Yonghui Feng
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View article: Immune Suppression, Preexisting Immunity, and Mutation Tendency Shaped SARS-CoV-2 Evolution in Persistent Infection
Immune Suppression, Preexisting Immunity, and Mutation Tendency Shaped SARS-CoV-2 Evolution in Persistent Infection Open
SARS-CoV-2 evolution in persistent infection, which may induce long COVID-19, is predominantly manifested in immunocompromised hosts, who act as the viral reservoirs for future outbreaks. Therefore, understanding the evolutionary mechanism…
View article: <i>Plasmodium berghei</i> IMC1j interacts with δ-tubulin to orchestrate subpellicular microtubule organization in ookinetes
<i>Plasmodium berghei</i> IMC1j interacts with δ-tubulin to orchestrate subpellicular microtubule organization in ookinetes Open
Apicomplexan parasites possess specialized structures for cell invasion and replication, notably the inner membrane complex (IMC) and the subpellicular microtubules (SPMTs) situated beneath it. SPMTs are thought to interact with proteins e…
View article: Research trend on quantum dots for tumor diagnosis and therapy: a bibliometric analysis
Research trend on quantum dots for tumor diagnosis and therapy: a bibliometric analysis Open
As nanoscale luminous materials, quantum dots (QDs) have gained extensive application in tumor diagnosis and therapy. Their size-tunable optical properties, compact nanoscale dimensions, high surface area, and excellent biocompatibility re…
View article: Loss of serine/threonine protein phosphatase 6 severely impairs sexual stage development in malaria parasite Plasmodium berghei
Loss of serine/threonine protein phosphatase 6 severely impairs sexual stage development in malaria parasite Plasmodium berghei Open
Protein phosphorylation plays a critical role during the development of malaria parasites. Here, we performed a functional analysis of the Plasmodium berghei Ser/Thr protein phosphatase 6 (PbPP6), which is associated with the plasma membra…
View article: Runoff and Sediment Yield and Shear Strength Characteristics of Slopes with Different Degradation Types of Alpine Grasslands in the Yellow River Source Region
Runoff and Sediment Yield and Shear Strength Characteristics of Slopes with Different Degradation Types of Alpine Grasslands in the Yellow River Source Region Open
View article: An inner membrane complex protein IMC1g in <i>Plasmodium berghei</i> is involved in asexual stage schizogony and parasite transmission
An inner membrane complex protein IMC1g in <i>Plasmodium berghei</i> is involved in asexual stage schizogony and parasite transmission Open
The inner membrane complex (IMC), a double-membrane organelle underneath the plasma membrane in apicomplexan parasites, plays a significant role in motility and invasion and confers shape to the cell. We characterized the function of PbIMC…
View article: Interventions for psychiatric disorders among university students: An umbrella review of systematic reviews and meta-analyses
Interventions for psychiatric disorders among university students: An umbrella review of systematic reviews and meta-analyses Open
View article: The associations between single nucleotide polymorphisms and diabetic retinopathy risk: an umbrella review
The associations between single nucleotide polymorphisms and diabetic retinopathy risk: an umbrella review Open
This umbrella review was conducted aiming to assess the association between genetic variations and the development of diabetic retinopathy (DR) by collecting and evaluating available systematic reviews and meta-analysis results. We evaluat…
View article: Efficacy and safety of hepatitis B vaccine: an umbrella review of meta-analyses
Efficacy and safety of hepatitis B vaccine: an umbrella review of meta-analyses Open
Targeted vaccination could effectively reduce HBV infection, and adjuvant and booster vaccinations enhance seroprotection without significant reaction. Factors such as obesity and genetic polymorphisms may affect the efficacy.
View article: Ketogenic Diet and Multiple Health Outcomes: An Umbrella Review of Meta-Analysis
Ketogenic Diet and Multiple Health Outcomes: An Umbrella Review of Meta-Analysis Open
Numerous studies have examined the effects of ketogenic diets (KD) on health-related outcomes through meta-analyses. However, the presence of biases may compromise the reliability of conclusions. Therefore, we conducted an umbrella review …
View article: The Interaction of Dietary Patterns and Genetic Variants on the Risk of Cardiovascular Diseases in Chinese Patients with Type 2 Diabetes
The Interaction of Dietary Patterns and Genetic Variants on the Risk of Cardiovascular Diseases in Chinese Patients with Type 2 Diabetes Open
Scope Diabetes is an important risk factor for cardiovascular disease (CVD), which in turn is the most common and serious complication of diabetes. This study analyzes dietary patterns and single nucleotide polymorphisms (SNPs) in 543 diab…
View article: Birth spacing and risk of adverse pregnancy and birth outcomes: A systematic review and dose–response meta‐analysis
Birth spacing and risk of adverse pregnancy and birth outcomes: A systematic review and dose–response meta‐analysis Open
Introduction The association between extreme birth spacing and adverse outcomes is controversial, and available evidence is fragmented into different classifications of birth spacing. Material and methods We conducted a systematic review o…
View article: Plasmodium falciparum GAP40 Plays an Essential Role in Merozoite Invasion and Gametocytogenesis
Plasmodium falciparum GAP40 Plays an Essential Role in Merozoite Invasion and Gametocytogenesis Open
Red blood cell invasion is central to the pathogenesis of the malaria parasite, and the parasite proteins involved in this process are potential therapeutic targets. Gliding motility powers merozoite invasion and is driven by a unique mole…
View article: The Associations between Nucleotide Polymorphisms and Diabetic Retinopathy Risk: An Umbrella Review
The Associations between Nucleotide Polymorphisms and Diabetic Retinopathy Risk: An Umbrella Review Open
View article: Efficacy and safety of hepatitis B vaccine: an umbrella review of meta-analyses
Efficacy and safety of hepatitis B vaccine: an umbrella review of meta-analyses Open
There is a lack of synthesis of literature to determine hepatitis B vaccine (HepB) strategies for hepatitis B virus (HBV) supported by quality evidence. We aimed to explore the efficacy and safety of HepB strategies among people with diffe…
View article: Online flipped classroom with team-based learning promoted learning activity in a clinical laboratory immunology class: response to the COVID-19 pandemic
Online flipped classroom with team-based learning promoted learning activity in a clinical laboratory immunology class: response to the COVID-19 pandemic Open
View article: The association between dietary branched-chain amino acids and the risk of cardiovascular diseases in Chinese patients with type 2 diabetes: A hospital-based case–control study
The association between dietary branched-chain amino acids and the risk of cardiovascular diseases in Chinese patients with type 2 diabetes: A hospital-based case–control study Open
Background Previous studies showed conflicting evidence on the association between the intake of dietary branched-chain amino acid (BCAA) and the risk of cardiovascular disease (CVD). However, this relationship has not been studied in pati…
View article: [Alert in germline mutation predisposed to myeloid neoplasm: myelodysplastic syndromes accompanied with GATA2 deficeincy syndrome].
[Alert in germline mutation predisposed to myeloid neoplasm: myelodysplastic syndromes accompanied with GATA2 deficeincy syndrome]. Open
View article: Trastuzumab emtansine (T-DM1) vs trastuzumab (H) in Chinese patients (pts) with residual invasive disease after neoadjuvant chemotherapy for HER2-positive breast cancer (BC) in the phase III KATHERINE study
Trastuzumab emtansine (T-DM1) vs trastuzumab (H) in Chinese patients (pts) with residual invasive disease after neoadjuvant chemotherapy for HER2-positive breast cancer (BC) in the phase III KATHERINE study Open
View article: Improved antitumor efficacy of neutrophils stimulated by bacillus Calmette‑Gu�rin
Improved antitumor efficacy of neutrophils stimulated by bacillus Calmette‑Gu�rin Open
Bacillus Calmette‑Guérin (BCG) has become a significant treatment for bladder cancer, and neutrophils are reported to be associated with the antitumor effect of BCG. The aim of the present study was to clarify the antitumor function of neu…
View article: Artemisinin enhances the anti-tumor immune response in 4T1 breast cancer cells in vitro and in vivo
Artemisinin enhances the anti-tumor immune response in 4T1 breast cancer cells in vitro and in vivo Open
ART supplementation hindered 4T1 tumor growth in vivo by promoting T cell activation and quelling immunosuppression from Tregs and MDSCs in the tumor.
View article: Oral administration of vitamin D and importance in prevention of cerebral malaria
Oral administration of vitamin D and importance in prevention of cerebral malaria Open
Cerebral malaria (CM) is a serious and fatal malaria-associated syndrome caused by the development of an overwhelming proinflammatory response. Vitamin D (Vit.D; cholecalciferol) has regulatory functions associated with both innate and ada…
View article: L-Arginine supplementation inhibits the growth of breast cancer by enhancing innate and adaptive immune responses mediated by suppression of MDSCs in vivo
L-Arginine supplementation inhibits the growth of breast cancer by enhancing innate and adaptive immune responses mediated by suppression of MDSCs in vivo Open
View article: Genetic diversity of the Plasmodium falciparum apical membrane antigen I gene in parasite population from the China–Myanmar border area
Genetic diversity of the Plasmodium falciparum apical membrane antigen I gene in parasite population from the China–Myanmar border area Open
View article: L-Arginine supplementation in mice enhances NO production in spleen cells and inhibits Plasmodium yoelii transmission in mosquitoes
L-Arginine supplementation in mice enhances NO production in spleen cells and inhibits Plasmodium yoelii transmission in mosquitoes Open
L-Arg enhances host immunity against blood-stage parasites as well as suppressing subsequent parasite development in mosquitoes. L-Arg as an inexpensive and safe supplement may be used as a novel adjunct treatment against malarial infectio…
View article: L-Arginine Exacerbates Experimental Cerebral Malaria by Enhancing Pro-Inflammatory Responses
L-Arginine Exacerbates Experimental Cerebral Malaria by Enhancing Pro-Inflammatory Responses Open
L-Arginine (L-Arg), the substrate for nitric oxide (NO) synthase, has been used to treat malaria to reverse endothelial dysfunction in adults. However, the safety and efficacy of L-Arg remains unknown in malaria patients under the age of f…