Yoann Lalatonne
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View article: Photodynamic Therapy Using Pulsed-Laser Irradiation of Gold Nanoparticles for the Treatment of Cancers with High Basal Oxidative Stress
Photodynamic Therapy Using Pulsed-Laser Irradiation of Gold Nanoparticles for the Treatment of Cancers with High Basal Oxidative Stress Open
For over 20 years, considerable research has been carried out on the use of nanotechnologies in cancer treatment. Beyond the photothermal effect of irradiating gold nanoparticles, the photodynamic effect with reactive oxygen species (ROS) …
View article: Tailoring the Optoelectronic Properties of MoOX Nanoparticles: A Novel Microwave-Assisted Synthesis for Near-Infrared Absorbing Polyoxometallic Clusters
Tailoring the Optoelectronic Properties of MoOX Nanoparticles: A Novel Microwave-Assisted Synthesis for Near-Infrared Absorbing Polyoxometallic Clusters Open
Emergence of novel catalytic, electrochemical and biomedical applications of nanomaterials necessitates an understanding of the structural basis of their stimuli-responsive performance. Chemistry of polyoxometallic nanomaterials with varie…
View article: Magnetite Nanoparticle Photothermal Therapy in a Pancreatic Tumor-on-Chip: A Dual-Action Approach Targeting Cancer Cells and their Microenvironment
Magnetite Nanoparticle Photothermal Therapy in a Pancreatic Tumor-on-Chip: A Dual-Action Approach Targeting Cancer Cells and their Microenvironment Open
The application of magnetite nanoparticles (MagNPs) for photothermal therapy (MagNP-PTT) has recently expanded in cancer treatment. This study introduces MagNP-PTT in a tumor-on-chip model to target highly aggressive pancreatic ductal aden…
View article: Elucidating the Dynamics of Biodegradation and Biosynthesis of Magnetic Nanoparticles in Human Stem Cells
Elucidating the Dynamics of Biodegradation and Biosynthesis of Magnetic Nanoparticles in Human Stem Cells Open
Iron oxide nanoparticles, due to their magnetic properties, are versatile tools for biomedical applications serving both diagnostic and therapeutic roles. Their performance is intricately intertwined with their fate in the demanding biolog…
View article: The Prognosis of Glutamic Acid Decarboxylase Antibodies in Women With Hyperglycemia in Pregnancy
The Prognosis of Glutamic Acid Decarboxylase Antibodies in Women With Hyperglycemia in Pregnancy Open
Context We recently reported that the presence of glutamic acid decarboxylase antibodies (GADA) was not associated with large-for-gestational-age infants in women with hyperglycemia in pregnancy (HIP). Objective We explored the association…
View article: The prognosis of glutamic acid decarboxylase antibodies in women with hyperglycemia in pregnancy
The prognosis of glutamic acid decarboxylase antibodies in women with hyperglycemia in pregnancy Open
Additional Figure 1: Flow chart Additional Table 1: Metabolic characteristics and adverse pregnancy outcomes in women with GADA measurement (study sample) or not (excluded from analyses) Additional Table 2: Metabolic characteristics accord…
View article: Photothermia at the nanoscale induces ferroptosis via nanoparticle degradation
Photothermia at the nanoscale induces ferroptosis via nanoparticle degradation Open
The Fe(II)-induced ferroptotic cell death pathway is an asset in cancer therapy, yet it calls into question the biocompatibility of magnetic nanoparticles. In the latter, Fe(II) is sequestered within the crystal structure and is released o…
View article: GAD Antibodies in Women With Hyperglycemia in Pregnancy: No Association With Large-for-Gestational-Age Birth Weight
GAD Antibodies in Women With Hyperglycemia in Pregnancy: No Association With Large-for-Gestational-Age Birth Weight Open
International audience
View article: Optical and X-ray attenuation properties of hafnium oxide nanoparticles surface functionalized with fucoidan: toward the early diagnosis of atherothrombotic diseases
Optical and X-ray attenuation properties of hafnium oxide nanoparticles surface functionalized with fucoidan: toward the early diagnosis of atherothrombotic diseases Open
HfO 2 NPs surface functionalized with fucoidan show specific targeting of aggregated platelets and appear as a new candidate for X-ray imaging for the molecular-scale diagnosis of atherothrombosis.
View article: Biomineralization of magnetic nanoparticles in stem cells
Biomineralization of magnetic nanoparticles in stem cells Open
Stem cell incubation was performed with ferric quinate for 36 days.
View article: Photothermia at the nanoscale induces ferroptosis via nanoparticle degradation
Photothermia at the nanoscale induces ferroptosis via nanoparticle degradation Open
The Fe(II)-induced ferroptotic cell death pathway has contrasted the biocompatibility of magnetic nanoparticles while offering an additional asset in cancer therapy. Nevertheless, in magnetic nanoparticles, Fe(II) is sequestered within the…
View article: The role of tumor model in magnetic targeting of magnetosomes and ultramagnetic liposomes
The role of tumor model in magnetic targeting of magnetosomes and ultramagnetic liposomes Open
The combined passive and active targeting of tumoral tissue remains an active and relevant cancer research field. Here, we exploit the properties of two highly magnetic nanomaterials, magnetosomes and ultramagnetic liposomes, in order to m…
View article: A Preclinical Validation of Iron Oxide Nanoparticles for Treatment of Perianal Fistulizing Crohn’s Disease
A Preclinical Validation of Iron Oxide Nanoparticles for Treatment of Perianal Fistulizing Crohn’s Disease Open
Fistulizing anoperineal lesions are severe complications of Crohn’s disease (CD) that affect quality of life with a long-term risk of anal sphincter destruction, incontinence, permanent stoma, and anal cancer. Despite several surgical proc…
View article: Real-Time Observation and Analysis of Magnetomechanical Actuation of Magnetic Nanoparticles in Cells
Real-Time Observation and Analysis of Magnetomechanical Actuation of Magnetic Nanoparticles in Cells Open
The origin of cell death in the magnetomechanical actuation of cells induced by magnetic nanoparticle motion under low-frequency magnetic fields is still elusive. Here, a miniaturized electromagnet fitted under a confocal microscope is use…
View article: Magneto-mechanical destruction of cancer-associated fibroblasts using ultra-small iron oxide nanoparticles and low frequency rotating magnetic fields
Magneto-mechanical destruction of cancer-associated fibroblasts using ultra-small iron oxide nanoparticles and low frequency rotating magnetic fields Open
The destruction of cells using the mechanical activation of magnetic nanoparticles with low-frequency magnetic fields opens new opportunities for cancer treatment.
View article: Ever-Evolving Identity of Magnetic Nanoparticles within Human Cells: The Interplay of Endosomal Confinement, Degradation, Storage, and Neocrystallization
Ever-Evolving Identity of Magnetic Nanoparticles within Human Cells: The Interplay of Endosomal Confinement, Degradation, Storage, and Neocrystallization Open
Considerable knowledge has been acquired in inorganic nanoparticles' synthesis and nanoparticles' potential use in biomedical applications. Among different materials, iron oxide nanoparticles remain unrivaled for several reasons. Not only …
View article: Photothermal Therapy: Endosomal Confinement of Gold Nanospheres, Nanorods, and Nanoraspberries Governs Their Photothermal Identity and Is Beneficial for Cancer Cell Therapy (Adv. Biosys. 4/2020)
Photothermal Therapy: Endosomal Confinement of Gold Nanospheres, Nanorods, and Nanoraspberries Governs Their Photothermal Identity and Is Beneficial for Cancer Cell Therapy (Adv. Biosys. 4/2020) Open
In article number 1900284, Yoann Lalatonne, Claire Wilhelm, and co-workers assess the photothermal potential of gold nano-spheres, rods, and raspberries-like multi-cores outside cancer cells (extracellular environment) or internalized with…
View article: Endosomal Confinement of Gold Nanospheres, Nanorods, and Nanoraspberries Governs Their Photothermal Identity and Is Beneficial for Cancer Cell Therapy
Endosomal Confinement of Gold Nanospheres, Nanorods, and Nanoraspberries Governs Their Photothermal Identity and Is Beneficial for Cancer Cell Therapy Open
Gold nanoparticles can act as photothermal agents to generate local tumor heating and subsequent depletion upon laser exposure. Herein, photothermal heating of four gold nanoparticles and the resulting induced cancer cell death are systema…
View article: Real-time in situ magnetic measurement of the intracellular biodegradation of iron oxide nanoparticles in a stem cell-spheroid tissue model
Real-time in situ magnetic measurement of the intracellular biodegradation of iron oxide nanoparticles in a stem cell-spheroid tissue model Open
International audience
View article: USPIO–PEG nanoparticles functionalized with a highly specific collagen-binding peptide: a step towards MRI diagnosis of fibrosis
USPIO–PEG nanoparticles functionalized with a highly specific collagen-binding peptide: a step towards MRI diagnosis of fibrosis Open
USPIO–PO–PEG–collagelin nanoparticles specifically target type I collagen and allow fibrosis detection at an early stage by Magnetic Resonance Imaging.
View article: Synthesis and activation of an iron oxide immobilized drug-mimicking reporter under conventional and pulsed X-ray irradiation conditions
Synthesis and activation of an iron oxide immobilized drug-mimicking reporter under conventional and pulsed X-ray irradiation conditions Open
The nano-sized delivery system allowed releasing complex organic ligands by X-ray irradiation. Marked difference was observed in the release efficiency by using conventional Cs-137 vs. pulsed sources.
View article: Bimodal Fucoidan-Coated Zinc Oxide/Iron Oxide-Based Nanoparticles for the Imaging of Atherothrombosis
Bimodal Fucoidan-Coated Zinc Oxide/Iron Oxide-Based Nanoparticles for the Imaging of Atherothrombosis Open
A polyol method was used to obtain ultrasmall ZnO nanoparticles (NPs) doped with iron ions and coated with a low molecular weight fucoidan in order to perform in vivo MR and ex vivo fluorescence imaging of athrothrombosis. During the synth…
View article: Biosynthesis of magnetic nanoparticles from nano-degradation products revealed in human stem cells
Biosynthesis of magnetic nanoparticles from nano-degradation products revealed in human stem cells Open
Significance Naturally occurring magnetic nanoparticles have been detected in human cells; however, their origin and role remain unknown. In the present paper, the observation of long-term transformations of man-made magnetic nanoparticles…