Yogesh B. Narkhede
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View article: Variants of the Ebola virus matrix protein VP40 have differential effects on oligomerization and plasma membrane interactions
Variants of the Ebola virus matrix protein VP40 have differential effects on oligomerization and plasma membrane interactions Open
The Ebola virus (EBOV) has been responsible for several outbreaks in Africa over the last decade causing severe hemorrhagic fever with limited treatment options. EBOV is a lipid-enveloped filamentous negative-sense RNA virus with a genome …
View article: Abstract 1544 A mutational analysis of the Ebola virus and Marburg virus matrix protein VP40 to assess effects on assembly and budding of these viruses
Abstract 1544 A mutational analysis of the Ebola virus and Marburg virus matrix protein VP40 to assess effects on assembly and budding of these viruses Open
View article: Editorial: Ion channels and transporters as drug targets in immune disorders
Editorial: Ion channels and transporters as drug targets in immune disorders Open
View article: Development of phenyl‐urea‐based small molecules that target penicillin‐binding protein 4
Development of phenyl‐urea‐based small molecules that target penicillin‐binding protein 4 Open
Staphylococcus aureus has the ability to invade cortical bone osteocyte lacuno‐canalicular networks (OLCNs) and cause osteomyelitis. It was recently established that the cell wall transpeptidase, penicillin‐binding protein 4 (PBP4), is cru…
View article: Computational and experimental identification of keystone interactions in Ebola virus matrix protein <scp>VP40</scp> dimer formation
Computational and experimental identification of keystone interactions in Ebola virus matrix protein <span>VP40</span> dimer formation Open
The Ebola virus (EBOV) is a lipid‐enveloped virus with a negative sense RNA genome that can cause severe and often fatal viral hemorrhagic fever. The assembly and budding of EBOV is regulated by the matrix protein, VP40, which is a periphe…
View article: Synthesis of a Cholesterol Cross-Linker with a Photoaffinity Label and Alkyne Tag at Minimally Interfering Sites for Cellular Studies
Synthesis of a Cholesterol Cross-Linker with a Photoaffinity Label and Alkyne Tag at Minimally Interfering Sites for Cellular Studies Open
View article: Foldscope microscope, an inexpensive alternative tool to conventional microscopy—Applications in research and education: A review
Foldscope microscope, an inexpensive alternative tool to conventional microscopy—Applications in research and education: A review Open
Microscope is a device used for the visualization of tiny objects which are not visible to the naked eye. Traditional microscopes have been crucial for the advancement of contemporary science and medicine. Recent advancements in the field …
View article: Targeting Viral Surface Proteins through Structure-Based Design
Targeting Viral Surface Proteins through Structure-Based Design Open
The emergence of novel viral infections of zoonotic origin and mutations of existing human pathogenic viruses represent a serious concern for public health. It warrants the establishment of better interventions and protective therapies to …
View article: Role of Electrostatic Hotspots in the Selectivity of Complement Control Proteins Toward Human and Bovine Complement Inhibition
Role of Electrostatic Hotspots in the Selectivity of Complement Control Proteins Toward Human and Bovine Complement Inhibition Open
Poxviruses are dangerous pathogens, which can cause fatal infection in unvaccinated individuals. The causative agent of smallpox in humans, variola virus , is closely related to the bovine vaccinia virus , yet the molecular basis of their …
View article: Cooperative Dynamics of REC-Nuc Lobes Prime Cas12a for DNA Processing
Cooperative Dynamics of REC-Nuc Lobes Prime Cas12a for DNA Processing Open
View article: Molecular Dynamics Reveals a DNA-Induced Dynamic Switch Triggering Activation of CRISPR-Cas12a
Molecular Dynamics Reveals a DNA-Induced Dynamic Switch Triggering Activation of CRISPR-Cas12a Open
CRISPR-Cas12a is a genome-editing system, recently also harnessed for nucleic acid detection, which is promising for the diagnosis of the SARS-CoV-2 coronavirus through the DETECTR technology. Here, a collective ensemble of multimicrosecon…
View article: Spontaneous Embedding of DNA Mismatches Within the RNA:DNA Hybrid of CRISPR-Cas9
Spontaneous Embedding of DNA Mismatches Within the RNA:DNA Hybrid of CRISPR-Cas9 Open
CRISPR-Cas9 is the forefront technology for editing the genome. In this system, the Cas9 protein is programmed with guide RNAs to process DNA sequences that match the guide RNA forming an RNA:DNA hybrid structure. However, the binding of D…
View article: Factor H-Inspired Design of Peptide Biomarkers of the Complement C3d Protein
Factor H-Inspired Design of Peptide Biomarkers of the Complement C3d Protein Open
C3d is a hallmark protein of the complement system, whose presence is critical to measure the progression of several immune diseases. Here, we propose to directly target C3d through small peptides mimicking the binding of its natural ligan…
View article: Allosteric Motions of the CRISPR–Cas9 HNH Nuclease Probed by NMR and Molecular Dynamics
Allosteric Motions of the CRISPR–Cas9 HNH Nuclease Probed by NMR and Molecular Dynamics Open
CRISPR-Cas9 is a widely employed genome-editing tool with functionality reliant on the ability of the Cas9 endonuclease to introduce site-specific breaks in double-stranded DNA. In this system, an intriguing allosteric communication has be…