Yoann Cotelle
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View article: Molecular building-blocks for anion–π interactions
Molecular building-blocks for anion–π interactions Open
Anion–π interactions are analyzed by focusing on the design of the π platform, quadrupole moments, substitution with electron withdrawing groups and structure flexibility.
View article: Electron-deficient hemicryptophanes for the recognition of anions through anion–π interactions
Electron-deficient hemicryptophanes for the recognition of anions through anion–π interactions Open
Hemicryptophane enables the synergy of several electron-deficient surfaces to selectively bind triiodide, compared to a less electron-deficient receptor.
View article: Self-assembled tetrazine cryptophane for ion pair recognition and guest release by cage disassembly
Self-assembled tetrazine cryptophane for ion pair recognition and guest release by cage disassembly Open
A cryptophane is able to release guests by the addition of thiols thanks to the dynamic nucleophilic substitution of tetrazines.
View article: CCDC 2283957: Experimental Crystal Structure Determination
CCDC 2283957: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: A Cyclotriveratrylene Solvent‐Dependent Chiral Switch
A Cyclotriveratrylene Solvent‐Dependent Chiral Switch Open
Chiral molecular switches are attracting attention as they could pave the way to chiral molecular machines. Herein, we report on the design and synthesis of a single molecule chiral switch based on a cyclotriveratrylene scaffold, in which …
View article: Probing the Importance of Host Symmetry on Carbohydrate Recognition
Probing the Importance of Host Symmetry on Carbohydrate Recognition Open
The design of molecular cages with low symmetry could allow for more specific tuning of their properties and better mimic the unsymmetrical and complex environment of protein pockets. However, the added value of lowering symmetry of molecu…
View article: A Dual Anchoring Strategy for the Directed Evolution of Improved Artificial Transfer Hydrogenases Based on Carbonic Anhydrase
A Dual Anchoring Strategy for the Directed Evolution of Improved Artificial Transfer Hydrogenases Based on Carbonic Anhydrase Open
Data underlying the figures in the publication “A Dual Anchoring Strategy for the Directed Evolution of Improved Artificial Transfer Hydrogenases Based on Carbonic Anhydrase”, published in ACS Cent. Sci. 2021, 7, 11, 1874–1884. https://pub…
View article: A Dual Anchoring Strategy for the Directed Evolution of Improved Artificial Transfer Hydrogenases Based on Carbonic Anhydrase
A Dual Anchoring Strategy for the Directed Evolution of Improved Artificial Transfer Hydrogenases Based on Carbonic Anhydrase Open
Data underlying the figures in the publication “A Dual Anchoring Strategy for the Directed Evolution of Improved Artificial Transfer Hydrogenases Based on Carbonic Anhydrase”, published in ACS Cent. Sci. 2021, 7, 11, 1874–1884. https://pub…
View article: Circularly polarized luminescence of encaged Eu(<scp>iii</scp>) and Tb(<scp>iii</scp>) complexes controlled by an inherently chiral remote unit
Circularly polarized luminescence of encaged Eu(<span>iii</span>) and Tb(<span>iii</span>) complexes controlled by an inherently chiral remote unit Open
The Tb( iii )@cage presents CPL properties although the chiral CTV unit is remote from the coordinating moiety, suggesting chiral transfer between these two parts.
View article: A Dual Anchoring Strategy for the Directed Evolution of Improved Artificial Transfer Hydrogenases Based on Carbonic Anhydrase
A Dual Anchoring Strategy for the Directed Evolution of Improved Artificial Transfer Hydrogenases Based on Carbonic Anhydrase Open
Artificial metalloenzymes result from anchoring a metal cofactor within a host protein. Such hybrid catalysts combine the selectivity and specificity of enzymes with the versatility of (abiotic) transition metals to catalyze new-to-nature …
View article: Chemical Optimization of Whole-Cell Transfer Hydrogenation Using Carbonic Anhydrase as Host Protein
Chemical Optimization of Whole-Cell Transfer Hydrogenation Using Carbonic Anhydrase as Host Protein Open
Artificial metalloenzymes combine a synthetic metallocofactor with a protein scaffold and can catalyze abiotic reactions in vivo. Herein, we report on our efforts to valorize human carbonic anhydrase II as a scaffold for whole-cell transfe…
View article: The Emergence of Anion−π Catalysis
The Emergence of Anion−π Catalysis Open
The objective of this Account is to summarize the first five years of anion-π catalysis. The general idea of anion-π catalysis is to stabilize anionic transition states on aromatic surfaces. This is complementary to the stabilization of ca…
View article: Chimeric Streptavidins as Host Proteins for Artificial Metalloenzymes
Chimeric Streptavidins as Host Proteins for Artificial Metalloenzymes Open
The streptavidin scaffold was expanded with well-structured naturally occurring motifs. These chimeric scaffolds were tested as host for biotinylated catalysts as artificial metalloenzymes (ArM) for asymmetric transfer hydrogenation, ring …
View article: Anion–π Catalysis of Diels–Alder Reactions
Anion–π Catalysis of Diels–Alder Reactions Open
Among concerted cycloadditions, the Diels–Alder reaction is the grand old classic, which is usually achieved with acid catalysis. In this report, hydroxypyrones, oxa‐, and thiazolones are explored because they provide access to anionic die…
View article: Anion–π catalysis: bicyclic products with four contiguous stereogenic centers from otherwise elusive diastereospecific domino reactions on π-acidic surfaces
Anion–π catalysis: bicyclic products with four contiguous stereogenic centers from otherwise elusive diastereospecific domino reactions on π-acidic surfaces Open
Delocalized over aromatic planes, anion–π interactions emerge as best to stabilize long-distance charge displacements in domino reactions of highest sophistication.
View article: Interfacing Functional Systems
Interfacing Functional Systems Open
The objective of molecular systems engineering is to move beyond functional components and primary systems, towards cumulate emergent properties in interfaced higher-order systems of unprecedented multifunctionality and sophistication.
View article: Asymmetric Anion−π Catalysis of Iminium/Nitroaldol Cascades To Form Cyclohexane Rings with Five Stereogenic Centers Directly on π-Acidic Surfaces
Asymmetric Anion−π Catalysis of Iminium/Nitroaldol Cascades To Form Cyclohexane Rings with Five Stereogenic Centers Directly on π-Acidic Surfaces Open
Anion−π interactions have been introduced to catalysis only recently, and evidence for their significance is so far limited to one classical model reaction in enolate and enamine chemistry. In this report, asymmetric anion−π catalysis is a…
View article: Anion-π Enzymes
Anion-π Enzymes Open
In this report, we introduce artificial enzymes that operate with anion-π interactions, an interaction that is essentially new to nature. The possibility to stabilize anionic intermediates and transition states on an π-acidic surface has b…
View article: Anion–π Catalysis of Enolate Chemistry: Rigidified Leonard Turns as a General Motif to Run Reactions on Aromatic Surfaces
Anion–π Catalysis of Enolate Chemistry: Rigidified Leonard Turns as a General Motif to Run Reactions on Aromatic Surfaces Open
To integrate anion–π, cation–π, and ion pair–π interactions in catalysis, the fundamental challenge is to run reactions reliably on aromatic surfaces. Addressing a specific question concerning enolate addition to nitroolefins, this study e…
View article: Anion–π Catalysis of Enolate Chemistry: Rigidified Leonard Turns as a General Motif to Run Reactions on Aromatic Surfaces
Anion–π Catalysis of Enolate Chemistry: Rigidified Leonard Turns as a General Motif to Run Reactions on Aromatic Surfaces Open
To integrate anion–π, cation–π, and ion pair–π interactions in catalysis, the fundamental challenge is to run reactions reliably on aromatic surfaces. Addressing a specific question concerning enolate addition to nitroolefins, this study e…