Linhui Li
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View article: Epigenetic Landscapes in Ulcerative Colitis: From Mechanistic Insights to Clinical Translation
Epigenetic Landscapes in Ulcerative Colitis: From Mechanistic Insights to Clinical Translation Open
Ulcerative colitis (UC) is distinguished by nonspecific inflammation and ulceration of the rectal and colonic mucosa. The conventional therapeutic modalities for UC exhibit restricted efficacy, underscoring the importance of advancing nove…
View article: Gastrointestinal insufficiency is a risk factor for severely burned patients: a case-control study among 185 victims in Kunshan explosion
Gastrointestinal insufficiency is a risk factor for severely burned patients: a case-control study among 185 victims in Kunshan explosion Open
Background The Kunshan explosion in 2014 brought about massive casualties and injuries. Gastrointestinal (GI) insufficiency secondary to burn injuries was one of the most critical risk factors. However, the impact of GI insufficiency on bu…
View article: Research on the Application of CBL Combined with OSCE in the Teaching of Anorectal Standardized Training Physician of Traditional Chinese Medicine
Research on the Application of CBL Combined with OSCE in the Teaching of Anorectal Standardized Training Physician of Traditional Chinese Medicine Open
Objective：To explore the application effect of case-based learning ( CBL ) combined with objective structured clinical examination ( OSCE ) in the standardized training of anorectal residents of traditional Chinese medicine. Methods：From J…
View article: B blood type indicates poorer overall survival in patients with severe burn injuries: a case-control study
B blood type indicates poorer overall survival in patients with severe burn injuries: a case-control study Open
Our findings indicated that blood type B was an independent and significant predictor of OS in patients with severe burn injuries, likely due to differences in immune and coagulation responses. Although the study focused on the relationshi…
View article: Kaempferol Alleviates Carbon Tetrachloride-Induced Liver Fibrosis in Mice by Regulating Intestinal Short-Chain Fatty Acids
Kaempferol Alleviates Carbon Tetrachloride-Induced Liver Fibrosis in Mice by Regulating Intestinal Short-Chain Fatty Acids Open
Liver fibrosis remains a critical health concern with limited therapeutic options. Kaempferol (Kae) is a natural flavonoid widely present in natural plants, yet its role in modulating gut–liver axis interactions during fibrosis is unexplor…
View article: Optimal Timing and Approaches for First Tangential Excision in Patients with ≥70% TBSA Burns
Optimal Timing and Approaches for First Tangential Excision in Patients with ≥70% TBSA Burns Open
Objective: We aim to determine the optimal timing and approaches for first tangential excision of severely burned patients ≥70% total body surface area (TBSA). Background: Early tangential excision is the gold-standard surgical therapy for…
View article: Novel antibiotics against <i>Staphylococcus aureus</i> without detectable resistance by targeting proton motive force and FtsH
Novel antibiotics against <i>Staphylococcus aureus</i> without detectable resistance by targeting proton motive force and FtsH Open
The increased prevalence of methicillin‐resistant Staphylococcus aureus (MRSA) and its biofilms poses a great threat to human health. Especially, S. aureus ‐related osteomyelitis was hardly cured even by conventional antibiotics combined w…
View article: Suppression of overactivated immunity in the early stage is the key to improve the prognosis in severe burns
Suppression of overactivated immunity in the early stage is the key to improve the prognosis in severe burns Open
Background Severe burns can lead to systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome (MODS) due to inflammation-immunity dysregulation. This study aimed to identify key immune-related molecules and pot…
View article: A 10-year mono-center study on patients with burns ≥70% TBSA: prediction model construction and multicenter validation – retrospective cohort
A 10-year mono-center study on patients with burns ≥70% TBSA: prediction model construction and multicenter validation – retrospective cohort Open
Background: Burn injuries with ≥70% total body surface area (TBSA) are especially acute and life-threatening, leading to severe complications and terrible prognosis, while a powerful model for the prediction of overall survival (OS) is lac…
View article: Mechanism of Mulberry Leaves and Black Sesame in Alleviating Slow Transit Constipation Revealed by Multi-Omics Analysis
Mechanism of Mulberry Leaves and Black Sesame in Alleviating Slow Transit Constipation Revealed by Multi-Omics Analysis Open
Traditional Chinese medicine (TCM) possesses the potential of providing good curative effects with no side effects for the effective management of slow transit constipation (STC), an intestinal disease characterized by colonic dyskinesia. …
View article: Subtype recognition and identification of a prognosis model characterized by antibody-dependent cell phagocytosis-related genes in breast cancer
Subtype recognition and identification of a prognosis model characterized by antibody-dependent cell phagocytosis-related genes in breast cancer Open
We identified two subtypes associated with ADCP gene expression in breast cancer. They have significant differences in immune cells, molecular functions, HLA family genes, immune scores, stromal scores, and inflammatory gene expression, wh…
View article: Repurposing of the antimalarial agent tafenoquine to combat MRSA
Repurposing of the antimalarial agent tafenoquine to combat MRSA Open
Staphylococcus aureus is an important human pathogen that often leads to hospital-acquired and community-acquired infections. The appearance of methicillin-resistant S. aureus (MRSA) has made the treatment extremely challenging. There is a…
View article: Identification of subtype recognition and prognosis model characterized by Antibody-dependent cell phagocytosis related genes in breast cancer
Identification of subtype recognition and prognosis model characterized by Antibody-dependent cell phagocytosis related genes in breast cancer Open
Background Breast cancer (BC) is a heterogeneous tumor with a variety of etiology and clinical features. Antibody-dependent cell phagocytosis (ADCP) is the last step of immune checkpoint inhibition (ICI), and macrophages destroy tumor cell…
View article: Inositol possesses antifibrotic activity and mitigates pulmonary fibrosis
Inositol possesses antifibrotic activity and mitigates pulmonary fibrosis Open
Background Myo-inositol (or inositol) and its derivatives not only function as important metabolites for multiple cellular processes but also act as co-factors and second messengers in signaling pathways. Although inositol supplementation …
View article: Human genetic history on the Tibetan Plateau in the past 5100 years
Human genetic history on the Tibetan Plateau in the past 5100 years Open
Using genome-wide data of 89 ancient individuals dated to 5100 to 100 years before the present (B.P.) from 29 sites across the Tibetan Plateau, we found plateau-specific ancestry across plateau populations, with substantial genetic structu…
View article: Maternal genetic history of ancient Tibetans over the past 4000 years
Maternal genetic history of ancient Tibetans over the past 4000 years Open
The settlement of the Tibetan Plateau epitomizes human adaptation to a high-altitude environment that poses great challenges to human activity. Here, we reconstruct a 4000-year maternal genetic history of Tibetans using 128 ancient mitocho…
View article: Antibacterial and antibiofilm efficacy of repurposing drug hexestrol against methicillin-resistant Staphylococcus aureus
Antibacterial and antibiofilm efficacy of repurposing drug hexestrol against methicillin-resistant Staphylococcus aureus Open
There has been an explosion in the prevalence of methicillin-resistant Staphylococcus aureus (MRSA) because of the indiscriminate use of antibiotics. In this study, we repurposed hexestrol (HXS) as an antibacterial agent to fight planktoni…
View article: Targeting AMPK/eNOS pathway and mitochondria by sonlicromanol protects myocardial cells against ischemia-reperfusion injury
Targeting AMPK/eNOS pathway and mitochondria by sonlicromanol protects myocardial cells against ischemia-reperfusion injury Open
This work evaluated the cardioprotective effects of sonlicromanol, a new mitochondrial-directed drug, on cardiac ischemia/reperfusion (I/R) injury and explored the involvement of inflammatory and oxidative responses via activation of AMPK-…
View article: Triple combination of SPR741, clarithromycin, and erythromycin against<i>Acinetobacter baumannii</i>and its tolerant phenotype
Triple combination of SPR741, clarithromycin, and erythromycin against<i>Acinetobacter baumannii</i>and its tolerant phenotype Open
Aims Extensively drug-resistant (XDR) Acinetobacter baumannii poses a severe threat to public health due to its ability to form biofilms and persister cells, which contributes to critical drug resistance and refractory device-associated in…
View article: Drug synergy discovery of tavaborole and aminoglycosides against Escherichia coli using high throughput screening
Drug synergy discovery of tavaborole and aminoglycosides against Escherichia coli using high throughput screening Open
High incidences of urinary tract infection (UTI) of aminoglycosides-resistant E.coli causes a severe burden for public health. A new therapeutic strategy to ease this crisis is to repurpose non-antibacterial compounds to increase aminoglyc…
View article: Pixantrone Sensitizes Gram-Negative Pathogens to Rifampin
Pixantrone Sensitizes Gram-Negative Pathogens to Rifampin Open
Bacterial resistance has become increasingly serious because of the widespread use and abuse of antibiotics. In particular, the emergence of multidrug-resistant bacteria has posed a serious threat to human public health.
View article: Effects of Climate Change on the Climatic Production Potential of Potatoes in Inner Mongolia, China
Effects of Climate Change on the Climatic Production Potential of Potatoes in Inner Mongolia, China Open
Understanding the impacts of regional climate change on crop production will benefit strategic decisions for future agricultural adaptation in China. In this study, the climatic production potential of potato over the past 61 years in Inne…
View article: Sding Chung: an early multi-burial cave site on the Tibetan Plateau
Sding Chung: an early multi-burial cave site on the Tibetan Plateau Open
This study presents preliminary discoveries from Sding Chung cave, an early multi-burial cave site in the Himalayan highlands dating from 300BC–AD 300. Multiple human and animal bones within the cave provide unique evidence for understandi…
View article: The efficacy and safety of simple-needling for the treatment of primary dysmenorrhea compared with ibuprofen
The efficacy and safety of simple-needling for the treatment of primary dysmenorrhea compared with ibuprofen Open
Background: Needling and ibuprofen are often used clinically to treat primary dysmenorrhea (PD). However, the difference between the efficacy and safety of the treatment of PD is not clear. This study evaluates the efficacy and safety of s…