Explanipedia

Corrigendum to “RNA and protein degradation in the aging process” [Cellular Signalling 136 (2025) 112166] Open

J X Lin, Yongchang Qiu, Zhi Zeng, Bo Yao, Limin Zhao · 2025

RNA and protein degradation in the aging process Open

J X Lin, Yongchang Qiu, Chun Ye, Yuhan Zhang, Zhi Zeng , et al. · 2025

Aging involves a profound reorganization of metabolic processes, marked by a progressive decline in anabolic activity and a compensatory increase in catabolic flux. This imbalance drives cellular dysfunction and contributes to age-related …

Corrigendum: Exogenous GM-CSF therapy for autoimmune pulmonary alveolar proteinosis: a systematic literature review Open

Wushu Chen, Xin Feng, Lun-Kai Yao, Xichen Li, Zhen-ming Yang , et al. · 2025

[This corrects the article DOI: 10.3389/fmed.2025.1552566.].

Exogenous GM-CSF therapy for autoimmune pulmonary alveolar proteinosis: a systematic literature review Open

Wushu Chen, Xin Feng, L. Yao, Xichen Li, Zhenming Yang , et al. · 2025

Background Granulocyte-macrophage colony-stimulating factor (GM-CSF) therapy is an important treatment for autoimmune pulmonary alveolar proteinosis (aPAP). Exogenous GM-CSF treatment can be administered either through subcutaneous injecti…

Reversing regulatory safeguards: Targeting the ATR pathway to overcome PARP inhibitor resistance Open

Xixi Lin, Yongchang Qiu, Aashish Soni, Martin Stuschke, George Iliakis · 2025

The development of poly (ADP-ribose) polymerase inhibitors (PARPis) is widely considered a therapeutic milestone in the management of BRCA1/2-deficient malignancies. Since a growing number of cancer treatment guidelines include PARPis, the…

Identification of Genes Associated with Pan-Vibrios Resistance (Pvr) Trait of Shrimp Litopenaeus Vannamei Through Genome-Wide Association Study Open

Shuyang Wen, Lihong Yuan, Chuhang Cheng, Ying Lv, Xin Zhang , et al. · 2025

Dynamics and Therapeutic Response of Myeloid Cells in Anti-Interferon-γ Autoantibody Syndrome Patients: A Prospective Multicentre Clinical Study Open

Wang Xi-dong, Haoru Wang, Yangqing Zhan, Hongling Liu, Jing Liu , et al. · 2025

Porous solid electrolyte synergistic with alkali metal cations to enhance nitrate electroreduction to ammonia Open

Yongchang Qiu, Xinwan Zhang, Pengfei Song, Wenxuan Xu, Zhengwu Yang , et al. · 2025

Seeking borophene on Ni<sub>3</sub>Al(111): an experimental characterization of boron segregation and oxidation Open

Yongchang Qiu, Pietro Biasin, Pietro Mantegazza, Stefania Baronio, Martin Heinrich , et al. · 2024

Synthesis of a stable, well ordered honeycomb borophene (hB) phase has been achieved to date by exploiting Al(111) as a growth substrate, which provides the necessary charge doping to compensate the high hexagonal-holes density. However, B…

Loss of H3K27 methylation identifies poor outcomes in adult-onset acute leukemia Open

Anneke D. van Dijk, Fieke W. Hoff, Yongchang Qiu, Joya Chandra, Elias Jabbour , et al. · 2021

Additional file 11 of Loss of H3K27 methylation identifies poor outcomes in adult-onset acute leukemia Open

Arjan D. van Dijk, Fieke W. Hoff, Yongchang Qiu, Joya Chandra, Elias Jabbour , et al. · 2021

Additional file 11: Table S5. Enriched biological processes by Gene Ontology analysis.

Additional file 8 of Loss of H3K27 methylation identifies poor outcomes in adult-onset acute leukemia Open

Arjan D. van Dijk, Fieke W. Hoff, Yongchang Qiu, Joya Chandra, Elias Jabbour , et al. · 2021

Additional file 8: Table S4. Pairwise associations between affected pathways presented by Pearson's Correlation Coefficient (cor) and p-value (p).

Additional file 5 of Loss of H3K27 methylation identifies poor outcomes in adult-onset acute leukemia Open

Arjan D. van Dijk, Fieke W. Hoff, Yongchang Qiu, Joya Chandra, Elias Jabbour , et al. · 2021

Additional file 5: Table S1. H3K27me3, H3K4me2 and H3K4me3 levels (median, IQR) according to patient and disease characteristics in AML.

Additional file 7 of Loss of H3K27 methylation identifies poor outcomes in adult-onset acute leukemia Open

Arjan D. van Dijk, Fieke W. Hoff, Yongchang Qiu, Joya Chandra, E. Jabbour , et al. · 2021

Additional file 7: Table S3. Pairwise associations between driver mutations presented by Pearson's Correlation Coefficient (cor) and p-value (p).

Additional file 6 of Loss of H3K27 methylation identifies poor outcomes in adult-onset acute leukemia Open

Arjan D. van Dijk, Fieke W. Hoff, Yongchang Qiu, Joya Chandra, Elias Jabbour , et al. · 2021

Additional file 6: Table S2. H3K27me3, H4K4me2, H3K4me3 levels (median, IQR) according to patient and disease characteristics in ALL.

Inter-assay variability influences migalastat amenability assessments among Fabry disease variants Open

Susan Oommen, Yanfeng Zhou, M. Muthuraman, Andrey Gurevich, Yongchang Qiu · 2019

Fabry disease is a lysosomal storage disorder caused by mutations in the GLA gene that encodes for the lysosomal enzyme α-galactosidase A (α-Gal A). Reduced or absent α-Gal A activity leads to substrate accumulation and deleterious effects…

A quantitative analysis of heterogeneities and hallmarks in acute myelogenous leukaemia Open

Chuanbo Hu, Yongchang Qiu, Andrew Ligeralde, A. Y. Raybon, Sang‐Bae Yoo , et al. · 2019

2018 White Paper on Recent Issues in Bioanalysis: Focus on Flow Cytometry, Gene Therapy, Cut Points and Key Clarifications on Bav (Part 3 – Lba/Cell-Based Assays: Immunogenicity, Biomarkers and Pk Assays) Open

Lauren Stevenson, Susan Richards, Renuka Pillutla, Albert Torri, John Kamerud , et al. · 2018

The 2018 12^th Workshop on Recent Issues in Bioanalysis took place in Philadelphia, PA, USA on April 9-13, 2018 with an attendance of over 900 representatives from pharmaceutical/biopharmaceutical companies, biotechnology compani…

2D-LC–MS/MS to Measure Cleaved High-Molecular-Weight Kininogen in Human Plasma as A Biomarker for C1-Inh-Hae Open

Guodong Zhang, Daniel J. Sexton, Ryan Faucette, Yongchang Qiu, Jiang Wu · 2017

A reagent-free LC-MS assay has been developed for the quantitation of 46 kDa cHMWK, which was shown to be elevated in plasma of C1-INH-HAE patients due to C1-INH deficiency relative to that of healthy subjects.

Reductions in glucosylsphingosine (lyso-Gb1) in treatment-naïve and previously treated patients receiving velaglucerase alfa for type 1 Gaucher disease: Data from phase 3 clinical trials Open

Deborah Elstein, Björn Mellgård, Quinn Dinh, Lan Lan, Yongchang Qiu , et al. · 2017

Gaucher disease (GD), an autosomal recessive lipid storage disorder, arises from mutations in the GBA1 (β-glucocerebrosidase) gene, resulting in glucosylceramide accumulation in tissue macrophages. Lyso-Gb1 (glucosylsphingosine, lyso-GL1),…

Evaluation of impact of anti-idursulfase antibodies during long-term idursulfase enzyme replacement therapy in mucopolysaccharidosis II patients Open

Roberto Giugliani, Paul Harmatz, Simon Jones, Nancy J. Mendelsohn, Ashok Vellodi , et al. · 2017

50% of study patients developed idursulfase antibodies. Notably Ab + patients had persistently higher average uGAG levels. A clear association between IRAEs and antibodies was not established.

A Rapid Two-Step Iduronate-2-Sulfatatse Enzymatic Activity Assay for MPSII Pharmacokinetic Assessment Open

Mitra Azadeh, Luying Pan, Yongchang Qiu, Rubén J. Boado · 2017

2016 White Paper on Recent Issues in Bioanalysis: Focus on Biomarker Assay Validation (BAV): (Part 3 – Lba, Biomarkers and Immunogenicity) Open

Susan Richards, Lakshmi Amaravadi, Renuka Pillutla, Herbert Birnboeck, Albert Torri , et al. · 2016

The 2016 10th Workshop on Recent Issues in Bioanalysis (10th WRIB) took place in Orlando, Florida with participation of close to 700 professionals from pharmaceutical/biopharmaceutical companies, biotechnology companies, contract research …

A phase 1/2 study of intrathecal heparan-N-sulfatase in patients with mucopolysaccharidosis IIIA Open

Simon Jones, Catherine Breen, Fiona Heap, Stewart Rust, Jessica de Ruijter , et al. · 2016

rhHNS administration via IDDD appeared generally safe and well tolerated. Treatment resulted in consistent declines in CSF heparan sulfate, suggesting in vivo activity in the relevant anatomical compartment. Results of this small study sho…

Development of anti-velaglucerase alfa antibodies in clinical trial-treated patients with Gaucher disease Open

Gregory M. Pastores, Hadhami Ben Turkia, Derlis Gonzalez, Hiroyuki Ida, Azza Abdel Gawad Tantawy , et al. · 2016

Anti-drug antibodies may develop with biological therapies, possibly leading to a reduction of treatment efficacy and to allergic and other adverse reactions. Patients with Gaucher disease were tested for anti-drug antibodies every 6 or 12…

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