Explanipedia

Protective effects of Notoginsenoside R1 on the ferroptosis of a human non‑small cell lung cancer cell line Open

Yuejiao Zhang, Z. Mao, Yong Diao · 2025

The present study investigated the effects of Notoginsenoside R1 (NG‑R1) on human non‑small cell lung cancer (NSCLC) A549 cells and explored its potential mechanisms. Cell viability was assessed using the MTT assay after 72 h of treatment …

Effectiveness of an Integrated Nursing Intervention by Physicians and Nurses in Improving Outcomes for Patients with Lower Extremity Deep Vein Thrombosis Open

Ruijiao Gao, Jiangbo Bai, Xue Cui, Yong Diao, Hui Zhao , et al. · 2025

Background: Traditional nursing models typically emphasize unilateral interventions within isolated medical domains, which may inadvertently constrain holistic patient management. In contrast, the integrated physician-nurse collaborative m…

Immunomodulatory Transcription Factor BATF2 regulates the Interferon Stimulated Genes Expression during Influenza A virus Infection Open

Mohsan Ullah Goraya, Nelam Sajjad, Jamal Muhammad Khan, Aftab Ullah, Yong Diao · 2025

The basic leucine zipper ATF-like transcription factor 2 (BATF2) is involved in regulating immune, inflammatory, and antitumor responses. However, its role in viral infections, particularly influenza virus, remains poorly understood. This …

A novel protein encoded by circUBE2G1 suppresses glycolysis in gastric cancer through binding to ENO1 Open

Lu Lu, Guoqing Guo, Jiahao Guo, Hanyang Li, Kexin Chen , et al. · 2025

High-resolution genome-wide profiling reveals intricate relationship between DNA damage and sperm physiology Open

Yufei Zhang, Huifen Cao, Fujian Yang, Chunlian Wang, Guihua Wang , et al. · 2025

Little is known about genome-wide profiles of different types of DNA damage in spermatozoa and how they relate to sperm quality. In this study, we for the first time constructed and analyzed high-resolution profiles of two very common DNA …

Application and evaluation of whole-process nursing in venous thromboembolism patients Open

Yong Diao, Yu‐Tung Huang, Xuemin Cui, Xinhua Ma, Hui Zhao , et al. · 2025

Background Venous thromboembolism (VTE) is a serious threat to patient health. Currently, its management faces the problems of lack of patient awareness, poor medical and nursing management, and lack of out-of-hospital management. The trad…

Intranasal Drug Delivery Technology in the Treatment of Central Nervous System Diseases: Challenges, Advances, and Future Research Directions Open

Xunxun Wu, Ranqing Zang, Yiting Qiu, Yufang Zhang, Peng Jiang , et al. · 2025

As population aging becomes an increasingly critical global issue, the incidence of central nervous system (CNS) diseases, including Alzheimer’s disease (AD), Parkinson’s disease (PD), and stroke, has risen sharply. However, the blood–brai…

Evaluation of Indigo Naturalis Prepared Using a Novel Method: Therapeutic Effects on Experimental Ulcerative Colitis in Mice Open

Xianxiang Xu, Lin Lin, Wenjie Ning, Xinyi Zhou, Aftab Ullah , et al. · 2025

Background/Objectives: Indigo naturalis (IN) is a traditional Chinese medicine concocted from medicinal plants such as Baphicacanthus cusia (Nees) Bremek. IN has multifaceted pharmacological activities. Recent research highlights the remar…

Regenerative Potential Nanomedicine of Adipocyte Stem Cell-Derived Exosomes in Senescent Skin Tissue [Response to Letter] Open

Anna Li, Jinghua Sun, Syafiqah Saidin, J. Cheah, Chia‐Hung Kuo , et al. · 2025

Molecular cloning and functional characterization of the shikimate kinase gene from Baphicacanthus cusia Open

Yuxiang Huang, Hexin Tan, Qing Li, Xunxun Wu, Zhiying Guo , et al. · 2025

Baphicacanthus cusia (Nee) Bremek, a perennial herbaceous plant with medicinal properties, has limited genomic insights regarding the genes involved in its indole alkaloid biosynthesis pathway. In this study, the BcSK gene was isolated and…

Evaluation of Indigo Naturalis Prepared Using a Novel Method: Therapeutic Effects on Experimental Ulcerative Colitis in Mice Open

Xianxiang Xu, Lin Lin, Wenjie Ning, Xinyi Zhou, Aftab Ullah , et al. · 2025

Indigo naturalis (IN) is a traditional Chinese medicine concocted from medicinal plants such as Baphicacanthus cusia (Nees) Bremek. IN has multifaceted pharmacological activities. Recent research highlights the remarkable efficacy of IN in…

Association of red and processed meat consumption with cancer incidence and mortality: An umbrella review protocol Open

Ying Li, Shuping Yang, Chengxin Yu, Mei‐Hwan Wu, S. Huang , et al. · 2025

Background Many meta-analyses have reported the associations between red and processed meat consumption and cancer outcomes, but few have assessed the credibility of the evidence. In addition, the results of dose-effect analyses of the ass…

Sodium Iodate-Induced Ferroptosis in Photoreceptor-Derived 661W Cells Through the Depletion of GSH Open

Chao Chen, Han Wang, Jiuyu Yang, Bi Zhao, Yutian Lei , et al. · 2025

Oxidative stress-induced photoreceptor cell death is closely associated with the etiology of age-related macular degeneration (AMD), and sodium iodate (SI) has been widely used as an oxidant stimulus in AMD models to induce retinal pigment…

The causal effects of 2,821 protein level ratios on non-small cell lung cancer: a two-sample Mendelian randomization study Open

Xinyun Zou, Jinlan Shen, Xiaokai Li, Yong Diao, Ling Zhang · 2025

Studying specific protein level ratios in patients can reveal the molecular mechanisms and pathological processes of NSCLC, which has certain clinical significance for early diagnosis of NSCLC, understanding drug resistance mechanisms and …

Advancing Therapeutic Strategies with Polymeric Drug Conjugates for Nucleic Acid Delivery and Treatment Open

Aftab Ullah, Marina Khan, Yibang Zhang, Muhammad Shafiq, Mahtab Ullah , et al. · 2025

The effective clinical translation of messenger RNA (mRNA), small interfering RNA (siRNA), and microRNA (miRNA) for therapeutic purposes hinges on the development of efficient delivery systems. Key challenges include their susceptibility t…

Effective Reduction of Transgene‐Specific Immune Response With rAAV Vectors Co‐Expressing miRNA‐UL112‐5p or ERAP1 shRNA Open

Huang Xiao-ping, Xiao Wang, Yaqi Sun, Xinrui Xie, Langtao Xiao , et al. · 2025

Recombinant adeno‐associated virus (rAAV) has emerged as one of the best gene delivery vectors for human gene therapy in vivo. However, the clinical efficacy of rAAV gene therapy is often hindered by the host immune response against its tr…

Regenerative Potential Nanomedicine of Adipocyte Stem Cell-Derived Exosomes in Senescent Skin Tissue Open

Anna Li, Jinghua Sun, Syafiqah Saidin, J. Cheah, Chia‐Hung Kuo , et al. · 2024

HADSCs-CM significantly alleviated signs of skin senescence, including reduced dermal thickness, decreased VEGF expression, and enhanced collagen production. Exosomes, identified in the HADSCs-CM, are the functional component of these rege…

A novel human protein-coding locus identified using a targeted RNA enrichment technique Open

Lu Tang, Dongyang Xu, Lingcong Luo, Weiyan Ma, Xiaojie He , et al. · 2024

Self-Assembly of Rhein and Matrine Nanoparticles for Enhanced Wound Healing Open

Xunxun Wu, Ranqing Zang, Yiting Qiu, Ni Yang, Meiyan Liu , et al. · 2024

Carrier-free self-assembly has gradually shifted the focus of research on natural products, which effectively improve the bioavailability and the drug-loading rate. However, in spite of the existing studies, the development of self-assembl…

Study of Highly Efficient Au/Pt Nanoparticles for Rapid Screening of Clostridium difficile Open

Ying-Tsang Lu, Yu-Xlang Zeng, Wu-Xiong Tsai, Hsin-Chang Huang, Ming-Yuan Tsai , et al. · 2024

This study synthesized core/shell gold-platinum nanoparticles and characterized their colorimetric properties; ultraviolet-visible spectroscopy revealed that the synthesized nanoparticles exhibited distinct colors from conventional gold na…

Baicalein Attenuates Myocardial Fibrosis via Directly Targeting Phosphoglycerate Mutase 1 Open

Xunxun Wu, Ranqing Zang, Changxin Zhang, Meiyan Liu, Site Wei , et al. · 2024

Myocardial fibrosis is a pivotal pathophysiological step of various cardiovascular diseases, which eventually leads to heart failure and death. Cardiac fibroblasts activation and subsequently differentiate into myofibroblasts are pivotal p…

The causal effects of immune cells on pancreatic cancer: A 2‑sample Mendelian randomization study Open

Xinyun Zou, Jinlan Shen, Xiaomei Yong, Yong Diao, Ling Zhang · 2024

Leveraging publicly available genetic datasets, we conducted a comprehensive 2-sample Mendelian randomization (MR) analysis to explore the causal links between 731 immunophenotypes and the risk of pancreatic cancer (PC). To ensure the robu…

Development and validation of two nomograms to predict prognostic factors for patients with pancreatic cancer: A population-based retrospective study Open

Xinyue Zeng, Peizhang Cheng, Wenfang Dai, Mengting Wu, Yaping Zhan , et al. · 2024

Background: Pancreatic cancer (PC) patients’ overall survival rate (OS) is associated with multiple factors. The prognosis is generally poor, and the overall survival rate is extremely low. Although there have been numerous prognostic stud…

Genome‐wide profiles of DNA damage represent highly accurate predictors of mammalian age Open

Huifen Cao, Bolin Deng, Tianrong Song, Jiabian Lian, Lu Xia , et al. · 2024

The identification of novel age‐related biomarkers represents an area of intense research interest. Despite multiple studies associating DNA damage with aging, there is a glaring paucity of DNA damage‐based biomarkers of age, mainly due to…

Laser speckle contrast imaging based on uniting spatiotemporal Fourier transform Open

Linjun Zhai, Yongzhao Du, Xunxun Wu, Yong Diao, Yuqing Fu · 2024

We propose a laser speckle contrast imaging method based on uniting spatiotemporal Fourier transform. First, the raw speckle images are entirely transformed to the spatiotemporal frequency domain with a three-dimensional (3D) fast Fourier …

Novel Indigo Naturalis Intervened in Colitis-Associated Inflammation-Cancer Transformation Open

Xianxiang Xu, Lin Lin, Wenjie Ning, Xinyi Zhou, Aftab Ullah , et al. · 2024

Novel Indigo Naturalis Intervened in Colitis-Associated Inflammation-Cancer Transformation Open

Xianxiang Xu, Lin Lin, Wenjie Ning, Xinyi Zhou, Aftab Ullah , et al. · 2024

Evaluating the Therapeutic Efficacy of Novel Indigo Naturalis in Ameliorating Ulcerative Colitis Open

Xianxiang Xu, Yong Diao, Lin Lin, Wenjie Ning, Xinyi Zhou , et al. · 2024

EFFECTIVENESS OF A STRUCTURED TRI-PHASIC INTENSIVE WEIGHT MANAGEMENT PROGRAMME ON DIABETES REMISSION IN MULTI-ETHIC ASIANS: AN INTERIM ANALYSIS Open

Angela Moh, Boon Lim, Yong Diao, Bhuvaneswari Pandian, Serena Low , et al. · 2023

INTRODUCTIONEvidence from the primary care-led United Kingdom Diabetes Remission Clinical Trial (DiRECT) demonstrated that type 2 diabetes mellitus (T2D) can be reversible through an intensive, very low-calorie diet (VLCD)-based weight man…

The anti-photoaging effect of C-phycocyanin on ultraviolet B-irradiated BALB/c-nu mouse skin Open

Yali Zhou, Renao Bai, Yifeng Huang, Weina Li, Jiana Chen , et al. · 2023

Introduction: C-phycocyanin (C-PC), a photosynthetic protein obtained from Spirulina , is regarded a highly promising commercially available biochemical. Numerous in vitro and in vivo studies have provided evidence of C-PC’s ability to mit…

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