Yong‐Yeon Cho
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View article: New Roles of bZIP-Containing Membrane-Bound Transcription Factors in Chromatin Tethering and Karyoptosis
New Roles of bZIP-Containing Membrane-Bound Transcription Factors in Chromatin Tethering and Karyoptosis Open
The nuclear membrane has emerged as a dynamic regulatory platform coordinating genome organization, mechanotransduction, and regulated cell death (RCD). Beyond its barrier function, the nuclear skeleton—comprising lamins, actin–myosin isof…
View article: Natural Products Targeting Notch Signaling in Cancer: Mechanistic Insights and Food‐Based Chemoprevention Potential
Natural Products Targeting Notch Signaling in Cancer: Mechanistic Insights and Food‐Based Chemoprevention Potential Open
Within the intricate network of oncogenic pathways that orchestrate the insidious growth and spread of cancer, the Notch signaling pathway is well known for its multiple roles in regulating cell differentiation, influencing metastasis, can…
View article: Targeting the Hippo/YAP Pathway: A Promising Approach for Cancer Therapy and Beyond
Targeting the Hippo/YAP Pathway: A Promising Approach for Cancer Therapy and Beyond Open
Cancer represents a growing cause of death and a threat to public health worldwide; thus, there is an urgent need to understand its pathological mechanism and design effective therapies. The Hippo pathway regulates diverse cellular process…
View article: Metabolite phenotyping of kobusin and identification of glutathione conjugates with kobusin catechol metabolite
Metabolite phenotyping of kobusin and identification of glutathione conjugates with kobusin catechol metabolite Open
We aimed to investigate the metabolic pathways of kobusin, a tetrahydrofurofuran lignan with benzo[1,3]dioxole group, which exhibits antioxidant, anti-inflammatory, and anticancer activities. The metabolic profiles of kobusin, following in…
View article: Extracts from Allium pseudojaponicum Makino Target STAT3 Signaling Pathway to Overcome Cisplatin Resistance in Lung Cancer
Extracts from Allium pseudojaponicum Makino Target STAT3 Signaling Pathway to Overcome Cisplatin Resistance in Lung Cancer Open
Lung cancer, particularly non-small-cell lung cancer (NSCLC), remains a leading cause of cancer-related mortality, with cisplatin-based chemotherapy being a standard treatment. However, the development of chemoresistance significantly limi…
View article: LncRNA gm40262 promotes liver fibrosis and parasite growth through the gm40262-miR-193b-5p-TLR4/Col1α1 axis
LncRNA gm40262 promotes liver fibrosis and parasite growth through the gm40262-miR-193b-5p-TLR4/Col1α1 axis Open
Alveolar echinococcosis (AE) is a severe and life-threatening parasitic disease caused by Echinococcus multilocularis . Liver fibrosis is a significant pathological feature of advanced AE, characterized by the excessive production and accu…
View article: Loss of TC-PTP in keratinocytes leads to increased UVB-induced autophagy
Loss of TC-PTP in keratinocytes leads to increased UVB-induced autophagy Open
View article: An Investigation of the Ethical and Social Risks of Wearable Robots in the Construction Industry
An Investigation of the Ethical and Social Risks of Wearable Robots in the Construction Industry Open
View article: The Indispensability of Nutrition Education in Regimens to Address Substance Use Disorders
The Indispensability of Nutrition Education in Regimens to Address Substance Use Disorders Open
View article: Ferroptosis Induction Enhances Anti-PD-1 Efficacy in NSCLC via HIF-1α/PD-L1 Modulation
Ferroptosis Induction Enhances Anti-PD-1 Efficacy in NSCLC via HIF-1α/PD-L1 Modulation Open
View article: SPOP-mediated RIPK3 destabilization desensitizes LPS/sMAC/zVAD-induced necroptotic cell death
SPOP-mediated RIPK3 destabilization desensitizes LPS/sMAC/zVAD-induced necroptotic cell death Open
RIPK1/RIPK3-MLKL signaling molecules are fundamental in initiating necroptotic cell death, but their roles in the development of colon cancer are unclear. This study reports that RIPK3 interacted with SPOP, a component of the E3 ligase wit…
View article: RSK2-mediated cGAS phosphorylation induces cGAS chromatin-incorporation-mediated cell transformation and cancer cell colony growth
RSK2-mediated cGAS phosphorylation induces cGAS chromatin-incorporation-mediated cell transformation and cancer cell colony growth Open
Cyclic guanosine-adenosine monophosphate synthase (cGAS) is a key cytosolic DNA sensor that plays a pivotal role in the innate immune response. Although a decade of research on the cGAS has advanced our understanding of inflammasome format…
View article: Introducing Open Dialogue as part of the WHO QualityRights Project in South Korea: experiences and opinions from an introductory workshop and 1-year pilot practice
Introducing Open Dialogue as part of the WHO QualityRights Project in South Korea: experiences and opinions from an introductory workshop and 1-year pilot practice Open
This study explores the subjective experiences of participants in a 5-day Open Dialogue (OD) workshop and a 1-year pilot practice, conducted as part of the WHO QualityRights Project in South Korea. Twenty-four participants, selected throug…
View article: Hepatocyte-specific RIG-I loss attenuates metabolic dysfunction-associated steatotic liver disease in mice via changes in mitochondrial respiration and metabolite profiles
Hepatocyte-specific RIG-I loss attenuates metabolic dysfunction-associated steatotic liver disease in mice via changes in mitochondrial respiration and metabolite profiles Open
View article: RCHY1 and OPTN: an E3-ligase and an autophagy receptor required for melanophagy, respectively
RCHY1 and OPTN: an E3-ligase and an autophagy receptor required for melanophagy, respectively Open
Dysregulation of melanin homeostasis is implicated in causing skin pigmentation disorders, such as melasma due to hyperpigmentation and vitiligo due to hypopigmentation. Although the synthesis of melanin has been well studied, the removal …
View article: Ribosomal S6 kinase 2-forkhead box protein O4 signaling pathway plays an essential role in melanogenesis
Ribosomal S6 kinase 2-forkhead box protein O4 signaling pathway plays an essential role in melanogenesis Open
View article: ELK3 destabilization by speckle-type POZ protein suppresses prostate cancer progression and docetaxel resistance
ELK3 destabilization by speckle-type POZ protein suppresses prostate cancer progression and docetaxel resistance Open
View article: RCHY1 and OPTN are required for melanophagy, selective autophagy of melanosomes
RCHY1 and OPTN are required for melanophagy, selective autophagy of melanosomes Open
Melanosomes are specific organelles dedicated to melanin synthesis and accumulation in melanocytes. Autophagy is suggestively involved in melanosome degradation, although the potential underlying molecular mechanisms remain elusive. In sel…
View article: Beyond Nanoparticle‐Based Intracellular Drug Delivery: Cytosol/Organelle‐Targeted Drug Release and Therapeutic Synergism
Beyond Nanoparticle‐Based Intracellular Drug Delivery: Cytosol/Organelle‐Targeted Drug Release and Therapeutic Synergism Open
Nanoparticle (NP)‐based drug delivery systems are conceived to solve poor water‐solubility and chemical/physical instability, and their purpose expanded to target specific sites for maximizing therapeutic effects and minimizing unwanted ev…
View article: Dysregulated CREB3 cleavage at the nuclear membrane induces karyoptosis-mediated cell death
Dysregulated CREB3 cleavage at the nuclear membrane induces karyoptosis-mediated cell death Open
View article: Induction of Autophagy by Extract from Corydalis heterocarpa for Skin Anti-Aging
Induction of Autophagy by Extract from Corydalis heterocarpa for Skin Anti-Aging Open
The extracts of Corydalis heterocarpa, a salt-tolerant plant, exhibit diverse physiological properties, including anti-inflammatory, anticancer, and antiadipogenic effects. However, the anti-aging effects of C. heterocarpa extract (CHE) on…
View article: Beyond nanoparticle-based oral drug delivery: transporter-mediated absorption and disease targeting
Beyond nanoparticle-based oral drug delivery: transporter-mediated absorption and disease targeting Open
GI transporter/receptor-mediated nanosized drug delivery systems could improve oral absorption and further target organs or diseases for effective therapeutic outcomes.
View article: Cyclic GMP-AMP Synthase in Cancer Prevention
Cyclic GMP-AMP Synthase in Cancer Prevention Open
Cyclic GMP-AMP (cGAMP), synthesized by cGAMP synthase (cGAS), serves as a secondary messenger that modulates various cellular processes, including cell proliferation, cell death, immune response, and inflammation. cGAS is activated upon de…
View article: Informed consent process experience in Alzheimer’s Prevention Initiative (API) Autosomal Dominant Alzheimer’s Disease Colombia trial
Informed consent process experience in Alzheimer’s Prevention Initiative (API) Autosomal Dominant Alzheimer’s Disease Colombia trial Open
Background Recruiting cognitively‐unimpaired volunteers at high genetic risk of developing dementia into the Alzheimer’s Prevention Initiative (API) Colombia trial, and maintaining study adherence for at least 5 years has been a monumental…
View article: Molecular Mechanisms for the Regulation of Nuclear Membrane Integrity
Molecular Mechanisms for the Regulation of Nuclear Membrane Integrity Open
The nuclear membrane serves a critical role in protecting the contents of the nucleus and facilitating material and signal exchange between the nucleus and cytoplasm. While extensive research has been dedicated to topics such as nuclear me…
View article: Comparative metabolism of fargesin in human, dog, monkey, mouse, and rat hepatocytes
Comparative metabolism of fargesin in human, dog, monkey, mouse, and rat hepatocytes Open
View article: Beyond DNA sensing: expanding the role of cGAS/STING in immunity and diseases
Beyond DNA sensing: expanding the role of cGAS/STING in immunity and diseases Open
Cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) synthase (cGAS) is a DNA sensor that elicits a robust type I interferon response by recognizing ubiquitous danger-associated molecules. The cGAS/stimulator of interferon genes …
View article: Data from (3-Chloroacetyl)-indole, a Novel Allosteric AKT Inhibitor, Suppresses Colon Cancer Growth <i>In Vitro</i> and <i>In Vivo</i>
Data from (3-Chloroacetyl)-indole, a Novel Allosteric AKT Inhibitor, Suppresses Colon Cancer Growth <i>In Vitro</i> and <i>In Vivo</i> Open
Indole-3-carbinol (I3C) is produced in Brassica vegetables such as broccoli and cabbage and has been shown to inhibit proliferation and induce apoptosis in various cancer cells, including breast, prostate, colon, and leukemia. Howev…
View article: Data from (3-Chloroacetyl)-indole, a Novel Allosteric AKT Inhibitor, Suppresses Colon Cancer Growth <i>In Vitro</i> and <i>In Vivo</i>
Data from (3-Chloroacetyl)-indole, a Novel Allosteric AKT Inhibitor, Suppresses Colon Cancer Growth <i>In Vitro</i> and <i>In Vivo</i> Open
Indole-3-carbinol (I3C) is produced in Brassica vegetables such as broccoli and cabbage and has been shown to inhibit proliferation and induce apoptosis in various cancer cells, including breast, prostate, colon, and leukemia. Howev…
View article: Supplementary Table 1 from (3-Chloroacetyl)-indole, a Novel Allosteric AKT Inhibitor, Suppresses Colon Cancer Growth <i>In Vitro</i> and <i>In Vivo</i>
Supplementary Table 1 from (3-Chloroacetyl)-indole, a Novel Allosteric AKT Inhibitor, Suppresses Colon Cancer Growth <i>In Vitro</i> and <i>In Vivo</i> Open
Supplementary Table 1 from (3-Chloroacetyl)-indole, a Novel Allosteric AKT Inhibitor, Suppresses Colon Cancer Growth In Vitro and In Vivo