Yoko Funasaka
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View article: Potassium 4‐Methoxysalicylate (<scp>4MSK</scp>) Exerts a Skin Lightening Effect by Acting on Melanocytes and Keratinocytes
Potassium 4‐Methoxysalicylate (<span>4MSK</span>) Exerts a Skin Lightening Effect by Acting on Melanocytes and Keratinocytes Open
Background Hyperpigmentation is a common acquired disorder that can be a cosmetic concern for many individuals. To reduce and prevent hyperpigmentation, numerous skin lightening agents have been developed. Potassium 4‐methoxysalicylate (4M…
View article: Excimer Laser Penetrates Deeper into Hair Follicles and Activates More Melanocyte Lineage Cells than Excimer Light
Excimer Laser Penetrates Deeper into Hair Follicles and Activates More Melanocyte Lineage Cells than Excimer Light Open
As compared with excimer light, the excimer laser penetrated more deeply into hair follicles, resulted in fewer epidermal side effects, and activated significantly more melanocyte-lineage cells.
View article: Dietary habits in adult Japanese patients with vitiligo
Dietary habits in adult Japanese patients with vitiligo Open
Vitiligo is an autoimmune skin disease with acquired depigmentation. Dietary habits may modulate the pathogenesis of vitiligo. We evaluated dietary habits in adult Japanese patients with nonsegmental vitiligo, and compared their results wi…
View article: Epidermal turnover and iron metabolism in senile lentigo
Epidermal turnover and iron metabolism in senile lentigo Open
Senile lentigo (SL) is a pigmentary disorder associated with disrupted epidermal turnover. Trace minerals in the skin are known to regulate keratinocyte proliferation and differentiation. To clarify the role of iron in SL, we compared the …
View article: Dietary Fiber Inulin Improves Murine Imiquimod-Induced Psoriasis-like Dermatitis
Dietary Fiber Inulin Improves Murine Imiquimod-Induced Psoriasis-like Dermatitis Open
Psoriasis is a chronic skin disease with interleukin (IL)-17-dominated inflammation and hyperproliferation of epidermis. Dietary fiber is fermented by the gut microbiome into short-chain fatty acids (SCFAs) that manifest anti-inflammatory …
View article: Supplementary Material for: Clinical Guidelines for Diagnosis and Management of Peutz-Jeghers Syndrome in Children and Adults
Supplementary Material for: Clinical Guidelines for Diagnosis and Management of Peutz-Jeghers Syndrome in Children and Adults Open
Background: Peutz-Jeghers syndrome (PJS) is a rare disease characterized by the presence of hamartomatous polyposis throughout the gastrointestinal tract, except for the esophagus, along with characteristic mucocutaneous pigmentation. It i…
View article: Clinical Guidelines for Diagnosis and Management of Peutz-Jeghers Syndrome in Children and Adults
Clinical Guidelines for Diagnosis and Management of Peutz-Jeghers Syndrome in Children and Adults Open
Background: Peutz-Jeghers syndrome (PJS) is a rare disease characterized by the presence of hamartomatous polyposis throughout the gastrointestinal tract, except for the esophagus, along with characteristic mucocutaneous pigmentation. It i…
View article: Enhancement of Ultraviolet B-Induced Apoptosis and Elimination of DNA Damage by Pre-Irradiation with Infrared Radiation A Does Not Depend on DNA Damage Repair
Enhancement of Ultraviolet B-Induced Apoptosis and Elimination of DNA Damage by Pre-Irradiation with Infrared Radiation A Does Not Depend on DNA Damage Repair Open
These results indicate that enhancement of UVB-induced apoptosis and acceleration of removal of CPDs by pre-irradiation with IRA does not depend on DNA damage repair.
View article: Intralymphatic histiocytosis in a patient with lung adenocarcinoma treated with pembrolizumab: a case report
Intralymphatic histiocytosis in a patient with lung adenocarcinoma treated with pembrolizumab: a case report Open
This is the first report of ILH induced by pembrolizumab in a patient with lung adenocarcinoma.
View article: The Effect of a Frequency-Doubled Q-Switched Nd:YAG Laser on Hairless Mice Harboring Eumelanin and Pheomelanin in the Epidermis
The Effect of a Frequency-Doubled Q-Switched Nd:YAG Laser on Hairless Mice Harboring Eumelanin and Pheomelanin in the Epidermis Open
The effect of the Nd:YAG laser on the cells containing different melanin subspecies was shown to be different in an in vivo irradiation system.
View article: Two Cases of Verrucous Carcinoma: Revisiting the Definition
Two Cases of Verrucous Carcinoma: Revisiting the Definition Open
Verrucous carcinoma (VC) is an uncommon, distinct type of well-differentiated squamous cell carcinoma. Here we present two cases of VC, one arising from the lower leg and the other from genital skin. Case 1, a female patient, aged 95 years…
View article: A Case of a Giant Cell Tumor of the Tendon Sheath of the Middle Phalanx of the Fourth Toe
A Case of a Giant Cell Tumor of the Tendon Sheath of the Middle Phalanx of the Fourth Toe Open
Giant cell tumors of the tendon sheath (GCT-TS) are one of the most common tumors of the hand, along with ganglions. However, occurrence in the toes is far less common. Here we present a rare case of GCT-TS at the middle phalanx level of t…
View article: A Case of Vitiligo Vulgaris Associated with Sjögren Syndrome Successfully Treated with Excimer Light Irradiation and Topical Vitamin D<sub>3</sub>
A Case of Vitiligo Vulgaris Associated with Sjögren Syndrome Successfully Treated with Excimer Light Irradiation and Topical Vitamin D<sub>3</sub> Open
A 72-year-old Japanese woman presented in July 2012 with a 5-year history of depigmented areas on the face. On physical examination, she had multiple well-demarcated depigmented areas on the face and neck. She had also experienced increase…
View article: A Case of External Dental Fistula Related to a Fixed Cantilever Bridge
A Case of External Dental Fistula Related to a Fixed Cantilever Bridge Open
An external dental fistula is a skin manifestation caused by an underlying dental problem. We report a rare case of external dental fistula associated with a fixed cantilever denture. A 77-year-old Japanese woman presented with an enlargin…
View article: Squamous Cell Carcinomas on Bilateral Feet Arising in Long-Standing Eczematous Lesions
Squamous Cell Carcinomas on Bilateral Feet Arising in Long-Standing Eczematous Lesions Open
We present a woman with squamous cell carcinomas on both feet in long-standing eczematous lesions. Histopathological examination of biopsies from the both feet revealed highly atypical cells invading the reticular layer of the dermis in th…
View article: Extranodal Natural Killer/T-Cell Lymphoma, Nasal Type, with Primary Manifestation as an Upper Eyelid Swelling
Extranodal Natural Killer/T-Cell Lymphoma, Nasal Type, with Primary Manifestation as an Upper Eyelid Swelling Open
Extranodal natural killer/T-cell lymphoma (ENK/TCL) is most often in the nose or the nasopharynx but can present elsewhere. We report a rare case of ENK/TCL that presented as swelling of an upper eyelid without ocular involvement. A 76-yea…
View article: A case of Spitz nevus on the right fifth toe, which was difficult to distinguish from malignant melanoma
A case of Spitz nevus on the right fifth toe, which was difficult to distinguish from malignant melanoma Open
29歳，女性。3年前より右第5足趾辺縁に褐色斑が出現した。辺縁不整で左右非対称な5×8mm大の黒褐色斑で，中央やや遠位側は軽度隆起し灰白色調であった。ダーモスコピー所見は二相性で，starburst patternを呈する病変の遠位半分に消退傾向を示す領域がみられた。病理組織学的所見では，表皮基底層を中心に紡錘形の大型細胞が胞巣を形成し，表皮内胞巣は境界明瞭で周囲には裂隙があった。表皮内胞巣にはKamino小体がみられ，真皮下層では腫瘍細胞はmaturationを示していた…