Yongbing Qian
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View article: Characterization and functional analysis of extrachromosomal circular DNA discovered from circulating extracellular vesicles in liver failure
Characterization and functional analysis of extrachromosomal circular DNA discovered from circulating extracellular vesicles in liver failure Open
View article: Long-term outcomes and risk factors for early bacterial infection after pediatric liver transplantation: a prospective cohort study
Long-term outcomes and risk factors for early bacterial infection after pediatric liver transplantation: a prospective cohort study Open
Background: Liver transplantation (LT) is the most efficient treatment for pediatric patients with end-stage liver diseases, while bacterial infection is the leading reason for post-transplant mortality. The present study is to explore the…
View article: Fatty acid oxidation-induced HIF-1α activation facilitates hepatic urate synthesis through upregulating NT5C2 and XDH
Fatty acid oxidation-induced HIF-1α activation facilitates hepatic urate synthesis through upregulating NT5C2 and XDH Open
Dyslipidemia affects approximately half of all people with gout, and prior Mendelian randomization analysis suggested a causal role for elevated triglycerides in hyperuricemia (HU), but the underlying mechanisms remain elusive. We hypothes…
View article: Early utilization of ruxolitinib in acute graft-versus-host disease after liver transplant
Early utilization of ruxolitinib in acute graft-versus-host disease after liver transplant Open
View article: Impact of pre-existing depression on severe COVID-19 outcomes
Impact of pre-existing depression on severe COVID-19 outcomes Open
The outbreak of the COVID-19 virus in 2019 had rapidly developed into a global pandemic, causing more than 6.8 million deaths and impacting the lives of billions of individuals around the world.1 Public healthcare around the work have main…
View article: WITHDRAWN: Identification and functional analysis of extrachromosomal circular DNA in plasma extracellular vesicles of liver failure patients
WITHDRAWN: Identification and functional analysis of extrachromosomal circular DNA in plasma extracellular vesicles of liver failure patients Open
Withdrawal statement The authors have withdrawn their manuscript owing to having identified certain issues with the current representation of the data in the manuscript after performing further analyses of the bioinformatics data from thei…
View article: Liver-derived extracellular vesicles from patients with hepatitis B virus-related acute-on-chronic liver failure impair hepatic regeneration by inhibiting on FGFR2 signaling via miR-218-5p
Liver-derived extracellular vesicles from patients with hepatitis B virus-related acute-on-chronic liver failure impair hepatic regeneration by inhibiting on FGFR2 signaling via miR-218-5p Open
Background: Impaired liver regeneration in hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) patients is closely related to prognosis, whereas the mechanisms are not yet defined. Liver-derived extracellular vesicles (EVs)…
View article: Decreasing Burden of Acute Viral Hepatitis Among Children and Adolescents: Findings from the Global Burden of Disease Study 2019
Decreasing Burden of Acute Viral Hepatitis Among Children and Adolescents: Findings from the Global Burden of Disease Study 2019 Open
View article: Investigation on the hesitancy of COVID-19 vaccination among liver transplant recipients: A cross-sectional study in China
Investigation on the hesitancy of COVID-19 vaccination among liver transplant recipients: A cross-sectional study in China Open
Objectives The hospitalization and mortality rate from COVID-19 appears to be higher in liver transplant recipients when compared with general populations. Vaccination is an effective strategy to reduce the risk during the COVID-19 pandemi…
View article: HTLV-1 infection of donor-derived T cells might promote acute graft-versus-host disease following liver transplantation
HTLV-1 infection of donor-derived T cells might promote acute graft-versus-host disease following liver transplantation Open
View article: Ruxolitinib as Adjunctive Therapy for Hemophagocytic LymPhohistiocytosis after Liver Transplantation: A Case Report and Literature Review
Ruxolitinib as Adjunctive Therapy for Hemophagocytic LymPhohistiocytosis after Liver Transplantation: A Case Report and Literature Review Open
Hemophagocytic lymphohistiocytosis (HLH) is a rare but potentially fatal hyperinflammatory disorder characterized by dysfunctional cytotoxic T and natural killer cells. Liver transplantation is a predisposing factor for HLH. High mortality…
View article: Transcriptome Sequencing Unveils Immune Heterogeneity between Systemic Immune Response and the Liver Immune Microenvironment along HBV-ACLF Development
Transcriptome Sequencing Unveils Immune Heterogeneity between Systemic Immune Response and the Liver Immune Microenvironment along HBV-ACLF Development Open
Background The COSSH-ACLF criteria provides a grading system feasible for Chinese ACLF population featured with HBV infection background. However, insufficient mechanical foundation is available for the grading system. In the present study…
View article: Renal histopathological lesions after liver transplantation: What can we find besides calcineurin inhibitor-induced nephrotoxicity?
Renal histopathological lesions after liver transplantation: What can we find besides calcineurin inhibitor-induced nephrotoxicity? Open
View article: Ceftazidime-Avibactam as Salvage Treatment for Infections Due to Carbapenem-Resistant Klebsiella pneumoniae in Liver Transplantation Recipients
Ceftazidime-Avibactam as Salvage Treatment for Infections Due to Carbapenem-Resistant Klebsiella pneumoniae in Liver Transplantation Recipients Open
CZA shows promising results, even in monotherapy, for the treatment of patients with severe infections due to carbapenem-resistant K. pneumoniae among LT recipients. The emergence of resistance to CZA was not observed.
View article: Next generation sequencing for diagnosis of central nervous system aspergillosis in liver transplant recipients
Next generation sequencing for diagnosis of central nervous system aspergillosis in liver transplant recipients Open
This is the first study to highlight the utility of NGS in early diagnosis of CNS aspergillosis in LT recipients. This new tool may be helpful in improving the diagnosis of CNS aspergillosis.
View article: High mortality associated with gram-negative bacterial bloodstream infection in liver transplant recipients undergoing immunosuppression reduction
High mortality associated with gram-negative bacterial bloodstream infection in liver transplant recipients undergoing immunosuppression reduction Open
BACKGROUND: Immunosuppression is an important factor in the incidence of infections in transplant recipient. Few studies are available on the management of immunosuppression (IS) treatment in the liver transplant (LT) recipients complicate…
View article: MELD Score Reflects the Mood, Sleep, and Daily Living Ability in Liver Transplantation Candidates: A Descriptive Study
MELD Score Reflects the Mood, Sleep, and Daily Living Ability in Liver Transplantation Candidates: A Descriptive Study Open
BACKGROUND This study aimed to assess the psychosocial status (mood, sleep quality, and activities of daily living) of candidates on an orthotopic liver transplantation (OLT) waiting list and to identify the association between psychosocia…
View article: Co-encapsulation of HNF4α overexpressing UMSCs and human primary hepatocytes ameliorates mouse acute liver failure
Co-encapsulation of HNF4α overexpressing UMSCs and human primary hepatocytes ameliorates mouse acute liver failure Open
View article: Co-encapsulation of HNF4α Overexpressing UMSCs and Human Primary Hepatocytes Ameliorates Mouse Acute Liver Failure
Co-encapsulation of HNF4α Overexpressing UMSCs and Human Primary Hepatocytes Ameliorates Mouse Acute Liver Failure Open
Background: Acute liver failure (ALF) is a complicated condition that is characterized by global hepatocyte death and often requires immediate liver transplantation. However, this therapy is limited by shortage of donor organs. Mesenchymal…
View article: Co-encapsulation of HNF4α Overexpressing UMSCs and Human Primary Hepatocytes Ameliorates Mouse Acute Liver Failure
Co-encapsulation of HNF4α Overexpressing UMSCs and Human Primary Hepatocytes Ameliorates Mouse Acute Liver Failure Open
Background: Acute liver failure (ALF) is a complicated condition that is characterized by global hepatocyte death and often requires immediate liver transplantation. However, this therapy is limited by shortage of donor organs. Mesenchymal…
View article: Co-encapsulation of HNF4α Overexpressing UMSCs and Human Primary Hepatocytes Ameliorates Mouse Acute Liver Failure
Co-encapsulation of HNF4α Overexpressing UMSCs and Human Primary Hepatocytes Ameliorates Mouse Acute Liver Failure Open
Background: Acute liver failure (ALF) is a complicated condition that is characterized by global hepatocyte death and often requires immediate liver transplantation. However, this therapy is limited by shortage of donor organs. Mesenchymal…
View article: Post-transplant infection improves outcome of hepatocellular carcinoma patients after orthotopic liver transplantation
Post-transplant infection improves outcome of hepatocellular carcinoma patients after orthotopic liver transplantation Open
PTI improves OS and RFS of the transplant HCC patients at a high risk for post-transplant death and tumor recurrence, which is attributed to suppressive effect of PTI on HCC recurrence.
View article: Deletion of C-C Motif Chemokine Ligand 5 Worsens Invariant Natural Killer T-Cell–Mediated Hepatitis via Compensatory Up-regulation of CXCR2–Related Chemokine Activity
Deletion of C-C Motif Chemokine Ligand 5 Worsens Invariant Natural Killer T-Cell–Mediated Hepatitis via Compensatory Up-regulation of CXCR2–Related Chemokine Activity Open
View article: Hypoxia-inducible factor-1α regulates epithelial-to-mesenchymal transition in paraquat-induced pulmonary fibrosis by activating lysyl oxidase
Hypoxia-inducible factor-1α regulates epithelial-to-mesenchymal transition in paraquat-induced pulmonary fibrosis by activating lysyl oxidase Open
Pulmonary fibrosis (PF) is one of the most prevalent causes of death following paraquat (PQ) poisoning. As demonstrated in previous studies by the present authors, epithelial-to-mesenchymal transition (EMT) is associated with PQ-induced PF…
View article: Effect of Platelet-derived P-selectin on Neutrophil Recruitment in a Mouse Model of Sepsis-induced Acute Kidney Injury
Effect of Platelet-derived P-selectin on Neutrophil Recruitment in a Mouse Model of Sepsis-induced Acute Kidney Injury Open
Platelets-derived P-selectin may be involved in the development of septic AKI through inducing neutrophil infiltration into kidney.
View article: TLR4-Upregulated IL-1β and IL-1RI Promote Alveolar Macrophage Pyroptosis and Lung Inflammation through an Autocrine Mechanism
TLR4-Upregulated IL-1β and IL-1RI Promote Alveolar Macrophage Pyroptosis and Lung Inflammation through an Autocrine Mechanism Open
Acute lung injury (ALI) is a major component of multiple organ dysfunction syndrome (MODS) following pulmonary infection. Alveolar macrophages (AM) are at the center of the pathogenesis of the development of ALI. Interleukin-1β (IL-1β) is …
View article: Effects of different doses of dexmedetomidine on heart rate and blood pressure in intensive care unit patients
Effects of different doses of dexmedetomidine on heart rate and blood pressure in intensive care unit patients Open
The aim of the present study was to observe and compare the sedative effect of different doses of DEX on heart rate (HR) and blood pressure (BP) in critically ill patients admitted to intensive care units (ICUs). The study included patient…