Yong-Dae Gwon
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View article: Open Source Repurposing Reveals Broad-Spectrum Antiviral Activity of Diphenylureas
Open Source Repurposing Reveals Broad-Spectrum Antiviral Activity of Diphenylureas Open
The pandemic threat from newly emerging viral diseases constitutes a major unsolved issue for global health. Antiviral therapy can play an important role in treating and preventing the spread of unprecedented viral infections. A repository…
View article: Evidence of dengue virus exposure and associated risk factors in Rwanda
Evidence of dengue virus exposure and associated risk factors in Rwanda Open
Objectives: Dengue virus (DENV) is a global public health concern owing to its widespread distribution, significant morbidity, and potentially severe outcomes. Although not yet reported in Rwanda, this study aimed to explore the DENV serop…
View article: Modulation of innate immune response to mRNA vaccination after SARS-CoV-2 infection or sequential vaccination in humans
Modulation of innate immune response to mRNA vaccination after SARS-CoV-2 infection or sequential vaccination in humans Open
mRNA vaccines are likely to become widely used for the prevention of infectious diseases in the future. Nevertheless, a notable gap exists in mechanistic data, particularly concerning the potential effects of sequential mRNA immunization o…
View article: At-home sampling to meet geographical challenges for serological assessment of SARS-CoV-2 exposure in a rural region of northern Sweden, March to May 2021: a retrospective cohort study
At-home sampling to meet geographical challenges for serological assessment of SARS-CoV-2 exposure in a rural region of northern Sweden, March to May 2021: a retrospective cohort study Open
Background The current SARS-CoV-2 pandemic has highlighted a need for easy and safe blood sampling in combination with accurate serological methodology. Venipuncture for testing is usually performed by trained staff at healthcare centres. …
View article: Vaccine-induced correlate of protection against fatal COVID-19 in the old and frail during waves of neutralization resistant variants of concern
Vaccine-induced correlate of protection against fatal COVID-19 in the old and frail during waves of neutralization resistant variants of concern Open
Background To inform future preventive measures including repeated vaccinations, we have searched for a clinically useful immune correlate of protection against fatal Covid-19 among nursing homes residents. Methods We performed repeated ca…
View article: Serological Evidence of Exposure to Onyong-Nyong and Chikungunya Viruses in Febrile Patients of Rural Taita-Taveta County and Urban Kibera Informal Settlement in Nairobi, Kenya
Serological Evidence of Exposure to Onyong-Nyong and Chikungunya Viruses in Febrile Patients of Rural Taita-Taveta County and Urban Kibera Informal Settlement in Nairobi, Kenya Open
Several alphaviruses, such as chikungunya (CHIKV) and Onyong-nyong (ONNV), are endemic in Kenya and often cause outbreaks in different parts of the country. We assessed the seroprevalence of alphaviruses in patients with acute febrile illn…
View article: Rift Valley Fever Virus Propagates in Human Villous Trophoblast Cell Lines and Induces Cytokine mRNA Responses Known to Provoke Miscarriage
Rift Valley Fever Virus Propagates in Human Villous Trophoblast Cell Lines and Induces Cytokine mRNA Responses Known to Provoke Miscarriage Open
The mosquito-borne Rift Valley fever (RVF) is a prioritised disease that has been listed by the World Health Organization for urgent research and development of counteraction. Rift Valley fever virus (RVFV) can cause a cytopathogenic effec…
View article: The Phosphatidylserine Receptor TIM-1 Enhances Authentic Chikungunya Virus Cell Entry
The Phosphatidylserine Receptor TIM-1 Enhances Authentic Chikungunya Virus Cell Entry Open
Chikungunya virus (CHIKV) is a re-emerging, mosquito-transmitted, enveloped positive stranded RNA virus. Chikungunya fever is characterized by acute and chronic debilitating arthritis. Although multiple host factors have been shown to enha…
View article: Heterologous ChAdOx1 nCoV-19 and mRNA-1273 Vaccination
Heterologous ChAdOx1 nCoV-19 and mRNA-1273 Vaccination Open
Heterologous Vaccination with ChAdOx1 nCoV-19 and mRNA-1273 Health care workers who had received a dose of ChAdOx1 nCoV-19 were offered a choice of receiving either ChAdOx1 nCoV-19 or mRNA-1273 9 t...
View article: The trends of Zika virus-related research from 2014 to 2018: a systematic review and meta-analysis
The trends of Zika virus-related research from 2014 to 2018: a systematic review and meta-analysis Open
Background Zika virus (ZIKV) is a mosquito-borne disease discovered in 1947, but with no reports of serious disease for almost 60 years. The first large ZIKV outbreak was reported from Yap island in 2007, then in 2015, the emergence of ZIK…
View article: N-glycosylation in the Pre-Membrane Protein Is Essential for the Zika Virus Life Cycle
N-glycosylation in the Pre-Membrane Protein Is Essential for the Zika Virus Life Cycle Open
Asparagine (N)-linked protein glycosylation plays an important role in protein synthesis and modification. Two Zika virus (ZIKV) structural proteins, the pre-membrane (prM) and envelope (E) protein are N-glycosylated. The prM protein of al…
View article: The trends of Zika virus-related research from 2014 to 2018: a systematic review and meta-analysis
The trends of Zika virus-related research from 2014 to 2018: a systematic review and meta-analysis Open
BackgroundZika virus (ZIKV) is a mosquito-borne disease discovered in 1947, but with no reports of serious disease for almost 60 years. The first large ZIKV outbreak was reported from Yap island in 2007, then in 2015, the emergence of ZIKV…
View article: Serological assessment of SARS-CoV-2 exposure in northern Sweden by the use of at-home sampling to meet geographical challenges in rural regions
Serological assessment of SARS-CoV-2 exposure in northern Sweden by the use of at-home sampling to meet geographical challenges in rural regions Open
The current SARS-CoV-2 pandemic has highlighted a need for easy and safe blood sampling in combination with accurate serological methodology. Venipuncture is usually performed by trained staff at health care centers. Long travel distances …
View article: Antiviral Activity of Benzavir-2 against Emerging Flaviviruses
Antiviral Activity of Benzavir-2 against Emerging Flaviviruses Open
Most flaviviruses are arthropod-borne viruses, transmitted by either ticks or mosquitoes, and cause morbidity and mortality worldwide. They are endemic in many countries and have recently emerged in new regions, such as the Zika virus (ZIK…
View article: Bibliometric analysis of the trends of Zika related research from 2015 to 2017
Bibliometric analysis of the trends of Zika related research from 2015 to 2017 Open
Background Zika virus (ZIKV) is a mosquito-borne disease discovered in 1947, which did not cause public concern for the next 68 years. However, when ZIKV emerged in Brazil 2015 the attention increased rapidly. The announcement by Brazilian…
View article: Transmission of Porcine Endogenous Retrovirus Produced from Different Recipient Cells In Vivo
Transmission of Porcine Endogenous Retrovirus Produced from Different Recipient Cells In Vivo Open
Humanized pigs have been developed to reduce the incidence of immune rejection in xenotransplantation, but significant concerns remain, such as transmission of viral zoonosis. Porcine endogenous retroviruses (PERV), which exist in the geno…
View article: Immunogenicity of Virus Like Particle Forming Baculoviral DNA Vaccine against Pandemic Influenza H1N1
Immunogenicity of Virus Like Particle Forming Baculoviral DNA Vaccine against Pandemic Influenza H1N1 Open
An outbreak of influenza H1N1 in 2009, representing the first influenza pandemic of the 21st century, was transmitted to over a million individuals and claimed 18,449 lives. The current status in many countries is to prepare influenza vacc…