Yong Wu
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View article: Drug Repurposing: An Emerging Strategy in <i>Staphylococcus aureus</i> Infections
Drug Repurposing: An Emerging Strategy in <i>Staphylococcus aureus</i> Infections Open
Infections are a growing global threat to public health, and the rapid spread of drug-resistant pathogens is a big challenge. The development and approval of novel antimicrobials targeting multi-drug-resistant infections lag significantly …
View article: Repurposing bunamidine hydrochloride as a potent antimicrobial agent targeting vancomycin-resistant <i>Enterococcus</i> membranes
Repurposing bunamidine hydrochloride as a potent antimicrobial agent targeting vancomycin-resistant <i>Enterococcus</i> membranes Open
Vancomycin-resistant enterococci (VRE) are a major cause of hospital-acquired infections, with limited treatment options due to rising antibiotic resistance. Targeting bacterial membranes offers a promising alternative to conventional ther…
View article: Metagenomic next-generation sequencing for pathogen detection of pulmonary infections in persons living with HIV
Metagenomic next-generation sequencing for pathogen detection of pulmonary infections in persons living with HIV Open
View article: Prognostic Value of Preoperative ICPI in Rectal Cancer: A Nomogram Based Approach
Prognostic Value of Preoperative ICPI in Rectal Cancer: A Nomogram Based Approach Open
Objective This study examines the prognostic significance of preoperative inflammatory combined prognostic index (ICPI) in patients having laparoscopic rectal cancer surgery and constructs a machine learning-derived nomogram to predict pat…
View article: Endothelin A receptor in nociceptors is essential for persistent mechanical pain in a chronic pancreatitis of mouse model
Endothelin A receptor in nociceptors is essential for persistent mechanical pain in a chronic pancreatitis of mouse model Open
BACKGROUND Chronic pancreatitis (CP) accompanied with persistent abdominal pain represents a major clinical challenge for the symptom management in patients. Although with clear involvement of neuropathy, the detailed mechanisms underlying…
View article: Carbon Lock-In Mechanisms in Transport Infrastructure and Temporal Spatial Dynamics
Carbon Lock-In Mechanisms in Transport Infrastructure and Temporal Spatial Dynamics Open
The persistent carbon lock-in in transport infrastructure hinders low-carbon transition and sustainable urban development. This study, situated within the context of building energy and systems environments, examines the spatial and tempor…
View article: Effect of Desulfurization Ash Content on the Low-Temperature Rheological Properties of Asphalt Mastic
Effect of Desulfurization Ash Content on the Low-Temperature Rheological Properties of Asphalt Mastic Open
Circulating fluidized bed combustion flue gas desulfurization generates large volumes of dry desulfurization ash requiring sustainable management. This study evaluated the impacts of substituting desulfurization ash for mineral powder fill…
View article: Prognostic impact of methylation-related gene mutations in elderly acute myeloid leukemia: a real-world retrospective analysis
Prognostic impact of methylation-related gene mutations in elderly acute myeloid leukemia: a real-world retrospective analysis Open
Objective This study aimed to evaluate the prognostic impact of methylation-related gene mutations in older patients with acute myeloid leukemia (AML). Methods We conducted a retrospective analysis of clinical characteristics in 645 patien…
View article: Development of a Multiplexed qPCR Kit for the Detection of Bloodstream Infection
Development of a Multiplexed qPCR Kit for the Detection of Bloodstream Infection Open
Background Bloodstream infection (BSI) is associated with high morbidity and mortality worldwide. Currently, BSI diagnosis relies on a time‐consuming blood culture method, which usually takes 2 or more days to identify the causative pathog…
View article: The hypoxia signaling pathway in the development of acute myeloid leukemia
The hypoxia signaling pathway in the development of acute myeloid leukemia Open
Acute myeloid leukemia (AML) is the most common acute leukemia in adults. Although advances in targeted agents have greatly improved the prognosis of patients with AML in recent years, those who fail to achieve remission or relapse after r…
View article: The Development and Application of a Method for the Detection of Viable but Nonculturable <i>Staphylococcus aureus</i> by Magnetic Bead Separation Combined With PMA‐qPCR
The Development and Application of a Method for the Detection of Viable but Nonculturable <i>Staphylococcus aureus</i> by Magnetic Bead Separation Combined With PMA‐qPCR Open
Staphylococcus aureus is a major food‐borne pathogen and easy to be induced into a viable but nonculturable state under stress conditions from food processing, causing a significant and potential risk to public health. In this study, the p…
View article: Novel antibiotics against <i>Staphylococcus aureus</i> without detectable resistance by targeting proton motive force and FtsH
Novel antibiotics against <i>Staphylococcus aureus</i> without detectable resistance by targeting proton motive force and FtsH Open
The increased prevalence of methicillin‐resistant Staphylococcus aureus (MRSA) and its biofilms poses a great threat to human health. Especially, S. aureus ‐related osteomyelitis was hardly cured even by conventional antibiotics combined w…
View article: Repurposing pinaverium bromide against Staphylococcus and its biofilms with new mechanisms
Repurposing pinaverium bromide against Staphylococcus and its biofilms with new mechanisms Open
Antibiotic resistance by methicillin-resistant Staphylococcus aureus (MRSA) is an urgent threat to human health. The biofilm and persister cells formation ability of MRSA and Staphylococcus epidermidis often companied with extremely high a…
View article: Assessing the prevalence of human enteric viruses in hospital wastewater to evaluate the effectiveness of wastewater treatment systems
Assessing the prevalence of human enteric viruses in hospital wastewater to evaluate the effectiveness of wastewater treatment systems Open
In this experiment, we employed Real-time PCR(RT-PCR) and metagenomic Next-Generation Sequencing (mNGS) techniques to detect the presence of Norovirus, Rotavirus Group A, Adenovirus Group F, and Astrovirus in untreated sewage from three ma…
View article: Preoperative Albumin to Alkaline Phosphatase Ratio and Inflammatory Burden Index for Rectal Cancer Prognostic Nomogram-Construction: Based on Multiple Machine Learning
Preoperative Albumin to Alkaline Phosphatase Ratio and Inflammatory Burden Index for Rectal Cancer Prognostic Nomogram-Construction: Based on Multiple Machine Learning Open
Preoperative AAPR and IBI can serve as effective indicators for predicting the OS of RC patients. We have developed a nomogram for predicting the OS of patients who underwent laparoscopic rectal cancer surgery.
View article: Transcriptomic and Metabolomic Responses to Growth Differences in Litopenaeus Vannamei Infected with Enterocytozoon Hepatopenaei
Transcriptomic and Metabolomic Responses to Growth Differences in Litopenaeus Vannamei Infected with Enterocytozoon Hepatopenaei Open
View article: Repurposing of the antimalarial agent tafenoquine to combat MRSA
Repurposing of the antimalarial agent tafenoquine to combat MRSA Open
Staphylococcus aureus is an important human pathogen that often leads to hospital-acquired and community-acquired infections. The appearance of methicillin-resistant S. aureus (MRSA) has made the treatment extremely challenging. There is a…
View article: Pulmonary infection associated with immune dysfunction is associated with poor prognosis in patients with myelodysplastic syndrome accompanied by TP53 abnormalities
Pulmonary infection associated with immune dysfunction is associated with poor prognosis in patients with myelodysplastic syndrome accompanied by TP53 abnormalities Open
The aim of this study was to examine the characteristics and prognosis of patients with myelodysplastic syndrome (MDS) accompanied by TP53 abnormalities and explore potential prognostic factors and treatment responses. This retrospective a…
View article: A rapid and high-throughput multiplex genetic detection assay for detection, semi-quantification and virulence genotyping of Helicobacter pylori in non-invasive oral samples
A rapid and high-throughput multiplex genetic detection assay for detection, semi-quantification and virulence genotyping of Helicobacter pylori in non-invasive oral samples Open
Aim This study established a high-throughput multiplex genetic detection assay (HMGA) for rapid identification, semi-quantification and virulence analysis of Helicobacter pylori directly from the clinical non-invasive oral samples. Methods…
View article: Repurposing 9-Aminoacridine as an Adjuvant Enhances the Antimicrobial Effects of Rifampin against Multidrug-Resistant Klebsiella pneumoniae
Repurposing 9-Aminoacridine as an Adjuvant Enhances the Antimicrobial Effects of Rifampin against Multidrug-Resistant Klebsiella pneumoniae Open
Klebsiella pneumoniae is a leading cause of clinically acquired infections. The increasing occurrence of drug-resistant K. pneumoniae has posed a serious threat to global public health.
View article: Correction of F8 intron 1 inversion in hemophilia A patient-specific iPSCs by CRISPR/Cas9 mediated gene editing
Correction of F8 intron 1 inversion in hemophilia A patient-specific iPSCs by CRISPR/Cas9 mediated gene editing Open
Introduction: Hemophilia A (HA) is the most common genetic bleeding disorder caused by mutations in the F8 gene encoding coagulation factor VIII (FVIII). As the second predominant pathogenic mutation in hemophilia A severe patients, F8 Int…
View article: Antibacterial and antibiofilm efficacy of repurposing drug hexestrol against methicillin-resistant Staphylococcus aureus
Antibacterial and antibiofilm efficacy of repurposing drug hexestrol against methicillin-resistant Staphylococcus aureus Open
There has been an explosion in the prevalence of methicillin-resistant Staphylococcus aureus (MRSA) because of the indiscriminate use of antibiotics. In this study, we repurposed hexestrol (HXS) as an antibacterial agent to fight planktoni…
View article: Identification of a small molecule 0390 as a potent antimicrobial agent to combat antibiotic-resistant Escherichia coli
Identification of a small molecule 0390 as a potent antimicrobial agent to combat antibiotic-resistant Escherichia coli Open
Introduction Antibiotic resistance has posed a serious challenge to global public health. With the increasing resistance emergence of E. coli and mortality caused by drug-resistant E. coli infections, it is urgent to develop novel antibiot…
View article: Triple combination of SPR741, clarithromycin, and erythromycin against<i>Acinetobacter baumannii</i>and its tolerant phenotype
Triple combination of SPR741, clarithromycin, and erythromycin against<i>Acinetobacter baumannii</i>and its tolerant phenotype Open
Aims Extensively drug-resistant (XDR) Acinetobacter baumannii poses a severe threat to public health due to its ability to form biofilms and persister cells, which contributes to critical drug resistance and refractory device-associated in…
View article: Drug synergy discovery of tavaborole and aminoglycosides against Escherichia coli using high throughput screening
Drug synergy discovery of tavaborole and aminoglycosides against Escherichia coli using high throughput screening Open
View article: Insights into the antimicrobial effects of ceritinib against Staphylococcus aureus in vitro and in vivo by cell membrane disruption
Insights into the antimicrobial effects of ceritinib against Staphylococcus aureus in vitro and in vivo by cell membrane disruption Open
According to a 2019 report from the Centers of Disease Control and Prevention (CDC), methicillin-resistant Staphylococcus aureus (MRSA) was listed as one of the “serious threats” that had become a global public challenge in hospitals and c…
View article: Rapid and precise identification of bloodstream infections using a pre-treatment protocol combined with high-throughput multiplex genetic detection system
Rapid and precise identification of bloodstream infections using a pre-treatment protocol combined with high-throughput multiplex genetic detection system Open
View article: Pixantrone Sensitizes Gram-Negative Pathogens to Rifampin
Pixantrone Sensitizes Gram-Negative Pathogens to Rifampin Open
Bacterial resistance has become increasingly serious because of the widespread use and abuse of antibiotics. In particular, the emergence of multidrug-resistant bacteria has posed a serious threat to human public health.
View article: L007-0069 kills Staphylococcus aureus in high resistant phenotypes
L007-0069 kills Staphylococcus aureus in high resistant phenotypes Open
View article: Developing a multiplex <scp>PCR</scp> ‐based assay kit for bloodstream infection by analyzing genomic big data
Developing a multiplex <span>PCR</span> ‐based assay kit for bloodstream infection by analyzing genomic big data Open
Background In recent years, the incidence of bloodstream infections (BSI) has increased, the composition of pathogenic bacteria has changed, and drug resistance among bacteria has gradually increased due to the widespread use of interventi…