Yongan Wang
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View article: Inhibiting the Interaction Between Phospholipase A2 and Phospholipid Serine as a Potential Therapeutic Method for Pneumonia
Inhibiting the Interaction Between Phospholipase A2 and Phospholipid Serine as a Potential Therapeutic Method for Pneumonia Open
Pneumonia is a severe lower respiratory tract infection. This study demonstrates that phospholipase A2 (PLA2), a potential biomarker for pneumonia, contributes to alveoli damage by hydrolyzing pulmonary surfactant phospholipids. This proce…
View article: Liposome-Based Silibinin for Mitigating Nonalcoholic Fatty Liver Disease: Dual Effects via Parenteral and Intestinal Routes
Liposome-Based Silibinin for Mitigating Nonalcoholic Fatty Liver Disease: Dual Effects via Parenteral and Intestinal Routes Open
Nonalcoholic fatty liver disease (NAFLD) is a clinicopathological entity that is typically characterized by intrahepatic ectopic steatosis. Nowadays, NAFLD has surpassed viral hepatitis and become the most common chronic liver disease worl…
View article: Noninvasive prenatal screening with conventional sequencing depth to screen fetal copy number variants: A retrospective study of 19 144 pregnant women
Noninvasive prenatal screening with conventional sequencing depth to screen fetal copy number variants: A retrospective study of 19 144 pregnant women Open
Aim To investigate the detectability of noninvasive prenatal screening (NIPS) with conventional sequencing depth to detect fetal copy number variants. Methods We performed a retrospective study in a total of 19 144 pregnant women. Their ce…
View article: Negatively charged phospholipids doped liposome delivery system for mRNA with high transfection efficiency and low cytotoxicity
Negatively charged phospholipids doped liposome delivery system for mRNA with high transfection efficiency and low cytotoxicity Open
Messenger RNA (mRNA) has become one of the most potential drugs in recent years. However, efficient and safe delivery of fragile and easily degradable mRNA is a major challenge. Appropriate delivery system (DS) determines the final effect …
View article: Activated Carbon nanoparticles Loaded with Metformin for Effective Against Hepatocellular Cancer Stem Cells
Activated Carbon nanoparticles Loaded with Metformin for Effective Against Hepatocellular Cancer Stem Cells Open
These results not only suggest that nanodrug delivery system increased the effects of MET, but also shed light on the mechanisms of the therapeutic effects of MET and ACNP-MET on hepatocellular cancers. ACNP, as a good nano-carrier, could …
View article: Risk assessment based on dose-responsive and time-responsive genes to build PLS-DA models for exogenously induced lung injury
Risk assessment based on dose-responsive and time-responsive genes to build PLS-DA models for exogenously induced lung injury Open
Xenobiotics can easily harm human lungs owing to the openness of the respiratory system. Identifying pulmonary toxicity remains challenging owing to several reasons: 1) no biomarkers for pulmonary toxicity are available that might help to …
View article: HI-6-loaded PEGylated liposomes: an on-site first-aid strategy for acute organophosphorus agent poisoning
HI-6-loaded PEGylated liposomes: an on-site first-aid strategy for acute organophosphorus agent poisoning Open
Organophosphorus agents, also known as nerve agents, are very dangerous chemicals that were used as chemical warfare agents. HI-6 is one of the most promising reactivators which is effective in reactivating AChE inhibited by many nerve age…
View article: Cation-Exchangeable Pralidoxime Chloride@bio-MOF-1 as a Treatment for Nerve Agent Poisoning and Sulfur Mustard Skin Poisoning in Animals
Cation-Exchangeable Pralidoxime Chloride@bio-MOF-1 as a Treatment for Nerve Agent Poisoning and Sulfur Mustard Skin Poisoning in Animals Open
A 2-PAM@bio-MOF-1 composite was prepared by cationic exchange of counter N,N-dimethylammonium cations in the pores of the anionic, biocompatible metal-organic framework (bio-MOF-1) with pralidoxime chloride (2-PAM-Cl) by impregnation. In v…
View article: Downregulation of CDK5 Signaling In the Dorsal Striatum Alters Striatal Microcircuits and Perturbs Circadian Behavior in Mice
Downregulation of CDK5 Signaling In the Dorsal Striatum Alters Striatal Microcircuits and Perturbs Circadian Behavior in Mice Open
Dysfunction of striatal dopaminergic circuits has been implicated in motor impairment as well as in Parkinson’s disease (PD)-related circadian perturbations that may represent an early prodromal marker of PD. Cyclin-dependent kinase 5 (CDK…
View article: An In Vitro Nerve Agent Brain Poisoning Transwell Model for Convenient and Accurate Antidote and Nanomedicine Evaluation
An In Vitro Nerve Agent Brain Poisoning Transwell Model for Convenient and Accurate Antidote and Nanomedicine Evaluation Open
Background: Nerve agents (NAs) can irreversibly inhibit acetylcholinesterase (AChE). An effective NA antidote should permeate the blood–brain barrier (BBB) to reactivate the inhibited AChE in brain. There is an urgent requirement for the l…
View article: Involvement of Cyclin Dependent Kinase 5 in M4 Muscarinic Acetylcholine Receptor-Mediated Cholinergic Transmission within the Mouse Dorsal Striatum
Involvement of Cyclin Dependent Kinase 5 in M4 Muscarinic Acetylcholine Receptor-Mediated Cholinergic Transmission within the Mouse Dorsal Striatum Open
Background: An imbalance between dopamine (DA) and acetylcholine (ACh) within the striatum has reemerged as key to the pathophysiology of the neurodegenerative disorder, Parkinson's disease (PD). M 4 is a prominent muscarinic ACh receptor …
View article: Dysfunction of EAAT3 enhances LPS-induced Postoperative Cognitive Dysfunction
Dysfunction of EAAT3 enhances LPS-induced Postoperative Cognitive Dysfunction Open
Background Studies have shown that excitatory amino acid transporter 3 (EAAT3) function inhibition is related to several neurodegenerative diseases. Our previous studies also found that the EAAT3 function is intimately linked to learning a…
View article: Dysfunction of EAAT3 Enhances LPS-induced Postoperative Cognitive Dysfunction
Dysfunction of EAAT3 Enhances LPS-induced Postoperative Cognitive Dysfunction Open
Background: Studies have shown that excitatory amino acid transporter 3 (EAAT3) function inhibition is related to several neurodegenerative diseases. Our previous studies also found that the EAAT3 function is intimately linked to learning …
View article: Dysfunction of EAAT3 Enhances LPS-induced Postoperative Cognitive Dysfunction
Dysfunction of EAAT3 Enhances LPS-induced Postoperative Cognitive Dysfunction Open
Background: Studies have shown that excitatory amino acid transporter 3 (EAAT3) function inhibition is related to several neurodegenerative diseases. Our previous studies also found that the EAAT3 function is intimately linked to learning …
View article: Dysfunction of EAAT3 Enhances LPS-Induced Postoperative Cognitive Dysfunction
Dysfunction of EAAT3 Enhances LPS-Induced Postoperative Cognitive Dysfunction Open
Background: Studies have shown that excitatory amino acid transporter 3 (EAAT3) function inhibition is related to several neurodegenerative diseases. Our previous studies also found that the EAAT3 function is intimately linked to learning …
View article: Synergistic enhancement of the emergency treatment effect of organophosphate poisoning by a supramolecular strategy
Synergistic enhancement of the emergency treatment effect of organophosphate poisoning by a supramolecular strategy Open
This work provides a feasible supramolecular strategy for improving the emergency treatment effect of OPs poisoning through synergistic effect.
View article: <p>Consumption of Lamb Meat or Basa Fish Shapes the Gut Microbiota and Aggravates Pulmonary Inflammation in Asthmatic Mice</p>
Consumption of Lamb Meat or Basa Fish Shapes the Gut Microbiota and Aggravates Pulmonary Inflammation in Asthmatic Mice Open
Collectively, long-term intake of lamb or fish shapes colonic bacterial communities and aggravates pulmonary inflammation in asthmatic mice, which provides reasonable food guidance for asthmatic patients.
View article: “Oil-soluble” Reversed Lipid Nanoparticles for Oral Insulin Delivery
“Oil-soluble” Reversed Lipid Nanoparticles for Oral Insulin Delivery Open
Background: In this study, we aimed to design a novel oral insulin delivery system, named “oil-soluble” reversed lipid nanoparticles (ORLN), in which a hydrophilic insulin molecule is encapsulated by a phospholipid (PC) shell and dissolved…
View article: Gua Sha attenuates the pulmonary inflammation in mice infected with PR8 virus by balancing the ratio of Treg/Th17
Gua Sha attenuates the pulmonary inflammation in mice infected with PR8 virus by balancing the ratio of Treg/Th17 Open
Background: Gua Sha, an ancient Chinese treatment which produces the pressure on the skin, is used to prevent and treat cold for thousands of years. There’re evidences to approve that it can activate immune response and reduce the inflamma…
View article: Taste masking of water-soluble drug by solid lipid microspheres: a child-friendly system established by reversed lipid-based nanoparticle technique
Taste masking of water-soluble drug by solid lipid microspheres: a child-friendly system established by reversed lipid-based nanoparticle technique Open
Objectives A child-friendly taste-masking strategy using solid lipid microsphere (SLM) has been proposed to obscure the undesirable taste of some water-soluble drugs. In this study, the reversed lipid-based nanoparticle (RLBN) technique wa…
View article: Why is glycocholic acid sodium salt better than deoxycholic acid sodium salt for the preparation of mixed micelle injections?
Why is glycocholic acid sodium salt better than deoxycholic acid sodium salt for the preparation of mixed micelle injections? Open
Classical mixed micelle systems make excellent parenteral drug carriers for lipophilic or poorly soluble drugs, but many formulations details are not fully understood and need further study. Thus, we constructed mixed micelle systems with …