Yoel Toledano
YOU?
Author Swipe
View article: Fetal sex and the development of future type 2 diabetes: a 5-year cohort study
Fetal sex and the development of future type 2 diabetes: a 5-year cohort study Open
Purpose Gestational Diabetes Mellitus (GDM) increases the risk of developing Type 2 Diabetes Mellitus (T2DM) postpartum, with emerging evidence suggesting that fetal sex may influence pregnancy outcomes. Some studies suggest that individua…
View article: Pregnancy and postpartum dynamics revealed by millions of lab tests
Pregnancy and postpartum dynamics revealed by millions of lab tests Open
Pregnancy and delivery involve dynamic alterations in many physiological systems. However, the physiological dynamics during pregnancy and after delivery have not been systematically analyzed at high temporal resolution in a large human po…
View article: Pregnancy lab test dynamics resemble rejuvenation of some organs and aging of others
Pregnancy lab test dynamics resemble rejuvenation of some organs and aging of others Open
Aging and pregnancy both involve changes in many physiological systems. Some of these changes are similar, leading to suggestions that pregnancy may be a model for aging. Recent studies using DNA methylation clocks showed apparent aging du…
View article: Chronobiological Factors Influencing Glycemic Control and Birth Outcomes in Gestational Diabetes Mellitus
Chronobiological Factors Influencing Glycemic Control and Birth Outcomes in Gestational Diabetes Mellitus Open
Background/Objectives: Studies have shown that chronobiological factors may adversely affect glycemic control in patients with type 2 diabetes mellitus. We assessed the association of chronobiological factors with glycemic control and neon…
View article: Hypoglycemia in Oral Glucose Tolerance Test during Pregnancy and Risk for Type 2 Diabetes—A Five-Year Cohort Study
Hypoglycemia in Oral Glucose Tolerance Test during Pregnancy and Risk for Type 2 Diabetes—A Five-Year Cohort Study Open
Objective: To evaluate the risk of progression to type 2 diabetes (T2D) following reactive hypoglycemia in 100 g oral glucose tolerance test (oGTT). Methods: A retrospective analysis of parturients with up to 5-year follow-up postpartum. D…
View article: Quantification of beta cell carrying capacity in prediabetes
Quantification of beta cell carrying capacity in prediabetes Open
Prediabetes, a subclinical state of high glucose, carries a risk of transition to diabetes. One cause of prediabetes is insulin resistance, which impairs the ability of insulin to control blood glucose. However, many individuals with high …
View article: Oral Glucose Tolerance Test Performed after 28 Gestational Weeks and Risk for Future Diabetes—A 5-Year Cohort Study
Oral Glucose Tolerance Test Performed after 28 Gestational Weeks and Risk for Future Diabetes—A 5-Year Cohort Study Open
Gestational diabetes mellitus (GDM) is diagnosed by an oral glucose tolerance test (oGTT), preferably performed at 24 + 0–28 + 6 gestational weeks, and is considered a risk factor for type 2 diabetes (T2DM). In this study, we aimed to eval…
View article: Does Iodine Intake Modify the Effect of Maternal Dysglycemia on Birth Weight in Mild-to-Moderate Iodine-Deficient Populations? A Mother–Newborn Prospective Cohort Study
Does Iodine Intake Modify the Effect of Maternal Dysglycemia on Birth Weight in Mild-to-Moderate Iodine-Deficient Populations? A Mother–Newborn Prospective Cohort Study Open
It is unclear how maternal glycemic status and maternal iodine status influence birth weight among individuals with mild-to-moderate iodine deficiency (ID). We studied the association between birth weight and both maternal glucose levels a…
View article: Does Iodine Intake Play a Role in Modifying the Relationship between Maternal Dysglycemia and Birth Weight?
Does Iodine Intake Play a Role in Modifying the Relationship between Maternal Dysglycemia and Birth Weight? Open
It is unclear how maternal glycemic status and maternal iodine status influence birth weight in mild-to-moderate iodine deficiency (ID). We studied the association between birth weight and both maternal glucose levels and iodine intake in …
View article: Pregnancy and postpartum dynamics revealed by millions of lab tests
Pregnancy and postpartum dynamics revealed by millions of lab tests Open
Pregnancy and delivery involve dynamic alterations in many physiological systems. However, the physiological dynamics during pregnancy and after delivery have not been systematically analyzed at high temporal resolution in a large human po…
View article: Autoimmune thyroid diseases as a cost of physiological autoimmune surveillance
Autoimmune thyroid diseases as a cost of physiological autoimmune surveillance Open
Graves' disease (GD) and Hashimoto's thyroiditis (HT) are common autoimmune diseases of the thyroid gland, causing hyperthyroidism and hypothyroidism, respectively. Despite their opposing clinical manifestation, they have several enigmatic…
View article: Dynamics of thyroid diseases and thyroid‐axis gland masses
Dynamics of thyroid diseases and thyroid‐axis gland masses Open
Thyroid disorders are common and often require lifelong hormone replacement. Treating thyroid disorders involves a fascinating and troublesome delay, in which it takes many weeks for serum thyroid-stimulating hormone (TSH) concentration to…
View article: Chronobiological disorders and their impact on gestational diabetes mellitus outcomes: the Chrono-Nutrition Gestational Diabetes Study
Chronobiological disorders and their impact on gestational diabetes mellitus outcomes: the Chrono-Nutrition Gestational Diabetes Study Open
Objective Studies have shown that chronobiological factors may adversely affect glycemic control in patients with type 2 diabetes mellitus (T2DM). Our objective was to assess the association of chronobiological disorders with glycemic cont…
View article: Flash Glucose Monitoring in Israel: Understanding Real-World Associations between Self-Monitoring Frequency and Metrics of Glycemic Control
Flash Glucose Monitoring in Israel: Understanding Real-World Associations between Self-Monitoring Frequency and Metrics of Glycemic Control Open
In Israel, people with diabetes under real-world conditions record higher rates of FreeStyle Libre scanning. These are associated with improvements in TIR, eA1c, and reduced time with glucose levels of >180 mg/dL or <54 mg/dL.
View article: Foetal Sonographic Anogenital Distance Is Longer in Polycystic Ovary Syndrome Mothers
Foetal Sonographic Anogenital Distance Is Longer in Polycystic Ovary Syndrome Mothers Open
Anogenital distance (AGD) is a biomarker for the prenatal hormonal environment. Androgen excess is a key element in polycystic ovary syndrome (PCOS). The aim of this study was to assess the sonographic foetal AGD in a population of PCOS mo…
View article: Hypoglycaemia and its management in primary care setting
Hypoglycaemia and its management in primary care setting Open
Hypoglycaemia is common in patients with type 1 diabetes and type 2 diabetes and constitutes a major limiting factor in achieving glycaemic control among people with diabetes. While hypoglycaemia is defined as a blood glucose level under 7…
View article: OC23.02: Fetal anogenital distance is longer in polycystic ovary syndrome mothers
OC23.02: Fetal anogenital distance is longer in polycystic ovary syndrome mothers Open
Anogenital distance (AGD) was reported as a biomarker for the prenatal hormonal environment in animal and human and studies. Androgen excess is a key element in polycystic ovary syndrome (PCOS). Women with PCOS and their infant girls were …
View article: Effect of prandial treatment timing adjustment, based on continuous glucose monitoring, in patients with type 2 diabetes uncontrolled with once‐daily basal insulin: A randomized, phase <scp>IV</scp> study
Effect of prandial treatment timing adjustment, based on continuous glucose monitoring, in patients with type 2 diabetes uncontrolled with once‐daily basal insulin: A randomized, phase <span>IV</span> study Open
Aims To evaluate the glycaemic control achieved by prandial once‐daily insulin glulisine injection timing adjustment, based on a continuous glucose monitoring sensor, in comparison to once‐daily insulin glulisine injection before breakfast…