Yong Chul Lee
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View article: Non-invasive aspergillosis following COVID-19 exacerbates the severity of SARS-CoV-2 infection
Non-invasive aspergillosis following COVID-19 exacerbates the severity of SARS-CoV-2 infection Open
Background A limited number of large-scale population-based studies regarding the causality between COVID-19 and respiratory aspergillosis exist. Herein, using nationwide data, we investigated whether SARS-CoV-2 infection increases inciden…
View article: A Novel Machine Learning Approach to Assist Early Diagnosis of Diffuse Panbronchiolitis
A Novel Machine Learning Approach to Assist Early Diagnosis of Diffuse Panbronchiolitis Open
View article: Growing chronic consolidative lesion with an air bronchogram
Growing chronic consolidative lesion with an air bronchogram Open
View article: Isolated recurrent metastatic pulmonary nodule from the kidney: An extraordinarily long interval
Isolated recurrent metastatic pulmonary nodule from the kidney: An extraordinarily long interval Open
Key message Our case highlights the importance of follow‐up. Previous meta‐analysis has shown that patients with sub‐centimetre nodules may have extended follow‐up intervals before requiring intervention, unlike those with larger nodules e…
View article: A rare occurrence of paragonimiasis accompanied by cryptococcal pneumonia
A rare occurrence of paragonimiasis accompanied by cryptococcal pneumonia Open
Key message Pulmonary paragonimiasis may be accompanied by a rare infectious disease, such as cryptococcal pneumonia. To our knowledge, this is the first case ever reported in the English literature.
View article: Calcifying fibrous tumour of the pleura without gross calcification
Calcifying fibrous tumour of the pleura without gross calcification Open
Key message Calcifying fibrous tumours of the pleura (CFTP) typically appear as calcified, non‐enhancing lesions on chest CT scans. However, enhancing pleural lesions can mimic malignancy like mesothelioma. We report a rare case that enhan…
View article: A patient with dyspnea and multiple pulmonary nodules
A patient with dyspnea and multiple pulmonary nodules Open
View article: Prior respiratory syncytial viral infection contributes to severe COVID‐19 illness: A nationwide cohort study
Prior respiratory syncytial viral infection contributes to severe COVID‐19 illness: A nationwide cohort study Open
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), continues to be a major threat to public health around the world.1 Recently, there has been a growing recognition of the influence…
View article: Non-Invasive Aspergillus Infections Following COVID-19 Exacerbate the Severity of SARS-CoV-2 Infection
Non-Invasive Aspergillus Infections Following COVID-19 Exacerbate the Severity of SARS-CoV-2 Infection Open
View article: An Analysis of Naval Academy Female Candidates’ Physical Fitness and Transition after Admission
An Analysis of Naval Academy Female Candidates’ Physical Fitness and Transition after Admission Open
View article: A Rare Case of Familial Schwannomatosis Showing Intrafamilial Variability with Identification of a Shared Novel Germline SMARCB1 Mutation
A Rare Case of Familial Schwannomatosis Showing Intrafamilial Variability with Identification of a Shared Novel Germline SMARCB1 Mutation Open
Schwannomatosis is characterized by the presence of multiple schwannomas without landmarks of NF2. It is considered the rarest form of neurofibromatosis (NF). Here, we report the first case of familial schwannomatosis with regard to the se…
View article: <scp>SARS‐CoV</scp>‐2 infection in severe asthma is associated with worsening of <scp>COVID</scp>‐19 through respiratory <scp>NLRP3</scp> inflammasome activation
<span>SARS‐CoV</span>‐2 infection in severe asthma is associated with worsening of <span>COVID</span>‐19 through respiratory <span>NLRP3</span> inflammasome activation Open
Recent clinical data suggest that the outcome of coronavirus disease 2019 (COVID-19) in asthmatic patients depends on the subtype and severity of asthma1, 2; however, there is limited information on the pathobiological outcomes of superimp…
View article: Tracheal neurofibroma treated by repeated flexible bronchoscopic cryotherapy: A case report
Tracheal neurofibroma treated by repeated flexible bronchoscopic cryotherapy: A case report Open
Rationale: Isolated endotracheal neurofibroma is very rare. The majority of neurofibromas are benign, but rarely, they can become cancerous. Furthermore, symptomatic neurofibroma is usually treated by surgical resection. Recently, several …
View article: Prevalence and comorbidities of bronchiolitis in adults
Prevalence and comorbidities of bronchiolitis in adults Open
Bronchiolitis generally refers to inflammation and/or fibrosis of the non-cartilaginous small airways located approximately from the 8th airway generation down to the terminal and respiratory bronchioles. In contrast to young children, the…
View article: Tyrosine Kinase Inhibitor Activity in Patients with NSCLC Harboring Uncommon <i>EGFR</i> Mutations: A Retrospective International Cohort Study (UpSwinG)
Tyrosine Kinase Inhibitor Activity in Patients with NSCLC Harboring Uncommon <i>EGFR</i> Mutations: A Retrospective International Cohort Study (UpSwinG) Open
Background Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR TKIs) are standard of care for patients with EGFR mutation-positive non–small-cell lung cancer (NSCLC) with common mutations (Del19 or L858R); however, 7%-23% of …
View article: COPD is a risk factor for COVID-19, but does not confer increased severity of the disease
COPD is a risk factor for COVID-19, but does not confer increased severity of the disease Open
View article: Sequential afatinib and osimertinib in patients with EGFR mutation-positive NSCLC and acquired T790M: A global non-interventional study (UpSwinG)
Sequential afatinib and osimertinib in patients with EGFR mutation-positive NSCLC and acquired T790M: A global non-interventional study (UpSwinG) Open
Sequential afatinib and osimertinib demonstrated encouraging activity in patients with EGFR mutation-positive NSCLC and acquired T790M. Activity was observed across all subgroups, including patients with poor ECOG PS or brain metastases. E…
View article: COPD is a Risk Factor for COVID-19, But Does Not Confer Increased Severity of the Disease
COPD is a Risk Factor for COVID-19, But Does Not Confer Increased Severity of the Disease Open
Epidemiologic studies suggest that COPD is associated with an increased risk of poor outcome in patients with COVID-19, although they failed to demonstrate COPD as a risk factor for acquiring COVID-19. However, most data have come from a l…
View article: Roles of PI3K pan-inhibitors and PI3K-δ inhibitors in allergic lung inflammation: a systematic review and meta-analysis
Roles of PI3K pan-inhibitors and PI3K-δ inhibitors in allergic lung inflammation: a systematic review and meta-analysis Open
Meta-analysis can be applied to study the effectiveness of the summary estimates for experimental papers, producing objective and unbiased results. We investigated the effects of phosphoinositide-3-kinase (PI3K) on the inflammatory profile…
View article: Epithelial PI3K-δ Promotes House Dust Mite-Induced Allergic Asthma in NLRP3 Inflammasome-Dependent and -Independent Manners
Epithelial PI3K-δ Promotes House Dust Mite-Induced Allergic Asthma in NLRP3 Inflammasome-Dependent and -Independent Manners Open
The results of this study suggest that PI3K-δ-isoform can promote HDM-induced allergic airway inflammation via NLRP3 inflammasome-dependent response as well as via NLRP3 inflammasome-independent epithelial cell activation.
View article: Defining Bronchial Asthma with Phosphoinositide 3-Kinase Delta Activation: Towards Endotype-Driven Management
Defining Bronchial Asthma with Phosphoinositide 3-Kinase Delta Activation: Towards Endotype-Driven Management Open
Phosphoinositide 3-kinase (PI3K) pathways play a critical role in orchestrating the chronic inflammation and the structural changes of the airways in patients with asthma. Recently, a great deal of progress has been made in developing sele…
View article: A Novel Insight on Endotyping Heterogeneous Severe Asthma Based on Endoplasmic Reticulum Stress: Beyond the “Type 2/Non-Type 2 Dichotomy”
A Novel Insight on Endotyping Heterogeneous Severe Asthma Based on Endoplasmic Reticulum Stress: Beyond the “Type 2/Non-Type 2 Dichotomy” Open
Severe asthma is an extremely heterogeneous clinical syndrome in which diverse cellular and molecular pathobiologic mechanisms exist, namely endotypes. The current system for endotyping severe asthma is largely based on inflammatory cellul…
View article: Phosphoinositide 3-kinase-delta could be a biomarker for eosinophilic nasal polyps
Phosphoinositide 3-kinase-delta could be a biomarker for eosinophilic nasal polyps Open
View article: Subcellular Organelles in Immune Responses of Severe Asthma: The Roles of Mitochondria and Endoplasmic Reticulum
Subcellular Organelles in Immune Responses of Severe Asthma: The Roles of Mitochondria and Endoplasmic Reticulum Open
Subcellular organelles including mitochondria and endoplasmic reticulum are now considered as one major target for many therapeutic approaches. In fact, recent evidence has uncovered the roles of mitochondria as a direct inflammatory and i…
View article: Airway epithelial phosphoinositide 3-kinase-δ contributes to the modulation of fungi-induced innate immune response
Airway epithelial phosphoinositide 3-kinase-δ contributes to the modulation of fungi-induced innate immune response Open
Background Respiratory fungal exposure is known to be associated with severe allergic lung inflammation. Airway epithelium is an essential controller of allergic inflammation. An innate immune recognition receptor, nucleotide-binding domai…
View article: Can Controlling Endoplasmic Reticulum Dysfunction Treat Allergic Inflammation in Severe Asthma With Fungal Sensitization?
Can Controlling Endoplasmic Reticulum Dysfunction Treat Allergic Inflammation in Severe Asthma With Fungal Sensitization? Open
Severe asthma is a heterogeneous disease entity to which diverse cellular components and pathogenetic mechanisms contribute. Current asthma therapies, including new biologic agents, are mainly targeting T helper type 2 cell-dominant inflam…
View article: Endobronchial epithelial-myoepithelial carcinoma of the lung
Endobronchial epithelial-myoepithelial carcinoma of the lung Open
An 83-year-old woman presented to our emergency department with mild dyspnoea. The patient had been in her usual state of health until 3 days prior to admission. Her medical history revealed no specific illness, and she was a never-smoker.…
View article: Endoplasmic Reticulum Stress and Allergic Diseases
Endoplasmic Reticulum Stress and Allergic Diseases Open
View article: Benign metastasizing leiomyoma presenting as multiple cystic pulmonary nodules: a case report
Benign metastasizing leiomyoma presenting as multiple cystic pulmonary nodules: a case report Open
View article: Inhaled indacaterol for the treatment of COPD patients with destroyed lung by tuberculosis and moderate-to-severe airflow limitation: results from the randomized INFINITY study
Inhaled indacaterol for the treatment of COPD patients with destroyed lung by tuberculosis and moderate-to-severe airflow limitation: results from the randomized INFINITY study Open
Indacaterol provided significantly superior bronchodilation, significant improvement in breathlessness and improved health status with comparable safety versus placebo in Korean COPD patients with destroyed lung by TB and moderate-to-sever…