Yonggoo Kim
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View article: MUTE‐Seq: An Ultrasensitive Method for Detecting Low‐Frequency Mutations in cfDNA With Engineered Advanced‐Fidelity FnCas9 (Adv. Mater. 47/2025)
MUTE‐Seq: An Ultrasensitive Method for Detecting Low‐Frequency Mutations in cfDNA With Engineered Advanced‐Fidelity FnCas9 (Adv. Mater. 47/2025) Open
View article: Clinical outcomes of WHO 2022 and ICC MDS entities with risk stratification by IPSS-R and IPSS-M
Clinical outcomes of WHO 2022 and ICC MDS entities with risk stratification by IPSS-R and IPSS-M Open
Not available.
View article: MUTE‐Seq: An Ultrasensitive Method for Detecting Low‐Frequency Mutations in cfDNA With Engineered Advanced‐Fidelity FnCas9
MUTE‐Seq: An Ultrasensitive Method for Detecting Low‐Frequency Mutations in cfDNA With Engineered Advanced‐Fidelity FnCas9 Open
In this study, we present the development of the Mutation tagging by CRISPR‐based Ultra‐precise Targeted Elimination in Sequencing (MUTE‐Seq) method. We engineered a highly precise advanced‐fidelity FnCas9 variant, named FnCas9‐AF2, to eff…
View article: Poor prognostic implication of CDKN2 deletion in adult patients with Philadelphia chromosome-positive ALL
Poor prognostic implication of CDKN2 deletion in adult patients with Philadelphia chromosome-positive ALL Open
View article: Tracing genomic instability in induced mesenchymal stromal cell manufacture: an integration-free transfection approach
Tracing genomic instability in induced mesenchymal stromal cell manufacture: an integration-free transfection approach Open
View article: Telomere Length and Genetic Variations in Acquired Pediatric Aplastic Anemia: A Flow-FISH Study in Korean Patients
Telomere Length and Genetic Variations in Acquired Pediatric Aplastic Anemia: A Flow-FISH Study in Korean Patients Open
Background: Aplastic anemia (AA) is a rare bone marrow failure syndrome characterized by notably short telomere length, which is associated with treatment responses. In this study, we measured telomere lengths in Korean pediatric AA patien…
View article: Alterations in RNA Expression Profile Following S. aureus and S. epidermidis Inoculation into Platelet Concentrates
Alterations in RNA Expression Profile Following S. aureus and S. epidermidis Inoculation into Platelet Concentrates Open
Microbial contamination of platelet concentrates (PC) remains a persistent challenge in transfusion medicine, necessitating robust preventive measures prior to product release. Differentially expressed gene (DEG) analysis of microbe inocul…
View article: Phytochemical and pharmacological profiles of various Salvia miltiorrhiza Bunge cultivars grown in Korea
Phytochemical and pharmacological profiles of various Salvia miltiorrhiza Bunge cultivars grown in Korea Open
View article: Classification and Prognostic Stratification Based on Genomic Features in Myelodysplastic and Myeloproliferative Neoplasm- and Their Overlapping Conditions
Classification and Prognostic Stratification Based on Genomic Features in Myelodysplastic and Myeloproliferative Neoplasm- and Their Overlapping Conditions Open
Background/Objectives: Myeloid neoplasms encompass a diverse group of disorders. In this study, we aimed to analyze the clinical and genomic data of patients with myeloproliferative neoplasm (MPN), myelodysplastic neoplasm (MDS), and their…
View article: Inhibitory Activity of Glycosides from <i>Elsholtzia ciliata</i> against Soluble Epoxide Hydrolase and Cytokines in RAW264.7 Cells
Inhibitory Activity of Glycosides from <i>Elsholtzia ciliata</i> against Soluble Epoxide Hydrolase and Cytokines in RAW264.7 Cells Open
Soluble epoxide hydrolase (sEH) and pro-inflammatory cytokines are associated with the development of inhibitors for cardiovascular and inflammatory diseases. Here, we report on four natural sEH inhibitors isolated from the aerial parts of…
View article: <i>TP53</i> Mutation Status in Myelodysplastic Neoplasm and Acute Myeloid Leukemia: Impact of Reclassification Based on the 5th WHO and International Consensus Classification Criteria: A Korean Multicenter Study
<i>TP53</i> Mutation Status in Myelodysplastic Neoplasm and Acute Myeloid Leukemia: Impact of Reclassification Based on the 5th WHO and International Consensus Classification Criteria: A Korean Multicenter Study Open
Collectively, we elucidated the molecular genetic characteristics of patients with TP53-mutated MDS and AML, highlighting key factors in applying TP53 mutation-related criteria in updated classifications, which will aid in es…
View article: Anti-Pruritic and Immunomodulatory Effects of Coix [Coix lacryma-jobi L. var. ma-yuen (Rom. Caill.) Stapf.] Sprouts Extract
Anti-Pruritic and Immunomodulatory Effects of Coix [Coix lacryma-jobi L. var. ma-yuen (Rom. Caill.) Stapf.] Sprouts Extract Open
This study explored the anti-pruritic and immunomodulatory effects of Coix sprouts extract, focusing on histamine release and IL-31 cytokine production in HMC-1 cells. The extract significantly inhibited both factors, indicating its potent…
View article: Influence of the Bone Marrow Microenvironment on Hematopoietic Stem Cell Behavior Post-Allogeneic Transplantation: Development of Clonal Hematopoiesis and Telomere Dynamics
Influence of the Bone Marrow Microenvironment on Hematopoietic Stem Cell Behavior Post-Allogeneic Transplantation: Development of Clonal Hematopoiesis and Telomere Dynamics Open
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a potential cure for myelodysplastic neoplasms (MDSs) and other hematologic malignancies. This study investigates post-transplantation genetic evolution and telomere dynamic…
View article: Minimal residual disease assessment in transplant-eligible patients with multiple myeloma: real-world applications of multiparametric flow cytometry-DURAClone (CAREMM-2104)
Minimal residual disease assessment in transplant-eligible patients with multiple myeloma: real-world applications of multiparametric flow cytometry-DURAClone (CAREMM-2104) Open
Not available.
View article: Genomic insights into inherited bone marrow failure syndromes in a Korean population
Genomic insights into inherited bone marrow failure syndromes in a Korean population Open
Summary Inherited bone marrow failure syndromes (IBMFS) pose significant diagnostic challenges due to overlapping symptoms and variable expressivity, despite evolving genomic insights. The study aimed to elucidate the genomic landscape amo…
View article: Classification and prognostic stratification based on genomic features in myelodysplastic neoplasms, myeloproliferative neoplasms, and their overlapping conditions
Classification and prognostic stratification based on genomic features in myelodysplastic neoplasms, myeloproliferative neoplasms, and their overlapping conditions Open
In this study, we analyzed clinical and genomic data from 1,585 patients diagnosed with myeloid neoplasms (MNs), including myeloproliferative neoplasms (MPN, n = 715), myelodysplastic neoplasms (MDS, n = 698), MDS/MPN (n = 94), and aplasti…
View article: The Inhibition Activity of Natural Methoxyflavonoid from Inula britannica on Soluble Epoxide Hydrolase and NO Production in RAW264.7 Cells
The Inhibition Activity of Natural Methoxyflavonoid from Inula britannica on Soluble Epoxide Hydrolase and NO Production in RAW264.7 Cells Open
Soluble epoxide hydrolase (sEH) is an enzyme targeted for the treatment of inflammation and cardiovascular diseases. Activated inflammatory cells produce nitric oxide (NO), which induces oxidative stress and exacerbates inflammation. We id…
View article: Analytical Performance Evaluation of a Digital Real‐Time <scp>PCR</scp> for Quantifying Major <i><scp>BCR</scp>::<scp>ABL1</scp></i> Transcripts
Analytical Performance Evaluation of a Digital Real‐Time <span>PCR</span> for Quantifying Major <i><span>BCR</span>::<span>ABL1</span></i> Transcripts Open
Background Accurate quantification of the BCR::ABL1 transcripts is essential for measurable residual disease (MRD) monitoring in chronic myeloid leukemia (CML) after tyrosine kinase inhibitor (TKI) treatment. This study evaluated the newly…
View article: MUTE-Seq: An Ultrasensitive Method for Detecting Low-Frequency Mutations in ctDNA with Engineered Advanced-Fidelity FnCas9
MUTE-Seq: An Ultrasensitive Method for Detecting Low-Frequency Mutations in ctDNA with Engineered Advanced-Fidelity FnCas9 Open
In this study, we present the development of the Mutation tagging by CRISPR-based Ultra-precise Targeted Elimination in Sequencing (MUTE-Seq) method. We engineered a highly precise advanced-fidelity FnCas9 variant, named FnCas9-AF2, to eff…
View article: Twins With an Identical Novel Mutation in <i>ITGB3</i>: A Case Report of Glanzmann Thrombasthenia–like Syndrome
Twins With an Identical Novel Mutation in <i>ITGB3</i>: A Case Report of Glanzmann Thrombasthenia–like Syndrome Open
Jaewoong Lee, M.D., Ph.D., Jong-Mi Lee, M.D., Ph.D., Hoon Seok Kim, M.D., Ph.D., Jin Jung, M.D., Yonggoo Kim, M.D., Ph.D., Suk Young Park, M.D., Ph.D., Myungshin Kim, M.D., Ph.D., and Eunhee Han, M.D., Ph.D.. Ann Lab Med -0001;0:. https://…
View article: Prognostic value of European Leukemia Net 2022 criteria and genomic clusters using machine learning in older adults with acute myeloid leukemia
Prognostic value of European Leukemia Net 2022 criteria and genomic clusters using machine learning in older adults with acute myeloid leukemia Open
This study aimed to validate the new European Leukemia Net (ELN) 2022 criteria for genetic risk stratification in older adults with acute myeloid leukemia (AML) and to determine the most likely set of clusters of similar cytogenetic and mu…
View article: Machine Learning Predicts 30-Day Outcome among Acute Myeloid Leukemia Patients: A Single-Center, Retrospective, Cohort Study
Machine Learning Predicts 30-Day Outcome among Acute Myeloid Leukemia Patients: A Single-Center, Retrospective, Cohort Study Open
Acute myeloid leukemia (AML) is a clinical emergency requiring treatment and results in high 30-day (D30) mortality. In this study, the prediction of D30 survival was studied using a machine learning (ML) method. The total cohort consisted…
View article: Thrombocytopenia Experienced by Healthy Peripheral Blood Stem Cell Donors at a Tertiary Hospital in Korea
Thrombocytopenia Experienced by Healthy Peripheral Blood Stem Cell Donors at a Tertiary Hospital in Korea Open
Soo Jung Lee, M.D., Seungwan Chae, M.D., Jung Sil Hwang, M.T., Seung Hyo Yoo, M.T., Jayho Han, M.D., Howon Lee, M.D., Dong Wook Jekarl, M.D., Yonggoo Kim, M.D.. KJBT 2023;34:108-17. https://doi.org/10.17945/kjbt.2023.34.2.108
View article: Comparison of Quality, Antioxidant Capacity, and Anti-Inflammatory Activity of Adlay [Coix lacryma-jobi L. var. ma-yuen (Rom. Caill.) Stapf.] Sprout at Several Harvest Time
Comparison of Quality, Antioxidant Capacity, and Anti-Inflammatory Activity of Adlay [Coix lacryma-jobi L. var. ma-yuen (Rom. Caill.) Stapf.] Sprout at Several Harvest Time Open
Recently, there has been a growing interest in the consumption of plant-based foods such as vegetables and grains for the purpose of disease prevention and treatment. Adlay seeds contain physiologically active substances, including coixol,…
View article: Perspectives on acute myeloid leukemia diagnosis: a comparative analysis of the latest World Health Organization and the International Consensus Classifications
Perspectives on acute myeloid leukemia diagnosis: a comparative analysis of the latest World Health Organization and the International Consensus Classifications Open
Recently, the 5th edition of 'The World Health Organization (WHO) Classification of Tumors of Haematopoietic and Lymphoid Tissues' (WHO2022) was released in beta version [1].In WHO2022, the classification of AML underwent changes, separati…
View article: WITHDRAWN: A novel digital PCR assay targeting major BCR::ABL1 fusion transcripts
WITHDRAWN: A novel digital PCR assay targeting major BCR::ABL1 fusion transcripts Open
Accurate quantification of the BCR::ABL1 transcripts is essential for measurable residual disease (MRD) monitoring in chronic myeloid leukaemia (CML) after tyrosine kinase inhibitor (TKI) treatment. This study evaluated the newly developed…
View article: Monitoring measurable residual disease and chimerism in patients with JAK2 V617F-positive myelofibrosis after allogeneic hematopoietic cell transplantation
Monitoring measurable residual disease and chimerism in patients with JAK2 V617F-positive myelofibrosis after allogeneic hematopoietic cell transplantation Open
Monitoring measurable residual disease and chimerism
View article: Genetic Variants Associated with Drug Resistance of Cytomegalovirus in Hematopoietic Cell Transplantation Recipients
Genetic Variants Associated with Drug Resistance of Cytomegalovirus in Hematopoietic Cell Transplantation Recipients Open
Cytomegalovirus (CMV) infection is a serious complication in hematopoietic cell transplantation (HCT) recipients. Drug-resistant strains make it more challenging to treat CMV infection. This study aimed to identify variants associated with…
View article: Perspectives on Acute Myeloid Leukemia Diagnosis: A Comparative Analysis of the Latest World Health Organization and the International Consensus Classifications
Perspectives on Acute Myeloid Leukemia Diagnosis: A Comparative Analysis of the Latest World Health Organization and the International Consensus Classifications Open
This study compares and analyzes the 5th edition of the WHO classification (WHO 2022) and the International Consensus Classification (ICC) in the context of 861 acute myeloid leukemia (AML) patients from Seoul St. Mary's Hospital. Using WH…
View article: Metabolic profiles of lung adenocarcinoma via peripheral blood and diagnostic model construction
Metabolic profiles of lung adenocarcinoma via peripheral blood and diagnostic model construction Open
The metabolic profile of cancerous cells is shifted to meet the cellular demand required for proliferation and growth. Here we show the features of cancer metabolic profiles using peripheral blood of healthy control subjects (n = 78) and l…