Yonghua Guo
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View article: Experimental and numerical study on helical piles in aeolian sand: bearing behavior and design methods
Experimental and numerical study on helical piles in aeolian sand: bearing behavior and design methods Open
In aeolian sand, the mechanical behavior of helical anchors involves complex performance evolution mechanisms that are not yet fully understood. This study employs a multi-scale integrated approach combining field tests, numerical simulati…
View article: Experimental Study on Compressive Capacity Behavior of Helical Anchors in Aeolian Sand and Optimization of Design Methods
Experimental Study on Compressive Capacity Behavior of Helical Anchors in Aeolian Sand and Optimization of Design Methods Open
The compressive capacity of helical anchors constitutes a pivotal performance parameter in geotechnical design. To precisely predict the compressive bearing behavior of helical anchors in aeolian sand, this study integrates in situ testing…
View article: Experimental Study on Uplift Capacity Behavior of Helical Anchors in Aeolian Sand and Optimization of Design Methods
Experimental Study on Uplift Capacity Behavior of Helical Anchors in Aeolian Sand and Optimization of Design Methods Open
The uplift capacity of helical anchors constitutes a pivotal performance parameter in geotechnical design. To precisely predict the compressive bearing behavior of helical anchors in aeolian sand, this study integrates in-situ testing with…
View article: UBE2Q2 promotes tumor progression and glycolysis of hepatocellular carcinoma through NF-κB/HIF1α signal pathway
UBE2Q2 promotes tumor progression and glycolysis of hepatocellular carcinoma through NF-κB/HIF1α signal pathway Open
View article: Corrigendum to “A2aR inhibits fibrosis and the EMT process in silicosis by regulating Wnt/β-catenin pathway” [Ecotoxicol. Environ. Saf. 249 (2023) 114410]
Corrigendum to “A2aR inhibits fibrosis and the EMT process in silicosis by regulating Wnt/β-catenin pathway” [Ecotoxicol. Environ. Saf. 249 (2023) 114410] Open
View article: Expression levels of key immune indicators and immune checkpoints in manganese-exposed rats
Expression levels of key immune indicators and immune checkpoints in manganese-exposed rats Open
Manganese is essential trace elements, to participate in the body a variety of biochemical reactions, has important physiological functions, such as stimulate the immune cell proliferation, strengthen the cellular immunity, etc. However, e…
View article: Changes in serum TIM-3 and complement C3 expression in workers due to Mn exposure
Changes in serum TIM-3 and complement C3 expression in workers due to Mn exposure Open
Mn (Manganese, Mn) is an essential trace element involved in various biological processes such as the regulation of immune, nervous and digestive system functions. However, excessive Mn exposure can lead to immune damage. Occupational work…
View article: Cavin1 activates the Wnt/β-catenin pathway to influence the proliferation and migration of hepatocellular carcinoma
Cavin1 activates the Wnt/β-catenin pathway to influence the proliferation and migration of hepatocellular carcinoma Open
Cavin1 suppresses HCC progression by modulating HCC proliferation and migration via inhibiting the Wnt/β-catenin axis activation.
View article: LncRNA SNHG6 binds to EEF1D through COPS5/P27 pathway to affect the cycle and proliferation of hepatocellular carcinoma
LncRNA SNHG6 binds to EEF1D through COPS5/P27 pathway to affect the cycle and proliferation of hepatocellular carcinoma Open
Our previous work had suggested that LncRNA SNHG6 interacted with COPS5 and their expression was positively correlated in hepatocellular carcinoma(HCC). In this study we found that SNHG6 and COPS5 was upregulated in HCC patients, and patie…
View article: Correction: USP53 plays an antitumor role in hepatocellular carcinoma through deubiquitination of cytochrome c
Correction: USP53 plays an antitumor role in hepatocellular carcinoma through deubiquitination of cytochrome c Open
View article: LncRNA TGFB2-OT1 Promotes Progression and Angiogenesis in Hepatocellular Carcinoma by Dephosphorylating β-Catenin
LncRNA TGFB2-OT1 Promotes Progression and Angiogenesis in Hepatocellular Carcinoma by Dephosphorylating β-Catenin Open
TGFB2-OT1 is overexpressed in HCC and predicts the poor prognosis of HCC patients. TGFB2-OT1 impedes the phosphorylation of β-catenin and acts as an alternative activator of the Wnt/β-catenin pathway to promote the progression and angiogen…
View article: A2aR inhibits fibrosis and the EMT process in silicosis by regulating Wnt/β-catenin pathway
A2aR inhibits fibrosis and the EMT process in silicosis by regulating Wnt/β-catenin pathway Open
Silicosis, a disease characterized by diffuse fibrosis of the lung tissue, is caused by long-term inhalation of free silica (SiO2) dust in the occupational environment and is currently the most serious occupational diseases of p…
View article: Lysophosphatidylcholine acyltransferase 1 alleviates silica-induced pulmonary fibrosis by modulating lipid metabolism
Lysophosphatidylcholine acyltransferase 1 alleviates silica-induced pulmonary fibrosis by modulating lipid metabolism Open
View article: Prognostic value of CSN5 in patients with digestive system cancers: a systematic review and meta-analysis
Prognostic value of CSN5 in patients with digestive system cancers: a systematic review and meta-analysis Open
View article: Glycyrrhizic Acid Attenuates Pulmonary Fibrosis of Silicosis by Inhibiting the Interaction between HMGB1 and BRG1 through PI3K/Akt/mTOR Pathway
Glycyrrhizic Acid Attenuates Pulmonary Fibrosis of Silicosis by Inhibiting the Interaction between HMGB1 and BRG1 through PI3K/Akt/mTOR Pathway Open
Purpose: High mobility group protein 1 (HMGB1) is a highly conserved DNA-binding nuclear protein that participates in the occurrence and development of silicosis. HMGB1 binds to its specific receptor and activates phosphatidylinositol 3-ki…
View article: A novel lncRNA RP11-386G11.10 reprograms lipid metabolism to promote hepatocellular carcinoma progression
A novel lncRNA RP11-386G11.10 reprograms lipid metabolism to promote hepatocellular carcinoma progression Open
Our results indicated that the lncRNA RP11-386G11.10 was a novel oncogenic lncRNA that was strongly correlated with the poor prognosis of HCC. The ZBTB7A-RP11-386G11.10-HNRNPU positive feedback loop promoted the progression of HCC by regul…
View article: USP53 plays an antitumor role in hepatocellular carcinoma through deubiquitination of cytochrome c
USP53 plays an antitumor role in hepatocellular carcinoma through deubiquitination of cytochrome c Open
Despite of advances in treatment options, hepatocellular carcinoma (HCC) remains nearly incurable and has been recognized as the third leading cause of cancer-related deaths worldwide. As a deubiquitinating enzyme, the antitumor effect of …
View article: Inhibition of HIF-1α Attenuates Silica-Induced Pulmonary Fibrosis
Inhibition of HIF-1α Attenuates Silica-Induced Pulmonary Fibrosis Open
Background: Excessive accumulation of extracellular matrix is a key feature of pulmonary fibrosis (PF), and myofibroblasts are the main producers of extracellular matrix. Fibroblasts are the major source of myofibroblasts, but the mechanis…
View article: PD-1/PD-L1 inhibitor ameliorates silica-induced pulmonary fibrosis by maintaining systemic immune homeostasis
PD-1/PD-L1 inhibitor ameliorates silica-induced pulmonary fibrosis by maintaining systemic immune homeostasis Open
Pulmonary fibrosis induced by silica particles is defined as silicosis, which is an incurable disease. The pathogenesis of silicosis is not completely clear, but it's certain that immune system dysfunction is closely related to it. Immune …
View article: The Clinicopathological Significance and Prognostic Value of PD-L2 in Patients with HCC, ICC and PAAD: A Meta-Analysis
The Clinicopathological Significance and Prognostic Value of PD-L2 in Patients with HCC, ICC and PAAD: A Meta-Analysis Open
Background: Programmed cell death ligand 2 (PD-L2) is overexpressed in several tumors, and is associated with cancer progression and patient prognosis. Our study was aimed to investigate the clinical and prognostic significance of PD-L2 in…
View article: Loss of FBP1 by aPKC-ι/Snail Pathway-Mediated Repression Promotes Invasion and Aerobic Glycolysis of Intrahepatic Cholangiocarcinoma
Loss of FBP1 by aPKC-ι/Snail Pathway-Mediated Repression Promotes Invasion and Aerobic Glycolysis of Intrahepatic Cholangiocarcinoma Open
Intrahepatic cholangiocarcinoma (ICC) is one of the most commonly diagnosed malignancies worldwide, and the second most common primary liver tumor. The lack of effective diagnostic and treatment methods results in poor patient prognosis an…
View article: What is the Impact of CSN5 on the Prognosis of Digestive System Cancers: A Systematic Review and Meta-Analysis
What is the Impact of CSN5 on the Prognosis of Digestive System Cancers: A Systematic Review and Meta-Analysis Open
Background : Despite the understanding of COP9 signalosome subunit 5 (CSN5) in tumor genesis, there is no conclusive evidence on CSN5 value to predict digestive system tumor patients' survival and prognosis. The article was performed to ev…
View article: Identification of a seven-long non-coding RNA signature associated with Jab1/CSN5 in predicting hepatocellular carcinoma
Identification of a seven-long non-coding RNA signature associated with Jab1/CSN5 in predicting hepatocellular carcinoma Open
View article: What is The Impact of CSN5 on The Prognosis of Digestive System Cancers: A Systematic Review and Meta-Analysis
What is The Impact of CSN5 on The Prognosis of Digestive System Cancers: A Systematic Review and Meta-Analysis Open
Background : Despite the understanding of COP9 signalosome subunit 5 (CSN5) in tumor genesis, there is no conclusive evidence on CSN5 value to predict digestive system tumor patients' survival and prognosis. The article was performed to ev…
View article: Serum deprivation-response protein induces apoptosis in hepatocellular carcinoma through ASK1-JNK/p38 MAPK pathways
Serum deprivation-response protein induces apoptosis in hepatocellular carcinoma through ASK1-JNK/p38 MAPK pathways Open
View article: Theabrownin Inhibits Cell Cycle Progression and Tumor Growth of Lung Carcinoma through c-myc-Related Mechanism
Theabrownin Inhibits Cell Cycle Progression and Tumor Growth of Lung Carcinoma through c-myc-Related Mechanism Open
Green tea, the fresh leaves of Camellia sinensis, is not only a health-promoting beverage but also a traditional Chinese medicine used for prevention or treatment of cancer, such as lung cancer. Theabrownin (TB) is the main fraction…
View article: Anti-Proliferative and Apoptosis-Inducing Effect of Theabrownin against Non-small Cell Lung Adenocarcinoma A549 Cells
Anti-Proliferative and Apoptosis-Inducing Effect of Theabrownin against Non-small Cell Lung Adenocarcinoma A549 Cells Open
With the highest cancer incidence rate, lung cancer, especially non-small cell lung cancer (NSCLC), is the leading cause of cancer death in the world. Tea (leaves of Camellia sinensis) has been widely used as a traditional beverage …
View article: Structural and functional probing of PorZ, an essential bacterial surface component of the type-IX secretion system of human oral-microbiomic Porphyromonas gingivalis.
Structural and functional probing of PorZ, an essential bacterial surface component of the type-IX secretion system of human oral-microbiomic Porphyromonas gingivalis. Open
View article: Purification and characterisation of recombinant His-tagged RgpB gingipain from Porphymonas gingivalis
Purification and characterisation of recombinant His-tagged RgpB gingipain from Porphymonas gingivalis Open
Gingipain proteases are important virulence factors from the periodontal pathogen Porphyromonas gingivalis and are the target of many in vitro studies. Due to their close biochemical properties, purification of individual gingipains is dif…