Yoko Hirano
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View article: Investigation of Differences Between Manufacturers and Public Analyses in Health Technology Assessment in Japan
Investigation of Differences Between Manufacturers and Public Analyses in Health Technology Assessment in Japan Open
Background Japan has a unique drug pricing system that in principle reimburses all regulatory-approved drugs. To ensure sustainability, a health technology assessment (HTA) system was introduced in 2019 to adjust the prices of highly innov…
View article: Cost-Effectiveness Analysis of a Bivalent RSVPreF Vaccine in Japanese Adults Aged 60 Years and Older
Cost-Effectiveness Analysis of a Bivalent RSVPreF Vaccine in Japanese Adults Aged 60 Years and Older Open
The RSVpreF vaccine is cost-effective compared to no vaccination for adults aged 60 years and older in Japan. It has the potential to provide significant public health benefits by reducing the burden of RSV-related diseases.
View article: Biallelic <i>LGI1</i> and <i>ADAM23</i> variants cause hippocampal epileptic encephalopathy via the LGI1–ADAM22/23 pathway
Biallelic <i>LGI1</i> and <i>ADAM23</i> variants cause hippocampal epileptic encephalopathy via the LGI1–ADAM22/23 pathway Open
Monoallelic pathogenic variants in LGI1 cause autosomal dominant epilepsy with auditory features with onset in childhood/adolescence. LGI1 is a secreted neuronal protein, functions as a ligand for ADAM22/23, and regulates excitatory synapt…
View article: A Chemical Investigation Approach of <i>Paraconiothyrium</i> sp. FKR‐0637 Fungal Strain Enables the Isolation of New Chlorinated Chromone, Nohocumone
A Chemical Investigation Approach of <i>Paraconiothyrium</i> sp. FKR‐0637 Fungal Strain Enables the Isolation of New Chlorinated Chromone, Nohocumone Open
The discovery of novel natural products (NPs) from diverse microorganisms is essential for advancing drug discovery. In this study, a chemical investigation approach was employed for NP exploration using the genus Paraconiothyrium sp. isol…
View article: A Chemical Investigation Approach of the Paraconiothyrium sp. FKR-0637 Fungal Strain Enables the Isolation of the New Chlorinated Chromone, Nohocumone
A Chemical Investigation Approach of the Paraconiothyrium sp. FKR-0637 Fungal Strain Enables the Isolation of the New Chlorinated Chromone, Nohocumone Open
The discovery of novel natural products (NPs) from diverse microorganisms is essential for advancing drug discovery. In this study, a chemical approach was employed for NP exploration using the genus Paraconiothyrium sp. isolated from the …
View article: A Chemical Investigation Approach of the Paraconiothyrium sp. FKR-0637 Fungal Strain Enables the Isolation of the New Chlorinated Chromone, (+)-Nohocumone
A Chemical Investigation Approach of the Paraconiothyrium sp. FKR-0637 Fungal Strain Enables the Isolation of the New Chlorinated Chromone, (+)-Nohocumone Open
The discovery of novel natural products (NPs) from diverse microorganisms is essential for advancing drug discovery. In this study, a chemical approach was employed for NP exploration using the genus Paraconiothyrium sp. isolated from the …
View article: Post-renal Biopsy Retroperitoneal Haematoma Accompanied by Decreased Coagulation Factor XIII Levels in Immunoglobulin A Nephropathy
Post-renal Biopsy Retroperitoneal Haematoma Accompanied by Decreased Coagulation Factor XIII Levels in Immunoglobulin A Nephropathy Open
View article: Biallelic <i>ADAM22</i> pathogenic variants cause progressive encephalopathy and infantile-onset refractory epilepsy
Biallelic <i>ADAM22</i> pathogenic variants cause progressive encephalopathy and infantile-onset refractory epilepsy Open
Pathogenic variants in A Disintegrin And Metalloproteinase (ADAM) 22, the postsynaptic cell membrane receptor for the glycoprotein leucine-rich repeat glioma-inactivated protein 1 (LGI1), have been recently associated with recessive develo…
View article: Trans-synaptic LGI1–ADAM22–MAGUK in AMPA and NMDA receptor regulation
Trans-synaptic LGI1–ADAM22–MAGUK in AMPA and NMDA receptor regulation Open
Exquisitely-regulated synaptic transmission and plasticity underlie higher brain functions such as learning and memory. PSD-95, a member of the MAGUK family, scaffolds an array of postsynaptic proteins including AMPA and NMDA receptors, an…
View article: LGI1–ADAM22–MAGUK configures transsynaptic nanoalignment for synaptic transmission and epilepsy prevention
LGI1–ADAM22–MAGUK configures transsynaptic nanoalignment for synaptic transmission and epilepsy prevention Open
Significance This study addresses a fundamental question in neuroscience, namely how does the presynaptic component of the synapse precisely align with the postsynaptic component? This is essential for the proper transmission of signals ac…
View article: Table of Contents
Table of Contents Open
View article: Characteristics of Patients with Hereditary Transthyretin Amyloidosis and an Evaluation of the Safety of Tafamidis Meglumine in Japan: An Interim Analysis of an All-case Postmarketing Surveillance
Characteristics of Patients with Hereditary Transthyretin Amyloidosis and an Evaluation of the Safety of Tafamidis Meglumine in Japan: An Interim Analysis of an All-case Postmarketing Surveillance Open
This interim analysis successfully provided comprehensive, nationwide epidemiologic data from 219 Japanese patients with ATTRv amyloidosis. The safety profile of tafamidis was largely consistent with that obtained from previous research. N…
View article: PF-06439535 (a bevacizumab biosimilar) for non-small cell lung cancer: subgroup analysis
PF-06439535 (a bevacizumab biosimilar) for non-small cell lung cancer: subgroup analysis Open
View article: Venlafaxine ER Blocks the Norepinephrine Transporter in the Brain of Patients with Major Depressive Disorder: a PET Study Using [18F]FMeNER-D2
Venlafaxine ER Blocks the Norepinephrine Transporter in the Brain of Patients with Major Depressive Disorder: a PET Study Using [18F]FMeNER-D2 Open
This study demonstrates that clinically relevant doses of venlafaxine extended-release block the norepinephrine transporter of the major depressive disorder patient's brain. The data support the notion that the antidepressant effect of ven…
View article: Association of Psychotropic Polypharmacy with Safety Events: A Sequence Symmetry Analysis
Association of Psychotropic Polypharmacy with Safety Events: A Sequence Symmetry Analysis Open
View article: Factors impacting the efficacy of venlafaxine extended release 75&ndash;225 mg/day in patients with major depressive disorder: exploratory post hoc subgroup analyses of a randomized, double-blind, placebo-controlled study in Japan
Factors impacting the efficacy of venlafaxine extended release 75–225 mg/day in patients with major depressive disorder: exploratory post hoc subgroup analyses of a randomized, double-blind, placebo-controlled study in Japan Open
These results suggest that a greater treatment response to venlafaxine ER (up to 225 mg/day) can be seen in patients with a longer duration of MDD. Further investigations are needed to identify additional factors impacting the efficacy of …
View article: Preventive Effect for Dispensing Errors and Incidents by Drug Verification and Quantity Management System Using Personal Digital Assistants and Medicine Barcodes
Preventive Effect for Dispensing Errors and Incidents by Drug Verification and Quantity Management System Using Personal Digital Assistants and Medicine Barcodes Open
In February 2015, we introduced a drug verification and quantity management system using personal digital assistants and medicine barcodes to prevent dispensing errors. We evaluated the effect of this system by comparing the number of disp…
View article: Possibility of Database Research as a Means of Pharmacovigilance in Japan Based on a Comparison with Sertraline Postmarketing Surveillance
Possibility of Database Research as a Means of Pharmacovigilance in Japan Based on a Comparison with Sertraline Postmarketing Surveillance Open
Our results support the concept of using database research as a cost-effective pharmacovigilance tool that is free of selection bias . Further investigation using database research is required to confirm our preliminary observations.
View article: A unique database for gathering data from a mobile app and medical prescription software: a useful data source to collect and analyse patient-reported outcomes of depression and anxiety symptoms
A unique database for gathering data from a mobile app and medical prescription software: a useful data source to collect and analyse patient-reported outcomes of depression and anxiety symptoms Open
A unique database named 'AN-SAPO' was developed by Iwato Corp. and Japan Brain Corp. in collaboration with the psychiatric clinics run by Himorogi Group in Japan. The AN-SAPO database includes patients' depression/anxiety score data from a…
View article: A Perspective Of Pharmacovigilance Using Health Care Claims Data Based On Comparison With Sertraline Postmarketing Surveillance In Japan
A Perspective Of Pharmacovigilance Using Health Care Claims Data Based On Comparison With Sertraline Postmarketing Surveillance In Japan Open