open
Full text Figures and data Side by side Abstract eLife assessment Introduction Results and discussion Methods Data availability References Peer review Author response Article and author information Abstract N6-methyladenine (6mA) DNA modif…
View article: Reviewer #1 (Public Review): Adenine methylation is very scarce in the drosophila genome and not erased by the Ten Eleven Translocation dioxygenase
Reviewer #1 (Public Review): Adenine methylation is very scarce in the drosophila genome and not erased by the Ten Eleven Translocation dioxygenase Open
N6-methyladenine (6mA) DNA modification has recently been described in metazoans, including in drosophila, for which the erasure of this epigenetic mark has been ascribed to the Ten Eleven Translocation (TET) enzyme. Here, we re-evaluated …
View article: Adenine methylation is very scarce in the drosophila genome and not erased by the Ten Eleven Translocation dioxygenase
Adenine methylation is very scarce in the drosophila genome and not erased by the Ten Eleven Translocation dioxygenase Open
N6-methyladenine (6mA) DNA modification has recently been described in metazoans, including in drosophila, for which the erasure of this epigenetic mark has been ascribed to the Ten Eleven Translocation (TET) enzyme. Here, we re-evaluated …
View article: Reviewer #2 (Public Review): Adenine methylation is very scarce in the drosophila genome and not erased by the Ten Eleven Translocation dioxygenase
Reviewer #2 (Public Review): Adenine methylation is very scarce in the drosophila genome and not erased by the Ten Eleven Translocation dioxygenase Open
N6-methyladenine (6mA) DNA modification has recently been described in metazoans, including in drosophila, for which the erasure of this epigenetic mark has been ascribed to the Ten Eleven Translocation (TET) enzyme. Here, we re-evaluated …
View article: Author Response: Adenine methylation is very scarce in the drosophila genome and not erased by the Ten Eleven Translocation dioxygenase
Author Response: Adenine methylation is very scarce in the drosophila genome and not erased by the Ten Eleven Translocation dioxygenase Open
N6-methyladenine (6mA) DNA modification has recently been described in metazoans, including in drosophila, for which the erasure of this epigenetic mark has been ascribed to the Ten Eleven Translocation (TET) enzyme. Here, we re-evaluated …
View article: Adenine methylation is very scarce in the drosophila genome and not erased by the Ten Eleven Translocation dioxygenase
Adenine methylation is very scarce in the drosophila genome and not erased by the Ten Eleven Translocation dioxygenase Open
N6-methyladenine (6mA) DNA modification has recently been described in metazoans, including in drosophila, for which the erasure of this epigenetic mark has been ascribed to the Ten Eleven Translocation (TET) enzyme. Here, we re-evaluated …
View article: Adenine methylation is very scarce in the drosophila genome and not erased by the Ten Eleven Translocation dioxygenase
Adenine methylation is very scarce in the drosophila genome and not erased by the Ten Eleven Translocation dioxygenase Open
N6-methyladenine (6mA) DNA modification has recently been described in metazoans, including in drosophila, for which the erasure of this epigenetic mark has been ascribed to the Ten Eleven Translocation (TET) enzyme. Here, we re-evaluated …
View article: Gap junction and amino acid import in somatic cells promote germ cell growth
Gap junction and amino acid import in somatic cells promote germ cell growth Open
Gap junctions allow the exchange of small molecules between cells. How this function could be used to promote cell growth is not yet fully understood. During Drosophila ovarian follicle development, germ cells, which are surrounded by epit…
View article: Sexually dimorphic activation of innate antitumor immunity prevents adrenocortical carcinoma development
Sexually dimorphic activation of innate antitumor immunity prevents adrenocortical carcinoma development Open
Unlike most cancers, adrenocortical carcinomas (ACCs) are more frequent in women than in men, but the underlying mechanisms of this sexual dimorphism remain elusive. Here, we show that inactivation of Znrf3 in the mouse adrenal cortex, rec…
View article: Deregulations of miR-1 and its target Multiplexin promote dilated cardiomyopathy associated with myotonic dystrophy type 1
Deregulations of miR-1 and its target Multiplexin promote dilated cardiomyopathy associated with myotonic dystrophy type 1 Open
Myotonic dystrophy type 1 (DM1) is the most common muscular dystrophy. It is caused by the excessive expansion of non-coding CTG repeat, which when transcribed affect functions of RNA-binding factors. Specifically, MBNL1 is sequestered in …
View article: Sexually dimorphic activation of innate antitumour immunity prevents adrenocortical carcinoma development
Sexually dimorphic activation of innate antitumour immunity prevents adrenocortical carcinoma development Open
Summary In contrast with most cancers, adrenocortical carcinomas (ACC) are more frequent in women than men, but the underlying mechanisms of this sexual dimorphism remain elusive. Homozygous deletion of the negative WNT pathway regulator Z…
View article: Identification of a Crosstalk among TGR5, GLIS2, and TP53 Signaling Pathways in the Control of Undifferentiated Germ Cell Homeostasis and Chemoresistance
Identification of a Crosstalk among TGR5, GLIS2, and TP53 Signaling Pathways in the Control of Undifferentiated Germ Cell Homeostasis and Chemoresistance Open
Spermatogonial stem cells regenerate and maintain spermatogenesis throughout life, making testis a good model for studying stem cell biology. The effects of chemotherapy on fertility have been well‐documented previously. This study investi…
View article: L1 chimeric transcripts are expressed in healthy brain and their deregulation in glioma follows that of their host locus
L1 chimeric transcripts are expressed in healthy brain and their deregulation in glioma follows that of their host locus Open
Besides the consequences of retrotransposition, long interspersed element 1 (L1) retrotransposons can affect the host genome through their antisense promoter. In addition to the sense promoter, the evolutionarily recent L1 retrotransposons…
View article: The Class I HDAC Inhibitor, MS-275, Prevents Oxaliplatin-Induced Chronic Neuropathy and Potentiates Its Antiproliferative Activity in Mice
The Class I HDAC Inhibitor, MS-275, Prevents Oxaliplatin-Induced Chronic Neuropathy and Potentiates Its Antiproliferative Activity in Mice Open
Oxaliplatin, the first-line chemotherapeutic agent against colorectal cancer (CRC), induces peripheral neuropathies, which can lead to dose limitation and treatment discontinuation. Downregulation of potassium channels, which involves hist…
View article: Transcriptomic and Genetic Analyses Identify the Krüppel-Like Factor Dar1 as a New Regulator of Tube-Shaped Long Tendon Development
Transcriptomic and Genetic Analyses Identify the Krüppel-Like Factor Dar1 as a New Regulator of Tube-Shaped Long Tendon Development Open
To ensure locomotion and body stability, the active role of muscle contractions relies on a stereotyped muscle pattern set in place during development. This muscle patterning requires a precise assembly of the muscle fibers with the skelet…
View article: m6A RNA methylation regulates promoter- proximal pausing of RNA polymerase II
m6A RNA methylation regulates promoter- proximal pausing of RNA polymerase II Open
View article: Characterization of the Drosophila adult hematopoietic system reveals a rare cell population with differentiation and proliferation potential
Characterization of the Drosophila adult hematopoietic system reveals a rare cell population with differentiation and proliferation potential Open
While many studies have described Drosophila embryonic and larval blood cells, the hematopoietic system of the imago remains poorly characterized and conflicting data have been published concerning adult hematopoiesis. Using a combination …
View article: Differential activation of JAK-STAT signaling reveals functional compartmentalization in Drosophila blood progenitors
Differential activation of JAK-STAT signaling reveals functional compartmentalization in Drosophila blood progenitors Open
Blood cells arise from diverse pools of stem and progenitor cells. Understanding progenitor heterogeneity is a major challenge. The Drosophila larval lymph gland is a well-studied model to understand blood progenitor maintenance and recapi…
View article: Author response: Differential activation of JAK-STAT signaling reveals functional compartmentalization in Drosophila blood progenitors
Author response: Differential activation of JAK-STAT signaling reveals functional compartmentalization in Drosophila blood progenitors Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Blood cells arise from diverse pools of st…