Yongfeng Chen
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View article: Global burden and cross-country inequality of infectious skin diseases in children: the Global Burden of Disease Study 2021
Global burden and cross-country inequality of infectious skin diseases in children: the Global Burden of Disease Study 2021 Open
Background Infectious skin diseases (ISDs) in children require greater attention; this study aims to explore their global burden from 1990 to 2021. Methods We obtained data from the Global Burden of Disease Study 2021 and present informati…
View article: CASE REPORT: Diagnostic Challenge in a 43-Year-Old Female - Acute Monocytic Leukemia (AML-M5) Presenting as Blastic Plasmacytoid Dendritic Cell Neoplasm
CASE REPORT: Diagnostic Challenge in a 43-Year-Old Female - Acute Monocytic Leukemia (AML-M5) Presenting as Blastic Plasmacytoid Dendritic Cell Neoplasm Open
Statement of the Problem Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive hematologic malignancy that originates from plasmacytoid dendritic cells (pDCs). BPDCN typically presents with skin lesions, which can a…
View article: <scp>LncRNA LINC01026</scp> Is Overexpressed in Psoriasis and Enhances Keratinocyte Cell Cycle Progression by Regulating the Ets Homologous Factor (<scp>EHF</scp>)
<span>LncRNA LINC01026</span> Is Overexpressed in Psoriasis and Enhances Keratinocyte Cell Cycle Progression by Regulating the Ets Homologous Factor (<span>EHF</span>) Open
Psoriasis is a chronic autoimmune skin disease characterised by a high recurrence rate and epidermal hyperproliferation. Recent studies have highlighted the pathogenic roles of long non‐coding RNAs (lncRNAs) in psoriasis. However, the cell…
View article: Endotracheal Actinomycosis Combined With Mucormycosis: A Case Report and Literature Review
Endotracheal Actinomycosis Combined With Mucormycosis: A Case Report and Literature Review Open
Actinomycosis and mucormycosis are rare infections, and their coexistence in a single host is extremely uncommon. Actinomycosis of the trachea is a chronic septic condition caused by actinomycete infection, often misdiagnosed due to the di…
View article: Two missense mutations in Dystonin lead to epidermolysis bullosa simplex complicated with lepromatous leprosy: a case report
Two missense mutations in Dystonin lead to epidermolysis bullosa simplex complicated with lepromatous leprosy: a case report Open
This case highlights EBS caused by DST mutations, emphasizing the importance of comprehensive diagnostic workup in patients with bullous diseases. Additionally, it underscores the importance of rational glucocorticoid use and carefu…
View article: Innovative Melanoma Treatment: Acoustic-Sensitive Oncolytic Foam Induces Tumor Cavitation Via the Nibbling Effect
Innovative Melanoma Treatment: Acoustic-Sensitive Oncolytic Foam Induces Tumor Cavitation Via the Nibbling Effect Open
View article: A novel and simple maneuver greatly improves rat liver transplantation
A novel and simple maneuver greatly improves rat liver transplantation Open
Background Orthotopic rat liver transplantation (OLT) is preferentially used to study transplant immunology; it remains challenging due to higher complications associated with 26-minute anhepatic time ceiling, here we safely extended the a…
View article: A rare case report of penile schwannoma
A rare case report of penile schwannoma Open
Penile neoplasms are rare, and diagnosis of these are challenging. There have been only 27 cases of penile schwannomas (PSs) documented in English medical literature. We report a case of PS. A 36-year-old male patient presented with a peni…
View article: Application of ‘CDC- Public Security Bureau-NGO’ Joint Prevention and Control Mechanism Allied AIDS prevention and control in Guigang, Guangxi
Application of ‘CDC- Public Security Bureau-NGO’ Joint Prevention and Control Mechanism Allied AIDS prevention and control in Guigang, Guangxi Open
View article: Decrease in the long non-coding RNA GAS6-AS2 in psoriasis induces cell cycle G0/G1 phase arrest via the NF-kB signaling pathway in keratinocytes
Decrease in the long non-coding RNA GAS6-AS2 in psoriasis induces cell cycle G0/G1 phase arrest via the NF-kB signaling pathway in keratinocytes Open
View article: The skin circadian clock gene F3 as a potential marker for psoriasis severity and its bidirectional relationship with IL-17 signaling in keratinocytes
The skin circadian clock gene F3 as a potential marker for psoriasis severity and its bidirectional relationship with IL-17 signaling in keratinocytes Open
Our research revealed a bidirectional link between the skin circadian gene F3 and the IL-17 signaling pathway in psoriasis, suggesting that F3 may interact with the IL-17 pathway by activating JAK-STAT within keratinocytes and inducing abn…
View article: Transcription Factor IRF7 is Involved in Psoriasis Development and Response to Guselkumab Treatment
Transcription Factor IRF7 is Involved in Psoriasis Development and Response to Guselkumab Treatment Open
IRF7 may be the key player in psoriasis pathogenesis and the therapeutic process involving guselkumab. Targeting IRF7 might offer new therapeutic strategies for psoriasis.
View article: The Teaching Reform of Building Structure course Based on the Training of Skilled Personnel
The Teaching Reform of Building Structure course Based on the Training of Skilled Personnel Open
Based on the requirements of enterprises for skilled talents of architectural engineering technology major in higher vocational colleges and the teaching status of Architectural Structure course, this paper explores teaching reform by opti…
View article: Tofu Wastewater as Carbon Source Flowing in Municipal Wastewater Treatment Plant for Reduction of Cost and Greenhouse Gas Emission
Tofu Wastewater as Carbon Source Flowing in Municipal Wastewater Treatment Plant for Reduction of Cost and Greenhouse Gas Emission Open
View article: The skin circadian clock gene F3 as a potential marker for psoriasis severity and its bidirectional relationship with IL-17 signaling in keratinocytes
The skin circadian clock gene F3 as a potential marker for psoriasis severity and its bidirectional relationship with IL-17 signaling in keratinocytes Open
Background Psoriasis is an immune-mediated skin disease where the IL-17 signaling pathway plays a crucial role in its development. Chronic circadian rhythm disorder in psoriasis pathogenesis is gaining more attention. The relationship betw…
View article: Comparative study on the application of tarsal tunnel block and spinal anesthesia in open osteotomy of hallux valgus
Comparative study on the application of tarsal tunnel block and spinal anesthesia in open osteotomy of hallux valgus Open
Background Hallux valgus is a common and frequently occurring forefoot disease. Surgical treatment is often required for moderate to severe cases, and the choice of anesthesia during surgery significantly impacts postoperative functional r…
View article: Exploring the Cause of Survival Disparities in EGFR-mutated Lung Cancer Subtypes: Unraveling Distinctive Genomic and Phenotypic Features of 19Del and L858R Mutation Subtypes
Exploring the Cause of Survival Disparities in EGFR-mutated Lung Cancer Subtypes: Unraveling Distinctive Genomic and Phenotypic Features of 19Del and L858R Mutation Subtypes Open
Differences in the efficacy of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKI) have been observed between lung cancer patients with 19 exon deletion (19Del) and L858R mutation. We investigate the multi-omics informat…
View article: Detection of sebaceous gland hyperplasia with dermoscopy and reflectance confocal microscopy
Detection of sebaceous gland hyperplasia with dermoscopy and reflectance confocal microscopy Open
Background Sebaceous gland hyperplasia (SGH) is a benign cutaneous proliferation of the sebaceous glands that are mostly present on the face or the neck of older adults. They typically appear as single or multiple soft umbilicated papules;…
View article: Endotracheal Actinomycosis Combined with Mucormycosis: A Case Report and Literature Review
Endotracheal Actinomycosis Combined with Mucormycosis: A Case Report and Literature Review Open
Background : Actinomycosis and mucormycosis are very uncommon in clinical work, a combination of both two infection is much rarer in one host. Actinomycosis of the trachea is a chronic septic disease caused by an actinomycete infection wit…
View article: Application of ‘CDC- Public security bureau-NGO’ Joint Prevention and Control Mechanism Allied AIDS Prevention and Control in Guangxi, China
Application of ‘CDC- Public security bureau-NGO’ Joint Prevention and Control Mechanism Allied AIDS Prevention and Control in Guangxi, China Open
Background HIV/AIDS has emerged as a nationwide epidemic and has taken the forefront position as the primary infectious killer of adults in China. The control and prevention of the disease have been hampered by a weak link in the form of h…
View article: <scp><i>Circular RNA circDLG1</i></scp> (has_circ_0068706) functions as an oncogene in nonsmall cell lung cancer through regulating <scp>AKT</scp>/<scp>mTOR</scp> signaling and direct binding to <scp>miR</scp>‐144
<span><i>Circular RNA circDLG1</i></span> (has_circ_0068706) functions as an oncogene in nonsmall cell lung cancer through regulating <span>AKT</span>/<span>mTOR</span> signaling and direct binding to <span>miR</span>‐144 Open
Nonsmall cell lung cancer (NSCLC) is a major subtype of lung cancer, causing substantial cancer‐related deaths worldwide. However, the molecular basis of NSCLC development and progression remains understudied. Recently, a circular RNA, cir…
View article: The SELP, CD93, IL2RG, and VAV1 Genes Associated with Atherosclerosis May Be Potential Diagnostic Biomarkers for Psoriasis
The SELP, CD93, IL2RG, and VAV1 Genes Associated with Atherosclerosis May Be Potential Diagnostic Biomarkers for Psoriasis Open
This study identified atherosclerosis-related genes SELP, CD93, VAV1, and IL2RG as potential psoriasis diagnostic markers. Provide novel insights into the possible regulatory mechanisms involved in psoriasis.
View article: Combination of single-cell and bulk RNA seq reveals the immune infiltration landscape and targeted therapeutic drugs in spinal cord injury
Combination of single-cell and bulk RNA seq reveals the immune infiltration landscape and targeted therapeutic drugs in spinal cord injury Open
Background In secondary spinal cord injury (SCI), the immune microenvironment of the injured spinal cord plays an important role in spinal regeneration. Among the immune microenvironment components, macrophages/microglia play a dual role o…
View article: Research on the Teaching Reform of Building Structure Course Integrating BIM Technology Based on the Training of Skilled Talents
Research on the Teaching Reform of Building Structure Course Integrating BIM Technology Based on the Training of Skilled Talents Open
"Building Structure" is the core course of the architectural engineering technology major in higher vocational colleges. When students learn all kinds of structural calculation, the lack of spatial imagination often makes them feel difficu…
View article: A Retrospective Study of Time to Relapse following Guselkumab Withdrawal in Patients with Psoriasis
A Retrospective Study of Time to Relapse following Guselkumab Withdrawal in Patients with Psoriasis Open
Background . Psoriasis is a chronic immune‐mediated skin disease requiring long‐term management. However, for various reasons such as financial issues, treatment cessation is common among psoriasis patients who have achieved clinical remis…
View article: Pemphigus during the COVID-19 Epidemic: Infection Risk, Vaccine Responses and Management Strategies
Pemphigus during the COVID-19 Epidemic: Infection Risk, Vaccine Responses and Management Strategies Open
Pemphigus is a rare autoimmune blistering disease, involving potentially life-threatening conditions often requiring immunosuppression. Currently, the COVID-19 pandemic caused by severe acute respiratory disease coronavirus 2 (SARS-CoV-2) …
View article: ZNF384: A Potential Therapeutic Target for Psoriasis and Alzheimer’s Disease Through Inflammation and Metabolism
ZNF384: A Potential Therapeutic Target for Psoriasis and Alzheimer’s Disease Through Inflammation and Metabolism Open
Background Psoriasis is an immune-related skin disease notable for its chronic inflammation of the entire system. Alzheimer’s disease (AD) is more prevalent in psoriasis than in the general population. Immune-mediated pathophysiologic proc…
View article: MicroRNA-17-3p is upregulated in psoriasis and regulates keratinocyte hyperproliferation and pro-inflammatory cytokine secretion by targeting <em>CTR9</em>
MicroRNA-17-3p is upregulated in psoriasis and regulates keratinocyte hyperproliferation and pro-inflammatory cytokine secretion by targeting <em>CTR9</em> Open
Psoriasis is a chronic inflammatory skin disease. Although miRNAs are reported to be associated with the pathogenesis of psoriasis, the contribution of individual microRNAs toward psoriasis remains unclear. The miR-17-92 cluster regulates …
View article: Interplay Between Skin Microbiota Dysbiosis and the Host Immune System in Psoriasis: Potential Pathogenesis
Interplay Between Skin Microbiota Dysbiosis and the Host Immune System in Psoriasis: Potential Pathogenesis Open
Psoriasis is a multifactorial immune-mediated disease. The highly effective and eligible treatment for psoriasis is limited, for its specific pathogenesis is incompletely elucidated. Skin microbiota is a research hotspot in the pathogenesi…
View article: Optimizing Slag Content to Control Ds-Type Inclusions in 10B21 Cold Heading Steel
Optimizing Slag Content to Control Ds-Type Inclusions in 10B21 Cold Heading Steel Open
Ds-type inclusions during production are an important factor affecting the performance and quality of manufactured 10B21 steel. To minimize Ds-type inclusions in steel and improve the production qualification rate of steelmaking plants, a …