Explanipedia

Carrier cross-reactivities of the bile acid reabsorption inhibitors elobixibat, linerixibat, maralixibat, and odevixibat Open

Veronica Billo, Christopher Neelen, Marie Wannowius, Anita Neubauer, Bärbel Fühler , et al. · 2025

Fluorescent 4-Nitrobenzo-2-oxa-1,3-diazole-Coupled Bile Acids as Probe Substrates of Hepatic and Intestinal Bile Acid Transporters of the Solute Carrier Families SLC10 and SLCO Open

Celine Drossel, Sebastian N. Kunz, Christopher Neelen, Mats Georg, Yohannes Hagos , et al. · 2025

Several bile acid (BA) transporters are involved in the enterohepatic BA circulation between the liver and gut, including the hepatic Na⁺/taurocholate cotransporting polypeptide (NTCP) and the intestinal apical sodium-dependent …

Validating Low‐Dose Iohexol as a Marker for Glomerular Filtration Rate by In Vitro and In Vivo Studies Open

Qian Dong, Zhendong Chen, Jana Boland, Charalampos Dokos, Yohannes Hagos , et al. · 2025

Clearance of an intravenous iohexol dose of 3235 mg is used to assess glomerular filtration rate (GFR), although systematic assessment of its pharmacokinetic (PK) properties is incomplete. The objectives of the present investigations were …

Interaction of the Atypical Tetracyclines Chelocardin and Amidochelocardin with Renal Drug Transporters Open

Katharina Rox, Annett Kühne, Jennifer Herrmann, Rolf Jansen, Stephan Hüttel , et al. · 2024

Antimicrobial resistance is expected to increase mortality rates by up to several million deaths per year by 2050 without new treatment options at hand. Recently, we characterized the pharmacokinetic (PK) and pharmacodynamic properties of …

In vitro validation of an in vivo phenotyping drug cocktail for major drug transporters in humans Open

Chih‐hsuan Hsin, Annett Kuehne, Yi Gu, Gabriele Jedlitschky, Yohannes Hagos , et al. · 2023

The inhibition of hOCT2 in vitro by sitagliptin is in agreement with the borderline inhibition of renal metformin elimination observed clinically, supporting a dose reduction of sitagliptin in the cocktail.

Investigations with Drugs and Pesticides Revealed New Species- and Substrate-Dependent Inhibition by Elacridar and Imazalil in Human and Mouse Organic Cation Transporter OCT2 Open

Annett Kuehne, Saskia Floerl, Yohannes Hagos · 2022

Multiple drugs are used to treat various indications as well as pesticides that are ingested unintentionally and enter the bloodstream. The residence time or bioavailability of these substances in circulation depends on several mechanisms,…

Functional characterization and comparison of human and mouse organic anion transporter 1 as drugs and pesticides uptake carrier Open

Saskia Floerl, Annett Kuehne, Yohannes Hagos · 2022

The organic anion transporter 1 (OAT1) is mainly expressed in proximal tubule cells, where it mediates the renal uptake of endogenous and exogenous compounds. Thereby, it has enormous clinical relevance particularly in drug-drug interactio…

Outbreak Investigation and Molecular Detection of Pox Virus Circulating in Sheep and Goats in Selected Districts of West Gojjam and Awi Zones Northwest, Ethiopia Open

Alemzewud Wondimu, Habtamu Tassew, Esayas Gelaye, Yohannes Hagos, Alebachew Belay , et al. · 2021

The disease was found in higher rate during the dry and short rainy season. Sheep were also found to be infected by goat pox virus. The study indicated that there was widespread sheep and goat pox in Northwest Ethiopia.

Poultry disease occurrences and their impacts in Ethiopia Open

Y. Asfaw, Gobena Ameni, Girmay Medhin, Balako Gumi, Yohannes Hagos , et al. · 2021

Poultry production contributes significantly to the livelihoods of Ethiopian farmers and to the national economy although it is hampered by different factors, including poultry diseases. There is scarcity of published evidences on the occu…

Functional and Pharmacological Comparison of Human, Mouse, and Rat Organic Cation Transporter 1 toward Drug and Pesticide Interaction Open

Saskia Floerl, Annett Kuehne, Yohannes Hagos · 2020

Extrapolation from animal to human data is not always possible, because several essential factors, such as expression level, localization, as well as the substrate selectivity and affinity of relevant transport proteins, can differ between…

Prevalence and identification of ectoparasites on indigenous chickens in Seharti-Samre District, Tigray, Northern Ethiopia Open

Girmay Hiluf, Abrha Bsrat, Etsay Kebede, Yohannes Hagos · 2018

A cross sectional study was conducted from February 2014 to February 2015 to estimate the prevalence of ectoparasites and to assess risk factors in indigenous free scavenging chickens in three sub-districts of Seharti-Samre District, north…

Interaction of the New Monofunctional Anticancer Agent Phenanthriplatin With Transporters for Organic Cations Open

Anna Hucke, Ga Young Park, Olivier Bauer, Georg Beyer, Christina Köppen , et al. · 2018

Cancer treatment with platinum compounds is an important achievement of modern chemotherapy. However, despite the beneficial effects, the clinical impact of these agents is hampered by the development of drug resistance as well as dose-lim…

Interaction of the New Monofunctional Anticancer Agent Phenanthriplatin With Transporters for Organic Cations Open

Anna Hucke, Ga Young Park, Olivier Bauer, Georg Beyer, Christina Köppen , et al. · 2018

Cancer treatment with platinum compounds is an important achievement of modern chemotherapy. However, despite the beneficial effects, the clinical impact of these agents is hampered by the development of drug resistance as well as dose-lim…

Knowledge Attitude and Practice towards Visceral Leishmaniasis among Residents and Health Professionals in Welkait District, Western Tigray, Ethiopia Open

Mebrahtu Berhe, Abrha Bsrat, Habtamu Taddele, Endalemaw Gadissa, Yohannes Hagos , et al. · 2018

Visceral Leishmaniasis is becoming a major public health problem both in terms of geographical spread and incidence in Ethiopia although failed to attract the attention it deserves.Magnitude,public health impact and dynamics of the disease…

Sero-prevalence and associated risk factors for Brucella sero-positivity among small ruminants in Tselemti districts, Northern Ethiopia Open

Mulalem Zenebe Kelkay, Getachew Gugsa, Yohannes Hagos, Habtamu Taddelle · 2017

A cross sectional study design was employed with the aim to determine sero-prevalence of brucellosis among sheep and goats and identify factors associated with sero-positivity to Brucella. A total of 558 sera were collected randomly and as…

Serological investigation of visceral Leishmania infection in human and its associated risk factors in Welkait District, Western Tigray, Ethiopia Open

Abrha Bsrat, Mebrahtu Berhe, Endalemaw Gadissa, Habtamu Taddele, Yohannes Tekle , et al. · 2017

Erratum to: Counter-flow suggests transport of dantrolene and 5-OH dantrolene by the organic anion transporters 2 (OAT2) and 3 (OAT3) Open

Birgitta C. Burckhardt, Maja Henjakovic, Yohannes Hagos, Gerhard Burckhardt · 2016

Distribution of organic anion transporters NaDC3 and OAT1-3 along the human nephron Open

Davorka Breljak, Marija Ljubojević, Yohannes Hagos, Vedran Micek, Daniela Balen Eror , et al. · 2016

The initial step in renal secretion of organic anions (OAs) is mediated by transporters in the basolateral membrane (BLM). Contributors to this process are primary active Na + -K + -ATPase (EC 3.6.3.9), secondary active Na + -dicarboxylate…

Human organic anion transporter 2 is distinct from organic anion transporters 1 and 3 with respect to transport function Open

Maja Henjakovic, Yohannes Hagos, Wolfgang Krick, Gerhard Burckhardt, Birgitta C. Burckhardt · 2015

Phylogentically, organic anion transporter (OAT)1 and OAT3 are closely related, whereas OAT2 is more distant. Experiments with human embryonic kidney-293 cells stably transfected with human OAT1, OAT2, or OAT3 were performed to compare sel…

Epithelial-to-mesenchymal transition induces cell cycle arrest and parenchymal damage in renal fibrosis Open

Sara Lovisa, Valerie S. LeBleu, Björn Tampe, Hikaru Sugimoto, Komal Vadnagara , et al. · 2015

Prevalence and public health significance of bovine cysticercosis at Elfora Abattoir, Bishoftu, Ethiopia Open

Emiru Lielt, Desalew Tadesse, Kifleyohannes Tsegabirhan, Teshale Sori, Yohannes Hagos · 2015

A cross sectional study was conducted from November 2013 to April 2014 to determine the prevalence of bovine cysticercosis, assess the associated risk factors and public health importance of Taeniasis at Elfora abattoir, Bishoftu town. Act…

Pre-slaughter, slaughter and post-slaughter defects of skins and hides at the Sheba Tannery and Leather Industry, Tigray region, northern Ethiopia Open

Tesfay Kahsay, Guesh Negash, Yohannes Hagos, Birhanu Hadush · 2015

Skins and hides are perishable resources that can be damaged by parasitic diseases and human error, which result in downgrading or rejection. This study was conducted to identify defect types and to determine their prevalence in pickled sh…

Interaction of human organic anion transporter polypeptides 1B1 and 1B3 with antineoplastic compounds Open

Venkata V.V.R. Marada, Saskia Flörl, Annett Kühne, Gerhard Burckhardt, Yohannes Hagos · 2015

The Isoquinolone Derived Prolyl Hydroxylase Inhibitor ICA Is a Potent Substrate of the Organic Anion Transporters 1 and 3 Open

Kei Schulz, Yohannes Hagos, Gerhard Burckhardt, Gunnar Schley, Nicolai Burzlaff , et al. · 2015

Objective: Many cellular responses to hypoxia are mediated by the transcription factor complex hypoxia-inducible factor (HIF). HIF stability is governed by a family of dioxygenases called HIF prolyl hydroxylases (PHDs). Isoqu…

Yohannes Hagos YOU? Author Swipe