Yong-Peng Tan
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View article: IRE1α RNase activity is critical for early embryo development by degrading maternal transcripts
IRE1α RNase activity is critical for early embryo development by degrading maternal transcripts Open
During maternal-to-zygotic transition, oocytes and embryos undergo massive maternal mRNA degradation. Three key events are related to RNA degradation: oocyte meiotic resumption, fertilization, and zygotic genome activation (ZGA). In this s…
View article: The effects of inhibiting IRE1α on the viability of ovarian granulosa cells
The effects of inhibiting IRE1α on the viability of ovarian granulosa cells Open
IRE1α, a type I transmembrane protein characterized by a cytoplasmic serine/threonine kinase domain, is related to ER stress and ER function maintenance. In this study, 4µ8c, a highly effective selective inhibitor of IRE1α RNase, and APY29…
View article: The effects of inhibiting IRE1α on the proliferation of ovarian granulosa cells
The effects of inhibiting IRE1α on the proliferation of ovarian granulosa cells Open
IRE1α, a type I transmembrane protein characterized by a cytoplasmic serine/threonine kinase domain, is related to ER stress and ER function maintenance. In this study, 4µ8c, a highly effective selective inhibitor of IRE1α RNase, and APY29…
View article: P300 regulates histone crotonylation and preimplantation embryo development
P300 regulates histone crotonylation and preimplantation embryo development Open
Histone lysine crotonylation, an evolutionarily conserved modification differing from acetylation, exerts pivotal control over diverse biological processes. Among these are gene transcriptional regulation, spermatogenesis, and cell cycle p…
View article: Effect of spermidine on ameliorating spermatogenic disorders in diabetic mice via regulating glycolysis pathway
Effect of spermidine on ameliorating spermatogenic disorders in diabetic mice via regulating glycolysis pathway Open
View article: Effect of Spermidine on Ameliorating Spermatogenic Disorders in Diabetic Mice Via Regulating Glycolysis Pathway.
Effect of Spermidine on Ameliorating Spermatogenic Disorders in Diabetic Mice Via Regulating Glycolysis Pathway. Open
Diabetes mellitus (DM), a high incidence metabolic disease, is related to the impairment of male spermatogenic function. Spermidine (SPM), one of the biogenic amines, was identified from human seminal plasma and believed to have multiple p…