Yongbing Chen
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View article: MISP promotes the progression of lung adenocarcinoma through Inhibition of the Hippo signaling pathway
MISP promotes the progression of lung adenocarcinoma through Inhibition of the Hippo signaling pathway Open
View article: Multi-center benchmarking of large language models for clinical decision support in lung cancer screening
Multi-center benchmarking of large language models for clinical decision support in lung cancer screening Open
Large language models (LLMs) are increasingly explored for clinical applications, but their ability to generate management recommendations for lung cancer screening remains uncertain. In this cross-sectional, multi-center study, 148 anonym…
View article: Characterization of tertiary lymphoid structure identifies competitive binding of CD40 and STING with TRAF2 driving IRF4-mediated B cell activation in esophageal squamous cell carcinoma
Characterization of tertiary lymphoid structure identifies competitive binding of CD40 and STING with TRAF2 driving IRF4-mediated B cell activation in esophageal squamous cell carcinoma Open
Esophageal squamous cell carcinoma (ESCC) is a highly aggressive malignancy with a dismal prognosis. Hitherto, little has been known regarding the clinical implications of tertiary lymphoid structures (TLS) and its biological mechanisms of…
View article: Exploration of multi-omics liquid biopsy approaches for multi-cancer early detection: The PROMISE study
Exploration of multi-omics liquid biopsy approaches for multi-cancer early detection: The PROMISE study Open
View article: Which descriptor should spread through air spaces (<scp>STAS</scp>) be incorporated into? T descriptor versus residual tumor classification
Which descriptor should spread through air spaces (<span>STAS</span>) be incorporated into? T descriptor versus residual tumor classification Open
It has not been determined which descriptor spread through air spaces (STAS) should be incorporated into the context of the ninth Tumor, Node and Metastasis (TNM) staging system: the T or the uncertain resection [R(un)] category. A multice…
View article: Genomic and Immune Profiling of Esophageal Squamous Cell Carcinoma Undergoing Neoadjuvant Therapy Versus Upfront Surgery Identifies Novel Immunogenic Cell Death‐Based Signatures for Predicting Clinical Outcomes
Genomic and Immune Profiling of Esophageal Squamous Cell Carcinoma Undergoing Neoadjuvant Therapy Versus Upfront Surgery Identifies Novel Immunogenic Cell Death‐Based Signatures for Predicting Clinical Outcomes Open
It remains undetermined regarding the impact of neoadjuvant therapy on immunogenic cell death (ICD) and subsequent tumor microenvironment (TME) remodeling in esophageal squamous cell carcinoma (ESCC). And it is of paramount significance to…
View article: A Novel Definition and Grading Diagnostic Criteria for Tumour‐Type‐Specific Comprehensive Cachexia Risk
A Novel Definition and Grading Diagnostic Criteria for Tumour‐Type‐Specific Comprehensive Cachexia Risk Open
Background The existing diagnostic criteria for cancer cachexia do not meet clinical needs. We aimed to establish novel comprehensive evaluation scales for cachexia specific to patients with solid tumours. Methods This study included 12 65…
View article: Enhancing Generalization in Chain of Thought Reasoning for Smaller Models
Enhancing Generalization in Chain of Thought Reasoning for Smaller Models Open
Chain-of-Thought (CoT) reasoning in smaller language models is a challenging natural language process problem yet highly desirable in many real-life applications. Existing CoT knowledge distillation methods often suffer from overly conserv…
View article: Highly Sensitive Detection of Epithelial Markers on Single Tumor Cell Surface by an Endonuclease-assisted Assay on Superwettable Droplet Microarrays (EASDM)
Highly Sensitive Detection of Epithelial Markers on Single Tumor Cell Surface by an Endonuclease-assisted Assay on Superwettable Droplet Microarrays (EASDM) Open
View article: Effect of High‐Flow Nasal Cannula Oxygen Therapy on Hypoxemia in Patients After Esophagectomy
Effect of High‐Flow Nasal Cannula Oxygen Therapy on Hypoxemia in Patients After Esophagectomy Open
Background: Patients with esophageal cancer (EC) who have undergone esophagectomy are at risk of developing hypoxemia and encountering postoperative complications. It is essential to ascertain whether the high‐flow nasal cannula (HFNC) the…
View article: A study on three commonly used GNSS integer estimators with probability of correct estimation
A study on three commonly used GNSS integer estimators with probability of correct estimation Open
View article: Hybrid Geomagnetic Data Forecasting Model Using Wavelet Packet Decomposition and Deep Neural Networks
Hybrid Geomagnetic Data Forecasting Model Using Wavelet Packet Decomposition and Deep Neural Networks Open
Accurate and reliable prediction of geomagnetic data is essential for its management and application. To improve the accuracy of geomagnetic data prediction and overcome the limitations of traditional machine learning algorithms in network…
View article: Does neoadjuvant therapy contribute to increased risk in anastomotic leakage of esophageal cancer? A network meta‐analysis
Does neoadjuvant therapy contribute to increased risk in anastomotic leakage of esophageal cancer? A network meta‐analysis Open
Aim Conflicting results have been reported about the impact of neoadjuvant therapy on anastomotic leakage (AL) after esophagectomy. We aimed to unravel the potential effect of neoadjuvant therapy on AL after esophagectomy through a network…
View article: CXCL5 impedes CD8+ T cell immunity by upregulating PD-L1 expression in lung cancer via PXN/AKT signaling phosphorylation and neutrophil chemotaxis
CXCL5 impedes CD8+ T cell immunity by upregulating PD-L1 expression in lung cancer via PXN/AKT signaling phosphorylation and neutrophil chemotaxis Open
View article: A Compensation Method for the Geomagnetic Measurement Error of an Underwater Ship-Borne Magnetometer Based on Constrained Total Least Squares
A Compensation Method for the Geomagnetic Measurement Error of an Underwater Ship-Borne Magnetometer Based on Constrained Total Least Squares Open
When magnetic matching aided navigation is applied to an underwater vehicle, the magnetometer must be installed inside the vehicle, considering the navigation safety and concealment of the underwater vehicle. Then, the interference magneti…
View article: New Methods of Series Expansions between Three Anomalies
New Methods of Series Expansions between Three Anomalies Open
The calculation of satellite orbit involves some very complex formula derivations and expansions, which are very difficult to manually derive and prone to errors. And the efficiency of manual derivation is not high. We can use computer alg…
View article: Fine-grained ship image classification and detection based on a vision transformer and multi-grain feature vector FPN model
Fine-grained ship image classification and detection based on a vision transformer and multi-grain feature vector FPN model Open
In naval and civilian domains, meticulous ship classification and detection are paramount. Nevertheless, predominant research has gravitated toward leveraging Convolutional Neural Network (CNN)-centered methodologies, often overlooking the…
View article: Inhaled immunoantimicrobials for the treatment of chronic obstructive pulmonary disease
Inhaled immunoantimicrobials for the treatment of chronic obstructive pulmonary disease Open
Effective therapeutic modalities and drug administration strategies for the treatment of chronic obstructive pulmonary disease (COPD) exacerbations are lacking. Here, mucus and biofilm dual-penetrating immunoantimicrobials (IMAMs) are deve…
View article: Temporal control in shell–core structured nanofilm for tracheal cartilage regeneration: synergistic optimization of anti-inflammation and chondrogenesis
Temporal control in shell–core structured nanofilm for tracheal cartilage regeneration: synergistic optimization of anti-inflammation and chondrogenesis Open
Cartilage tissue engineering offers hope for tracheal cartilage defect repair. Establishing an anti-inflammatory microenvironment stands as a prerequisite for successful tracheal cartilage restoration, especially in immunocompetent animals…
View article: Single-Cell Transcriptomic Landscape of Lung Adenocarcinoma with Spread Through Air Spaces
Single-Cell Transcriptomic Landscape of Lung Adenocarcinoma with Spread Through Air Spaces Open
View article: <scp>GIMAP7</scp> inhibits epithelial‐mesenchymal transition and glycolysis in lung adenocarcinoma cells via regulating the Smo/<scp>AMPK</scp> signaling pathway
<span>GIMAP7</span> inhibits epithelial‐mesenchymal transition and glycolysis in lung adenocarcinoma cells via regulating the Smo/<span>AMPK</span> signaling pathway Open
Background GTPase immunity‐associated protein 7 (GIMAP7) has been previously recognized as a prognostic marker in pan‐cancer. Our objective was to explore the function of GIMAP7 in the progression of lung adenocarcinoma (LUAD). Methods GIM…
View article: Impact of CT-guided hookwire localization on tumor spread through air spaces in stage IA lung adenocarcinoma
Impact of CT-guided hookwire localization on tumor spread through air spaces in stage IA lung adenocarcinoma Open
View article: Identification of epithelial-mesenchymal transition-related biomarkers in lung adenocarcinoma using bioinformatics and lab experiments
Identification of epithelial-mesenchymal transition-related biomarkers in lung adenocarcinoma using bioinformatics and lab experiments Open
This study developed a novel EMT-related gene signature benefiting precision medicine, and identified four pivotal genes which can serve as therapeutic targets in LUAD. Four key genes can serve as molecular targets for patients with LUAD; …
View article: THPLM: a sequence-based deep learning framework for protein stability changes prediction upon point variations using pretrained protein language model
THPLM: a sequence-based deep learning framework for protein stability changes prediction upon point variations using pretrained protein language model Open
Motivation Quantitative determination of protein thermodynamic stability is a critical step in protein and drug design. Reliable prediction of protein stability changes caused by point variations contributes to developing-related fields. O…
View article: Relationship between Composite Dietary Antioxidant Index and Aging
Relationship between Composite Dietary Antioxidant Index and Aging Open
Background: Numerous studies have demonstrated a close relationship between antioxidant-rich diets and comorbidities as well as mortality. However, the relationship between such diets and aging remains unclear. The purpose of this study wa…
View article: Engineering Nucleotidoproteins for Base‐Pairing‐Assisted Cytosolic Delivery and Genome Editing
Engineering Nucleotidoproteins for Base‐Pairing‐Assisted Cytosolic Delivery and Genome Editing Open
Protein therapeutics targeting intracellular machineries hold profound potential for disease treatment, and hence robust cytosolic protein delivery technologies are imperatively demanded. Inspired by the super‐negatively charged, nucleotid…
View article: Pan-mediastinal neoplasm diagnosis via nationwide federated learning: a multicentre cohort study
Pan-mediastinal neoplasm diagnosis via nationwide federated learning: a multicentre cohort study Open
National Key R&D Program of China, National Natural Science Foundation of China, and Beijing Natural Science Foundation.
View article: Characterization of <scp>TCF</scp>‐1 and its relationship between <scp>CD8</scp>+ <scp>TIL</scp> densities and immune checkpoints and their joint influences on prognoses of lung adenocarcinoma patients
Characterization of <span>TCF</span>‐1 and its relationship between <span>CD8</span>+ <span>TIL</span> densities and immune checkpoints and their joint influences on prognoses of lung adenocarcinoma patients Open
Background T cell factor‐1 (TCF‐1) + stem‐like tumor‐infiltrating lymphocytes (stem‐like TILs) are important memory cells in the tumor microenvironment. However, their relationship with clinicopathological features, CD8+ TIL densities, imm…
View article: In Situ Formed, Peritoneum‐Adhesive Immunogels Synergizing Low‐Dose Fractionated Radiotherapy Against Colorectal Peritoneal Carcinomatosis
In Situ Formed, Peritoneum‐Adhesive Immunogels Synergizing Low‐Dose Fractionated Radiotherapy Against Colorectal Peritoneal Carcinomatosis Open
Immune checkpoint blockade (ICB) therapy holds great potentials for the treatment of colorectal peritoneal carcinomatosis (CRPC). However, its efficacy is often suboptimal due to the low immunogenic tumor phenotype, immunosuppressive tumor…
View article: Clinical implications and molecular features of tertiary lymphoid structures in stage I lung adenocarcinoma
Clinical implications and molecular features of tertiary lymphoid structures in stage I lung adenocarcinoma Open
Aims We investigated the clinical implications and molecular features of TLS in stage I lung adenocarcinoma (LUAD). Methods We retrospectively reviewed the clinicopathological characteristics of 540 patients with p ‐stage I LUAD. Logistic …