Yonghua Tong
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View article: Genetically engineered T cell membrane-camouflaged nanoparticles triggered cuproptosis for synergistic bladder cancer photothermal-immunotherapy
Genetically engineered T cell membrane-camouflaged nanoparticles triggered cuproptosis for synergistic bladder cancer photothermal-immunotherapy Open
Immunotherapy has become a promising and transformative approach for treating advanced or treatment-resistant bladder cancer (BCa). However, its efficacy remains limited due to the immunosuppressive tumor microenvironment (TME) and insuffi…
View article: Ultrasound-triggered piezoelectric biomaterials for enhanced cancer sonodynamic immunotherapy
Ultrasound-triggered piezoelectric biomaterials for enhanced cancer sonodynamic immunotherapy Open
Compared to traditional tumor treatment modalities, such as radiotherapy, chemotherapy, and surgical intervention, tumor immunotherapy offers potential benefits by enhancing the immune system's functionality, diminish immune evasion, and e…
View article: Genetically Engineered T Cell Membrane-Camouflaged Nanoparticles Triggered Cuproptosis for Synergistic Bladder Cancer Photothermal-Immunotherapy
Genetically Engineered T Cell Membrane-Camouflaged Nanoparticles Triggered Cuproptosis for Synergistic Bladder Cancer Photothermal-Immunotherapy Open
Immunotherapy has become a promising and transformative approach for treating advanced or treatment-resistant bladder cancer (BCa). However, its efficacy remains limited due to the immunosuppressive tumor microenvironment (TME) and insuffi…
View article: Reprogramming of Glucose Metabolism by Nanocarriers to Improve Cancer Immunotherapy: Recent Advances and Applications
Reprogramming of Glucose Metabolism by Nanocarriers to Improve Cancer Immunotherapy: Recent Advances and Applications Open
Although immunotherapy has made significant progress in cancer treatment, its limited responsiveness has greatly hindered widespread clinical application. The Warburg effect in tumor cells creates a tumor microenvironment (TME) characteriz…
View article: METTL3 promotes an immunosuppressive microenvironment in bladder cancer via m6A-dependent CXCL5/CCL5 regulation
METTL3 promotes an immunosuppressive microenvironment in bladder cancer via m6A-dependent CXCL5/CCL5 regulation Open
Background Bladder cancer (BLCA) is a challenging malignancy with a poor prognosis, particularly in muscle-invasive cases. Despite recent advancements in immunotherapy, response rates remain suboptimal. This study investigates the role of …
View article: The Application of Nanoparticles Targeting Cancer-Associated Fibroblasts
The Application of Nanoparticles Targeting Cancer-Associated Fibroblasts Open
Cancer-associated fibroblasts (CAF) are the most abundant stromal cells in the tumor microenvironment (TME), especially in solid tumors. It has been confirmed that it can not only interact with tumor cells to promote cancer progression and…
View article: The application of nanoparticles-based ferroptosis, pyroptosis and autophagy in cancer immunotherapy
The application of nanoparticles-based ferroptosis, pyroptosis and autophagy in cancer immunotherapy Open
Immune checkpoint blockers (ICBs) have been applied for cancer therapy and achieved great success in the field of cancer immunotherapy. Nevertheless, the broad application of ICBs is limited by the low response rate. To address this issue,…
View article: CircRPPH1 accelerates the proliferation and migration of bladder cancer via enhancing the STAT3 signaling pathway
CircRPPH1 accelerates the proliferation and migration of bladder cancer via enhancing the STAT3 signaling pathway Open
Bladder cancer (BCa) is a common malignant disease with high recurrence and variable prognosis. Circular RNAs (circRNAs) are implicated in the development of multiple diseases. However, the biological activities of circRNAs in BCa remain l…
View article: Second near-infrared nanomaterials for cancer photothermal immunotherapy
Second near-infrared nanomaterials for cancer photothermal immunotherapy Open
Photothermal immunotherapy has drawn worldwide attentions for malignant tumors based on noninvasive methods of nanomaterials and immune-associated drugs in the past years. Photothermal immunotherapy performed excellent effects and less adv…
View article: Predictive value of CD3+ cells and interleukin 2 receptor in systemic inflammatory response syndrome after percutaneous nephrolithotomy
Predictive value of CD3+ cells and interleukin 2 receptor in systemic inflammatory response syndrome after percutaneous nephrolithotomy Open
Objective The aim of the current study was to evaluate the risk factors that influence the development of postoperative systemic inflammatory response syndrome (SIRS) after percutaneous nephrolithotomy (PCNL), including cytokines and lymph…
View article: Circular RNAs in prostate cancer: Biogenesis, biological functions, and clinical significance
Circular RNAs in prostate cancer: Biogenesis, biological functions, and clinical significance Open
Circular RNAs (circRNAs) are covalently closed RNA molecules that play important regulatory roles in various tumors. Prostate cancer (PCa) is one of the most common malignant tumors in the world, with high morbidity and mortality. In recen…
View article: Biological Roles and Clinical Significance of Exosome-Derived Noncoding RNAs in Bladder Cancer
Biological Roles and Clinical Significance of Exosome-Derived Noncoding RNAs in Bladder Cancer Open
Bladder cancer (BCa) is a common heterogeneous urinary system tumor with high malignancy and limited advancement in treatment. Limited understanding of BCa has not contributed to any significant progress in diagnosis or treatment, explorin…