Yang Yu
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View article: Estrogen improves sevoflurane-induced cognitive dysfunction by regulating synaptic zinc homeostasis
Estrogen improves sevoflurane-induced cognitive dysfunction by regulating synaptic zinc homeostasis Open
Background Sevoflurane is known to induce cognitive dysfunction, but the underlying mechanisms remain unclear. Recent evidence suggests that disruptions in synaptic zinc homeostasis may contribute to neurotoxicity and cognitive impairment.…
View article: Estrogen Alleviates Sevoflurane‐Induced Neurotoxicity by Inhibiting ERα‐Tau Binding
Estrogen Alleviates Sevoflurane‐Induced Neurotoxicity by Inhibiting ERα‐Tau Binding Open
Sevoflurane‐induced neurotoxicity is age‐dependent, but the role of sex differences is unclear. While testosterone has protective effects, the impact of estrogen remains unknown. This study investigates the effects of sevoflurane on neurot…
View article: Diagnostic Accuracy of 24‐Hour Urinary Aldosterone for Primary Aldosteronism in Northeast China
Diagnostic Accuracy of 24‐Hour Urinary Aldosterone for Primary Aldosteronism in Northeast China Open
This study aimed to evaluate the diagnostic accuracy of 24‐hour urinary aldosterone (UALD) for primary aldosteronism (PA) in Northeast China. A total of 423 patients with hypertension were consecutively enrolled. After 1:2 propensity score…
View article: Long-chain PFAS potently disrupt renal carboxylesterase activity and exacerbate nephrotoxicity: an investigation of the chain length-dependent nephrotoxicity of PFAS
Long-chain PFAS potently disrupt renal carboxylesterase activity and exacerbate nephrotoxicity: an investigation of the chain length-dependent nephrotoxicity of PFAS Open
Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are recognized as critical environmental health hazards, however, their toxicity mechanisms in specific organ systems remain poorly characterized. This study systematically investigated …
View article: Impact of ejaculation frequency on semen parameters and DNA fragmentation: a cross-sectional study
Impact of ejaculation frequency on semen parameters and DNA fragmentation: a cross-sectional study Open
November 11th, 2023. Date of enrollment of the first subject: November 11th, 2023.
View article: Structures and Biological Evaluation of 8,4′-oxyneolignans from the Roots of Platycodon grandifloras
Structures and Biological Evaluation of 8,4′-oxyneolignans from the Roots of Platycodon grandifloras Open
View article: Repeated Exposure to Sevoflurane in Neonatal Mice Induces Cognitive and Synaptic Impairments in a <scp>TTLL6</scp>‐Mediated Tubulin Polyglutamylation Manner
Repeated Exposure to Sevoflurane in Neonatal Mice Induces Cognitive and Synaptic Impairments in a <span>TTLL6</span>‐Mediated Tubulin Polyglutamylation Manner Open
Aims Repeated sevoflurane exposure during the neonatal stage may induce Tau phosphorylation, dendritic spine loss, and neurocognitive impairment in the developing brain. Tubulin tyrosine ligase like‐6 (TTLL6), which aggregates in dendrites…
View article: Cardiac repair using regenerating neonatal heart tissue-derived extracellular vesicles
Cardiac repair using regenerating neonatal heart tissue-derived extracellular vesicles Open
View article: Enriched environment mitigates cognitive impairment in pre-adolescent mice following repeated neonatal sevoflurane exposure by reducing TTBK1 expression and Tau phosphorylation
Enriched environment mitigates cognitive impairment in pre-adolescent mice following repeated neonatal sevoflurane exposure by reducing TTBK1 expression and Tau phosphorylation Open
Enriched environment (EE) is a living setting that provides visual, olfactory, tactile, and cognitive stimulation and has demonstrated potential treatment results in neurodevelopmental diseases. We aimed to elucidate whether the neurodevel…
View article: High-frequency jet ventilation in managing airway during whole-lung lavage under general anesthesia: A case report
High-frequency jet ventilation in managing airway during whole-lung lavage under general anesthesia: A case report Open
View article: Aggravation of photoinhibition during fruit development in Actinidia arguta (Sieb. et Zucc.) Planch. ex Miq
Aggravation of photoinhibition during fruit development in Actinidia arguta (Sieb. et Zucc.) Planch. ex Miq Open
View article: Characteristics, Outcomes, and Survival Factors of In-Hospital Cardiac Arrest in Cardiovascular Patients: A Multicenter Retrospective Cohort Study in Beijing, China
Characteristics, Outcomes, and Survival Factors of In-Hospital Cardiac Arrest in Cardiovascular Patients: A Multicenter Retrospective Cohort Study in Beijing, China Open
View article: CircIRAK3 Promotes Neutrophil Extracellular Trap Formation by Improving the Stability of ELANE mRNA in Sepsis
CircIRAK3 Promotes Neutrophil Extracellular Trap Formation by Improving the Stability of ELANE mRNA in Sepsis Open
Excessive formation of neutrophil extracellular traps (NETs) has been shown to exacerbate inflammatory injury and organ damage in patients with sepsis. Circular RNAs (circRNAs) abnormally expressed in immune cells of sepsis patients, and p…
View article: Comparison of the accuracy of procalcitonin, neutrophil CD64, and C-reactive protein for the diagnosis and prognosis of septic patients after antibiotic therapy
Comparison of the accuracy of procalcitonin, neutrophil CD64, and C-reactive protein for the diagnosis and prognosis of septic patients after antibiotic therapy Open
View article: Neuroprotective effects of testosterone on sevoflurane-induced neurotoxicity in testosterone-deprived male mice
Neuroprotective effects of testosterone on sevoflurane-induced neurotoxicity in testosterone-deprived male mice Open
This study aims to investigate whether androgen deprivation, simulating conditions of aging or disease-induced low testosterone levels, increases the susceptibility of male mice to sevoflurane neurotoxicity, and whether testosterone supple…
View article: Association between penultimate ejaculatory abstinence and sperm quality: a cross-sectional study
Association between penultimate ejaculatory abstinence and sperm quality: a cross-sectional study Open
Background Ejaculatory abstinence (EA) duration influences semen parameters. However, the impact of penultimate ejaculatory abstinence (PEA) on conventional and functional sperm parameters remains underexplored. Method A cross-sectional st…
View article: Hyaluronic Acid-Modified Micelles of Azithromycin and Quercetin Against Infections Caused by Methicillin-Resistant Staphylococcus Aureus
Hyaluronic Acid-Modified Micelles of Azithromycin and Quercetin Against Infections Caused by Methicillin-Resistant Staphylococcus Aureus Open
HA-AZI/Qe-M is a novel and effective nano-drug delivery system that can target intracellular bacterial infection, and it is expected to be safely used for the treatment of MRSA infection.
View article: Increased opioid consumption in neoadjuvant immunotherapy plus chemotherapy for patients with non‐small‐cell lung cancer: A multicenter, prospective cohort study
Increased opioid consumption in neoadjuvant immunotherapy plus chemotherapy for patients with non‐small‐cell lung cancer: A multicenter, prospective cohort study Open
Aims PD‐1 block was reported to impair opioid‐induced antinociception and affect cognitive function in rodents and non‐human primates. This prospective multicenter cohort study aims to investigate the possible impact of neoadjuvant immunot…
View article: Surveillance des infections invasives à streptocoques du groupe A au Canada, 2021–2022
Surveillance des infections invasives à streptocoques du groupe A au Canada, 2021–2022 Open
Contexte : L'infection invasive à streptocoques du groupe A (IISGA) (causée par Streptococcus pyogenes) est une maladie à déclaration obligatoire au Canada depuis 2000.Ce rapport résume les données démographiques, les types emm et la résis…
View article: Invasive pneumococcal disease surveillance in Canada, 2021–2022
Invasive pneumococcal disease surveillance in Canada, 2021–2022 Open
The number of cases of IPD continued to decrease in 2021 in comparison to previous years, however, 2022 saw a return to pre-COVID-19 levels. Disease due to PCV13 serotypes 3, 4, 9V and 19F, as well as non-PCV13 serotypes 12F and 20, is inc…
View article: Occludin and collagen IV degradation mediated by the T9SS effector SspA contributes to blood–brain barrier damage in ducks during Riemerella anatipestifer infection
Occludin and collagen IV degradation mediated by the T9SS effector SspA contributes to blood–brain barrier damage in ducks during Riemerella anatipestifer infection Open
View article: SIRT2 promotes base excision repair by transcriptionally activating OGG1 in an ATM/ATR-dependent manner
SIRT2 promotes base excision repair by transcriptionally activating OGG1 in an ATM/ATR-dependent manner Open
Sirtuin 2 (SIRT2) regulates the maintenance of genome integrity by targeting pathways of DNA damage response and homologous recombination repair. However, whether and how SIRT2 promotes base excision repair (BER) remain to be determined. H…
View article: Comparison of saline infusion test and captopril challenge test in the diagnosis of Chinese with primary aldosteronism in different age groups
Comparison of saline infusion test and captopril challenge test in the diagnosis of Chinese with primary aldosteronism in different age groups Open
Background To explore the diagnostic accuracy and the optimal cutoff value between the saline infusion test (SIT) and captopril challenge test (CCT) [including the value and suppression of plasma aldosterone concentration (PAC)] for primar…
View article: Focus on Upper Urinary Tract Stones Combined With Parenchymal Infiltrative Renal Pelvis Cancer
Focus on Upper Urinary Tract Stones Combined With Parenchymal Infiltrative Renal Pelvis Cancer Open
Introduction: Upper urinary tract stones combined with parenchymal infiltrative renal pelvic cancer is challenging to detect on imaging, and to evaluate the differential diagnosis. Case Presentation: The symptoms and diagnoses in three cas…
View article: High-Performance Photodynamic Therapy of Tongue Squamous Cell Carcinoma with Multifunctional Nano-Verteporfin
High-Performance Photodynamic Therapy of Tongue Squamous Cell Carcinoma with Multifunctional Nano-Verteporfin Open
The findings collectively suggest that RPV holds promise as a safe and effective therapeutic strategy for TSCC, offering a combination of targeted drug delivery with photodynamic therapy.
View article: Comparative analyses of Pleurotus pulmonarius mitochondrial genomes reveal two major lineages of mini oyster mushroom cultivars
Comparative analyses of Pleurotus pulmonarius mitochondrial genomes reveal two major lineages of mini oyster mushroom cultivars Open
View article: Meeting Report on the 3rd Chinese American Society for Mass Spectrometry Conference—Advancing Biological and Pharmaceutical Mass Spectrometry
Meeting Report on the 3rd Chinese American Society for Mass Spectrometry Conference—Advancing Biological and Pharmaceutical Mass Spectrometry Open
Following the highly successful Chinese American Society for Mass Spectrometry (CASMS) conferences in the previous 2 years, the 3rd CASMS Conference was held virtually on August 28–31, 2023, using the Gather.Town platform to bring together…
View article: Effects of the PI3K/Akt/HO-1 pathway on autophagy in a sepsis-induced acute lung injury mouse model
Effects of the PI3K/Akt/HO-1 pathway on autophagy in a sepsis-induced acute lung injury mouse model Open
Sepsis-induced lung injury is an acute hypoxic respiratory insufficiency caused by systemic infectious factors that results in alveolar epithelial cell and capillary endothelial cell injury, diffuse pulmonary interstitial edema, and alveol…
View article: Application of medium-chain fatty acids in metabolic diseases
Application of medium-chain fatty acids in metabolic diseases Open
Medium-chain fatty acids (MCFAs), which are important dietary fats, can be rapidly metabolized to efficiently produce a high amount of energy owing to their unique transportation system. MCFAs have thus become high-value functional foods. …
View article: Editorial: Anesthetic neurotoxicity in developing brains: mechanisms, biomarkers, and therapeutic targets
Editorial: Anesthetic neurotoxicity in developing brains: mechanisms, biomarkers, and therapeutic targets Open
EDITORIAL article Front. Neurol., 31 August 2023Sec. Pediatric Neurology Volume 14 - 2023 | https://doi.org/10.3389/fneur.2023.1279529