Yoichi Kakuta
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View article: Evaluation of Everolimus Pharmacokinetic Monitoring Based on Trough Concentration and Area Under the Blood Concentration Time Curve in Kidney Transplantation
Evaluation of Everolimus Pharmacokinetic Monitoring Based on Trough Concentration and Area Under the Blood Concentration Time Curve in Kidney Transplantation Open
Backgrounds Everolimus (EVR) is an mTOR inhibitor used in kidney transplantation to minimize calcineurin inhibitor exposure. Although therapeutic drug monitoring (TDM) based on trough concentrations (C0) is standard, the relationship betwe…
View article: Laparoscopic Partial Cystectomy for Inflammatory Myofibroblastic Tumor of the Urinary Bladder
Laparoscopic Partial Cystectomy for Inflammatory Myofibroblastic Tumor of the Urinary Bladder Open
Introduction Inflammatory myofibroblastic tumor (IMT) of the bladder is a rare benign tumor characterized by atypical spindle cell proliferation and inflammatory cell infiltration, typically involving lymphocytes and plasma cells. Case Pre…
View article: Differences in Anti-αvβ6 Integrin Antibody Expression between U.S. and Japanese Cohorts in Inflammatory Bowel Disease
Differences in Anti-αvβ6 Integrin Antibody Expression between U.S. and Japanese Cohorts in Inflammatory Bowel Disease Open
Background Inflammatory bowel diseases (IBDs), including ulcerative colitis (UC) and Crohn’s disease (CD), have complex pathologies requiring precise diagnostic tools. We evaluated the clinical utility of anti-integrin αvβ6 antibodies in d…
View article: Theoretical Analysis of <scp>d</scp>‐Serine and <scp>d</scp>‐Asparagine as Biomarkers for Glomerular Filtration Rate
Theoretical Analysis of <span>d</span>‐Serine and <span>d</span>‐Asparagine as Biomarkers for Glomerular Filtration Rate Open
Chronic kidney disease (CKD) is a major global health issue, requiring accurate and noninvasive renal function assessment. Glomerular filtration rate (GFR) is the standard measure, but current methods, including inulin clearance and creati…
View article: Evaluation of Organoid‐Derived Exosomal <scp>microRNA</scp> as Liquid Biopsy for Colorectal Cancer: A Multicenter Cross‐Sectional Study
Evaluation of Organoid‐Derived Exosomal <span>microRNA</span> as Liquid Biopsy for Colorectal Cancer: A Multicenter Cross‐Sectional Study Open
Exosomal microRNAs (miRNAs) are candidates for liquid biopsies. Organoid culture systems enable long‐term expansion of the colon epithelium. This study evaluated exosomal miRNAs from colorectal cancer organoids for liquid biopsy. Organoids…
View article: Autoantibodies against endothelial protein C receptor and integrin αvβ6 predict the development of ulcerative colitis
Autoantibodies against endothelial protein C receptor and integrin αvβ6 predict the development of ulcerative colitis Open
View article: Evolving Trends in Pediatric Inflammatory Bowel Disease Management in Japan: A Decade of Nationwide Data
Evolving Trends in Pediatric Inflammatory Bowel Disease Management in Japan: A Decade of Nationwide Data Open
Aims This study aimed to investigate the trends in pediatric inflammatory bowel diseases (IBD) management in Japan over the past decade. Methods We retrospectively analyzed data from Japan's nationwide database from 2012 to 2022. Patients …
View article: Endoscopic radial incision and cutting using balloon-assisted enteroscopy for small intestinal stenosis related to Crohn’s disease: a pilot study
Endoscopic radial incision and cutting using balloon-assisted enteroscopy for small intestinal stenosis related to Crohn’s disease: a pilot study Open
Background/Aims: Radial incision and cutting (RIC) is an alternative dilation method for stenosis of the lower gastrointestinal tract. However, its safety and efficacy for the small intestine requiring balloon-assisted enteroscopy (BAE) re…
View article: The outcomes of electronic personal health records in patients with heart failure or coronary artery disease
The outcomes of electronic personal health records in patients with heart failure or coronary artery disease Open
Background There are limited data on the efficacy of smartphone‐based personal health records (PHRs) in patients with cardiovascular disease. This study aimed to examine the processes, outcomes and challenges associated with the implementa…
View article: Kinetic analysis of D-Alanine upon oral intake in humans
Kinetic analysis of D-Alanine upon oral intake in humans Open
D-Alanine, a rare enantiomer of alanine, can potentially alleviate the worsening of viral infections and maintain circadian rhythm. This study aimed to analyze the kinetics of D-Alanine upon oral intake. Five healthy volunteers were admini…
View article: Safety and effectiveness of additional triamcinolone acetonide with endoscopic radial incision and cutting for benign stenosis of the lower gastrointestinal tract: A pilot study
Safety and effectiveness of additional triamcinolone acetonide with endoscopic radial incision and cutting for benign stenosis of the lower gastrointestinal tract: A pilot study Open
Objectives Radial incision and cutting (RIC) is being investigated as an alternative endoscopic dilation method for lower intestinal tract stenosis, providing a high technical success rate and improving subjective symptoms. However, severa…
View article: White spots around colorectal tumors are cancer-related findings and may aid endoscopic diagnosis: a prospective study in Japan
White spots around colorectal tumors are cancer-related findings and may aid endoscopic diagnosis: a prospective study in Japan Open
Background/Aims: During endoscopy, white spots (WS) are sometimes observed around benign or malignant colorectal tumors; however, few reports have investigated WS, and their significance remains unknown. Therefore, we investigated the sign…
View article: Impact of Upadacitinib Induction and Maintenance Therapy on Health-related Quality of Life, Fatigue, and Work Productivity in Patients with Moderately-to-severely Active Crohn’s Disease
Impact of Upadacitinib Induction and Maintenance Therapy on Health-related Quality of Life, Fatigue, and Work Productivity in Patients with Moderately-to-severely Active Crohn’s Disease Open
Background and Aims Quality of life in patients with active Crohn’s disease may be significantly reduced. We evaluated the effects of upadacitinib induction and maintenance therapy on fatigue, quality of life, and work productivity in the …
View article: Clinical practice and outcome of patients with elderly‐onset ulcerative colitis: Insights from a nationwide claims database study in Japan
Clinical practice and outcome of patients with elderly‐onset ulcerative colitis: Insights from a nationwide claims database study in Japan Open
Background and Aim The number of older patients with ulcerative colitis is increasing; however, limited data exist regarding the differences between elderly‐ and non‐elderly‐onset ulcerative colitis. We aimed to compare the clinical practi…
View article: Kinetical analysis of D-alanine upon oral intake in humans
Kinetical analysis of D-alanine upon oral intake in humans Open
D-Alanine, a rare enantiomer of alanine in life, can potentially alleviate the worsening of viral infections and maintain circadian rhythm. This study aimed to analyze the kinetics of D-alanine upon oral intake. Five healthy volunteers wer…
View article: Real-world NUDT15 genotyping and thiopurine treatment optimization in inflammatory bowel disease: a multicenter study
Real-world NUDT15 genotyping and thiopurine treatment optimization in inflammatory bowel disease: a multicenter study Open
Background This study evaluated the effectiveness of NUDT15 codon 139 genotyping in optimizing thiopurine treatment for inflammatory bowel disease (IBD) in Japan, using real-world data, and aimed to establish genotype-based treatment strat…
View article: Prescribing in pregnant women with inflammatory bowel disease and its relationship to congenital malformations in Japan
Prescribing in pregnant women with inflammatory bowel disease and its relationship to congenital malformations in Japan Open
Background and Aim Inflammatory bowel disease (IBD) frequently affects younger patients and poses various challenges concerning pregnancy and childbirth. Maintaining good disease control throughout pregnancy is crucial, but expectant and p…
View article: Live-attenuated vaccination in patients with inflammatory bowel disease while continuing or after elective switch to vedolizumab
Live-attenuated vaccination in patients with inflammatory bowel disease while continuing or after elective switch to vedolizumab Open
Background/Aims: Vedolizumab (VDZ) is a gut-selective agent with a favorable safety profile. We aimed to assess the feasibility of elective switch from other advanced therapies to VDZ and subsequent live-attenuated vaccination while contin…
View article: Clinical Practice and Safety of Endoscopic Balloon Dilation for Crohn’s Disease–Related Strictures: A Nationwide Claim Database Analysis in Japan
Clinical Practice and Safety of Endoscopic Balloon Dilation for Crohn’s Disease–Related Strictures: A Nationwide Claim Database Analysis in Japan Open
Introduction: Although endoscopic balloon dilation (EBD) is a common therapeutic approach for managing strictures associated with Crohn’s disease (CD), the clinical application and complication rates of EBD remain unclear. Methods: We coll…
View article: Dickkopf 1 is expressed in normal fibroblasts during early stages of colorectal tumorigenesis
Dickkopf 1 is expressed in normal fibroblasts during early stages of colorectal tumorigenesis Open
Background and Purpose Colorectal cancer progression from adenoma to cancer is a time‐intensive process; however, the interaction between normal fibroblasts (NFs) with early colorectal tumors, such as adenomas, remains unclear. Here, we an…
View article: Clinical Utilization of Generic Drugs and Biosimilars for Ulcerative Colitis Treatment: Insights from a Nationwide Database Study in Japan
Clinical Utilization of Generic Drugs and Biosimilars for Ulcerative Colitis Treatment: Insights from a Nationwide Database Study in Japan Open
Introduction: Limited data exist regarding the prevalence and clinical practice involving generic drugs and biosimilars for treating ulcerative colitis (UC) in Japan. We aimed to clarify the clinical usage of these generic dr…
View article: Differences in Clinical Practice and Disease Course Between Elderly-Onset and Long-Standing Elderly Ulcerative Colitis: A Single-Center Study in Japan
Differences in Clinical Practice and Disease Course Between Elderly-Onset and Long-Standing Elderly Ulcerative Colitis: A Single-Center Study in Japan Open
The optimal immunosuppressive therapy for elderly patients with ulcerative colitis (UC) remains unclear. We aimed to evaluate clinical practice and prognosis in elderly patients with UC through comparing between those with elderly-onset UC…
View article: The Efficacy of Combination Therapy with Ustekinumab and Budesonide for Crohn’s Disease: A Randomized Controlled Trial
The Efficacy of Combination Therapy with Ustekinumab and Budesonide for Crohn’s Disease: A Randomized Controlled Trial Open
Introduction: Limited data exist on the efficacy of combination therapy with ustekinumab and budesonide in patients with Crohn’s disease. Our objective was to compare the clinical outcomes of ustekinumab and budesonide combin…
View article: Effectiveness of Antibiotics for Uncomplicated Diverticulitis: A Retrospective Investigation Using a Nationwide Database in Japan
Effectiveness of Antibiotics for Uncomplicated Diverticulitis: A Retrospective Investigation Using a Nationwide Database in Japan Open
Introduction: The efficacy of antibiotics for diverticulitis without abscess or peritonitis (uncomplicated diverticulitis) is controversial. We aimed to investigate the effectiveness of antibiotics for uncomplicated diverticu…
View article: Long‐term prognosis and clinical practice for new‐onset ulcerative colitis in the era of biologics: A Japanese retrospective study
Long‐term prognosis and clinical practice for new‐onset ulcerative colitis in the era of biologics: A Japanese retrospective study Open
Background and Aim There is a scarcity of data on long‐term outcomes in patients with new‐onset ulcerative colitis (UC) in the era of biologics. We aimed to clarify the long‐term prognosis of UC and the clinical practice of prescriptions f…
View article: Comparative Effectiveness of Tacrolimus and Infliximab in Hospitalized Patients With Ulcerative Colitis
Comparative Effectiveness of Tacrolimus and Infliximab in Hospitalized Patients With Ulcerative Colitis Open
INTRODUCTION: Cyclosporine or infliximab (IFX) have been used to avoid surgery in patients with severe refractory ulcerative colitis (UC). Tacrolimus (Tac) is occasionally used as an alternative to cyclosporine; however, the comparative ef…
View article: Usefulness and difficulties with the thiopurine pharmacogenomic NUDT15 genotyping test: Analysis of real-world data in Japan
Usefulness and difficulties with the thiopurine pharmacogenomic NUDT15 genotyping test: Analysis of real-world data in Japan Open
The usefulness of NUDT15 genotyping as a pharmacogenomic test for thiopurine has been established. The first such test developed to date, NUDT15 genotyping was approved for reimbursement in Japan in February 2019 for all indicated patients…
View article: Rupture of ectopic varices of the ascending colon occurring after pancreatic cancer surgery: A case report and literature review
Rupture of ectopic varices of the ascending colon occurring after pancreatic cancer surgery: A case report and literature review Open
A 69‐year‐old woman, a long‐term survivor of subtotal stomach‐preserving pancreatoduodenectomy with the splenic vein resection for pancreatic cancer, visited our hospital with a chief complaint of bloody stools. Previously, she was diagnos…
View article: A Phase II Clinical Trial to Study the Safety of Triamcinolone after Endoscopic Radial Incision and Cutting Dilatation for Benign Stenosis of the Lower Gastrointestinal Tract: A Study Protocol
A Phase II Clinical Trial to Study the Safety of Triamcinolone after Endoscopic Radial Incision and Cutting Dilatation for Benign Stenosis of the Lower Gastrointestinal Tract: A Study Protocol Open
This explorative study will provide useful information regarding the safety of TA administration after RIC, which may contribute to further investigations.
View article: Genetics of inflammatory bowel disease in East Asia: From population to individual
Genetics of inflammatory bowel disease in East Asia: From population to individual Open
Genetic analysis of inflammatory bowel disease has identified many disease susceptibility genes in a large number of cases, mainly in Europe and North America. However, because of the ethnic differences in genetic background, analysis in v…