Yolla German
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View article: Morphological profiling of human T and NK lymphocytes by high-content cell imaging
Morphological profiling of human T and NK lymphocytes by high-content cell imaging Open
The immunological synapse is a complex structure that decodes stimulatory signals into adapted lymphocyte responses. It is a unique window to monitor lymphocyte activity because of development of systematic quantitative approaches. Here we…
View article: RhoG deficiency abrogates cytotoxicity of human lymphocytes and causes hemophagocytic lymphohistiocytosis
RhoG deficiency abrogates cytotoxicity of human lymphocytes and causes hemophagocytic lymphohistiocytosis Open
Exocytosis of cytotoxic granules (CG) by lymphocytes is required for the elimination of infected and malignant cells. Impairments in this process underly a group of diseases with dramatic hyperferritinemic inflammation termed hemophagocyti…
View article: High content cell imaging reveals actin cytoskeleton-mediated control of the immunological synapse
High content cell imaging reveals actin cytoskeleton-mediated control of the immunological synapse Open
Les lymphocytes cytotoxiques dépendent du remodelage du cytosquelette d'actine pour atteindre leur fonction. En
\nparticulier, les lymphocytes T cytotoxiques et les cellules NK assemblent la synapse immunologique (SI), structure
\ncomple…
View article: Morphological profiling of human T and NK lymphocytes identifies actin-mediated control of the immunological synapse
Morphological profiling of human T and NK lymphocytes identifies actin-mediated control of the immunological synapse Open
The detection and neutralization of infected cells and tumors by cytotoxic lymphocytes is a vital immune defense mechanism. The immunological synapse orchestrates the target recognition process and the subsequent cytotoxic activity. Here, …
View article: GermanVulliard2021
GermanVulliard2021 Open
This dataset contains the CellProfiler pipelines and the corresponding morphological measurements used in the study on morphological profiling of immunological synapses by German, Vulliard et al.
View article: GermanVulliard2020.zip
GermanVulliard2020.zip Open
This dataset contains the CellProfiler pipelines and the corresponding morphological measurements used in the study on morphological profiling of immunological synapses by German, Vulliard et al.
View article: Granulysin- and granzyme-dependent elimination of myeloid cells by therapeutic ova-specific type 1 regulatory T cells
Granulysin- and granzyme-dependent elimination of myeloid cells by therapeutic ova-specific type 1 regulatory T cells Open
The intrinsic immunosuppressive properties of regulatory T (Treg) cells can be harnessed for therapeutic approaches aiming at down-modulating harmful immune reactions. In this context, expanded type 1 Treg cells (Tr1 cells) specific for ov…