Yong Beom Cho
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View article: Molecular Networking-Guided Isolation of Anti-Inflammatory Isolariciresinol and Seco-Isolariciresinol Type Lignans from <i>Alnus japonica</i>
Molecular Networking-Guided Isolation of Anti-Inflammatory Isolariciresinol and Seco-Isolariciresinol Type Lignans from <i>Alnus japonica</i> Open
A comparative analysis of UPLC-DAD and MS chromatograms revealed distinct chemical profiles between the methanolic extracts of the branch and cortex of Alnus japonica. MS/MS-based molecular networking further identified unique molec…
View article: Changes in Cancer Care for Patients Aged 80 and Above: A Cohort Study from Samsung Comprehensive Cancer Center in South Korea
Changes in Cancer Care for Patients Aged 80 and Above: A Cohort Study from Samsung Comprehensive Cancer Center in South Korea Open
Background/Objectives: With an estimated 70% of new cancer diagnoses expected to be in older adults within the next decade, cancer care for this population has attracted increasing global attention. Additionally, older patients are less li…
View article: Prognostic value of pseudotime from texture parameters of FDG PET/CT in locally advanced rectal cancer with neoadjuvant concurrent chemoradiotherapy
Prognostic value of pseudotime from texture parameters of FDG PET/CT in locally advanced rectal cancer with neoadjuvant concurrent chemoradiotherapy Open
View article: LINC02257 regulates malignant phenotypes of colorectal cancer via interacting with miR-1273g-3p and YB1
LINC02257 regulates malignant phenotypes of colorectal cancer via interacting with miR-1273g-3p and YB1 Open
Colorectal cancer (CRC) is the third most common cancer diagnosed and the second leading cause of cancer-related deaths. Emerging evidence has indicated that long non-coding RNAs (lncRNAs) are involved in the progression of various types o…
View article: LC-HRMS/MS-Guided Isolation of Unusual Diarylheptanoids from the Rhizomes of <i>Alpinia officinarum</i>
LC-HRMS/MS-Guided Isolation of Unusual Diarylheptanoids from the Rhizomes of <i>Alpinia officinarum</i> Open
LC-HRMS/MS analysis facilitated the precise targeting, isolation, and identification of unusual dimeric diarylheptanoids from Alpinia officinarum (A. officinarum). The tandem MS data for (4E)-1,7-diphenyl-4-hepten-3-on…
View article: 1344 AR092, a proprietary HLA-G/CD3 T cell engager, induces anti-tumor activity and minimal toxicity in solid tumors
1344 AR092, a proprietary HLA-G/CD3 T cell engager, induces anti-tumor activity and minimal toxicity in solid tumors Open
View article: Can neoadjuvant chemoradiotherapy affect exfoliated cancer cells in colorectal cancer?
Can neoadjuvant chemoradiotherapy affect exfoliated cancer cells in colorectal cancer? Open
Our study suggests that neoadjuvant chemoradiotherapy could reduce exfoliated cancer cells, and rectal washout for the purpose of eliminating exfoliated cancer cells might be unnecessary in patients who have received neoadjuvant chemoradio…
View article: Anti-inflammatory Activity of Norisoprenoids from the Aerial Parts of Celosia cristata L.
Anti-inflammatory Activity of Norisoprenoids from the Aerial Parts of Celosia cristata L. Open
Celosia cristata, belongs to Amaranthaceae family, has been utilized in many traditional medicinal systems to treat hemostasis, eye and mouth inflammation, and gynecological diseases. The various physiological investigations on C. cristata…
View article: Clinical outcomes of neoadjuvant chemoradiotherapy followed by total mesorectal excision in locally advanced rectal cancer with mesorectal fascia involvement
Clinical outcomes of neoadjuvant chemoradiotherapy followed by total mesorectal excision in locally advanced rectal cancer with mesorectal fascia involvement Open
Purpose: For the treatment of locally advanced rectal cancer (LARC), research on primary lesions with mesorectal fascia (MRF) involvement is lacking. This study analyzed the clinical outcomes and efficacy of dose-escalated neoadjuvant conc…
View article: Comparative Analysis of Functional End-to-End and End-to-Side Anastomosis in Laparoscopic Right Hemicolectomy for Colon Cancer
Comparative Analysis of Functional End-to-End and End-to-Side Anastomosis in Laparoscopic Right Hemicolectomy for Colon Cancer Open
Purpose: Despite advancements in laparoscopic right hemicolectomy for right-sided colon cancer, the choice between functional end-to-end anastomosis (FETE) and end-to-side anastomosis (ETS) remains a topic of debate. This study aimed to co…
View article: ASO Visual Abstract: Is Robotic Surgery Beneficial for Rectal Cancer Patients with Unfavorable Characteristic After Neoadjuvant Chemoradiotherapy?
ASO Visual Abstract: Is Robotic Surgery Beneficial for Rectal Cancer Patients with Unfavorable Characteristic After Neoadjuvant Chemoradiotherapy? Open
View article: Comprehensive profiling of DNA methylation in Korean patients with colorectal cancer
Comprehensive profiling of DNA methylation in Korean patients with colorectal cancer Open
Alterations in DNA methylation play an important pathophysiological role in the development and progression of colorectal cancer. We comprehensively profiled DNA methylation alterations in 165 Korean patients with colorectal cancer (CRC), …
View article: Vascularized tissue on mesh-assisted platform (VT-MAP): a novel approach for diverse organoid size culture and tailored cancer drug response analysis
Vascularized tissue on mesh-assisted platform (VT-MAP): a novel approach for diverse organoid size culture and tailored cancer drug response analysis Open
VT-MAP, a novel in vitro platform, offers better physiological reflection through the vascularized organoid. This advancement supports drug assessment with deeper insights into cancer biology through correlation between morphology and drug…
View article: Improved Drug-Response Prediction Model of APC Mutant Colon Cancer Patient-Derived Organoids for Precision Medicine
Improved Drug-Response Prediction Model of APC Mutant Colon Cancer Patient-Derived Organoids for Precision Medicine Open
Colorectal cancer is the third most common cancer in the world, with an annual incidence of 2 million cases. The success of first-line chemotherapy plays a crucial role in determining the disease outcome. Therefore, there is an increasing …
View article: Two antisense RNAs—AFAP1-AS1 and MLK7-AS1—promote colorectal cancer progression by sponging miR-149-5p and miR-485-5p
Two antisense RNAs—AFAP1-AS1 and MLK7-AS1—promote colorectal cancer progression by sponging miR-149-5p and miR-485-5p Open
Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths. Antisense RNAs (asRNAs) are closely associated with cancer malignancy. This study aimed to identify the action mechanism of asRNAs in controlling CRC malignancy…
View article: Correction: Transcriptomes of the tumor-adjacent normal tissues are more informative than tumors in predicting recurrence in colorectal cancer patients
Correction: Transcriptomes of the tumor-adjacent normal tissues are more informative than tumors in predicting recurrence in colorectal cancer patients Open
View article: Public effect of the 2022 Colorectal Cancer Awareness Campaign delivered through a metaverse platform
Public effect of the 2022 Colorectal Cancer Awareness Campaign delivered through a metaverse platform Open
Purpose: The Korean Society of Coloproctology has been conducting Colorectal Cancer Awareness Campaign, also known as the Gold Ribbon Campaign, every September since 2007. The 2022 campaign was held through a metaverse platform targeting t…
View article: Information about immune cell proportions and tumor stage improves the prediction of recurrence in patients with colorectal cancer
Information about immune cell proportions and tumor stage improves the prediction of recurrence in patients with colorectal cancer Open
View article: Figure S2 from Tumor Heterogeneity Predicts Metastatic Potential in Colorectal Cancer
Figure S2 from Tumor Heterogeneity Predicts Metastatic Potential in Colorectal Cancer Open
Supplementary Figure 2. Circle chart of the number of KRAS and TP53 mutation occurrences belonging to the four categories of CCFs. The four categories are based on CCF distribution (G1: 1st quantile, G2: 2nd quantile, G3: 3rd quantile, and…
View article: Data from Tumor Heterogeneity Predicts Metastatic Potential in Colorectal Cancer
Data from Tumor Heterogeneity Predicts Metastatic Potential in Colorectal Cancer Open
Purpose: Tumors continuously evolve to maintain growth; secondary mutations facilitate this process, resulting in high tumor heterogeneity. In this study, we compared mutations in paired primary and metastatic colorectal cancer tumo…
View article: Table S1 from Tumor Heterogeneity Predicts Metastatic Potential in Colorectal Cancer
Table S1 from Tumor Heterogeneity Predicts Metastatic Potential in Colorectal Cancer Open
Supplementary Table S1. Read mapping information of CRC samples
View article: Supplementary Figure Legends from Tumor Heterogeneity Predicts Metastatic Potential in Colorectal Cancer
Supplementary Figure Legends from Tumor Heterogeneity Predicts Metastatic Potential in Colorectal Cancer Open
Supplementary Figure 1. Survival plot using Kaplan-Meier survival analysis between two patient groups with high- and low-heterogeneity. Supplementary Figure 2. Circle chart of the number of KRAS and TP53 mutation occurrences belonging to t…
View article: Table S2 from Tumor Heterogeneity Predicts Metastatic Potential in Colorectal Cancer
Table S2 from Tumor Heterogeneity Predicts Metastatic Potential in Colorectal Cancer Open
Supplementary Table S2. Transition types of clonality and mutation prifiles in CRC patients
View article: Figure S1 from Tumor Heterogeneity Predicts Metastatic Potential in Colorectal Cancer
Figure S1 from Tumor Heterogeneity Predicts Metastatic Potential in Colorectal Cancer Open
Supplementary Figure 1. Survival plot using Kaplan-Meier survival analysis between two patient groups with high- and low-heterogeneity.
View article: Table S2 from Tumor Heterogeneity Predicts Metastatic Potential in Colorectal Cancer
Table S2 from Tumor Heterogeneity Predicts Metastatic Potential in Colorectal Cancer Open
Supplementary Table S2. Transition types of clonality and mutation prifiles in CRC patients
View article: Supplementary Figure Legends from Tumor Heterogeneity Predicts Metastatic Potential in Colorectal Cancer
Supplementary Figure Legends from Tumor Heterogeneity Predicts Metastatic Potential in Colorectal Cancer Open
Supplementary Figure 1. Survival plot using Kaplan-Meier survival analysis between two patient groups with high- and low-heterogeneity. Supplementary Figure 2. Circle chart of the number of KRAS and TP53 mutation occurrences belonging to t…
View article: Figure S3 from Tumor Heterogeneity Predicts Metastatic Potential in Colorectal Cancer
Figure S3 from Tumor Heterogeneity Predicts Metastatic Potential in Colorectal Cancer Open
Supplementary Figure 3. Signatures of mutational processes in oligo- and multi-clones. Each signature was extracted by decomposing the patterns of mutations.
View article: Data from Tumor Heterogeneity Predicts Metastatic Potential in Colorectal Cancer
Data from Tumor Heterogeneity Predicts Metastatic Potential in Colorectal Cancer Open
Purpose: Tumors continuously evolve to maintain growth; secondary mutations facilitate this process, resulting in high tumor heterogeneity. In this study, we compared mutations in paired primary and metastatic colorectal cancer tumo…
View article: Figure S1 from Tumor Heterogeneity Predicts Metastatic Potential in Colorectal Cancer
Figure S1 from Tumor Heterogeneity Predicts Metastatic Potential in Colorectal Cancer Open
Supplementary Figure 1. Survival plot using Kaplan-Meier survival analysis between two patient groups with high- and low-heterogeneity.
View article: Figure S3 from Tumor Heterogeneity Predicts Metastatic Potential in Colorectal Cancer
Figure S3 from Tumor Heterogeneity Predicts Metastatic Potential in Colorectal Cancer Open
Supplementary Figure 3. Signatures of mutational processes in oligo- and multi-clones. Each signature was extracted by decomposing the patterns of mutations.