Yohei Kitamura
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View article: 10174-CS-18Upfront chemotherapy and subsequent resection utilizing neoadjuvant chemotherapy for oligodendrogliomas
10174-CS-18Upfront chemotherapy and subsequent resection utilizing neoadjuvant chemotherapy for oligodendrogliomas Open
Functional preservation and maximal resection are both critical in glioma surgery, however, neoadjuvant chemotherapy has not been utilized so far. Although IDH-mutant and 1p/19q-codeled oligodendroglioma is known as relatively indolent tum…
View article: Variations in venous anatomy associated with the suboccipital transhorizontal fissure approach: Imaging and cadaveric studies with clinical application
Variations in venous anatomy associated with the suboccipital transhorizontal fissure approach: Imaging and cadaveric studies with clinical application Open
The SOTHF approach is feasible for accessing deep cerebellar lesions, the medial aspect of cerebellopontine angle, and the upper fourth ventricle. Preoperative analysis and prediction of the venous architecture around the HF can enhance th…
View article: 10022- ET-2 DEVELOPMENT OF MICROSURGICAL FORCEPS EQUIPPED WITH HAPTICS TECHNOLOGY FOR IN SITU DIFFERENTIATION OF BRAIN TUMORS DURING MICROSURGERY
10022- ET-2 DEVELOPMENT OF MICROSURGICAL FORCEPS EQUIPPED WITH HAPTICS TECHNOLOGY FOR IN SITU DIFFERENTIATION OF BRAIN TUMORS DURING MICROSURGERY Open
The stiffness of human cancers may be corelated with their pathology, and can be used as a biomarker for diagnosis, malignancy prediction, molecular expression, and postoperative complications. Neurosurgeons perform tumor resection based o…
View article: EXTH-05. STEM CELL-BASED THERAPEUTIC STRATEGY FOR LEPTOMENINGEAL METASTASIS OF SOLID CANCERS
EXTH-05. STEM CELL-BASED THERAPEUTIC STRATEGY FOR LEPTOMENINGEAL METASTASIS OF SOLID CANCERS Open
Leptomeningeal dissemination (LMD), known as carcinomatous meningitis, presents an extremely poor prognosis with an average life expectancy of 4-6 weeks. Although whole brain/spinal cord irradiation and intrathecal injection of anticancer …
View article: SURG-04. DEVELOPMENT OF MICROSURGICAL FORCEPS EQUIPPED WITH HAPTICS TECHNOLOGY FOR IN SITU DIFFERENTIATION OF BRAIN TUMORS DURING MICROSURGERY
SURG-04. DEVELOPMENT OF MICROSURGICAL FORCEPS EQUIPPED WITH HAPTICS TECHNOLOGY FOR IN SITU DIFFERENTIATION OF BRAIN TUMORS DURING MICROSURGERY Open
BACKGROUND The stiffness of human cancers is correlated with their pathology, and can be used as a biomarker for diagnosis, malignancy prediction, molecular expression, and postoperative complications. Neurosurgeons perform tumor resection…
View article: Development of microsurgical forceps equipped with haptic technology for in situ differentiation of brain tumors during microsurgery
Development of microsurgical forceps equipped with haptic technology for in situ differentiation of brain tumors during microsurgery Open
The stiffness of human cancers may be correlated with their pathology, and can be used as a biomarker for diagnosis, malignancy prediction, molecular expression, and postoperative complications. Neurosurgeons perform tumor resection based …
View article: TRSC-01 STEM CELL THERAPY HAS EFFICACY FOR LEPTOMENINGEAL DISSEMINATION OF DIVERSE TYPES OF SOLID CANCERS
TRSC-01 STEM CELL THERAPY HAS EFFICACY FOR LEPTOMENINGEAL DISSEMINATION OF DIVERSE TYPES OF SOLID CANCERS Open
Leptomeningeal dissemination (LMD), known as carcinomatous meningitis, occurs in approximately 5% of all cancer patients. LMD presents an extremely poor prognosis, with an average life expectancy of 4-6 weeks. While treatments such as whol…
View article: Awake Surgery for Right Frontal Lobe Glioma: Preserving Emotional Recognition and Facilitating Early Return to Work
Awake Surgery for Right Frontal Lobe Glioma: Preserving Emotional Recognition and Facilitating Early Return to Work Open
Background Many glioma patients struggle to return to work after surgery because of higher brain dysfunction. Although the right frontal lobe has historically been considered functionally silent, reports of performing awake surgery to eval…
View article: Detection of novel PPP1R1B::STARD3 fusion transcript in acute myeloid leukemia: a case report
Detection of novel PPP1R1B::STARD3 fusion transcript in acute myeloid leukemia: a case report Open
Background Acute myeloid leukemia (AML) is the second most common type of leukemia in children. Although prognostic and diagnostic tests of AML patients have improved, there is still a great demand for new reliable clinical biomarkers for …
View article: Comparison of protein digestibility of human milk and infant formula using the INFOGEST method under infant digestion conditions
Comparison of protein digestibility of human milk and infant formula using the INFOGEST method under infant digestion conditions Open
Many improvements have been made to bring infant formula (IF) closer to human milk (HM) regarding its nutritional and biological properties. Nevertheless, the protein components of HM and IF are still different, which may affect their dige…
View article: The Role of Genetic Analysis in Distinguishing Multifocal and Multicentric Glioblastomas: An Illustrative Case
The Role of Genetic Analysis in Distinguishing Multifocal and Multicentric Glioblastomas: An Illustrative Case Open
Introduction: Glioblastomas can manifest as multiple, simultaneous, noncontiguous lesions. We genetically analyzed multiple glioblastomas and discuss their etiological origins in this report. Case Presentation: We present the case of a 47-…
View article: Impact of tumor-treating fields on the survival of Japanese patients with newly diagnosed glioblastoma: A multicenter, retrospective cohort study
Impact of tumor-treating fields on the survival of Japanese patients with newly diagnosed glioblastoma: A multicenter, retrospective cohort study Open
Background The EF-14 clinical trial demonstrated the safety and efficacy of tumor-treating fields (TTFields) for newly diagnosed glioblastoma. This study aimed to clarify the current status, safety, and efficacy of TTFields in Japanese pat…
View article: EXTH-01. STEM CELL THERAPY FOR LEPTOMENINGEAL DISEASE
EXTH-01. STEM CELL THERAPY FOR LEPTOMENINGEAL DISEASE Open
Leptomeningeal disease (LMD), known as carcinomatous meningitis, occurs in approximately 5% of all cancer patients. LMD presents an extremely poor prognosis, with an average life expectancy of 4-6 weeks. Although, whole brain/spinal cord i…
View article: SURG-01. DIFFERENTIATION OF GLIOBLASTOMA AND MALIGNANT MENINGIOMA FROM NORMAL BRAIN BY TISSUE STIFFNESS UTILIZING MICROSURGICAL FORCEPS EQUIPPED WITH HAPTICS TECHNOLOGY
SURG-01. DIFFERENTIATION OF GLIOBLASTOMA AND MALIGNANT MENINGIOMA FROM NORMAL BRAIN BY TISSUE STIFFNESS UTILIZING MICROSURGICAL FORCEPS EQUIPPED WITH HAPTICS TECHNOLOGY Open
Stiffness of human cancers strongly correlate with their pathology, and it is reported that stiffness can be used as a biomarker. Furthermore, comprehensive analysis has suggested the usefulness of cancer stiffness in diagnosis and maligna…
View article: CTNI-45. UPFRONT CHEMOTHERAPY AND SUBSEQUENT RESECTION UTILIZING NEOADJUVANT STRATEGY FOR OLIGODENDROGLIOMAS
CTNI-45. UPFRONT CHEMOTHERAPY AND SUBSEQUENT RESECTION UTILIZING NEOADJUVANT STRATEGY FOR OLIGODENDROGLIOMAS Open
Although both of functional preservation and higher extent of resection are required in glioma surgery, maximal resection with the risk of functional sequela is uniformly performed regardless of tumor pathology and treatment sensitivity in…
View article: Gene-edited and -engineered stem cell platform drives immunotherapy for brain metastatic melanomas
Gene-edited and -engineered stem cell platform drives immunotherapy for brain metastatic melanomas Open
Oncolytic virus therapy has shown activity against primary melanomas; however, its efficacy in brain metastases remains challenging, mainly because of the delivery and immunosuppressive nature of tumors in the brain. To address this challe…
View article: Fate and Efficacy of Engineered Allogeneic Stem Cells Targeting Cell Death and Proliferation Pathways in Primary and Brain Metastatic Lung Cancer
Fate and Efficacy of Engineered Allogeneic Stem Cells Targeting Cell Death and Proliferation Pathways in Primary and Brain Metastatic Lung Cancer Open
Primary and metastatic lung cancer is a leading cause of cancer-related death and novel therapies are urgently needed. Epidermal growth factor receptor (EGFR) and death receptor (DR) 4/5 are both highly expressed in primary and metastatic …
View article: Volumetric measurement of paranasal sinuses and its clinical significance in pituitary neuroendocrine tumors operated using an endoscopic endonasal approach
Volumetric measurement of paranasal sinuses and its clinical significance in pituitary neuroendocrine tumors operated using an endoscopic endonasal approach Open
Objective Endoscopic endonasal surgery (EES) for deep intracranial lesions has gained popularity following recent developments in endoscopic technology. The operability of invasive pituitary neuroendocrine tumors (PitNETs) depends on the a…
View article: LW-8 TREATMENT STRATEGY FOR OLIGODENDROGLIOMAS WITH NEOADJUVANT STRATEGY AND STAGED RESECTION UTILIZING THEIR CHEMOTHERAPEUTIC RESPONSIVENESS
LW-8 TREATMENT STRATEGY FOR OLIGODENDROGLIOMAS WITH NEOADJUVANT STRATEGY AND STAGED RESECTION UTILIZING THEIR CHEMOTHERAPEUTIC RESPONSIVENESS Open
Background In glioma surgery, both of functional preservation and maximal safe resection are critical, however, neoadjuvant strategy has never been used because of difficulty of tissue sampling without craniotomy. Method In Keio University…
View article: SURG-21. DEVELOPMENT OF MICROSURGICAL FORCEPS EQUIPPED WITH HAPTICS TECHNOLOGY FOR IN SITU DIFFERENTIATION OF TUMOR TISSUE FROM NORMAL BRAIN DURING MICROSURGERY BY TISSUE STIFFNESS
SURG-21. DEVELOPMENT OF MICROSURGICAL FORCEPS EQUIPPED WITH HAPTICS TECHNOLOGY FOR IN SITU DIFFERENTIATION OF TUMOR TISSUE FROM NORMAL BRAIN DURING MICROSURGERY BY TISSUE STIFFNESS Open
Neurosurgeons perform tumor resection based on their tactile perception. However, many years of experience and training are required to appropriately differentiate tumor tissue from surrounding parenchymal tissue. It was reported that the …
View article: SPDR-2 Histopathological investigation of the oligodendroglial tumors resected following alkylating agent chemotherapy
SPDR-2 Histopathological investigation of the oligodendroglial tumors resected following alkylating agent chemotherapy Open
Oligodendrogliomas, i.e., lower grade gliomas with 1p/19q codeletion, are often responsive to chemotherapy, however, those tumors eventually recur and life-limiting in the majority of patients despite initial chemotherapeutic response. We …
View article: OTHR-02. Engineered “of the shelf” allogeneic cellular therapies for metastatic brain tumors
OTHR-02. Engineered “of the shelf” allogeneic cellular therapies for metastatic brain tumors Open
Brain metastatic patients have multiple metastatic lesions or diagnostically challenging asymptomatic lesions, making surgery an inadequate therapeutic option. Given the challenges related to systemic delivery of a majority of therapeutic …
View article: Anti-EGFR VHH-armed death receptor ligand–engineered allogeneic stem cells have therapeutic efficacy in diverse brain metastatic breast cancers
Anti-EGFR VHH-armed death receptor ligand–engineered allogeneic stem cells have therapeutic efficacy in diverse brain metastatic breast cancers Open
This study presents a mechanism-based receptor-targeted cellular therapy approach to treat breast to brain metastasis.
View article: Molecular Investigation of Brain Tumors Progressing During Pregnancy or Postpartum Period: The Association Between Tumor Type, Their Receptors, and the Timing of Presentation
Molecular Investigation of Brain Tumors Progressing During Pregnancy or Postpartum Period: The Association Between Tumor Type, Their Receptors, and the Timing of Presentation Open
Brain tumors are frequently present during pregnancy; however, the mechanism has not been well elucidated. Purpose of this study is to investigate the influence of molecular genetic factors on the progression of brain tumors during pregnan…
View article: TMOD-01. DEVELOPING CLINICALLY RELEVANT BRAIN METASTATIC TUMOR MODELS FOR TARGETED STEM CELL THERAPEUTICS
TMOD-01. DEVELOPING CLINICALLY RELEVANT BRAIN METASTATIC TUMOR MODELS FOR TARGETED STEM CELL THERAPEUTICS Open
Brain metastasis is associated with increased mortality in patients with cancer, 15-20% of patients will develop brain metastasis during the course of the disease. Characterizing clinically relevant brain metastasis models and exploring di…
View article: Incidence of Nonalcoholic Fatty Liver Disease due to Tamoxifen
Incidence of Nonalcoholic Fatty Liver Disease due to Tamoxifen Open
肝障害は薬物治療に際して普遍的に認められる副作用の一つである．