Yongbo Yang
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View article: Engineered Low‐Endotoxin Bacterial Biomimetic Vesicles for Enhanced Oral Dual‐Antigen Subunit Vaccine Delivery
Engineered Low‐Endotoxin Bacterial Biomimetic Vesicles for Enhanced Oral Dual‐Antigen Subunit Vaccine Delivery Open
Subunit vaccines are promising for disease prevention because of their safety and cost‐effectiveness. However, their efficacy is limited by low immunogenicity and gastrointestinal degradation after oral administration. To address this issu…
View article: PRV gD-Based DNA Vaccine Candidates Adjuvanted with cGAS, UniSTING, or IFN-α Enhance Protective Immunity
PRV gD-Based DNA Vaccine Candidates Adjuvanted with cGAS, UniSTING, or IFN-α Enhance Protective Immunity Open
Pseudorabies virus (PRV), a major swine pathogen, causes severe neurological, respiratory, and reproductive disorders, resulting in substantial economic losses to the global swine industry. Previous studies have shown that the gD glycoprot…
View article: Analysis of Factors Influencing Surgical Approach Selection in Patients with Thyroid Cancer: A Retrospective Study of 411 Cases
Analysis of Factors Influencing Surgical Approach Selection in Patients with Thyroid Cancer: A Retrospective Study of 411 Cases Open
Thyroid cancer is the most common malignancy of the endocrine system, and its incidence has risen rapidly over the past decade. It is more prevalent in females, with a male-to-female ratio ranging from 1:2 to 1:3. Thyroid cancer is general…
View article: The intraoperative hemodynamic and clinical research of three direct bypasses in moyamoya disease a prospective cohort of 98 cases
The intraoperative hemodynamic and clinical research of three direct bypasses in moyamoya disease a prospective cohort of 98 cases Open
The goal of this study was to investigate clinical and hemodynamic differences in moyamoya disease patients underwent direct bypass using one donor-one recipient (1D1R), one donor-two recipients (1D2R), and two donors-two recipients (2D2R)…
View article: Recombinant pseudorabies virus expressing the consensus VP2 protein of porcine parvovirus 1 (PPV1) protects pigs against pseudorabies virus and PPV1
Recombinant pseudorabies virus expressing the consensus VP2 protein of porcine parvovirus 1 (PPV1) protects pigs against pseudorabies virus and PPV1 Open
View article: Effects of nutritional support during neoadjuvant therapy on perioperative outcome in esophageal cancer: a real-world cohort study
Effects of nutritional support during neoadjuvant therapy on perioperative outcome in esophageal cancer: a real-world cohort study Open
Nasogastric tube feeding plays a pivotal role in effective nutritional support during neoadjuvant therapy. Effective nutritional intervention not only improves preoperative nutritional status and enhances neoadjuvant therapy completion but…
View article: The updated duplex fluorescence quantitative RT-PCR assay for simultaneous detection of PRRSV-1 and PRRSV-2
The updated duplex fluorescence quantitative RT-PCR assay for simultaneous detection of PRRSV-1 and PRRSV-2 Open
Introduction Porcine reproductive and respiratory syndrome (PRRS) is one of the most economically devastating infectious diseases in the global swine industry. With the continuous mutation and recombination of PRRSV, existing detection met…
View article: Development and validation of a scoring system to evaluate and clinically manage postoperative acute infarction complications in moyamoya disease
Development and validation of a scoring system to evaluate and clinically manage postoperative acute infarction complications in moyamoya disease Open
View article: Elasticity of Substitution, Technological Progress Bias and Labor Income Share: Evidence From China
Elasticity of Substitution, Technological Progress Bias and Labor Income Share: Evidence From China Open
Long-time low-level stagnation of labor income share (LIS) could lead to continuous deterioration of national income distribution status and increase the uncertainty of national development trend. A deep analysis into the root of long-time…
View article: Refining Lineage Classification and Updated RFLP Patterns of PRRSV‐2 Revealed Viral Spatiotemporal Distribution Characteristics in China in 1991–2023
Refining Lineage Classification and Updated RFLP Patterns of PRRSV‐2 Revealed Viral Spatiotemporal Distribution Characteristics in China in 1991–2023 Open
Porcine reproductive and respiratory syndrome virus (PRRSV) is a significant infectious disease impacting the global swine industry. Due to high frequency of viral mutation and recombination, PRRSV exhibits complex genetic diversity; howev…
View article: Streptococcus suis Induces Macrophage M1 Polarization and Pyroptosis
Streptococcus suis Induces Macrophage M1 Polarization and Pyroptosis Open
Streptococcus suis is an important bacterial pathogen that affects the global pig industry. The immunosuppressive nature of S. suis infection is recognized, and our previous research has confirmed thymus atrophy with a large number of necr…
View article: New era for intracerebral haemorrhage management: Lessons from INTERACT3
New era for intracerebral haemorrhage management: Lessons from INTERACT3 Open
Commentary: Intracerebral haemorrhage (ICH) accounts for approximately 15% of all strokes throughout the world and 20%−30% of strokes in Asian countries.1 Although numerous efforts have been made in recent decades, there is still a lack of…
View article: Isolation, Pathogenicity, and Comparative Phylogenetic Characteristics of an Intralineage Recombinant NADC34-Like PRRSV in China
Isolation, Pathogenicity, and Comparative Phylogenetic Characteristics of an Intralineage Recombinant NADC34-Like PRRSV in China Open
Porcine reproductive and respiratory syndrome (PRRS), which causes reproductive failure in sows and respiratory symptoms in piglets, poses a significant threat to the global pig industry. PRRS virus (PRRSV) variants continue to emerge and …
View article: Immunogenicity Characterization of the Recombinant gI Protein Fragment from Pseudorabies Virus and an Evaluation of Its Diagnostic Use in Pigs
Immunogenicity Characterization of the Recombinant gI Protein Fragment from Pseudorabies Virus and an Evaluation of Its Diagnostic Use in Pigs Open
Serological testing is an important method for the diagnosis of pseudorabies virus (PRV) infection. We aimed to investigate the envelope glycoprotein I (gI) of PRV, a strong immunogen, and its potential as an efficient and low-cost diagnos…
View article: Risk Factors for Cerebrovascular Events in Moyamoya Angiopathy Using 4D Flow MRI: A Pilot Study
Risk Factors for Cerebrovascular Events in Moyamoya Angiopathy Using 4D Flow MRI: A Pilot Study Open
View article: Intraoperative Hemodynamics of Parasylvian Cortical Arteries for Predicting Postoperative Symptomatic Cerebral Hyperperfusion after Direct Revascularization in Patients with Moyamoya Disease: A Preliminary Study
Intraoperative Hemodynamics of Parasylvian Cortical Arteries for Predicting Postoperative Symptomatic Cerebral Hyperperfusion after Direct Revascularization in Patients with Moyamoya Disease: A Preliminary Study Open
Objective. The search for methods by which to predict the risks of cerebral hyperperfusion syn-drome (CHS) in adults with moyamoya disease (MMD), including those utilizing new biomarkers, still deserves further research. The objective of t…
View article: Single-cell RNA analysis reveals the cell atlas of human intracranial aneurysm and rupture-related inflammation features
Single-cell RNA analysis reveals the cell atlas of human intracranial aneurysm and rupture-related inflammation features Open
Background Intracranial aneurysms (IA) is a common condition and may ultimately result in life-threatening hemorrhagic strokes. A precise understanding of the cellular and gene expression perturbations in human IA tissue may enlighten addi…
View article: Single-cell transcriptome analysis reveals the cellular atlas of human intracranial aneurysm and highlights inflammation features associated with aneurysm rupture
Single-cell transcriptome analysis reveals the cellular atlas of human intracranial aneurysm and highlights inflammation features associated with aneurysm rupture Open
Intracranial aneurysm (IA) is pouch-like pathological dilations of cerebral arteries, which often affects middle-aged people and culminates in life-threatening hemorrhagic stroke. A deeper knowledge of the cellular and gene expression pert…
View article: Risk factors of postoperative cerebral hyperperfusion syndrome and its relationship with clinical prognosis in adult patients with moyamoya disease
Risk factors of postoperative cerebral hyperperfusion syndrome and its relationship with clinical prognosis in adult patients with moyamoya disease Open
View article: The comparison of neuronavigation combined with CT three-dimensional angiography vs. CT angiography in the guidance of clipping treatment in distal intracranial aneurysm surgery: a retrospective clinical study
The comparison of neuronavigation combined with CT three-dimensional angiography vs. CT angiography in the guidance of clipping treatment in distal intracranial aneurysm surgery: a retrospective clinical study Open
BACKGROUND: Distal intracranial aneurysms are often located deep in the lateral or longitudinal fissure pool or brain parenchyma, lacking a fixed anatomical location. Precise intraoperative localization of distal intracranial aneurysms is …
View article: Preoperative Collateral Perfusion Using Arterial Spin Labeling: A Predictor of Surgical Collaterals in Moyamoya Angiopathy
Preoperative Collateral Perfusion Using Arterial Spin Labeling: A Predictor of Surgical Collaterals in Moyamoya Angiopathy Open
Objectives Various degrees of surgical collateral circulation are often found in moyamoya angiopathy (MMA) patients after revascularization. Little is known about arterial spin labeling (ASL) that affects surgical collateral circulation. T…
View article: Clinical Significance of Multiparameter Intracranial Pressure Monitoring in the Prognosis Prediction of Hypertensive Intracerebral Hemorrhage
Clinical Significance of Multiparameter Intracranial Pressure Monitoring in the Prognosis Prediction of Hypertensive Intracerebral Hemorrhage Open
Objective: The present study aimed to investigate the clinical significance of multiparameter intracranial pressure (ICP) monitoring in the prediction of the prognosis of hypertensive intracerebral hemorrhage (HICH). Methods: A retrospecti…
View article: Recurrent hemorrhage risk associated with medial target medullary artery anastomosis from the periventricular collateral vessel in adult patients with moyamoya disease
Recurrent hemorrhage risk associated with medial target medullary artery anastomosis from the periventricular collateral vessel in adult patients with moyamoya disease Open
View article: Identification of critical pathways and potential therapeutic targets in poorly differentiated duodenal papilla adenocarcinoma
Identification of critical pathways and potential therapeutic targets in poorly differentiated duodenal papilla adenocarcinoma Open
Background Duodenal papilla carcinoma (DPC) is a rare malignancy of the gastrointestinal tract with high recurrence rate, and the pathogenesis of this highly malignant neoplasm is yet to be fully elucidated. This study aims to identify key…
View article: Scaffolds of Macroporous Tannin Spray With Human-Induced Pluripotent Stem Cells
Scaffolds of Macroporous Tannin Spray With Human-Induced Pluripotent Stem Cells Open
Skeletal defects resulting from trauma and disease represent a major clinical problem worldwide exacerbated further by global population growth and an increasing number of elderly people. As treatment options are limited, bone tissue engin…
View article: Peer Review #2 of "PHACTR1 is associated with disease progression in Chinese Moyamoya disease (v0.1)"
Peer Review #2 of "PHACTR1 is associated with disease progression in Chinese Moyamoya disease (v0.1)" Open
Moyamoya disease (MMD) is a progressive stenosis at the terminal portion of internal carotid artery and frequently occurs in East Asian countries.The etiology of MMD is still largely unknown.We performed a case-control design with whole-ex…
View article: Peer Review #2 of "PHACTR1 is associated with disease progression in Chinese Moyamoya disease (v0.2)"
Peer Review #2 of "PHACTR1 is associated with disease progression in Chinese Moyamoya disease (v0.2)" Open
Moyamoya disease (MMD) is a progressive stenosis at the terminal portion of internal carotid artery and frequently occurs in East Asian countries.The etiology of MMD is still largely unknown.We performed a case-control design with whole-ex…
View article: PHACTR1 is associated with disease progression in Chinese Moyamoya disease
PHACTR1 is associated with disease progression in Chinese Moyamoya disease Open
Moyamoya disease (MMD) is a progressive stenosis at the terminal portion of internal carotid artery and frequently occurs in East Asian countries. The etiology of MMD is still largely unknown. We performed a case-control design with whole-…
View article: HOXB7 mediates cisplatin resistance in esophageal squamous cell carcinoma through involvement of DNA damage repair
HOXB7 mediates cisplatin resistance in esophageal squamous cell carcinoma through involvement of DNA damage repair Open
Background DNA damage repair is an important mechanism of platinum resistance. HOXB7 is one member of HOX family genes, which are essential developmental regulators and frequently dysregulated in cancer. Recently, its relevance in chemothe…
View article: P2.09-20 Minor Components of Solid Pattern is a Significant Poor Prognostic Factor in Pathological Stage I Lung Adenocarcinoma
P2.09-20 Minor Components of Solid Pattern is a Significant Poor Prognostic Factor in Pathological Stage I Lung Adenocarcinoma Open