Yongan Meng
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View article: <i>PRRX1</i> Orchestrates Pericyte–Myofibroblast Transition in Pathological Retinal Fibrosis
<i>PRRX1</i> Orchestrates Pericyte–Myofibroblast Transition in Pathological Retinal Fibrosis Open
PRRX1 is a key regulator of pericyte-mediated fibrotic remodeling in the retina. Targeting PRRX1 offers a potential therapeutic approach for retinal fibrosis.
View article: PRRX1 drives pericyte–endothelial cell crosstalk in pathological retinal angiogenesis via regulation of the IGFBP7–JAK1–STAT3 axis
PRRX1 drives pericyte–endothelial cell crosstalk in pathological retinal angiogenesis via regulation of the IGFBP7–JAK1–STAT3 axis Open
Pathological angiogenesis is a hallmark of vision‑threatening retinal neovascular diseases, yet therapeutic options beyond anti-vascular endothelial growth factor treatments remain limited and often yield incomplete responses. This study i…
View article: Radiomics Analysis Based on Optical Coherence Tomography to Prognose the Efficacy of Anti-VEGF Therapy of Retinal Vein Occlusion-Related Macular Edema
Radiomics Analysis Based on Optical Coherence Tomography to Prognose the Efficacy of Anti-VEGF Therapy of Retinal Vein Occlusion-Related Macular Edema Open
The machine learning models based on OCT technology developed here demonstrated a promising ability to prognose anti-VEGF therapeutic responses for RVO-ME. The utilization of machine learning provides a new promising approach to assessing …
View article: Machine Learning and Optical-Coherence-Tomography-Derived Radiomics Analysis to Predict the Postoperative Anatomical Outcome of Full-Thickness Macular Hole
Machine Learning and Optical-Coherence-Tomography-Derived Radiomics Analysis to Predict the Postoperative Anatomical Outcome of Full-Thickness Macular Hole Open
Full-thickness macular hole (FTMH) leads to central vision loss. It is essential to identify patients with FTMH at high risk of postoperative failure accurately to achieve anatomical closure. This study aimed to construct a predictive mode…
View article: Machine learning and optical coherence tomography-derived radiomics analysis to predict persistent diabetic macular edema in patients undergoing anti-VEGF intravitreal therapy
Machine learning and optical coherence tomography-derived radiomics analysis to predict persistent diabetic macular edema in patients undergoing anti-VEGF intravitreal therapy Open
View article: Machine Learning and Optical Coherence Tomography-Derived Radiomics Analysis to Predict Persistent Diabetic Macular Edema in Patients Undergoing Anti-Vascular Endothelial Growth Factor Intravitreal Therapy
Machine Learning and Optical Coherence Tomography-Derived Radiomics Analysis to Predict Persistent Diabetic Macular Edema in Patients Undergoing Anti-Vascular Endothelial Growth Factor Intravitreal Therapy Open
View article: Proportion and risk factors of diabetic retinopathy by stage in less-developed rural areas of Hunan province of China: A multi-site cross-sectional study
Proportion and risk factors of diabetic retinopathy by stage in less-developed rural areas of Hunan province of China: A multi-site cross-sectional study Open
View article: Effect of High Myopia on Delayed Absorption of Subretinal Fluid after Scleral Buckling Surgery
Effect of High Myopia on Delayed Absorption of Subretinal Fluid after Scleral Buckling Surgery Open
This study compared the absorption of subretinal fluid (SRF) in patients with rhegmatogenous retinal detachment (RRD) with and without high myopia after scleral buckling (SB) and investigated the effect of high myopia on SRF absorption. Th…
View article: Exploring the Immune Infiltration Landscape and M2 Macrophage-Related Biomarkers of Proliferative Diabetic Retinopathy
Exploring the Immune Infiltration Landscape and M2 Macrophage-Related Biomarkers of Proliferative Diabetic Retinopathy Open
Backgrounds Diabetic retinopathy (DR), especially proliferative diabetic retinopathy (PDR), is the major cause of irreversible blindness in the working-age population. Increasing evidence indicates that immune cells and the inflammatory mi…
View article: Application of Improved U-Net Convolutional Neural Network for Automatic Quantification of the Foveal Avascular Zone in Diabetic Macular Ischemia
Application of Improved U-Net Convolutional Neural Network for Automatic Quantification of the Foveal Avascular Zone in Diabetic Macular Ischemia Open
Objectives.The foveal avascular zone (FAZ) is a biomarker for quantifying diabetic macular ischemia (DMI), to automate the identification and quantification of the FAZ in DMI, using an improved U-Net convolutional neural network (CNN) and …
View article: PRRX1 Is a Novel Prognostic Biomarker and Facilitates Tumor Progression Through Epithelial–Mesenchymal Transition in Uveal Melanoma
PRRX1 Is a Novel Prognostic Biomarker and Facilitates Tumor Progression Through Epithelial–Mesenchymal Transition in Uveal Melanoma Open
Uveal melanoma (UM) is the most common primary intraocular malignancy in adults. UM develops and is sustained by inflammation and immunosuppression from the tumor microenvironment (TME). This study sought to identify a reliable TME-related…
View article: Microvascular Structure Changes After Intravitreal Ranibizumab Injection in Retinal Vein Occlusion Patients With and Without Macular Ischemia
Microvascular Structure Changes After Intravitreal Ranibizumab Injection in Retinal Vein Occlusion Patients With and Without Macular Ischemia Open
Purpose: To investigate the changes in the macular microvascular structure after anti-vascular endothelial growth factor (anti-VEGF) treatment in retinal vein occlusion (RVO) patients with and without macular ischemia. Methods: A total of …
View article: Effect of anti-VEGF treatment on nonperfusion areas in ischemic retinopathy
Effect of anti-VEGF treatment on nonperfusion areas in ischemic retinopathy Open
In recent years, retinal ischemia such as that which occurs in diabetic retinopathy (DR) and retinal vein occlusion (RVO) has become a hotspot of ischemic retinopathy research. High levels of vascular endothelial growth factor (VEGF) are r…
View article: Comparison of Inflammatory and Angiogenic Factors in the Aqueous Humor of Vitrectomized and Non-Vitrectomized Eyes in Diabetic Macular Edema Patients
Comparison of Inflammatory and Angiogenic Factors in the Aqueous Humor of Vitrectomized and Non-Vitrectomized Eyes in Diabetic Macular Edema Patients Open
Objectives: To compare the aqueous concentrations of inflammatory and angiogenetic factors in vitrectomized vs. non-vitrectomized eyes with diabetic macular edema (DME). Methods: Aqueous samples were obtained from 107 eyes with DME before …
View article: Multifactor analysis of delayed absorption of subretinal fluid after scleral buckling surgery
Multifactor analysis of delayed absorption of subretinal fluid after scleral buckling surgery Open
View article: The interplay of circulating tumor DNA and chromatin modification, therapeutic resistance, and metastasis
The interplay of circulating tumor DNA and chromatin modification, therapeutic resistance, and metastasis Open
Peripheral circulating free DNA (cfDNA) is DNA that is detected in plasma or serum fluid with a cell-free status. For cancer patients, cfDNA not only originates from apoptotic cells but also from necrotic tumor cells and disseminated tumor…