Yangsoo Jang
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View article: Efficacy and safety of mono antiplatelet therapy with colchicine in acute coronary syndrome patients following percutaneous coronary intervention: rationale and design of the MACT II trial
Efficacy and safety of mono antiplatelet therapy with colchicine in acute coronary syndrome patients following percutaneous coronary intervention: rationale and design of the MACT II trial Open
Introduction Early discontinuation of aspirin after percutaneous coronary intervention (PCI) reduces bleeding risk, while inflammation-targeted strategies may offer additional benefit in patients with acute coronary syndrome (ACS). Residua…
View article: Twenty‐Four–Month Outcomes of Intravascular Ultrasound‐Guided Drug‐Coated Balloon Angioplasty for Femoropopliteal Artery Disease
Twenty‐Four–Month Outcomes of Intravascular Ultrasound‐Guided Drug‐Coated Balloon Angioplasty for Femoropopliteal Artery Disease Open
Background The IVUS‐DCB (Intravascular Ultrasound‐Guided Drug‐Coated Balloon Angioplasty for Femoropopliteal Artery Disease) trial found that intravascular ultrasound (IVUS)–guided drug‐coated balloon (DCB) angioplasty was associated with …
View article: CRISPR/Cas9-mediated simultaneous targeting of GmP34 and its homologs produces T-DNA-free soybean mutants with reduced allergenic potential
CRISPR/Cas9-mediated simultaneous targeting of GmP34 and its homologs produces T-DNA-free soybean mutants with reduced allergenic potential Open
Soybean ( Glycine max L.) P34 (GmP34) is a prominent allergenic seed protein belonging to the papain-like cysteine protease family. To mitigate its allergenic potential, we implemented a CRISPR/Cas9-based genome editing strategy targeting …
View article: Prognostic implication of venoarterial extracorporeal membrane oxygenation in acute myocardial infarction-related cardiogenic shock
Prognostic implication of venoarterial extracorporeal membrane oxygenation in acute myocardial infarction-related cardiogenic shock Open
Background Given the conflicting results regarding the clinical outcomes of venoarterial extracorporeal membrane oxygenation (VA-ECMO) based on etiology, its benefit for patients with cardiogenic shock (CS) remains controversial. This stud…
View article: Fermented Morinda citrifolia extract improves late-onset hypogonadism in aged rats
Fermented Morinda citrifolia extract improves late-onset hypogonadism in aged rats Open
FME alleviated LOH-related symptoms in aged rats by modulating testosterone metabolism, enhancing reproductive and physical health, and maintaining a favorable safety profile. These findings validate the in vivo efficacy of FME and highlig…
View article: Benefits and Challenges of Community-Based Rehabilitation in Rural Stroke Patients: A Scoping Review
Benefits and Challenges of Community-Based Rehabilitation in Rural Stroke Patients: A Scoping Review Open
View article: Real-world outcomes of venoarterial extracorporeal membrane oxygenation in cardiogenic shock patients related to acute myocardial infarction: a single-center experience
Real-world outcomes of venoarterial extracorporeal membrane oxygenation in cardiogenic shock patients related to acute myocardial infarction: a single-center experience Open
Background The benefit of venoarterial extracorporeal membrane oxygenation (VA-ECMO) for cardiogenic shock (CS) patients is still on controversy and the previous results regarding clinical outcome according to etiology are conflicting. Obj…
View article: Continuous Renal Replacement Therapy and Extracorporeal Membrane Oxygenation in Patients with Cardiogenic Shock: Results from the Rescue Registry
Continuous Renal Replacement Therapy and Extracorporeal Membrane Oxygenation in Patients with Cardiogenic Shock: Results from the Rescue Registry Open
Background: Cardiogenic shock (CS) frequently leads to multiorgan failure, often necessitating continuous renal replacement therapy (CRRT) or extracorporeal membrane oxygenation (ECMO). We evaluated the association between CRRT, ECMO, and …
View article: Simulation study for the energy and position reconstruction performances of the beam monitoring system of Carbon Ion Radiation Therapy using GEANT4
Simulation study for the energy and position reconstruction performances of the beam monitoring system of Carbon Ion Radiation Therapy using GEANT4 Open
Carbon Ion Radiation Therapy is operated in several countries because of its advantage to have high dose concentration and/or high linear energy transfer (LET). To estimate the beam performance of Carbon Ion Radiation Therapy, we target th…
View article: Prognostic Implication of LDL-C Variability and Its Association with Lipid-Lowering Strategies: Insights from the RACING and LODESTAR Trials
Prognostic Implication of LDL-C Variability and Its Association with Lipid-Lowering Strategies: Insights from the RACING and LODESTAR Trials Open
Compared to high-intensity statin therapy, LDL-C variability was not increased with the moderate-intensity statin plus ezetimibe combination therapy; however, it was increased in the treat-to-target strategy. Even among those treated with …
View article: Ticagrelor Monotherapy <i>vs.</i> Ticagrelor With Aspirin in Bleeding and Cardiovascular Events in Acute Coronary Syndrome Patients According to Renal Function: The Subanalysis From the TICO Trial
Ticagrelor Monotherapy <i>vs.</i> Ticagrelor With Aspirin in Bleeding and Cardiovascular Events in Acute Coronary Syndrome Patients According to Renal Function: The Subanalysis From the TICO Trial Open
Regardless of renal function, ticagrelor monotherapy after 3 months of DAPT resulted in a reduced risk of not only NACE but also major or minor bleeding at 1 year compared with ticagrelor-based 12-month DAPT. Irrespective of renal function…
View article: Improvement of Late-Onset Hypogonadism Symptoms of Fermented Morinda citrifolia Extract in TM3 Leydig and TM4 Sertoli Cells
Improvement of Late-Onset Hypogonadism Symptoms of Fermented Morinda citrifolia Extract in TM3 Leydig and TM4 Sertoli Cells Open
Background/Objectives: Late-onset hypogonadism (LOH), characterized by declining testosterone levels with age, negatively affects the health of men, causing physical, psychological, and sexual dysfunction. Conventional testosterone replace…
View article: Effect of rosuvastatin versus atorvastatin on new-onset diabetes mellitus in patients treated with high-intensity statin therapy for coronary artery disease: a post-hoc analysis from the LODESTAR randomized clinical trial
Effect of rosuvastatin versus atorvastatin on new-onset diabetes mellitus in patients treated with high-intensity statin therapy for coronary artery disease: a post-hoc analysis from the LODESTAR randomized clinical trial Open
Background The impact of rosuvastatin versus atorvastatin on new-onset diabetes mellitus (NODM) among patients treated with high-intensity statin therapy for coronary artery disease (CAD) remains to be clarified. This study aimed to evalua…
View article: One-Month Dual Antiplatelet Therapy in High Bleeding Risk Asian Patients Undergoing Percutaneous Coronary Intervention ― Onyx ONE Clear 2-Year Results ―
One-Month Dual Antiplatelet Therapy in High Bleeding Risk Asian Patients Undergoing Percutaneous Coronary Intervention ― Onyx ONE Clear 2-Year Results ― Open
After propensity score matching, HBR patients from Asian countries undergoing PCI treated with 1-month DAPT had similar ischemic outcomes but fewer bleeding events between 1 month and 2 years compared with patients from non-Asian countries.
View article: Capacitance and Inductance Selection in High Power Inverters
Capacitance and Inductance Selection in High Power Inverters Open
The paper outlines a procedure for selecting capacitance and inductance for the modular multilevel converter.In the direct modulation method of the modular multilevel converter, sinusoidal modulating signals cause circulating currents to f…
View article: Global Consensus Recommendations on Improving the Safety of Chronic Total Occlusion Interventions
Global Consensus Recommendations on Improving the Safety of Chronic Total Occlusion Interventions Open
View article: C-67 | Ticagrelor monotherapy in ST-elevation myocardial infarction: An individual patient-level meta-analysis from TICO and T-PASS trials
C-67 | Ticagrelor monotherapy in ST-elevation myocardial infarction: An individual patient-level meta-analysis from TICO and T-PASS trials Open
Patients with ST-elevation myocardial infarction (STEMI) tend to be excluded or under-represented in randomized clinical trials evaluating the effects of potent P2Y12 inhibitor monotherapy after short-term dual antiplatelet therapy (DAPT).…
View article: Intravascular ultrasound-guided versus angiography-guided percutaneous coronary intervention for acute myocardial infarction with cardiogenic shock
Intravascular ultrasound-guided versus angiography-guided percutaneous coronary intervention for acute myocardial infarction with cardiogenic shock Open
The benefits of intravascular ultrasonography (IVUS)-guided percutaneous coronary intervention (PCI) in the clinical context of cardiogenic shock (CS) complicating acute myocardial infarction are lacking. We aimed to investigate the impact…
View article: Inflammation and platelet reactivity during adjunctive colchicine versus aspirin in patients with acute coronary syndrome treated with potent P2Y12 inhibitor
Inflammation and platelet reactivity during adjunctive colchicine versus aspirin in patients with acute coronary syndrome treated with potent P2Y12 inhibitor Open
Background In patients undergoing percutaneous coronary intervention (PCI), the use of anti-inflammatory therapy with colchicine is associated with a reduction of recurrent ischemic events. The mechanisms of such findings are not fully elu…
View article: Continuous Renal Replacement Therapy and Extracorporeal Membrane Oxygenation in Patients with Cardiogenic Shock: A Multicenter Observational Study: Results from the RESCUE Registry
Continuous Renal Replacement Therapy and Extracorporeal Membrane Oxygenation in Patients with Cardiogenic Shock: A Multicenter Observational Study: Results from the RESCUE Registry Open
Backgrounds: Cardiogenic shock (CS) frequently leads to multiorgan failure, potentially necessitating either continuous renal replacement therapy (CRRT) or extracorporeal membrane oxygenation (ECMO). However, there is a lack of comprehensi…
View article: Ticagrelor or Clopidogrel Monotherapy vs Dual Antiplatelet Therapy After Percutaneous Coronary Intervention
Ticagrelor or Clopidogrel Monotherapy vs Dual Antiplatelet Therapy After Percutaneous Coronary Intervention Open
Importance Among patients undergoing percutaneous coronary intervention (PCI), it remains unclear whether the treatment efficacy of P2Y 12 inhibitor monotherapy after a short course of dual antiplatelet therapy (DAPT) depends on the type o…
View article: Long-term outcomes of percutaneous transluminal renal artery intervention: a retrospective study at a single center
Long-term outcomes of percutaneous transluminal renal artery intervention: a retrospective study at a single center Open
PTRI was associated with a blood pressure reduction. Despite a higher rate of restenosis, patients with TA showed significant improvement in estimated glomerular filtration rate. Diabetes mellitus, chronic kidney disease, and peripheral ar…
View article: Author Correction: Optical coherence tomography in coronary atherosclerosis assessment and intervention
Author Correction: Optical coherence tomography in coronary atherosclerosis assessment and intervention Open
View article: Effect of moderate-intensity statin with ezetimibe combination vs. high-intensity statin therapy according to sex in patients with atherosclerosis
Effect of moderate-intensity statin with ezetimibe combination vs. high-intensity statin therapy according to sex in patients with atherosclerosis Open
We aimed to evaluate sex differences in the effects of moderate-intensity statin with ezetimibe combination therapy (rosuvastatin 10 mg plus ezetimibe) versus high-intensity statin (rosuvastatin 20 mg) monotherapy in patients with atherosc…
View article: Combination therapy with moderate-intensity atorvastatin and ezetimibe vs. high-intensity atorvastatin monotherapy in patients treated with percutaneous coronary intervention in practice: assessing RACING generalizability
Combination therapy with moderate-intensity atorvastatin and ezetimibe vs. high-intensity atorvastatin monotherapy in patients treated with percutaneous coronary intervention in practice: assessing RACING generalizability Open
Aims Using rosuvastatin, the RACING (randomized comparison of efficacy and safety of lipid-lowering with statin monotherapy versus statin/ezetimibe combination for high-risk cardiovascular diseases) trial showed the beneficial effects of c…
View article: Moderate-intensity statin plus ezetimibe combination therapy versus high-intensity statin monotherapy according to baseline LDL-C levels: a prespecified subgroup analysis of RACING Trial
Moderate-intensity statin plus ezetimibe combination therapy versus high-intensity statin monotherapy according to baseline LDL-C levels: a prespecified subgroup analysis of RACING Trial Open
Aims To compare the effects of moderate-intensity statin plus ezetimibe combination therapy to high-intensity statin monotherapy based on baseline low-density lipoprotein cholesterol (LDL-C) levels. Methods and results In the RACING trial,…
View article: Rosuvastatin versus atorvastatin treatment in adults with coronary artery disease: secondary analysis of the randomised LODESTAR trial
Rosuvastatin versus atorvastatin treatment in adults with coronary artery disease: secondary analysis of the randomised LODESTAR trial Open
Objective To compare the long term efficacy and safety of rosuvastatin with atorvastatin treatment in adults with coronary artery disease. Design Randomised, open label, multicentre trial. Setting 12 hospitals in South Korea, September 201…
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View article: Treat-to-target versus high-intensity statin treatment in patients with or without diabetes mellitus: a pre-specified analysis from the LODESTAR trial
Treat-to-target versus high-intensity statin treatment in patients with or without diabetes mellitus: a pre-specified analysis from the LODESTAR trial Open
Sam Jin Pharmaceutical, Seoul, Korea and Chong Kun Dang Pharmaceutical, Seoul, Korea.
View article: LB1793 Hibiscus-derived peptide, Tyr-Pro (YP) promotes human keratinocyte migration by activating FAK/ERK/MAPK signaling pathway
LB1793 Hibiscus-derived peptide, Tyr-Pro (YP) promotes human keratinocyte migration by activating FAK/ERK/MAPK signaling pathway Open