Yohko Yoshida
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View article: Canagliflozin enhances endogenous eliminatiton of senescent cells through downregulation of PD-L1
Canagliflozin enhances endogenous eliminatiton of senescent cells through downregulation of PD-L1 Open
Sodium-glucose co-transporter 2 (SGLT2) inhibitors have been developed as a new class of anti-diabetic drug, and shown cardio- and renal-protective effects in patients with diabetes, heart failure, and chronic kidney diseases. Also, there'…
View article: The effect of intra-aortic balloon pumping on hemodynamics and left ventricular load in Impella-supported condition: A simulation study
The effect of intra-aortic balloon pumping on hemodynamics and left ventricular load in Impella-supported condition: A simulation study Open
Introduction Intra-aortic balloon pumping (IABP) is a commonly used percutaneous mechanical circulatory support device. Although IABP combined with Impella, a percutaneous left ventricular assist device, has shown positive outcomes in a fe…
View article: Coagulation factors promote brown adipose tissue dysfunction and abnormal systemic metabolism in obesity
Coagulation factors promote brown adipose tissue dysfunction and abnormal systemic metabolism in obesity Open
Brown adipose tissue (BAT) has a role in maintaining systemic metabolic health in rodents and humans. Here, we show that metabolic stress induces BAT to produce coagulation factors, which then-together with molecules derived from the circu…
View article: Capillaries as a Therapeutic Target for Heart Failure
Capillaries as a Therapeutic Target for Heart Failure Open
Prognosis of heart failure remains poor, and it is urgent to find new therapies for this critical condition. Oxygen and metabolites are delivered through capillaries; therefore, they have critical roles in the maintenance of cardiac functi…
View article: Empagliflozin maintains capillarization and improves cardiac function in a murine model of left ventricular pressure overload
Empagliflozin maintains capillarization and improves cardiac function in a murine model of left ventricular pressure overload Open
Patients with type 2 diabetes treated with Sodium glucose transporter 2 (SGLT2) inhibitors show reduced mortality and hospitalization for heart failure (HF). SGLT2 inhibitors are considered to activate multiple cardioprotective pathways; h…
View article: Cardiac mitofusin-1 is reduced in non-responding patients with idiopathic dilated cardiomyopathy
Cardiac mitofusin-1 is reduced in non-responding patients with idiopathic dilated cardiomyopathy Open
Prognosis of severe heart failure remains poor. Urgent new therapies are required. Some heart failure patients do not respond to established multidisciplinary treatment and are classified as “non-responders”. The outcome is especially poor…
View article: A novel senolytic drug, seno-7284 ameliorates aging phenotype and age-related cardiometabolic diseases
A novel senolytic drug, seno-7284 ameliorates aging phenotype and age-related cardiometabolic diseases Open
Background Cellular senescence occurs as a result of various genotoxic stresses and it plays a pivotal role in aging and age-related disorders. Recently, it was shown that elimination of senescent cells, so-called “senolysis” has the poten…
View article: ALDH-Dependent Glycolytic Activation Mediates Stemness and Paclitaxel Resistance in Patient-Derived Spheroid Models of Uterine Endometrial Cancer
ALDH-Dependent Glycolytic Activation Mediates Stemness and Paclitaxel Resistance in Patient-Derived Spheroid Models of Uterine Endometrial Cancer Open
Uterine endometrial cancer is associated with poor survival outcomes in patients with advanced-stage disease. Here, we developed a three-dimensional cell cultivation method of endometrioid cancer stem-like cells with high aldehyde dehydrog…
View article: Role of smooth muscle cell p53 in pulmonary arterial hypertension
Role of smooth muscle cell p53 in pulmonary arterial hypertension Open
Pulmonary arterial hypertension (PAH) is characterized by remodeling and narrowing of the pulmonary arteries, which lead to elevation of right ventricular pressure, heart failure, and death. Proliferation of pulmonary artery smooth muscle …
View article: Boysenberry polyphenol inhibits endothelial dysfunction and improves vascular health
Boysenberry polyphenol inhibits endothelial dysfunction and improves vascular health Open
Endothelial cells have an important role in maintaining vascular homeostasis. Age-related disorders (including obesity, diabetes, and hypertension) or aging per se induce endothelial dysfunction that predisposes to the development of ather…
View article: 5212Impaired function of brown adipose tissue is involved in the pathologies of pressure overload-induced heart failure
5212Impaired function of brown adipose tissue is involved in the pathologies of pressure overload-induced heart failure Open
The basic science of diabetes and the metabolic syndrome 1077 tracking echocardiography in diabetic and control mice of both strains (6 mice per group).Then, the animals were euthanized and LV specimens were collected to determine cardiac …
View article: Catecholamine-Induced Senescence of Endothelial Cells and Bone Marrow Cells Promotes Cardiac Dysfunction in Mice
Catecholamine-Induced Senescence of Endothelial Cells and Bone Marrow Cells Promotes Cardiac Dysfunction in Mice Open
Previous studies have suggested that cellular senescence plays a central role in the progression of pathologic changes in the failing heart. It is well known that the sympathetic nervous system is activated in patients with heart failure, …
View article: Amlodipine Inhibits Vascular Cell Senescence and Protects Against Atherogenesis Through the Mechanism Independent of Calcium Channel Blockade
Amlodipine Inhibits Vascular Cell Senescence and Protects Against Atherogenesis Through the Mechanism Independent of Calcium Channel Blockade Open
Vascular cells have a finite lifespan and eventually enter irreversible growth arrest called cellular senescence. We have previously suggested that vascular cell senescence contributes to the pathogenesis of human atherosclerosis. Amlodipi…
View article: Vascular Senescence in Cardiovascular and Metabolic Diseases
Vascular Senescence in Cardiovascular and Metabolic Diseases Open
In mammals, aging is associated with accumulation of senescent cells. Stresses such as telomere shortening and reactive oxygen species induce "cellular senescence", which is characterized by growth arrest and alteration of the gene express…
View article: Metabolomic Analysis in Heart Failure
Metabolomic Analysis in Heart Failure Open
It is thought that at least 6,500 low-molecular-weight metabolites exist in humans, and these metabolites have various important roles in biological systems in addition to proteins and genes. Comprehensive assessment of endogenous metaboli…
View article: Inhibition of dipeptidyl peptidase-4 ameliorates cardiac ischemia and systolic dysfunction by up-regulating the FGF-2/EGR-1 pathway
Inhibition of dipeptidyl peptidase-4 ameliorates cardiac ischemia and systolic dysfunction by up-regulating the FGF-2/EGR-1 pathway Open
Dipeptidyl peptidase 4 inhibitors are used worldwide in the management of diabetes, but their role in the prevention or treatment of cardiovascular disorders has yet to be defined. We found that linagliptin, a DPP-4 inhibitor, suppressed c…
View article: P3997Catecholamine-induced cellular senescence in endothelium and bone marrow promotes cardiac inflammation and remodeling in mice
P3997Catecholamine-induced cellular senescence in endothelium and bone marrow promotes cardiac inflammation and remodeling in mice Open
Background:The aim of this prospective, randomized and controlled training study was to assess the molecular effects of different physical training modalities on cellular ageing regulators in circulating mononuclear cells and to test wheth…