Yoko Tajima
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View article: A humanized NOVA1 splicing factor alters mouse vocal communications
A humanized NOVA1 splicing factor alters mouse vocal communications Open
NOVA1, a neuronal RNA-binding protein expressed in the central nervous system, is essential for survival in mice and normal development in humans. A single amino acid change (I197V) in NOVA1’s second RNA binding domain is unique to modern …
View article: NOVA1 acts on Impact to regulate hypothalamic function and translation in inhibitory neurons
NOVA1 acts on Impact to regulate hypothalamic function and translation in inhibitory neurons Open
We describe a patient haploinsufficient for the neuronal RNA binding protein NOVA1 who developed a behavioral motor hyperactivity disorder, suggesting a role of NOVA1 in postnatal motor inhibition. To investigate Nova1's action in adult Ga…
View article: Reverse genetics-based biochemical studies of the ribosomal exit tunnel constriction region in eukaryotic ribosome stalling: spatial allocation of the regulatory nascent peptide at the constriction
Reverse genetics-based biochemical studies of the ribosomal exit tunnel constriction region in eukaryotic ribosome stalling: spatial allocation of the regulatory nascent peptide at the constriction Open
A number of regulatory nascent peptides have been shown to regulate gene expression by causing programmed ribosome stalling during translation. Nascent peptide emerges from the ribosome through the exit tunnel, and one-third of the way alo…
View article: Whole-genome deep learning analysis reveals causal role of noncoding mutations in autism
Whole-genome deep learning analysis reveals causal role of noncoding mutations in autism Open
We address the challenge of detecting the contribution of noncoding mutations to disease with a deep-learning-based framework that predicts specific regulatory effects and deleterious disease impact of genetic variants. Applying this frame…
View article: Neuron-specific cTag-CLIP reveals cell-specific diversity of functional RNA regulation in the brain
Neuron-specific cTag-CLIP reveals cell-specific diversity of functional RNA regulation in the brain Open
SUMMARY RNA-binding proteins (RBPs) regulate genetic diversity, but the degree to which they do so in individual cell-types in vivo is unknown. We employed NOVA2 cTag-CLIP to generate functional RBP-RNA maps from single neuronal population…
View article: Cross-Classification of Human Urinary Lipidome by Sex, Age, and Body Mass Index
Cross-Classification of Human Urinary Lipidome by Sex, Age, and Body Mass Index Open
Technological advancements in past decades have led to the development of integrative analytical approaches to lipidomics, such as liquid chromatography-mass spectrometry (LC/MS), and information about biogenic lipids is rapidly accumulati…