Yonas Redae
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View article: Nicotinamide riboside supplementation restores microglial health and improves cognition in aged male mice
Nicotinamide riboside supplementation restores microglial health and improves cognition in aged male mice Open
Cognitive impairment affects 1 in 6 individuals over 60, with over 75 million projected by 2030. Age-related changes in microglial function and declining nicotinamide adenine dinucleotide (NAD + ) levels may contribute to cognitive decline…
VO2MAX, 6-minute walk, and muscle strength each correlate with frailty in US veterans Open
Introduction Frailty often manifests as an increased vulnerability to adverse outcomes, and detecting frailty is useful for informed healthcare decisions. Veterans are at higher risk for developing frailty and at younger ages. The goal of …
View article: Both Vitamin D Supplementation and HIIT Boost Muscle VDR Expression, Which May Underlie Benefits for Frailty
Both Vitamin D Supplementation and HIIT Boost Muscle VDR Expression, Which May Underlie Benefits for Frailty Open
Frailty is a condition of poor response to stressors that increases susceptibility to adverse outcomes - including disability and death. Declining physical function is an important hallmark of frailty, and we previously published that long…
Cognitively Impaired Old Mice Display Correlated Reduction in Cortical NMDA Receptor and Complex IV Open
Cognitive decline in older adults represents a major challenge since cognitive impairment is found in 10% of those ≥ 65 and 50% ≥ 85. Thus it is increasingly important to understand the impact of aging on cognitive health. We performed a b…
Vitamin D Insufficiency Reduces Grip Strength, Grip Endurance and Increases Frailty in Aged C57Bl/6J Mice Open
Low 25-OH serum vitamin D (VitD) is pervasive in older adults and linked to functional decline and progression of frailty. We have previously shown that chronic VitD insufficiency in “middle-aged” mice results in impaired anaerobic exercis…
Short Session High Intensity Interval Training and Treadmill Assessment in Aged Mice Open
High intensity interval training (HIIT) is emerging as a therapeutic approach to prevent, delay, or ameliorate frailty. In particular short session HIIT, with regimens less than or equal to 10 min is of particular interest as several human…
View article: C5a induces caspase‐dependent apoptosis in brain vascular endothelial cells in experimental lupus
C5a induces caspase‐dependent apoptosis in brain vascular endothelial cells in experimental lupus Open
Summary Blood–brain barrier ( BBB ) dysfunction complicates central nervous system lupus, an important aspect of systemic lupus erythematosus. To gain insight into the underlying mechanism, vascular corrosion casts of brain were generated …