Yoichiro Kamimura
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View article: Field model for multistate lateral diffusion of various transmembrane proteins observed in living<i>Dictyostelium</i>cells
Field model for multistate lateral diffusion of various transmembrane proteins observed in living<i>Dictyostelium</i>cells Open
The lateral diffusion of transmembrane proteins on plasma membranes is a fundamental process for various cellular functions. Diffusion properties specific for individual protein species have been extensively studied, but the common feature…
View article: A dynamic partitioning mechanism polarizes membrane protein distribution
A dynamic partitioning mechanism polarizes membrane protein distribution Open
The plasma membrane is widely regarded as the hub of the signal transduction network activities that drives numerous physiological responses, including cell polarity and migration. Yet, the symmetry breaking process in the membrane, that l…
View article: CRISPR/Cas9-based genome-wide screening of Dictyostelium
CRISPR/Cas9-based genome-wide screening of Dictyostelium Open
Genome-wide screening is powerful method used to identify genes and pathways associated with a phenotype of interest. The simple eukaryote Dictyostelium discoideum has a unique life cycle and is often used as a crucial research model for a…
View article: CRISPR Toolbox for Genome Editing in Dictyostelium
CRISPR Toolbox for Genome Editing in Dictyostelium Open
The development of new techniques to create gene knockouts and knock-ins is essential for successful investigation of gene functions and elucidation of the causes of diseases and their associated fundamental cellular processes. In the biom…
View article: Different Heterotrimeric G Protein Dynamics for Wide-Range Chemotaxis in Eukaryotic Cells
Different Heterotrimeric G Protein Dynamics for Wide-Range Chemotaxis in Eukaryotic Cells Open
Chemotaxis describes directional motility along ambient chemical gradients and has important roles in human physiology and pathology. Typical chemotactic cells, such as neutrophils and Dictyostelium cells, can detect spatial differences in…
View article: Talin B regulates collective cell migration via PI3K signaling in Dictyostelium discoideum mounds
Talin B regulates collective cell migration via PI3K signaling in Dictyostelium discoideum mounds Open
Collective cell migration is a key process during the development of multicellular organisms, in which the migrations of individual cells are coordinated through chemical guidance and physical contact between cells. Talin has been implicat…
View article: Parallel signaling pathways regulate excitable dynamics differently to mediate pseudopod formation during eukaryotic chemotaxis
Parallel signaling pathways regulate excitable dynamics differently to mediate pseudopod formation during eukaryotic chemotaxis Open
In eukaryotic chemotaxis, parallel signaling pathways regulate the spatiotemporal pseudopod dynamics at the leading edge of a motile cell through the characteristic dynamics of an excitable system; however, differences in the excitability …
View article: Dynamic Range Extension of Eukaryotic Chemotaxis through the Regulation of G Protein Localization
Dynamic Range Extension of Eukaryotic Chemotaxis through the Regulation of G Protein Localization Open
Various types of cells display chemotaxis in a wide-range of attractant concentration gradient. However, mechanisms underlying the wide-range sensing are not fully understood. We have identified a novel regulator of heterotrimeric G protei…
View article: Heterotrimeric G-protein shuttling via Gip1 extends the dynamic range of eukaryotic chemotaxis
Heterotrimeric G-protein shuttling via Gip1 extends the dynamic range of eukaryotic chemotaxis Open
Significance Eukaryotic chemotactic cells can recognize chemical gradients over a wide range of concentrations. This ability is physiologically important for numerous biological processes; however, its underlying mechanism is unknown. Here…