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Nuclear porcupine mediates XRCC6/Ku70 S-palmitoylation in the DNA damage response Open

Yang Chen, Mingming Xiao, Yaqi Mo, Jinlu Ma, Yamei Han , et al. · 2024

Background The activation of the DNA damage response (DDR) heavily relies on post-translational modifications (PTMs) of proteins, which play a crucial role in the prevention of genetic instability and tumorigenesis. Among these PTMs, palmi…

Supplementary Figure 1 from Effect of Niclosamide on Basal-like Breast Cancers Open

Angelina I. Londoño-Joshi, Rebecca C. Arend, Laura Aristizabal, Wenyan Lü, Rajeev S. Samant , et al. · 2023

PDF file - 128KB, Supplementary Figure S1. Sensitivity of MF10A mammary epithelial cells to niclosamide and TRA-8 mediated cytotoxicity. (A) Attached MCF10A cell line was treated for 48 hours with niclosamide (0.08, 0.1, 0.25 and 0.5 micro…

Supplementary Figure 1 from Effect of Niclosamide on Basal-like Breast Cancers Open

Angelina I. Londoño-Joshi, Rebecca C. Arend, Laura Aristizabal, Wenyan Lü, Rajeev S. Samant , et al. · 2023

PDF file - 128KB, Supplementary Figure S1. Sensitivity of MF10A mammary epithelial cells to niclosamide and TRA-8 mediated cytotoxicity. (A) Attached MCF10A cell line was treated for 48 hours with niclosamide (0.08, 0.1, 0.25 and 0.5 micro…

Supplementary Figure 2 from Effect of Niclosamide on Basal-like Breast Cancers Open

Angelina I. Londoño-Joshi, Rebecca C. Arend, Laura Aristizabal, Wenyan Lü, Rajeev S. Samant , et al. · 2023

PDF file - 209KB, Supplementary Figure S2. Niclosamide effect on Wnt/beta-catenin signaling. Activity of TCF/LEF plasmid reporter in the TOPflash assay was evaluated on adherent 2LMP, SUM159, HCC143 and HCC1187 cells. Cell lines were treat…

Supplementary Figure 3 from Effect of Niclosamide on Basal-like Breast Cancers Open

Angelina I. Londoño-Joshi, Rebecca C. Arend, Laura Aristizabal, Wenyan Lü, Rajeev S. Samant , et al. · 2023

PDF file - 99KB, Supplementary Figure S3. ATPlite viability of cells treated with niclosamide. 2LMP, SUM159, HCC1143 and HCC1187 adherent (A) or NAAE (B) cells were treated with niclosamide for 24 hours and analyzed for viability using ATP…

Data from Effect of Niclosamide on Basal-like Breast Cancers Open

Angelina I. Londoño-Joshi, Rebecca C. Arend, Laura Aristizabal, Wenyan Lü, Rajeev S. Samant , et al. · 2023

Basal-like breast cancers (BLBC) are poorly differentiated and display aggressive clinical behavior. These tumors become resistant to cytotoxic agents, and tumor relapse has been attributed to the presence of cancer stem cells (CSC). One o…

Supplementary Figure 3 from Effect of Niclosamide on Basal-like Breast Cancers Open

Angelina I. Londoño-Joshi, Rebecca C. Arend, Laura Aristizabal, Wenyan Lü, Rajeev S. Samant , et al. · 2023

PDF file - 99KB, Supplementary Figure S3. ATPlite viability of cells treated with niclosamide. 2LMP, SUM159, HCC1143 and HCC1187 adherent (A) or NAAE (B) cells were treated with niclosamide for 24 hours and analyzed for viability using ATP…

Supplementary Figure 2 from Effect of Niclosamide on Basal-like Breast Cancers Open

Angelina I. Londoño-Joshi, Rebecca C. Arend, Laura Aristizabal, Wenyan Lü, Rajeev S. Samant , et al. · 2023

PDF file - 209KB, Supplementary Figure S2. Niclosamide effect on Wnt/beta-catenin signaling. Activity of TCF/LEF plasmid reporter in the TOPflash assay was evaluated on adherent 2LMP, SUM159, HCC143 and HCC1187 cells. Cell lines were treat…

Supplementary Figure 4 from Effect of Niclosamide on Basal-like Breast Cancers Open

Angelina I. Londoño-Joshi, Rebecca C. Arend, Laura Aristizabal, Wenyan Lü, Rajeev S. Samant , et al. · 2023

PDF file - 96KB, Supplementary Figure S4. Wnt/beta-catenin signaling proteins in LRP6 KD cells. Western blot for expression of Wnt/beta-catenin signaling proteins in adherent 2LMP shRNA LRP6 knockdown cells compared to shRNA control cells.

Supplementary Figure 4 from Effect of Niclosamide on Basal-like Breast Cancers Open

Angelina I. Londoño-Joshi, Rebecca C. Arend, Laura Aristizabal, Wenyan Lü, Rajeev S. Samant , et al. · 2023

PDF file - 96KB, Supplementary Figure S4. Wnt/beta-catenin signaling proteins in LRP6 KD cells. Western blot for expression of Wnt/beta-catenin signaling proteins in adherent 2LMP shRNA LRP6 knockdown cells compared to shRNA control cells.

Supplementary Table 1 from Effect of Niclosamide on Basal-like Breast Cancers Open

Angelina I. Londoño-Joshi, Rebecca C. Arend, Laura Aristizabal, Wenyan Lü, Rajeev S. Samant , et al. · 2023

PDF file - 89KB, Supplementary Table S1. Sensitivity of BLBC cell lines to niclosamide mediated cytotoxicity. SUM159, HCC1187, HCC1143 and 2LMP BLBC NAAE and adherent cell lines were treated with niclosamide for 48 hours and analyzed for v…

Supplementary Table 1 from Effect of Niclosamide on Basal-like Breast Cancers Open

Angelina I. Londoño-Joshi, Rebecca C. Arend, Laura Aristizabal, Wenyan Lü, Rajeev S. Samant , et al. · 2023

PDF file - 89KB, Supplementary Table S1. Sensitivity of BLBC cell lines to niclosamide mediated cytotoxicity. SUM159, HCC1187, HCC1143 and 2LMP BLBC NAAE and adherent cell lines were treated with niclosamide for 48 hours and analyzed for v…

Data from Low-Density Lipoprotein Receptor-Related Protein 1 Promotes Cancer Cell Migration and Invasion by Inducing the Expression of Matrix Metalloproteinases 2 and 9 Open

Heesang Song, Yonghe Li, Jiyeon Lee, Alan L. Schwartz, Guojun Bu · 2023

The low-density lipoprotein receptor-related protein 1 (LRP1) is a multifunctional endocytic receptor involved in the metabolism of various extracellular ligands, including proteinases, that play critical roles in tumor invasion. Although …

Data from Low-Density Lipoprotein Receptor-Related Protein 1 Promotes Cancer Cell Migration and Invasion by Inducing the Expression of Matrix Metalloproteinases 2 and 9 Open

Heesang Song, Yonghe Li, Jiyeon Lee, Alan L. Schwartz, Guojun Bu · 2023

The low-density lipoprotein receptor-related protein 1 (LRP1) is a multifunctional endocytic receptor involved in the metabolism of various extracellular ligands, including proteinases, that play critical roles in tumor invasion. Although …

Supplementary Methods and Materials, Figures 1-3 from Low-Density Lipoprotein Receptor-Related Protein 1 Promotes Cancer Cell Migration and Invasion by Inducing the Expression of Matrix Metalloproteinases 2 and 9 Open

Heesang Song, Yonghe Li, Jiyeon Lee, Alan L. Schwartz, Guojun Bu · 2023

Supplementary Methods and Materials, Figures 1-3 from Low-Density Lipoprotein Receptor-Related Protein 1 Promotes Cancer Cell Migration and Invasion by Inducing the Expression of Matrix Metalloproteinases 2 and 9

Supplementary Video 1 from Low-Density Lipoprotein Receptor-Related Protein 1 Promotes Cancer Cell Migration and Invasion by Inducing the Expression of Matrix Metalloproteinases 2 and 9 Open

Heesang Song, Yonghe Li, Jiyeon Lee, Alan L. Schwartz, Guojun Bu · 2023

Supplementary Video 1 from Low-Density Lipoprotein Receptor-Related Protein 1 Promotes Cancer Cell Migration and Invasion by Inducing the Expression of Matrix Metalloproteinases 2 and 9

Supplementary Methods and Materials, Figures 1-3 from Low-Density Lipoprotein Receptor-Related Protein 1 Promotes Cancer Cell Migration and Invasion by Inducing the Expression of Matrix Metalloproteinases 2 and 9 Open

Heesang Song, Yonghe Li, Jiyeon Lee, Alan L. Schwartz, Guojun Bu · 2023

Supplementary Methods and Materials, Figures 1-3 from Low-Density Lipoprotein Receptor-Related Protein 1 Promotes Cancer Cell Migration and Invasion by Inducing the Expression of Matrix Metalloproteinases 2 and 9

Supplementary Video 2 from Low-Density Lipoprotein Receptor-Related Protein 1 Promotes Cancer Cell Migration and Invasion by Inducing the Expression of Matrix Metalloproteinases 2 and 9 Open

Heesang Song, Yonghe Li, Jiyeon Lee, Alan L. Schwartz, Guojun Bu · 2023

Supplementary Video 2 from Low-Density Lipoprotein Receptor-Related Protein 1 Promotes Cancer Cell Migration and Invasion by Inducing the Expression of Matrix Metalloproteinases 2 and 9

Supplementary Video 1 from Low-Density Lipoprotein Receptor-Related Protein 1 Promotes Cancer Cell Migration and Invasion by Inducing the Expression of Matrix Metalloproteinases 2 and 9 Open

Heesang Song, Yonghe Li, Jiyeon Lee, Alan L. Schwartz, Guojun Bu · 2023

Supplementary Video 1 from Low-Density Lipoprotein Receptor-Related Protein 1 Promotes Cancer Cell Migration and Invasion by Inducing the Expression of Matrix Metalloproteinases 2 and 9

Supplementary Video 2 from Low-Density Lipoprotein Receptor-Related Protein 1 Promotes Cancer Cell Migration and Invasion by Inducing the Expression of Matrix Metalloproteinases 2 and 9 Open

Heesang Song, Yonghe Li, Jiyeon Lee, Alan L. Schwartz, Guojun Bu · 2023

Supplementary Video 2 from Low-Density Lipoprotein Receptor-Related Protein 1 Promotes Cancer Cell Migration and Invasion by Inducing the Expression of Matrix Metalloproteinases 2 and 9

Correction: Niclosamide and its analogs are potent inhibitors of Wnt/β-catenin, mTOR and STAT3 signaling in ovarian cancer Open

Rebecca C. Arend, Angelina I. Londoño-Joshi, Abhishek Gangrade, Ashwini A. Katre, Chandrika Kurpad , et al. · 2018

[This corrects the article DOI: 10.18632/oncotarget.13466.].

Retraction notice to “SRI36160 is a specific inhibitor of Wnt/-catenin signaling in human pancreatic and colorectal cancer cells” [Canc. Lett. 389C (2017) 41–48] Open

Yonghe Li, Patsy G. Oliver, Wenyan Lü, Vibha Pathak, Sivaram Sridharan , et al. · 2018

Discovery of novel frizzled-7 inhibitors by targeting the receptor’s transmembrane domain Open

Wei Zhang, Wenyan Lü, Subramaniam Ananthan, Mark J. Suto, Yonghe Li · 2017

Frizzled (Fzd) proteins are seven transmembrane receptors that belong to a novel and separated family of G-protein-coupled receptors (GPCRs). The Fzd receptors can respond to Wnt proteins to activate the canonical β-catenin pathway which i…

Synthesis and preliminary assessment of the anticancer and Wnt/β-catenin inhibitory activity of small amide libraries of fenamates and profens Open

Bini Mathew, Judith V. Hobrath, Wenyan Lü, Yonghe Li, Robert C. Reynolds · 2017

As part of an ongoing program to study the anticancer activity of non-steroidal anti-inflammatory drugs (NSAIDs) through generating diversity libraries of multiple NSAID scaffolds, we synthesized a series of NSAID amide derivatives and scr…

Role of Wnt Co-Receptor LRP6 in Triple Negative Breast Cancer Cell Migration and Invasion Open

Jinlu Ma, Wenyan Lü, Dongquan Chen, Bo Xu, Yonghe Li · 2017

The low-density lipoprotein receptor-related protein 6 (LRP6) is an essential Wnt co-receptor of the Wnt/β-catenin signaling pathway. Although studies have shown an increased expression of LRP6 in several types of cancer, its function in t…

Niclosamide and its analogs are potent inhibitors of Wnt/β-catenin, mTOR and STAT3 signaling in ovarian cancer Open

Rebecca C. Arend, Angelina I. Londoño-Joshi, Abhishek Gangrade, Ashwini A. Katre, Chandrika Kurpad , et al. · 2016

Epithelial ovarian cancer (EOC) is the leading cause of gynecologic cancer mortality worldwide. Platinum-based therapy is the standard first line treatment and while most patients initially respond, resistance to chemotherapy usually arise…

Discovery of Novel Allosteric Eg5 Inhibitors Through Structure‐Based Virtual Screening Open

Wei Zhang, Ling Zhai, Wenyan Lü, Rebecca J. Boohaker, Indira Padmalayam , et al. · 2016

Mitotic kinesin Eg5 is an attractive anticancer drug target. Discovery of Eg5 inhibitors has been focused on targeting the ‘ monastrol ‐binding site’. However, acquired drug resistance has been reported for such inhibitors. Therefore, iden…

Discovery of a novel inhibitor of kinesin-like protein KIFC1 Open

Wei Zhang, Ling Zhai, Yimin Wang, Rebecca J. Boohaker, Wenyan Lü , et al. · 2016

Historically, drugs used in the treatment of cancers also tend to cause damage to healthy cells while affecting cancer cells. Therefore, the identification of novel agents that act specifically against cancer cells remains a high priority …

Identification of quinazoline compounds as novel potent inhibitors of Wnt/β-catenin signaling in colorectal cancer cells Open

Yonghe Li, Wenyan Lü, Surendra Kumar Saini, Omar Moukha‐Chafiq, Vibha Pathak , et al. · 2016

The Wnt/β-catenin signaling pathway is critical for the initiation and progression of most colon cancers, and has emerged as one of the most promising targets for colorectal cancer chemoprevention and treatment. In this study, we have disc…

Effects of niclosamide on Wnt/β-catenin signaling in cancer cells. Open

Wenyan Lü, Cuihong Lin, J. Roberts Michael, Ramos-Lewis William, Piazza Gary A. , et al. · 2015

(A) Prostate cancer PC-3 and breast cancer MDA-MB-231 cells in 6-well plates were treated with niclosamide at the indicated concentrations for 24 h. The levels of cytosolic free β-catenin were then examined by GST-E-cadherin binding assay.…

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