Yonghui Lv
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View article: Clathrin mediated endocytosis targeting chimera for targeted membrane proteins degradation and enhance CAR-T cell anti-tumor therapy
Clathrin mediated endocytosis targeting chimera for targeted membrane proteins degradation and enhance CAR-T cell anti-tumor therapy Open
View article: Monocyte-to-albumin ratio outperforms triglyceride-glucose index in associating with stroke prevalence among diabetics: an NHANES cross-sectional study
Monocyte-to-albumin ratio outperforms triglyceride-glucose index in associating with stroke prevalence among diabetics: an NHANES cross-sectional study Open
This NHANES analysis (N = 15,679) establishes elevated MAR as significantly associated with prevalent Stroke, outperforming the TyG Index especially in diabetics. Diabetic individuals in the highest MAR quartile exhibited 2.5-fold greater …
View article: Quercetin attenuates acute lung injury after intracerebral hemorrhage in rats via PI3K/AKT/NF-κB-mediated anti-inflammatory mechanisms
Quercetin attenuates acute lung injury after intracerebral hemorrhage in rats via PI3K/AKT/NF-κB-mediated anti-inflammatory mechanisms Open
View article: Mechanisms underlining R-loop biology and implications for human disease
Mechanisms underlining R-loop biology and implications for human disease Open
R-loops are three-stranded non-canonical nucleic acid structures composed of nascent RNA hybridized with the template DNA strand, leaving the non-template DNA strand displaced. These structures play crucial roles in regulating gene express…
View article: A Fluorinated Supramolecular Self‐Assembled Peptide as Nanovaccine Adjuvant for Enhanced Cancer Vaccine Therapy (Small Methods 5/2023)
A Fluorinated Supramolecular Self‐Assembled Peptide as Nanovaccine Adjuvant for Enhanced Cancer Vaccine Therapy (Small Methods 5/2023) Open
Front Cover In article number 2201409, Daqing Sun, Dan Ding, and co-workers propose a fluorinated supramolecular strategy for developing a cancer vaccine adjuvant, of which 4RDP(F5) containing tetra-arginine (4R) and dipentafluorophenylala…
View article: Prognostic value of immune biomarkers in renal clear cell carcinoma
Prognostic value of immune biomarkers in renal clear cell carcinoma Open
Objective: To analyze the expression of tumor infiltrating lymphocytes (TILs) and immune biomarkers to investigate their prognostic value in patients with Clear cell renal cell carcinoma (ccRCC). Methods: This retrospective study enrolled …
View article: Melittin Tryptophan Substitution with a Fluorescent Amino Acid Reveals the Structural Basis of Selective Antitumor Effect and Subcellular Localization in Tumor Cells
Melittin Tryptophan Substitution with a Fluorescent Amino Acid Reveals the Structural Basis of Selective Antitumor Effect and Subcellular Localization in Tumor Cells Open
Melittin is a membrane-active peptide with strong anticancer activity against various cancers. Despite decades of research, the role of the singular Trp in the anticancer activity and selectivity of melittin remains poorly understood. Here…
View article: An in Silico Approach to Reveal the Nanodisc Formulation of Doxorubicin
An in Silico Approach to Reveal the Nanodisc Formulation of Doxorubicin Open
Molecular dynamic behaviors of nanodisc (ND) formulations of free doxorubicin (DOX) and DOX conjugated lipid prodrug molecules were investigated by molecular dynamics (MD) simulations. We have unveiled how formulation design affects the dr…
View article: Intravascular ultrasound-guided percutaneous coronary intervention for patients with coronary bifurcation lesions
Intravascular ultrasound-guided percutaneous coronary intervention for patients with coronary bifurcation lesions Open
Background and Objective: Intravascular ultrasound (IVUS) could take on a vital position when angiographic images are not clear enough to be precisely visualized or measured by computer-aided technology. This meta-analysis was designed to …
View article: Comparison of early and delayed invasive strategies in short-medium term among patients with non-ST segment elevation acute coronary syndrome: A systematic review and meta-analysis
Comparison of early and delayed invasive strategies in short-medium term among patients with non-ST segment elevation acute coronary syndrome: A systematic review and meta-analysis Open
The systematic review and meta-analysis demonstrated that the early invasive strategy had a beneficial trend on all-cause death and significantly reduced the composite endpoint in patients with NSTE-ACS, but increased the rate of revascula…
View article: Drug-coated balloon versus drug-eluting stent in de novo small coronary vessel disease
Drug-coated balloon versus drug-eluting stent in de novo small coronary vessel disease Open
Background: Drug-coated balloon as a novel therapeutic strategy has been used to treat restenosis in cases of bare metal and drug-eluting stents. However, evidence of its safety and efficacy is scarce in de novo small coronary artery vesse…
View article: De-escalation versus standard dual antiplatelet therapy in patients undergoing percutaneous coronary intervention: a systematic review and meta-analysis
De-escalation versus standard dual antiplatelet therapy in patients undergoing percutaneous coronary intervention: a systematic review and meta-analysis Open
Switching from a potent P2Y12 blocker to clopidogrel is not uncommon for antiplatelet therapy in patients undergoing percutaneous coronary intervention. This meta-analysis aimed to investigate the efficacy and safety of this de-…
View article: De-escalation versus standard dual antiplatelet therapy in patients undergoing percutaneous coronary intervention: a systematic review and meta-analysis
De-escalation versus standard dual antiplatelet therapy in patients undergoing percutaneous coronary intervention: a systematic review and meta-analysis Open
Switching from a potent P2Y12 blocker to clopidogrel is not uncommon for antiplatelet therapy in patients undergoing percutaneous coronary intervention. This meta-analysis aimed to investigate the efficacy and safety of this de-…
View article: Modified double-stent strategy may be an optimal choice for coronary bifurcation lesions
Modified double-stent strategy may be an optimal choice for coronary bifurcation lesions Open
Background and objective: The modified double-stent and provisional stenting strategies have been widely used in patients with coronary bifurcation lesions, but what is the optimization has not been clearly defined. This meta-analysis is t…