Yôko Tanaka
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View article: Senescence-associated lysosomal dysfunction impairs cystine deprivation-induced lipid peroxidation and ferroptosis
Senescence-associated lysosomal dysfunction impairs cystine deprivation-induced lipid peroxidation and ferroptosis Open
View article: Supplementary Data from Cancer-Specific Targeting of Taurine-Upregulated Gene 1 Enhances the Effects of Chemotherapy in Pancreatic Cancer
Supplementary Data from Cancer-Specific Targeting of Taurine-Upregulated Gene 1 Enhances the Effects of Chemotherapy in Pancreatic Cancer Open
Figure S1-S8 & Table S1-S6
View article: Real-World Treatment Patterns and Clinical Outcomes Among Patients with Metastatic or Unresectable EGFR-Mutated Non-Small Cell Lung Cancer Previously Treated with Osimertinib and Platinum-Based Chemotherapy
Real-World Treatment Patterns and Clinical Outcomes Among Patients with Metastatic or Unresectable EGFR-Mutated Non-Small Cell Lung Cancer Previously Treated with Osimertinib and Platinum-Based Chemotherapy Open
View article: <scp>D</scp>ipeptidylpeptidase‐4‐targeted activatable fluorescent probes visualize senescent cells
<span>D</span>ipeptidylpeptidase‐4‐targeted activatable fluorescent probes visualize senescent cells Open
Senescent cells promote cancer development and progression through chronic inflammation caused by a senescence‐associated secretory phenotype (SASP). Although various senotherapeutic strategies targeting senescent cells have been developed…
View article: The Rubicon-WIPI axis regulates exosome biogenesis during aging
The Rubicon-WIPI axis regulates exosome biogenesis during aging Open
Cells release intraluminal vesicles (ILVs) in multivesicular bodies as exosomes to communicate with other cells. Although recent studies suggest an intimate link between exosome biogenesis and autophagy, the detailed mechanism is not fully…
View article: A multi-hierarchical approach reveals d-serine as a hidden substrate of sodium-coupled monocarboxylate transporters
A multi-hierarchical approach reveals d-serine as a hidden substrate of sodium-coupled monocarboxylate transporters Open
Transporter research primarily relies on the canonical substrates of well-established transporters. This approach has limitations when studying transporters for the low-abundant micromolecules, such as micronutrients, and may not reveal ph…
View article: Author response: A multi-hierarchical approach reveals d-serine as a hidden substrate of sodium-coupled monocarboxylate transporters
Author response: A multi-hierarchical approach reveals d-serine as a hidden substrate of sodium-coupled monocarboxylate transporters Open
View article: Reviewer #2 (Public Review): A multi-hierarchical approach reveals D-serine as a hidden substrate of sodium-coupled monocarboxylate transporters
Reviewer #2 (Public Review): A multi-hierarchical approach reveals D-serine as a hidden substrate of sodium-coupled monocarboxylate transporters Open
Transporter research primarily relies on the canonical substrates of well-established transporters. This approach has limitations when studying transporters for the low-abundant micromolecules, such as micronutrients, and may not reveal ph…
View article: Author Response: A multi-hierarchical approach reveals D-serine as a hidden substrate of sodium-coupled monocarboxylate transporters
Author Response: A multi-hierarchical approach reveals D-serine as a hidden substrate of sodium-coupled monocarboxylate transporters Open
Transporter research primarily relies on the canonical substrates of well-established transporters. This approach has limitations when studying transporters for the low-abundant micromolecules, such as micronutrients, and may not reveal ph…
View article: High Glucose Promotes Invasion of <i>Fusobacterium nucleatum</i> and Inflammatory Responses in Human Bronchial Fibroblasts
High Glucose Promotes Invasion of <i>Fusobacterium nucleatum</i> and Inflammatory Responses in Human Bronchial Fibroblasts Open
Hyperglycemia is a major factor of diabetes. Respiratory symptoms are frequently observed in people with diabetes. It is well known that periodontitis is associated with developmental of diabetes. Fusobacterium nucleatum(F. nucleatum)is on…
View article: A multi-hierarchical approach reveals D-serine as a hidden substrate of sodium-coupled monocarboxylate transporters
A multi-hierarchical approach reveals D-serine as a hidden substrate of sodium-coupled monocarboxylate transporters Open
Transporter research primarily relies on the canonical substrates of well-established transporters. This approach has limitations when studying transporters for the low-abundant micromolecules, such as micronutrients, and may not reveal ph…
View article: Reviewer #3 (Public Review): A multi-hierarchical approach reveals D-serine as a hidden substrate of sodium-coupled monocarboxylate transporters
Reviewer #3 (Public Review): A multi-hierarchical approach reveals D-serine as a hidden substrate of sodium-coupled monocarboxylate transporters Open
Transporter research primarily relies on the canonical substrates of well-established transporters. This approach has limitations when studying transporters for the low-abundant micromolecules, such as micronutrients, and may not reveal ph…
View article: Reviewer #1 (Public Review): A multi-hierarchical approach reveals D-serine as a hidden substrate of sodium-coupled monocarboxylate transporters
Reviewer #1 (Public Review): A multi-hierarchical approach reveals D-serine as a hidden substrate of sodium-coupled monocarboxylate transporters Open
Transporter research primarily relies on the canonical substrates of well-established transporters. This approach has limitations when studying transporters for the low-abundant micromolecules, such as micronutrients, and may not reveal ph…
View article: Augmenting external control arms using Bayesian borrowing: a case study in first-line non-small cell lung cancer
Augmenting external control arms using Bayesian borrowing: a case study in first-line non-small cell lung cancer Open
Aim: This study aimed to improve comparative effectiveness estimates and discuss challenges encountered through the application of Bayesian borrowing (BB) methods to augment an external control arm (ECA) constructed from real-world data (R…
View article: YBX1 Regulates Satellite II RNA Loading into Small Extracellular Vesicles and Promotes the Senescent Phenotype
YBX1 Regulates Satellite II RNA Loading into Small Extracellular Vesicles and Promotes the Senescent Phenotype Open
Senescent cells secrete inflammatory proteins and small extracellular vesicles (sEVs), collectively termed senescence-associated secretory phenotype (SASP), and promote age-related diseases. Epigenetic alteration in senescent cells induces…
View article: Reviewer #2 (Public Review): A multi-hierarchical approach reveals D-serine as a hidden substrate of sodium-coupled monocarboxylate transporters
Reviewer #2 (Public Review): A multi-hierarchical approach reveals D-serine as a hidden substrate of sodium-coupled monocarboxylate transporters Open
Transporter research primarily relies on the canonical substrates of well-established transporters. This approach has limitations when studying transporters for the low-abundant micromolecules, such as micronutrients, and may not reveal ph…
View article: Reviewer #3 (Public Review): A multi-hierarchical approach reveals D-serine as a hidden substrate of sodium-coupled monocarboxylate transporters
Reviewer #3 (Public Review): A multi-hierarchical approach reveals D-serine as a hidden substrate of sodium-coupled monocarboxylate transporters Open
Transporter research primarily relies on the canonical substrates of well-established transporters. This approach has limitations when studying transporters for the low-abundant micromolecules, such as micronutrients, and may not reveal ph…
View article: A multi-hierarchical approach reveals d-serine as a hidden substrate of sodium-coupled monocarboxylate transporters
A multi-hierarchical approach reveals d-serine as a hidden substrate of sodium-coupled monocarboxylate transporters Open
Transporter research primarily relies on the canonical substrates of well-established transporters. This approach has limitations when studying transporters for the low-abundant micromolecules, such as micronutrients, and may not reveal ph…
View article: A multi-hierarchical approach reveals D-serine as a hidden substrate of sodium-coupled monocarboxylate transporters
A multi-hierarchical approach reveals D-serine as a hidden substrate of sodium-coupled monocarboxylate transporters Open
Transporter research primarily relies on the canonical substrates of well-established transporters. This approach has limitations when studying transporters for the low-abundant micromolecules, such as micronutrients, and may not reveal ph…
View article: New Template Synthesis of Anomalously Large Capacity Hard Carbon for Na‐ and K‐Ion Batteries
New Template Synthesis of Anomalously Large Capacity Hard Carbon for Na‐ and K‐Ion Batteries Open
Hard carbon (HC) is a promising negative‐electrode material for Na‐ion batteries. HC electrochemically stores Na + ions, resulting in a non‐stoichiometric chemical composition depending on their nanoscale structure, including the carbon fr…
View article: Imbalance of IL-1 Family mRNA Expression and IL-37 as a Potential Therapeutic Target for Periodontal Inflammation in Down Syndrome
Imbalance of IL-1 Family mRNA Expression and IL-37 as a Potential Therapeutic Target for Periodontal Inflammation in Down Syndrome Open
Individuals with Down syndrome（DS）are prone to periodontitis. No studies have focused on mRNA expression of a pro-inflammatory cytokine, IL-1β and an anti-inflam matory cytokine, IL-37 in gingival fibroblasts（GFs）derived from individuals w…
View article: Data from Cancer-Specific Targeting of Taurine-Upregulated Gene 1 Enhances the Effects of Chemotherapy in Pancreatic Cancer
Data from Cancer-Specific Targeting of Taurine-Upregulated Gene 1 Enhances the Effects of Chemotherapy in Pancreatic Cancer Open
Overcoming drug resistance is one of the biggest challenges in cancer chemotherapy. In this study, we examine whether targeting the long noncoding RNA taurine upregulated gene 1 (TUG1) could be an effective therapeutic approach to o…
View article: D-Asparagine is an Ideal Endogenous Molecule for Measuring the Glomerular Filtration Rate
D-Asparagine is an Ideal Endogenous Molecule for Measuring the Glomerular Filtration Rate Open
D-Asparagine acts similar to inulin in the kidney. Therefore, d-asparagine is an ideal endogenous molecule that can be used for GFR measurement.
View article: Blood levels of d-amino acids reflect the clinical course of COVID-19
Blood levels of d-amino acids reflect the clinical course of COVID-19 Open
View article: Identification of Novel Senescent Markers in Small Extracellular Vesicles
Identification of Novel Senescent Markers in Small Extracellular Vesicles Open
Senescent cells exhibit several typical features, including the senescence-associated secretory phenotype (SASP), promoting the secretion of various inflammatory proteins and small extracellular vesicles (EVs). SASP factors cause chronic i…
View article: A Young Male Patient with Nuclear Protein in Testis Carcinoma of the Thorax
A Young Male Patient with Nuclear Protein in Testis Carcinoma of the Thorax Open
背景．Nuclear protein in testis（NUT）carcinomaはNUT midline carcinoma family member 1（NUTM1）遺伝子の転座により形成される融合遺伝子を認め，近年報告が散見される．症例．26歳男性．血痰，胸部痛の精査で，最大径約6 cmの前縦隔腫瘍を認めた．CTガイド下針生検で胸腺扁平上皮癌の診断に至りCBDCA＋PTXを4コース施行した．原発巣は縮小したが，縦隔リンパ節が増大し，姑息的放射線治療を行ったが，胸膜…
View article: Fatigue Life Prediction of Electronic Components Using Random Response Analysis and Dirlik Method
Fatigue Life Prediction of Electronic Components Using Random Response Analysis and Dirlik Method Open
Print circuit board (PCB) mounted on transportation equipment receive various random loads from the outside as vibrations during running. We sometimes experience that fatigue failure of electrical component leads under random loading and s…
View article: The Effect of <i>Porphyromonas gingivalis</i> Augmented Invasion by TNF-α on Gingival Fibroblasts Derived from Down Syndrome
The Effect of <i>Porphyromonas gingivalis</i> Augmented Invasion by TNF-α on Gingival Fibroblasts Derived from Down Syndrome Open
It is well known the high prevalence of periodontal disease in Down syndrome (DS) .Tumor necrosis factor alpha (TNF-α) augments invasion of Porphyromonas gingivalis (P.gingivalis) in human gingival epithelial cells.We examined the effect o…
View article: Both microRNA-455-5p and -3p repress hypoxia-inducible factor-2α expression and coordinately regulate cartilage homeostasis
Both microRNA-455-5p and -3p repress hypoxia-inducible factor-2α expression and coordinately regulate cartilage homeostasis Open
View article: Developing the wide-spectral coverage, very high-efficiency grisms for MOIRCS on Subaru Telescope (Erratum)
Developing the wide-spectral coverage, very high-efficiency grisms for MOIRCS on Subaru Telescope (Erratum) Open
Publisher's Note: This paper, originally published on 13 December 2020, was replaced with a corrected/revised version on 18 May 2021. If you downloaded the original PDF but are unable to access the revision, please contact SPIE Digital Lib…