Yonathan H. Maatuf
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View article: Two-year post-distraction cartilage-related structural improvement is accompanied by increased serum full-length SIRT1
Two-year post-distraction cartilage-related structural improvement is accompanied by increased serum full-length SIRT1 Open
Background Previously, fragments from Sirtuin 1 (SIRT1) were identified in preclinical and clinical samples to display an increase in serum levels for N-terminal (NT) SIRT1 vs. C-terminal (CT) SIRT1, indicative of early signs of OA. Here w…
View article: Diverse Response to Local Pharmacological Blockade of Sirt1 Cleavage in Age-Induced versus Trauma-Induced Osteoarthritis Female Mice
Diverse Response to Local Pharmacological Blockade of Sirt1 Cleavage in Age-Induced versus Trauma-Induced Osteoarthritis Female Mice Open
Objective: Previous studies have shown that the cleavage of Sirt1 contributes to the development of osteoarthritis (OA). In fact, OA was effectively abrogated by the intra-articular (IA) administration of two compounds, one blocking Sirt1 …
View article: Lef1 ablation alleviates cartilage mineralization following posttraumatic osteoarthritis induction
Lef1 ablation alleviates cartilage mineralization following posttraumatic osteoarthritis induction Open
Significance Cartilage mineralization is imperative in various processes such as skeletal growth and fracture repair. However, this process may also be pathological, as in the case of the degenerative joint disease, osteoarthritis (OA). Us…
View article: A predicted unstructured C-terminal loop domain in SIRT1 is required for cathepsin B cleavage
A predicted unstructured C-terminal loop domain in SIRT1 is required for cathepsin B cleavage Open
The C-terminus of SIRT1 can be cleaved by cathepsin B at amino acid H533 to generate a lower-functioning, N-terminally intact 75 kDa polypeptide (75SIRT1) that might be involved in age-related pathologies. However, the mechanisms underlyin…