Yonggong Yang
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View article: Lipid metabolites affected by deficient autophagy antagonize the occurrence of autophagy through AMPK signaling in insects
Lipid metabolites affected by deficient autophagy antagonize the occurrence of autophagy through AMPK signaling in insects Open
View article: Pharmacovigilance analysis of polatuzumab plus bendamustine and rituximab treatment protocol: identifying comprehensive safety signals using FDA database
Pharmacovigilance analysis of polatuzumab plus bendamustine and rituximab treatment protocol: identifying comprehensive safety signals using FDA database Open
Background The combination of polatuzumab, bendamustine and rituximab (pola+BR) was authorized for the treatment of relapsed or refractory Diffuse large B cell lymphoma (DLBCL). This study used the FDA database to identify safety signals r…
View article: Diagnostic performance of metagenomic next-generation sequencing among hematological malignancy patients with bloodstream infections after antimicrobial therapy
Diagnostic performance of metagenomic next-generation sequencing among hematological malignancy patients with bloodstream infections after antimicrobial therapy Open
The antimicrobial treatment will greatly reduce the positive rate of mNGS. The duration of mNGS is significantly longer than that of BC. The prolonged duration of mNGS suggests an increased risk of septic shock and could be identified as a…
View article: Correction to: Identification of a novel fusion gene, RARA::ANKRD34C, in acute promyelocytic leukemia
Correction to: Identification of a novel fusion gene, RARA::ANKRD34C, in acute promyelocytic leukemia Open
View article: Reduced‐dose chemotherapy followed by blinatumomab in induction therapy for newly diagnosed B‐cell acute lymphoblastic leukemia
Reduced‐dose chemotherapy followed by blinatumomab in induction therapy for newly diagnosed B‐cell acute lymphoblastic leukemia Open
Background Blinatumomab early‐line treatment in B‐cell precursor acute lymphoblastic leukemia (B‐ALL) might improve clinical outcomes. Methods We conducted a retrospective real‐world cohort analysis in 20 newly diagnosed B‐ALL patients who…
View article: A disproportionality analysis for assessing the safety of FLT3 inhibitors using the FDA Adverse Event Reporting System (FAERS)
A disproportionality analysis for assessing the safety of FLT3 inhibitors using the FDA Adverse Event Reporting System (FAERS) Open
Objectives: This pharmacovigilance analysis was conducted to assess the safety signals of FMS-related tyrosine kinase 3 (FLT3) inhibitors in a real-world setting using the United States Food and Drug Administration Adverse Event Reporting …
View article: 161P Biomarkers of neoadjuvant combinational therapy for locally advanced gastric or gastroesophageal junction adenocarcinoma
161P Biomarkers of neoadjuvant combinational therapy for locally advanced gastric or gastroesophageal junction adenocarcinoma Open
View article: P401: INNOVATIVE REDUCED-DOSE CHEMOTHERAPY FOLLOWED BY BLINATUMOMAB INDUCTION THERAPY FOR SUCCESSFUL MANAGEMENT OF TREATMENT NAIVE B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA ADULTS: A MULTICENTER, REAL-WORLD STUDY
P401: INNOVATIVE REDUCED-DOSE CHEMOTHERAPY FOLLOWED BY BLINATUMOMAB INDUCTION THERAPY FOR SUCCESSFUL MANAGEMENT OF TREATMENT NAIVE B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA ADULTS: A MULTICENTER, REAL-WORLD STUDY Open
Background: B-cell precursor acute lymphoblastic leukemia (B-ALL) is a hematological malignancy characterized by proliferation and accumulation of B-cell lymphoid progenitor cells in the bone marrow or in extramedullary sites. Since half o…
View article: An unusual hematopoietic stem cell transplantation for donor acute lymphoblastic leukemia: a case report
An unusual hematopoietic stem cell transplantation for donor acute lymphoblastic leukemia: a case report Open
Background Donor acute lymphoblastic leukemia with recipient intact is a rare condition. We report a case of donor developing acute lymphoblastic leukemia 8 yrs after donating both bone marrow and peripheral blood hematopoietic stem cells.…
View article: Hepatitis B virus infection and 1q21 amplification in multiple myeloma
Hepatitis B virus infection and 1q21 amplification in multiple myeloma Open
Hepatitis B virus (HBV) is a hepatotropic and a lymphotropic virus. An association between HBV and hematologic malignancies has been determined previously; however, the association between HBV infection and multiple myeloma (MM) remains co…
View article: A phase I/II Trial of CRISPR-Cas9-mediated PD-1 knockout Epstein-Barr virus cytotoxic lymphocytes (EBV-CTLs) for advanced stage EBV associated malignancies - Trial in progress
A phase I/II Trial of CRISPR-Cas9-mediated PD-1 knockout Epstein-Barr virus cytotoxic lymphocytes (EBV-CTLs) for advanced stage EBV associated malignancies - Trial in progress Open
Introduction: EBV associated malignancies exhibits high amplification of PD-L1 as distinguished from EBV non-associated malignancies (Kim et al. Gastroenterology 2015; Chen et al. Clinical Cancer Research 2013). The up-regulation of PD-L1 …
View article: Prognostic relevance of protein expression, clinical factors, and <i>MYD88</i> mutation in primary bone lymphoma
Prognostic relevance of protein expression, clinical factors, and <i>MYD88</i> mutation in primary bone lymphoma Open
Primary bone lymphomas (PBLs) are composed of malignant lymphoid cells presenting in osseous sites, without supra-regional lymph node or extranodal involvement. We systematically characterized the immunophenotype and the myeloid differenti…
View article: [Distribution and drug resistance of pathogens at hematology department of Jiangsu Province from 2014 to 2015: results from a multicenter, retrospective study].
[Distribution and drug resistance of pathogens at hematology department of Jiangsu Province from 2014 to 2015: results from a multicenter, retrospective study]. Open
Objective: To describe the distribution and drug resistance of pathogens at hematology department of Jiangsu Province from 2014 to 2015 to provide reference for empirical anti-infection treatment. Methods: Pathogens were from…
View article: Prognostic value of expression of nuclear factor kappa-B/p65 in non-GCB DLBCL patients
Prognostic value of expression of nuclear factor kappa-B/p65 in non-GCB DLBCL patients Open
The expression of NF-κB/p65 has prognostic value in high risk non-GCB DLBCL, and it is a suitable target for the development of new therapies.
View article: JAK2, MPL, and CALR mutations in Chinese Han patients with essential thrombocythemia
JAK2, MPL, and CALR mutations in Chinese Han patients with essential thrombocythemia Open
Genotyping for CALR could be a useful diagnostic tool for JAK2/MPL-negative ET, since the data suggest that CALR is much more prevalent than MPL, therefore testing for CALR should be considered in patients who are JAK2 negative as its freq…
View article: Prognostic role of pretreatment neutrophil-lymphocyte ratio in patients with diffuse large B-cell lymphoma treated with RCHOP
Prognostic role of pretreatment neutrophil-lymphocyte ratio in patients with diffuse large B-cell lymphoma treated with RCHOP Open
This study aims to investigate whether neutrophil to lymphocyte ratio (NLR) is an independent predictor in newly diagnosed diffuse large B-cell lymphoma (DLBCL) patients in the rituximab era. Data from newly diagnosed DLBCL patients at Nan…
View article: FBXL10 contributes to the progression of nasopharyngeal carcinoma via involving in PI3K/mTOR pathway
FBXL10 contributes to the progression of nasopharyngeal carcinoma via involving in PI3K/mTOR pathway Open
Our study aimed to investigate whether F-box and leucine-rich repeat protein 10 (FBXL10) may play a pivotal role in nasopharyngeal carcinoma (NPC) development via involving in PI3K/mTOR pathway. We .constructed an FBXL10 expression vector …