Yohan Bossé
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View article: Oncogenic driver mutations underlie the spatial tumour immune landscape of non-small cell lung cancer
Oncogenic driver mutations underlie the spatial tumour immune landscape of non-small cell lung cancer Open
View article: A prognostic signature for lung adenocarcinoma in people who have never smoked
A prognostic signature for lung adenocarcinoma in people who have never smoked Open
Knowledge of tumor cell dynamics can inform prognosis and treatment yet is largely lacking for lung adenocarcinoma in people who have never smoked (NS-LUAD). With RNA-seq data from 684 NS-LUAD and validation in an independent dataset, we i…
View article: Early-onset multivalvular disease caused by a missense variant in lamin A/C
Early-onset multivalvular disease caused by a missense variant in lamin A/C Open
View article: Cell-Specific Transcriptomic and Mito-Nuclear Imbalance in Lungs Under Intermittent Hypoxia in Adult Male Mice
Cell-Specific Transcriptomic and Mito-Nuclear Imbalance in Lungs Under Intermittent Hypoxia in Adult Male Mice Open
Obstructive sleep apnea and its characteristic intermittent hypoxia (IH) are widely recognized as significant contributors to various pulmonary diseases, including asthma, pulmonary arterial hypertension, fibrosis, and chronic obstructive …
View article: Appraisal of multiple polygenic risk scores to estimate the risk of myocardial infarction and coronary artery lesions
Appraisal of multiple polygenic risk scores to estimate the risk of myocardial infarction and coronary artery lesions Open
Screening multiple validated PRS may significantly improve genetic risk estimation of MI as well as the extent and recurrence of coronary artery lesions.
View article: The long non-coding RNA<i>TRIB1AL</i>links metabolic dysfunction-associated steatotic liver disease, cardiometabolic risk and human lifespan
The long non-coding RNA<i>TRIB1AL</i>links metabolic dysfunction-associated steatotic liver disease, cardiometabolic risk and human lifespan Open
Genome-wide association studies (GWAS) have identified dozens of genetic loci linked with metabolic dysfunction-associated steatotic liver disease (MASLD). To identify liver-expressed genes that may represent therapeutic candidates for MAS…
View article: A Comprehensive Evaluation of Clinicopathologic Characteristics, Molecular Features and Prognosis in Lung Adenocarcinoma with an Acinar Component
A Comprehensive Evaluation of Clinicopathologic Characteristics, Molecular Features and Prognosis in Lung Adenocarcinoma with an Acinar Component Open
Introduction: Lung adenocarcinoma (LUAD) is the leading cause of cancer-related mortality worldwide. Acinar is the most prevalent architectural pattern and is associated with an intermediate prognosis. Several studies have investigated the…
View article: Aortic valve-specific genes dysregulated in calcific aortic valve stenosis as potential biomarkers and therapeutic targets
Aortic valve-specific genes dysregulated in calcific aortic valve stenosis as potential biomarkers and therapeutic targets Open
View article: Transcriptomic Signatures of Calcific Aortic Valve Stenosis Severity in Human Tricuspid and Bicuspid Aortic Valves
Transcriptomic Signatures of Calcific Aortic Valve Stenosis Severity in Human Tricuspid and Bicuspid Aortic Valves Open
View article: Frequency of targetable genetic alterations in resectable lung adenocarcinoma: Results from the LORD project
Frequency of targetable genetic alterations in resectable lung adenocarcinoma: Results from the LORD project Open
There is still limited data on the prevalence of actionable molecular alterations in patients with early-stage resectable lung adenocarcinoma and prior studies reported important differences across geographic locations, demographic and pat…
View article: Deciphering lung adenocarcinoma evolution and the role of LINE-1 retrotransposition
Deciphering lung adenocarcinoma evolution and the role of LINE-1 retrotransposition Open
Understanding lung cancer evolution can identify tools for intercepting its growth. In a landscape analysis of 1024 lung adenocarcinomas (LUAD) with deep whole-genome sequencing integrated with multiomic data, we identified 542 LUAD that d…
View article: A Transcriptomic Approach to Sex Differences in Calcific Aortic Valve Stenosis in Patients with a Tricuspid Aortic Valve
A Transcriptomic Approach to Sex Differences in Calcific Aortic Valve Stenosis in Patients with a Tricuspid Aortic Valve Open
View article: A versatile and efficient method to isolate nuclei from low-input cryopreserved tissues for single-nuclei transcriptomics
A versatile and efficient method to isolate nuclei from low-input cryopreserved tissues for single-nuclei transcriptomics Open
View article: Context-specific eQTLs provide deeper insight into causal genes underlying shared genetic architecture of COVID-19 and idiopathic pulmonary fibrosis
Context-specific eQTLs provide deeper insight into causal genes underlying shared genetic architecture of COVID-19 and idiopathic pulmonary fibrosis Open
View article: Improved Annotation of Asthma Gene Variants with Cell Type Deconvolution of Nasal and Lung Expression Quantitative Trait Loci
Improved Annotation of Asthma Gene Variants with Cell Type Deconvolution of Nasal and Lung Expression Quantitative Trait Loci Open
Asthma is a genetically complex inflammatory airway disease associated with more than 200 SNPs. However, the functional effects of many asthma-associated SNPs in lung and airway epithelial samples are unknown. Here, we aimed to conduct exp…
View article: The clinical value and most informative threshold of polygenic risk score in the Quebec City Case-Control Asthma Cohort
The clinical value and most informative threshold of polygenic risk score in the Quebec City Case-Control Asthma Cohort Open
View article: Multi-ancestry GWAS meta-analyses of lung cancer reveal susceptibility loci and elucidate smoking-independent genetic risk
Multi-ancestry GWAS meta-analyses of lung cancer reveal susceptibility loci and elucidate smoking-independent genetic risk Open
Lung cancer remains the leading cause of cancer mortality, despite declining smoking rates. Previous lung cancer GWAS have identified numerous loci, but separating the genetic risks of lung cancer and smoking behavioral susceptibility rema…
View article: Metabolomic Profiling of Pulmonary Neuroendocrine Neoplasms
Metabolomic Profiling of Pulmonary Neuroendocrine Neoplasms Open
Background/Objectives: Pulmonary neuroendocrine neoplasms (NENs) account for 20% of malignant lung tumors. Their management is challenging due to their diverse clinical features and aggressive nature. Currently, metabolomics offers a range…
View article: Efficient molecular mendelian randomization screens with LaScaMolMR.jl
Efficient molecular mendelian randomization screens with LaScaMolMR.jl Open
Summary The ever-growing genetic cohorts lead to an increase in scale of molecular Quantitative Trait Loci (QTL) studies, creating opportunities for more extensive two samples Mendelian randomization (MR) investigations aiming to identify …
View article: Context-specific eQTLs reveal causal genes underlying shared genetic architecture of critically ill COVID-19 and idiopathic pulmonary fibrosis
Context-specific eQTLs reveal causal genes underlying shared genetic architecture of critically ill COVID-19 and idiopathic pulmonary fibrosis Open
SUMMARY Most genetic variants identified through genome-wide association studies (GWAS) are suspected to be regulatory in nature, but only a small fraction colocalize with expression quantitative trait loci (eQTLs, variants associated with…
View article: Polygenic inheritance and its interplay with smoking history in predicting lung cancer diagnosis: a French-Canadian case-control cohort
Polygenic inheritance and its interplay with smoking history in predicting lung cancer diagnosis: a French-Canadian case-control cohort Open
View article: Mendelian randomization reveals interactions of the blood proteome and immunome in mitral valve prolapse
Mendelian randomization reveals interactions of the blood proteome and immunome in mitral valve prolapse Open
Background Mitral valve prolapse (MVP) is a common heart disorder characterized by an excessive production of proteoglycans and extracellular matrix in mitral valve leaflets. Large-scale genome-wide association study (GWAS) underlined that…
View article: Single-cell and single-nucleus RNA-sequencing from paired normal-adenocarcinoma lung samples provide both common and discordant biological insights
Single-cell and single-nucleus RNA-sequencing from paired normal-adenocarcinoma lung samples provide both common and discordant biological insights Open
Whether single-cell RNA-sequencing (scRNA-seq) captures the same biological information as single-nucleus RNA-sequencing (snRNA-seq) remains uncertain and likely to be context-dependent. Herein, a head-to-head comparison was performed in m…
View article: Prognostic implication of methylation-based circulating tumor DNA detection prior to surgery in stage I non-small cell lung cancer
Prognostic implication of methylation-based circulating tumor DNA detection prior to surgery in stage I non-small cell lung cancer Open
Our findings suggest preoperative ctDNA detection in patients with resectable clinical stage I NSCLC using MCED, a pan-cancer screening test developed for use in an asymptomatic population, has no detectable prognostic value for relapse ≤5…
View article: A murine model of hypertensive heart disease in older women
A murine model of hypertensive heart disease in older women Open
We propose a new mouse (C57Bl6/J) model combining several features of heart failure with preserved ejection fraction encountered in older women, including hypertension from Angiotensin II infusion (AngII), menopause, and advanced age. To m…
View article: Biological sex, sex steroids and sex chromosomes contribute to mouse cardiac aging
Biological sex, sex steroids and sex chromosomes contribute to mouse cardiac aging Open
After menopause, the incidence of cardiovascular disease rapidly rises in women. The disappearing protection provided by sex steroids is a consequence of the development of many risk factors. Preclinical studies are necessary to understand…
View article: Association of Genetically Predicted Levels of Circulating Blood Lipids with Coronary Artery Disease Incidence
Association of Genetically Predicted Levels of Circulating Blood Lipids with Coronary Artery Disease Incidence Open
Background Estimating the genetic risk of coronary artery disease (CAD) is now possible by aggregating data from genome-wide association studies (GWAS) into polygenic risk scores (PRS). Combining multiple PRS for specific circulating blood…
View article: Multi-ancestry meta-analyses of lung cancer in the Million Veteran Program reveal novel risk loci and elucidate smoking-independent genetic risk
Multi-ancestry meta-analyses of lung cancer in the Million Veteran Program reveal novel risk loci and elucidate smoking-independent genetic risk Open
Lung cancer remains the leading cause of cancer mortality, despite declines in smoking rates. Previous lung cancer genome-wide association studies (GWAS) have identified numerous loci, but separating the genetic risks of lung cancer and sm…
View article: Author Correction: New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries
Author Correction: New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries Open
View article: Integrative genomic analyses identify candidate causal genes for calcific aortic valve stenosis involving tissue-specific regulation
Integrative genomic analyses identify candidate causal genes for calcific aortic valve stenosis involving tissue-specific regulation Open