Yoji Tsugawa
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View article: Discovery of anti-SARS-CoV-2 S2 protein antibody CV804 with broad-spectrum reactivity with various beta coronaviruses and analysis of its pharmacological properties in vitro and in vivo
Discovery of anti-SARS-CoV-2 S2 protein antibody CV804 with broad-spectrum reactivity with various beta coronaviruses and analysis of its pharmacological properties in vitro and in vivo Open
The SARS-CoV-2 pandemic alerted the potential for significant harm due to future cross-species transmission of various animal coronaviruses to human. There is a significant need of antibody-based drugs to treat patients infected with previ…
View article: Discovery of anti-SARS-CoV-2 S2 protein antibody CV804 with broad-spectrum reactivity with various beta coronaviruses and analysis of its pharmacological properties in vitro and in vivo
Discovery of anti-SARS-CoV-2 S2 protein antibody CV804 with broad-spectrum reactivity with various beta coronaviruses and analysis of its pharmacological properties in vitro and in vivo Open
SARS-CoV-2 pandemic alerts us that spillovers of various animal coronaviruses to human in the future may bring us enormous damages. Thus, there is a significant need of antibody-based drugs to treat patients infected with previously unseen…
View article: UDP-glucose, cereblon-dependent proinsulin degrader
UDP-glucose, cereblon-dependent proinsulin degrader Open
Insulin secretion is regulated in multiple steps, and one of the main steps is in the endoplasmic reticulum (ER). Here, we show that UDP-glucose induces proinsulin ubiquitination by cereblon, and uridine binds and competes for proinsulin d…
View article: UDP-Glucose: A Cereblon-Dependent Glucokinase Protein Degrader
UDP-Glucose: A Cereblon-Dependent Glucokinase Protein Degrader Open
We previously reported that glucokinase is ubiquitinated and degraded by cereblon with an unknown endogenous glucokinase protein degrader. Here, we show that UDP-glucose is a glucokinase protein degrader. We identified that both glucose an…
View article: Impaired arginine-induced insulin secretion in MODY2 patient with UGGT1R1526C variant
Impaired arginine-induced insulin secretion in MODY2 patient with UGGT1R1526C variant Open
Arginine releases proinsulin from binding to UGGT1 in the endoplasmic reticulum (ER). PSIPRED analysis showed that the arginine/proinsulin binding domain (A/PBD) in the C-terminal region of UGGT1 forms a disordered region, which is flexibl…
View article: Uridine, a Sustainable Insulin Secretagogue, Inhibits UDP-Glucose and Cereblon Dependent Proinsulin Degradation
Uridine, a Sustainable Insulin Secretagogue, Inhibits UDP-Glucose and Cereblon Dependent Proinsulin Degradation Open
Insulin secretion is regulated in multiple steps, and one of the main steps is in the endoplasmic reticulum (ER). Here, we show that UDP-glucose induces proinsulin ubiquitination by cereblon (CRBN), and uridine binds and competes for proin…
View article: Chorionic gonadotropin stimulates maternal hepatocyte proliferation during pregnancy
Chorionic gonadotropin stimulates maternal hepatocyte proliferation during pregnancy Open
View article: Transient microglial absence assists postmigratory cortical neurons in proper differentiation
Transient microglial absence assists postmigratory cortical neurons in proper differentiation Open
In the developing cortex, postmigratory neurons accumulate in the cortical plate (CP) to properly differentiate consolidating subtype identities. Microglia, despite their extensive surveying activity, temporarily disappear from the midembr…
View article: <p>Estradiol accelerates liver regeneration through estrogen receptor α</p>
Estradiol accelerates liver regeneration through estrogen receptor α Open
Background: We previously demonstrated that liver resection triggers estradiol production, which, in turn, induces the proliferation of hepatocytes to promote liver regeneration in mice. In this study, we demonstrated estradiol-indu…